Twenty years after undergoing a life-saving treatment at Loyola University Medical Center, cancer survivor Carolyn Gatenby returned to Loyola to donate 20 handmade quilts. “I wanted to give back,” Mrs. Gatenby said. “I’ve had 20 good years that I didn’t think I’d have.”
Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.
Scientists at The Scripps Research Institute (TSRI) have discovered why some cancers may reoccur after years in remission.
Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells—a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.
Cell therapy company jCyte has received Regenerative Medicine Advanced Therapy designation from the FDA for their developmental retinitis pigmentosa therapy.
UCLA study identifies a potential test that may help select patients for whom combination therapy could be most effective
A new $5 million challenge gift aims to boost scientific research on bipolar disorder, while honoring the legacy of an automotive pioneer who battled the condition during his life.
A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers. The finding, reported in the Apr. 28 issue of Nature Communications, adds to evidence for the intimate link between stem cells and cancer, and advances prospects for regenerative medicine and cancer treatments.
Using CRISPR technology, a team of researchers led by Farshid Guilak, PhD, at Washington University School of Medicine in St. Louis, rewired stem cells' genetic circuits to produce an anti-inflammatory arthritis drug when the cells encounter inflammation. The technique eventually could act as a vaccine for arthritis and other chronic conditions.
A team of scientists led by Lorenzo Puri, M.D., Ph.D., has identified a previously unrecognized step in stem cell-mediated muscle regeneration. The study, published in Genes and Development, helps explain why muscle stem cells lose the ability to generate new muscle as they age and provides insight into accelerated muscle stem cell aging in muscular dystrophy.
On Monday, April 24, the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine will host its third Stem Cell Symposium, focusing on the importance of cell metabolism and epigenetics. Leading scientists from the U.S., Japan and Germany will present their latest research and describe the hurdles to translating new finding into therapeutics.
New research by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA overturns a long-standing paradigm about how axons grow during embryonic development. The findings of the study, led by Samantha Butler, associate professor of neurobiology, could help scientists replicate or control the way axons grow, which may be applicable for diseases that affect the nervous system, such as diabetes, as well as injuries that sever nerves.
Cell-based therapy company jCyte is launching a Phase 2b clinical trial to study the effectiveness of its developmental therapy for retinitis pigmentosa.
Two Iowa State research groups are combining their expertise to change stem cells for nerve regrowth. The groups -- one led by a mechanical engineer and the other by a chemical engineer -- just published their findings in Advanced Healthcare Materials.
St. Jude Children’s Research Hospital study examines origin of blood stem cells during development and offers clues for making “donor blood” in the laboratory for therapeutic use
Researchers from the University of Illinois at Chicago have identified a molecular switch that converts skin cells into cells that make up blood vessels, which could ultimately be used to repair damaged vessels in patients with heart disease or to engineer new vasculature in the lab.
In a new paper, a large team of researchers led by senior author Kelly Frazer, PhD, professor of pediatrics and director of the Institute for Genomic Medicine at University of California San Diego School of Medicine describe a new collection of 222 systematically derived and characterized iPSC lines generated as part of the National Heart, Lung and Blood Institute’s NextGen consortium.
Encouraging more high school students to pursue careers in agriculture—that’s the idea behind USDA iLEARN professional development workshops for science and ag teachers.
Two prominent Cedars-Sinai investigators — one leading the development of biological treatments for heart disease, the other spearheading the design and analysis of clinical trials for cancer research — were inducted April 3 into the Johns Hopkins University Society of Scholars. Eduardo Marbán, MD, PhD, and Steven Piantadosi, MD, PhD, are among a select group of medical researchers to receive the honor.
Phase I clinical trial evaluating safety of neural stem cell transplantation being expanded to four more qualifying participants.
Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. They identified individual and shared defects in the cells that could inform treatment efforts.
Researchers from Case Western Reserve University School of Medicine have developed a breakthrough technique to harvest cells directly from urine, and grow them into durable, clinically relevant stem cells to study Down syndrome.
Scientists at the University of Wisconsin-Madison are using the decellularized husks of plants such as parsley, vanilla and orchids to form three-dimensional scaffolds that can then be primed and seeded with human stem cells to optimize their growth in the lab dish and, ultimately, create novel biomedical implants.
Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians at the University of Illinois Hospital & Health Sciences System have documented the first cure of an adult patient with congenital dyserythropoietic anemia.
The Galat laboratory at Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC). This type of stem cell has the potential to develop into many different kinds of cells in the body, and is capable of participating in organ repair and function. These qualities have prompted scientists to test the use of hPSC to treat some diseases. However, the development of a fully defined system to generate functional blood cell precursors has proven to be a significant challenge. The Galat lab’s findings hold promise to overcome this challenge.
The effect of multipotent adult progenitor stem cells on stroke recovery were the focus of two recently published papers that include researchers at the Institute for Stroke and Cerebrovascular Disease at The University of Texas Health Science Center at Houston (UTHealth).
