Virologists and immunologists at The Scripps Research Institute have found a major clue to the mystery of “hemorrhagic fever” syndromes. The team showed that Interferon Type I immune proteins are key drivers of a viral syndrome in mice that closely mimics human hemorrhagic fevers.
A team led by scientists at The Scripps Research Institute has received a grant of more than $13 million from the National Institute of Allergy and Infectious Disease to study antibodies to the human immunodeficiency virus (HIV)—with the goal of creating an effective anti-HIV vaccine.
Scientists led by a group of researchers at The Scripps Research Institute (TSRI) in La Jolla, CA, have discovered some of the key proteins involved in one type of DNA repair gone awry.
Scientists at The Scripps Research Institute have discovered that a protein with a propensity to form harmful aggregates in the body when produced in the liver protects against Alzheimer’s disease aggregates when it is produced in the brain.
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2 million grant from the National Institute on Aging of the National Institutes of Health to study the effects of early nutrition on lifespan and overall health.
A vaccine or other therapy directed at a single site on a surface protein of HIV could in principle neutralize nearly all strains of the virus—thanks to the diversity of targets the site presents to the human immune system.
Mice crippled by an autoimmune disease similar to multiple sclerosis regained the ability to walk and run after a research team led by scientists at The Scripps Research Institute, University of Utah and University of California, Irvine implanted human stem cells into their injured spinal cords.
Scripps Research Institute scientists have engineered a bacterium whose genetic material includes an added pair of DNA “letters,” or bases, not found in nature; the bacterium’s cells can replicate the unnatural DNA bases more or less normally, as long as the molecular building blocks are supplied.
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis
Two scientists from San Diego county—Dale Boger and Benjamin Cravatt of The Scripps Research Institute—have been elected to the National Academy of Sciences in recognition of their “distinguished and continuing achievements in original research,” the academy announced today.
Scientists from the Florida campus of The Scripps Research Institute have now identified one of the molecular pathways that resveratrol uses to achieve its beneficial action.
Scientists have known that abnormal brain growth is associated with autism spectrum disorder. However, the relationship between the two has not been well understood.
A team led by scientists at The Scripps Research Institute has deciphered the surprisingly versatile code by which chemical cues help trigger some of the most basic behaviors in mice.
A team led by scientists at The Scripps Research Institute (TSRI) working with the International AIDS Vaccine Initiative (IAVI) has discovered a new vulnerable site on the HIV virus.
Scientists from the Florida campus of The Scripps Research Institute have identified a protein complex that plays a critical but previously unknown role in learning and memory formation.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.1 million from the National Institutes of Health to study the therapeutic potential of safer and more effective alternatives to the current crop of anti-diabetic drugs.
The Scripps Research Institute (TSRI) today announced the formation of Scripps Advance, a new drug discovery initiative to translate early-stage biomedical research projects, both internal and external to TSRI, into clinical development candidates. Scripps Advance’s first collaborator in this new endeavor is the Johnson & Johnson Innovation Center in California.
A team led by scientists at The Scripps Research Institute (TSRI) has identified a long-sought protein that facilitates one of the most basic functions of cells: regulating their volume to keep from swelling excessively.
Scientists from The Scripps Research Institute Florida campus have been awarded a $472,500 Cutting Edge Basic Research Award by the National Institute on Drug Abuse to study models of the brain development of newborns who have been exposed to prescription pain medication while still in the womb.
Scientists thought they basically knew how the most common drugs used to treat type 2 diabetes worked, but a new study from the Florida campus of The Scripps Research Institute reveals unexpected new aspects of the process.
A study led by scientists at The Scripps Research Institute has helped solve a long-standing mystery about the sense of touch.
Discovery could help scientists develop new diagnostics and therapies and help physicians determine the best long-term treatments for patients with these cancers.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed what amounts to a best practices guide to the most accurate way of measuring fruit fly food consumption.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.3 million to study a category of viruses that cause dengue fever, West Nile, yellow fever and other diseases.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been able to pinpoint a handful of neurons where certain types of memory formation occur.
