The blood-brain barrier is a network of specialized cells that surrounds the arteries and veins within the brain. It forms a unique gateway that both provides brain cells with the nutrients they require and protects them from potentially harmful compounds. An interdisciplinary team of researchers from the Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE) headed by Gordon A.
Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment.
The patent relates to the use of Streck’s proprietary Cell-Free DNA BCT CE product for the collection of samples to analyze fetal nucleic acid for non-invasive prenatal testing (NIPT).
Researchers found that the browning program in white fat cells is normally suppressed by a protein called FLCN. It performs this function in cooperation with a major cellular signaling hub, a protein complex known as mTOR. Harnessing this knowledge may one day provide the key to better treatments for obesity.
Demonstration that bacteria can drive mating in eukaryotes raises possibility that environmental bacteria or bacterial symbionts may influence mating in animals
The combination of two new drugs that harness the body’s immune system is safe and effective, destroying most cancer cells in 64 percent of patients with recurrent Hodgkin lymphoma, according to the results of an early-phase study.
Fred Hutchinson Cancer Research Center announced promising results from an early trial in which patients with high-risk acute myeloid leukemia received genetically engineered immune cells. Of the 12 AML patients who received this experimental T-cell therapy after a transplant put their disease in remission, all are still in remission after a median follow-up of more than two years.
Researchers at the University of Wisconsin-Madison have developed a novel strategy to reprogram cells from one type to another in a more efficient and less biased manner than previous methods.
UCLA scientists provides further evidence that the brains of people with autism, despite different causes, tend to have the same molecular “signature.”
In a recent study, a Yale Cancer Center team confirmed expectations of higher healthcare utilization and costs with relapsed Diffuse Large B-Cell Lymphoma (DLBCL).
A team of researchers, co-led by a University of California, Riverside professor, has found a long-sought-after mechanism in human cells that creates immunity to influenza A virus, which causes annual seasonal epidemics and occasional pandemics.
TAMPA, Fla. – Immune cellular therapy is a promising new area of cancer treatment. Anti-cancer therapeutics, such as chimeric antigen receptor (CAR) modified T cells, can be engineered to target tumor-associated antigens to attack and kill cancer cells. This allows for an improved precision medicine approach to treating cancer.
The University of Arkansas for Medical Sciences (UAMS) is collaborating with Dana-Farber Cancer Institute and Celgene Corp. to compile the largest set of high-quality
Riding a wave of powerful new imaging technologies, three ASCB member labs will take you inside the world of living cells with the release of three short 2016 Celldance videos at the ASCB Annual Meeting in San Francisco
Stephen Elledge, the Gregor Mendel Professor of Genetics and of Medicine at Brigham and Women’s Hospital and Harvard Medical School, has been named a 2017 recipient of the Breakthrough Prize, which recognizes paradigm-shifting discoveries in the life sciences, physics and mathematics. Elledge is being honored for his wide-ranging contributions across multiple fields in biology.
A highly innovative, personalized cell-based treatment for a high-risk form of the most common childhood cancer continues to move through clinical trials. Pediatric oncologists from Children’s Hospital of Philadelphia (CHOP) today reported new results using T cell immunotherapy against relapsed or refractory acute lymphoblastic leukemia (ALL).
In a small, early phase trial, a high percentage of patients who had exhausted most traditional treatments for chronic lymphocytic leukemia saw their tumors shrink or even disappear after an infusion of a highly targeted, experimental CAR T-cell immunotherapy developed at Seattle’s Fred Hutchinson Cancer Research Center.
ASCB names 10 "Novel & Newsworthy" Honor abstracts out of 1263 being presented in San Francisco, Dec. 3-7
Researchers from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP) will present the latest advances from their studies of personalized cellular therapies for blood cancers during the 58th Annual Meeting of the American Society of Hematology (ASH) in San Diego.
Research team has discovered an important molecular link between a rare childhood genetic disease and a major cancer gene. The discovery could lead to improved treatment outcomes for some cancer patients.
The Monell Center announced today that it has received a $345,000 grant from the Bill & Melinda Gates Foundation. The grant supports an innovative global health research project titled, "Developing Novel Pediatric Formulation Technologies for Global Health: Human Taste Assays."
Researchers led by scientists at Dana-Farber Cancer Institute say they have identified unique genomic changes that may be integral to testicular cancer development and explain why the great majority are highly curable with chemotherapy – unlike most solid tumors.
Previous studies identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, but new research led by University of California San Diego School of Medicine scientists reveals a surprising role for these enzymes in subduing cancer immunity. The findings could have a clinical role in improving efficiency of immunotherapy drugs.
Scientists from the Institute of Molecular Biotechnology (IMBA) in Vienna, Austria, have discovered how an embryo’s genomic integrity is safeguarded during the first 24 h after fertilization. Insights into this mechanism have implications for improving in vitro fertilization.
PHILADELPHIA—An existing drug known as a JAK inhibitor may help patients who don’t respond to the so-called checkpoint inhibitor immunotherapy drugs overcome that resistance, suggests a new preclinical study published online in Cell today by Penn Medicine researchers. Importantly, the results demonstrate that shutting down the interferon pathway, shown here to be critical to a tumor’s resistance to immunotherapy, with a JAK inhibitor may improve checkpoint inhibitor drugs and even bypass the need for combinations of these drugs, which often come with serious side effects.
Mayo Clinic Monthly News Tips — November 2016
The Bill & Melinda Gates Foundation has awarded an $8,777,578 million grant to The Wistar Institute to create a preventative Zika therapy utilizing synthetic DNA monoclonal antibodies (dMAbs).
