In a groundbreaking new study, researchers at the University of Minnesota used a customized, low-cost 3D printer to print electronics on a real hand for the first time.
Doctors at the University of Illinois Hospital have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol.
Almost all forms of animal life – from fruit flies to butterflies to mammals – contain a pause in transcription, a step that appears to allow the transcription machinery to take a break to fine-tune its copying process. No one knows when this pause originated in the evolution of life. Charles Danko, assistant professor of genetics and molecular biology at the Cornell University Baker Institute for Animal Health, will investigate with a three-year, $790,000 grant from NASA’s Exobiology program.
Researchers investigating a key signaling protein in Huntington’s disease describe deleterious effects on heart function, going beyond the disease’s devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in mice, shedding light on the biology of this fatal disease.
A genomic analysis of a large study population has identified uncommon gene variants involved in responses to dietary fats and medicine. Although these variants are rare, they may play a large role in a carrier's risk of heart disease.
UAH Ph.D. student Shristi Shrestha is honing her skills in single-cell gene expression as a graduate research assistant at the HudsonAlpha Institute for Biotechnology. She recently served as first co-author of a paper that was published in the journal "Cell Reports."
Low “mental energy” may affect walking patterns in older adults more than physical fatigue. New research about the relationship between walking ability and self-reported mood will be presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2018 in San Diego.
A new study by Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers helps explain the connection between a tumor suppressor called protein kinase C zeta (PKC zeta) and metastatic colorectal cancer.
Sara Biela and Chase Turner, graduate students in the lab of Wasana Sumanasekera at Sullivan University College of Pharmacy in Kentucky, will present new findings tied to hemp’s anti-cancer properties at the American Society for Biochemistry and Molecular Biology annual meeting during the 2018 Experimental Biology meeting to be held April 21-25 in San Diego.
Using new technologies to track how vision guides foot placement, researchers at The University of Texas at Austin come one step closer in determining what is going on in the brain while we walk, paving the way for better treatment for mobility impairments — strokes, aging and Parkinson’s — and technology development — prosthetics and robots.
A team led by Columbia University Biomedical Engineering Professor Gordana Vunjak-Novakovic has designed a creative new approach to help injured hearts regenerate by applying extracellular vesicles secreted by cardiomyocytes rather than implanting the cells. The study shows that the cardiomyocytes derived from human pluripotent stem cells (derived in turn from a small sample of blood) could be a powerful, untapped source of therapeutic microvesicles that could lead to safe and effective treatments of damaged hearts.
Investigators at Rutgers Cancer Institute have discovered that some mutations detected in comprehensive, clinical genome sequencing of patients with solid tumors do not originate from cancer cells, but arise from mutated hematopoietic cells that infiltrate the tumor microenvironment. The findings, they say, have direct implications for cancer patients, specifically in accurately interpreting their molecular testing results and ensuring that treatment is focused on somatic tumor-specific mutations.
The University of Texas Health Science Center at Houston (UTHealth) has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury.
Older people should drink more water to reap the full cognitive benefits of exercise, new research suggests. The study, to be presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2018 in San Diego, explores the association between hydration status before exercising and exercise-enhanced cognition in older adults.
Differences in the way women with obesity burn calories during pregnancy may be a contributor to long-term postpartum weight retention in black moms, according to researchers in Baton Rouge, La. Their new study shows that despite similar levels of food intake and activity levels—and a higher proportion of fat-free mass—obese black women burned fewer calories than their white counterparts. The findings, which suggest a need for more individualized pregnancy weight gain recommendations for obese women, will be presented today at the APS annual meeting at Experimental Biology 2018 in San Diego.
Research into cancer can provide new insight into how this disease works and how it can be stopped. The Experimental Biology 2018 meeting (EB 2018) will showcase innovative research that could lead to new ways to treat and prevent cancer.
A treatment gap remains for many conditions involving damage to the liver, the body’s main organ for removing toxins, among other functions. The Experimental Biology 2018 meeting (EB 2018) will feature important research announcements related to the causes of liver degradation and possible treatments.
Housed in the historic and newly renovated George Thomas Building, the Crocker Science Center will be the new home to the Henry Eyring Center for Cell and Genome Science, the Center for Science and Math Education, modern classrooms and laboratories for interdisciplinary science and math education, and a technology incubator space.
A $2 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) will allow Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso) to create a new lab focusing on breast cancer, pushing forward breast cancer research in West Texas.
In the largest study of its kind, researchers at the University of Minnesota and University of Toronto have revealed a complex network of genes that work together. Understanding those genetic connections can help develop new life-saving treatments to combat diseases such as cancer, heart disease, and diabetes.
Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure. Creating such a complex biological module is an important step towards an even more ambitious goal: building a complete and functioning synthetic cell from the bottom up.
Scientists have re-created brain neurons of obese patients using "disease in a dish" technology, offering a new method to study the brain's role in obesity and possibly help tailor treatments to specific individuals.
Cancer immune cell therapy has made headlines with astounding successes like saving former U.S. President Jimmy Carter from brain cancer. But immunotherapy has also had many tragic flops. Georgia Tech researchers working to optimize the innovative treatment have implanted a genetic switch that activates T-cells when they are inside of tumors. Remote-control light waves resembling those used in a TV remote combine with gold nanorods to flip the switch.
A host of nuclear RNA-binding proteins, when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including FTD and ALS. Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells.