The National Institutes of Health has awarded a five-year grant of up to $28 million to establish a new center for excellence to find an antibody “cocktail” to fight the deadly Ebola virus. The project, which involves researchers from 15 institutions, will be led by Erica Ollmann Saphire, professor at The Scripps Research Institute.
Chemists at The Scripps Research Institute have devised a greatly improved technique for making amino acids not found in nature. These “unnatural” amino acids traditionally have been very difficult to synthesize, but are sought after by the pharmaceutical industry for their potential medical uses.
Scientists from The Scripps Research Institute have devised a new, more efficient method with the potential to convert the major components found in natural gas into useable fuels and chemicals—opening the door to cheaper, more abundant energy and materials with much lower emissions.
Scientists have discovered a mechanism underlying sensory feedback that guides balance and limb movements. If the findings can be fully replicated in humans, they could lead to a better understanding of and treatments for disorders arising from faulty proprioception, the detection of body position.
Renowned virologist Karla Kirkegaard, PhD, will join the Florida campus of The Scripps Research Institute as chair of the Department of Infectious Diseases. She joins Scripps Florida from Stanford University School of Medicine.
Scientists at The Scripps Research Institute have developed a method for modifying organic molecules that significantly expands the possibilities for developing new pharmaceuticals and improving old ones.
Researchers at The Scripps Research Institute and Vanderbilt University have created the most detailed 3-D picture yet of a membrane protein linked to learning, memory, anxiety, pain and brain disorders such as schizophrenia, Parkinson’s, Alzheimer’s and autism.
Scientists at The Scripps Research Institute have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.
Scientists at The Scripps Research Institute have mapped key elements of a severe immune overreaction—a “cytokine storm.” Their findings also clarify the workings of a potent new class of anti-inflammatory compounds that prevent this immune overreaction in animal models.
A new study by scientists from the Florida campus of The Scripps Research Institute has uncovered a mechanism of drug resistance. This knowledge could have a major impact on the development of a pair of highly potent new antibiotic drug candidates.
Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $2.3 million from the National Institute of Mental Health to study the processes involved in long-term memory and how deficits in those processes contribute to brain diseases.
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence.
A team led by scientists at The Scripps Research Institute has discovered an unusual bacterial protein that attaches to virtually any antibody and prevents it from binding to its target.
Scientists at The Scripps Research Institute have invented a new method for designing artificial proteins and have used it to make key ingredients for a candidate vaccine against a dangerous virus, respiratory syncytial virus (RSV), a significant cause of infant mortality.
Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.8 million from the National Cancer Institute to identify signaling pathways that underlie lung cancer and to develop new therapeutic approaches.
More than 350 business, political, community and scientific leaders from across Palm Beach County will gather at the Kravis Center on Thursday, February 6 to celebrate Scripps Florida’s 10th anniversary.
Chi-Huey Wong, professor of chemistry at The Scripps Research Institute, has won the 2014 Wolf Prize in Chemistry for his pioneering contributions to the synthesis of compounds vitally important to biology and medicine.
Scientists from the Florida campus of The Scripps Research Institute have identified a critical regulator of a molecule deeply involved in the progression of Alzheimer’s disease.
A new study from the Florida campus of The Scripps Research Institute offers insights into how aging affects the brain’s neural circuitry, in some cases significantly altering gene expression in single neurons.
Scientists at The Scripps Research Institute have demonstrated the power of a new drug discovery technique, which allows them to find—relatively quickly and cheaply—antibodies that have a desired effect on cells.
Scientists from the Florida campus of The Scripps Research Institute have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.
Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery suggests new therapeutic approaches to a host of brain-related medical conditions.
A new “fluid biopsy” technique that could identify patients at high risk of a heart attack by identifying specific cells as markers in the bloodstream has been developed by a group of researchers at The Scripps Research Institute.
Collaborating scientists at The Scripps Research Institute, the National Institutes of Health and the University of Camerino in Italy have published new findings on a system in the brain that naturally moderates the effects of stress.
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