The study, “A Real-World Multicentre Retrospective Observational Study of Paclitaxel-Bevacizumab and Maintenance Therapy as First-Line Treatment for HER2-Negative Metastatic Breast Cancer,” was recently published in the Journal of Cell Physiology.
Scientists from the University of Utah and University of Washington have developed blueprints that instruct human cells to make a virus-like delivery system that shuttles custom cargo from one cell to another. As reported online in Nature on Nov. 30, the research is a step toward a nature-inspired means for bringing therapeutics directly to specific types of cells.
CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations. For the first time, researchers have developed a dual gene therapy approach to deliver key components of a CRISPR/Cas9-mediated gene targeting system to mice to treat hemophilia B.
Researchers at Thomas Jefferson University’s Sidney Kimmel Cancer Center discovered a cell-surface receptor highly expressed by cancerous and brain cells that directly and tightly binds progranulin. Importantly, the researchers also showed that this binding activates a cellular program that makes cancer cells more aggressive.
Doctors, pilots, air traffic controllers and bus drivers have at least one thing in common — if they're exhausted at work, they could be putting lives at risk. But the development of a new urine test, reported in the ACS journal Analytical Chemistry, could help monitor just how weary they are. The results could potentially reduce fatigue-related mistakes by allowing workers to recognize when they should take a break.
ROCHESTER, Minn. — Mayo Clinic’s 3-D anatomic modeling program started with a realization that surgeons needed a new way to look at human anatomy that went beyond two-dimensional images.
A new bioinformatics platform called Empowering the Development of Genomics Expertise (EDGE) will help democratize the genomics revolution by allowing users with limited bioinformatics expertise to quickly analyze and interpret genomic sequence data.
Fluorescence is an incredibly useful tool for experimental biology and it just got easier to tap into, thanks to the work of a group of University of Chicago researchers.
Australian researchers have discovered remarkable evolutionary changes to insulin regulation in two of the nation's most iconic native animal species – the platypus and the echidna – which could pave the way for new treatments for type 2 diabetes in humans.
Phil Manning and his colleagues have used synchrotron light for nearly a decade to help interpret the chemical signatures locked within fossilized life. Bright X-rays have allowed them to study fossilized worm burrows, recreate pigment patterns in ancient bird feathers, see how Jurassic dinosaur bones heal and image the living chemistry of 50-million year old plant fossils.
The human eye often falls short in the hunt for faint genetic drivers that raise the risk of devastating neurological diseases such as autism and schizophrenia. But little eludes a microscope optic attached to a computer, and algorythms that can relate previously hidden phenotypes to subtle genetic mutations. The computational screening developed by Georgia Tech researchers has the potential to reveal webs of genetic dangers that produce disease risk by compounding tiny traits that, when take alone, may appear trivial and harmless.
It may be possible to safely prevent one of the most common – and costly to treat – infections contracted by hospitalized patients undergoing bone marrow transplantation for the treatment of blood cancers, according to a study from the Abramson Cancer Center at the University of Pennsylvania. The researchers will present their findings at this week’s 58th Annual American Society of Hematology Meeting and Exposition in San Diego.
A new study finds that environment and genetics determine relative abundance of specific microbes in the gut. The findings represent an attempt to untangle the forces that shape the gut microbiome, which plays an important role in keeping us healthy.
Regenerative medicine company jCyte has completed enrollment in a phase I/IIa trial studying the safety of its stem cell therapy for retinitis pigmentosa. Early results are promising.
How does a cancer cell burn calories? New research from Thomas Jefferson University shows that breast cancer cells rely on a different process for turning fuel into energy than normal cells. The results were recently published in the Journal of Biological Chemistry.
A laboratory study of four animal species and their microbiota finds that each species hosts a unique community of microbes that can significantly improve its health and fitness.
Patients with the most lethal form of acute myeloid leukemia (AML) – based on genetic profiles of their cancers – typically survive for only four to six months after diagnosis, even with aggressive chemotherapy. But new research indicates that such patients, paradoxically, may live longer if they receive a milder chemotherapy drug.
Researchers from the University of Wisconsin School of Medicine and Public Health and Carbone Cancer Center have better defined a pro-growth signaling pathway common to many cancers that, when blocked, kills cancer cells but leaves healthy cells comparatively unharmed. The study, published Nov. 21 in the journal Nature Cell Biology, could establish new avenues of therapeutic treatments for many types of solid tumors.
Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes.
Writing online this week (Nov. 23, 2016) in the journal Molecular Cell, a team of researchers from the University of Wisconsin-Madison describes new research helping tease out the mechanics of how the gut microbiome communicates with the cells of its host to switch genes on and off. The upshot of the study, another indictment of the so-called Western diet (high in saturated fats, sugar and red meat), reveals how the metabolites produced by the bacteria in the stomach chemically communicate with cells, including cells far beyond the colon, to dictate gene expression and health in its host.
Scientists at Washington University in St. Louis isolated an enzyme that controls the levels of two plant hormones simultaneously, linking the molecular pathways for growth and defense. Similar to animals, plants have evolved small molecules called hormones to control key events such as growth, reproduction and responses to infections.
Biochemical “cross talk” in an important pathway can be altered so that immune system cells that have turned cancerous can be eliminated. The findings could have future implications for treating cancer with the help of microRNAs.
Sleepiness after a large meal is something we all experience, and new research with fruit flies suggests higher protein and salt content in our food, as well as the volume consumed, can lead to longer naps.
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