In a groundbreaking paper published today in the journal Cell, investigators at the Cancer Research Institute Beth Israel Deaconess Medical Center (BIDMC) have found dozens of important new genes, both coding and non-coding that impact sensitivity to chemotherapy. In doing so, the scientists developed a novel technique that marries CRISPR technology with big data mining to identify and assign function to non-coding RNAs
An international team of scientists have developed a new cell imaging technology combining lattice light sheet microscopy (LLSM) and adaptive optics (AO) to create high-resolution “movies” of cells in their 3D environment that also captures subcellular processes
The research team will develop software tools allowing efficient and interactive exploratory data analysis of unprecedented amounts of single-cell data
Five Johns Hopkins scientists, with specialties spanning computation, genetics, statistics and engineering, are among 83 others from 53 institutions in the U.S and eight other countries, who will share in a $15 million award from the Chan Zuckerberg Initiative.
Johns Hopkins scientist Steven Salzberg, Ph.D., known for his ability to tackle the most difficult projects in genome sequencing, has been elected as a member of the American Academy of Arts and Sciences. He joins the group of 213 scientists, scholars, writers, artists and other leaders, including former President Barack Obama and Supreme Court Justice Sonia Sotomayor, who make up the class of 2018.
Scientists at The Scripps Research Institute have identified a protein, called GPR68, that senses blood flow and tells small blood vessels called arterioles when to dilate.
A protein that plays an important role in embryonic development and nervous system wiring in humans appears to have been borrowed from bacteria. In a new study, scientists from the UChicago and Stanford describe the three-dimensional structure of proteins called teneurins for the first time.
Triple-negative breast cancer (TNBC) is an aggressive form of the disease accounting for 12 to 18 percent of breast cancers. It is a scary diagnosis, and even though chemotherapy can be effective as standard-of-care, many patients become resistant to treatment. A team at The University of Texas MD Anderson led a study which may explain how resistance evolves over time, and potentially which patients could benefit from chemotherapy.
A new University of Kansas research effort featured in the current edition of Integrative Biology has resulted in a low-cost, reliable blood test that uses a small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone biopsy — but using a simple blood draw instead.
Scientists at Christiana Care Health System’s Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.
UNLV scientist Kelly Tseng, Ph.D. and her team have found that frog embryos can fully regrow their eyes after injuries, a breakthrough that may lead one day to the ability to orchestrate tissue regeneration in humans.
Interim results of clinical trials by investigators at UCSF Benioff Children’s Hospital Oakland and Ann and Robert H. Lurie Children’s Hospital of Chicago reveal that a majority of the 22 patients in two Phase 1/2 studies followed for two years or longer remained free from transfusions. The results of the trials “Gene Therapy in Patients with Transfusion-Dependentβ-Thalassemia,” are published today in the New England Journal of Medicine (NEJM). The results are from two separate, two-year clinical studies using LentiGlobin® gene therapy to stop or reduce chronic blood transfusions in patients with transfusion-dependent β-thalassemia (TDT).
Scientists identified a neural circuit in the hypothalamus as the primary mechanism mediating the hormone leptin’s anti-obesity and anti-diabetes effects and found two mechanisms underlying leptin’s inhibition of appetite. The work in mice advances efforts to treat human obesity and diabetes.
Researchers at the University of Michigan Rogel Cancer Center designed this new delivery system – a drug hidden in a nanodisc – to increase the number of patients who can be treated successfully with cancer immunotherapy drugs.
Virginia Tech researcher Chang Lu and his team found significant difference in the molecular machinery that turns on and off gene expression between cerebellum and prefrontal cortex of a mouse brain. Their results provide clues to the molecular apparatus that is involved in conscious thinking in brains.
A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study at Washington University School of Medicine in St. Louis.
A Vanderbilt team and their international colleagues characterized for the first time a complex, little-understood cellular receptor type that, when activated, shuts off hunger.
Roswell Park Comprehensive Cancer Center researchers have once again identified a link between physical inactivity and an increased risk of mortality among cancer patients, emphasizing the importance of regular exercise as therapy for cancer patients both during and after treatment.
A group led by the Abramson Cancer Center of the University of Pennsylvania has proposed three solutions to maximize the clinical benefit and affordability of targeted cancer drugs.
PAs increasingly used in dermatology to cut costs and improve access, but are less likely than dermatologists to accurately diagnose early stage skin cancers, according to new research.
Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that “direct electrical current” can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed.
ROCHESTER, Minn. – A Mayo Clinic study finds no evidence that children given anesthesia before their third birthdays have lower IQs than those who did not have it. A more complex picture emerges among people who had anesthesia several times as small children: Although their intelligence is comparable, they score modestly lower on tests measuring fine motor skills, and their parents are more likely to report behavioral and learning problems. The findings are published in Anesthesiology
Investigators at Cedars-Sinai are exploring a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting specially engineered neural cells into the brain. Their new study shows the transplanted cells delayed disease progression and extended survival in animal models.
This month’s issue of the journal Molecular & Cellular Proteomics features research using novel proteomics methods to address unanswered questions in cancer research, including protein variation within tumors; the failure of a candidate cancer drug; and how a chemotherapeutic combination acts synergistically.
The American Physiological Society (APS) has announced the 2018 recipients of its distinguished lecturer awards. APS is pleased to recognize these outstanding honorees, who will present their lectures at the APS annual meeting at Experimental Biology 2018 (April 21–25 in San Diego).
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