A new study published in the journal Stem Cells demonstrates how electroacupuncture triggers a neurological mechanism that can help promote tissue repair and relieve injury-induced pain. The findings provide the most comprehensive picture yet of how electroacupuncture stimulates the brain to facilitate the release of stem cells and adds new insight relating to the cells’ healing properties.
A discovery, several years in the making, by University at Buffalo researchers proves that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain. The applications could be significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient’s own cells.
An international research team, led by scientists at University of California San Diego School of Medicine, has created the first cellular model of anorexia nervosa (AN), reprogramming induced pluripotent stem cells (iPSCs) derived from adolescent females with the eating disorder.
Intestinal stem cells rejuvenate daily so bowels will stay healthy and function normally, but a new study in Cell Reports suggests they also age along with people and lose their regenerative capacity. Reporting their data online March 14, researchers suggest that reactivating the signaling of a key molecule lost in aging intestinal stem cells could restore healthy intestinal function in older people.
Mount Sinai study on psychosis reveals the importance of clarifying the precise structure of any genetic mutation before moving forward with human-induced pluripotent stem cell studies
Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry. Head and neck squamous cell carcinoma is a highly invasive form of cancer and frequently spreads to the cervical lymph nodes.
Researchers at Vanderbilt University in Nashville, Tennessee have discovered that in zebrafish, decreased levels of the neurotransmitter gamma-aminobutyric acid (GABA) cue the retina, the light-sensing tissue in the back of the eye, to produce stem cells. The finding sheds light on how the zebrafish regenerates its retina after injury and informs efforts to restore vision in people who are blind.
Cedars-Sinai investigators have identified a stem cell-regulating gene that affects tumor growth in patients with brain cancer and can strongly influence survival rates of patients. The findings, published in the online edition of Nature Scientific Reports, could move physicians closer to their goal of better predicting the prognosis of patients with brain tumors and developing more personalized treatments for them.
Researchers from Columbia Engineering and Columbia University Medical Center have—for the first time—maintained a fully functional lung outside the body for several days. They designed the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient over 36-56 hours, used the advanced support system to fully recover the functionality of lungs injured by ischemia and made them suitable for transplant. (Nature Biomedical Engineering 3/6)
Researchers have developed a new way to identify and sort stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient’s own eye tissue.
As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal EMBO that the bone marrow niche where HSC’s form also ages, contributing to the problem. In a study published March 2, scientists in Germany and the United States propose rejuvenating the bone marrow niche where HSCs are created.
A research team comprised of members from The University of Kansas Cancer Center, Stowers Institute for Medical Research, and Children’s Mercy are looking at ways to target cancer stem cells to ensure that once a cancer patient goes into remission, they are not at risk of their cancer returning.
The regenerative biology team at the Morgridge Institute for Research, led by stem cell pioneer and University of Wisconsin-Madison Professor James Thomson, is studying whether stem cell differentiation rates can be accelerated in the lab and made available to patients faster.
Scientists at Rutgers and other universities have created a new way to identify the state and fate of stem cells earlier than previously possible. Understanding a stem cell’s fate – the type of cell it will eventually become – and how far along it is in the process of development can help scientists better manipulate cells for stem cell therapy.
In a significant advance in improving the safety of donor stem cell transplants, a major clinical trial led by researchers at Dana-Farber Cancer Institute has shown that a novel agent can protect against the most common viral infection that patients face after transplantation.
Sanford Research scientists recently published a review article in an issue of Stem Cells Translational Medicine focused on the study of and utility of adult-derived stem cells.
Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.
In 2013, Mass. Eye and Ear researchers restored partial hearing to mice by regenerating hair cells — tiny, sound-sensing cells in the ear, which are lost through noise damage, age, etc., and do not regenerate on their own — by converting stem cells found in the ear into hair cells. However, the success of restoring hearing through this approach was limited by the small number of cells that could be turned into hair cells. In a new study in Cell Reports, a research team from Mass. Eye and Ear, Brigham and Women's Hospital and MIT has shown that they can augment the number of those cells, and then convert that large population into hair cells, lending hope that full hearing can be restored to those with hearing loss due to damaged hair cells.
Today, the latest rocket launch from NASA’s Kennedy Space Center in Cape Canaveral, Florida, included a payload of several samples of donated adult stem cells from a research laboratory at Mayo Clinic’s Florida campus.
Upstate Medical University has opened a $15 million, 20,000 square foot cord blood bank that features a state of the art processing laboratory and cryogenic storage containers that can store nearly 14,500 units of cord blood. The bank will collect, test, process, store and distribute umbilical cord blood donated by families throughout central and northern New York to be used by those in need of life-saving medical treatments and for medical research.
Adult stem cells collected directly from human fat are more stable than other cells – such as fibroblasts from the skin – and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to study chronological aging of these cells.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right