A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
When Jimmy Carter was diagnosed with end-stage metastatic melanoma in 2015, he began taking a drug developed in part using 3D molecular data. Insights like these into drug discovery and other fields of scientific research are possible using the 140,000-plus 3D molecular structures made freely available in the RCSB Protein Data Bank at Rutgers University–New Brunswick.
In an article published today in the New England Journal of Medicine, University of Pennsylvania researchers call for modernizing the way Medicare pays for training nurses, and highlight a successful new model of cost-effectively training more advanced practice nurses to practice community-based primary care.
Over time, half of the people taking certain drugs for Parkinson’s disease may develop impulse control disorders such as compulsive gambling, shopping or eating, according to a study published in the June 20, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Cornell University researchers have discovered there is a division of labor among immune cells that fight invading pathogens in the body.
In recent articles in Molecular & Cellular Proteomics, scientists optimize experimental design for understanding potential chemotherapeutic agents, delve into crop responses to salt-water stress, and present a better way to ensure consistency in long-term proteomics studies.
A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will be published June 19 in the Journal of Cell Biology, suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.
Value in Health, the official journal of ISPOR (the professional society for health economics and outcomes research), announced today the publication of a study introducing a novel strategy for obtaining reasonable drug cost estimates for US-based cost-effectiveness analyses.
Results Do Not Support Routine Use of This Expensive Drug
Researchers from the Icahn School of Medicine at Mount Sinai found an elevated risk of major congenital malformations in fetuses after first-trimester exposure to lithium, in the largest study ever to examine the risk of birth defects in lithium-exposed babies.
A JAMA Pediatrics study shows that since 2003, the use of alternative medicines among children has doubled. Increased use of Omega-3 fatty acids and melatonin among adolescents ages 13 to 18 drives the change.
Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized ‘miniecosystems’ to quickly see if a molecule can function as a potential therapeutic.
"This new method should allow us to explore a large ‘chemical space’ that had been essentially off-limits."
Research published in JAMA Internal Medicine found that tamsulosin does not significantly effect patient-reported passage or capture of kidney stones.
Hackensack Meridian Health Riverview Medical Center in Red Bank, has again been nominated as one of the most beautiful hospitals in the U.S. in an annual competition run by Soliant Health, a leading specialty health care staffing provider and part of Adecco Group. Last year, the medical center placed second in the competition and is looking to claim the top spot, which is determined by number of votes.
A new study by Scripps Research, published today in Nature Communications, suggests scientists could build better drugs by learning from bacteria-derived molecules called thiocarboxylic acids.
Benjamin A.Garcia, PhD, an expert in quantitative proteomics has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry. Garcia’s lab has develop
Using a targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors, researchers at The University of Texas MD Anderson Cancer Center report today in the Journal of Clinical Investigation.
People react differently to positive events in their lives. For some, a small reward can have a large impact on their mood, while others may get a smaller emotional boost from the same positive event.These reactions can not only be objectively measured in a simple office evaluation, but researchers from the University of Illinois at Chicago report that they can help clinicians determine whether a patient with anxiety or depression is responding to treatment and if they will do better on an antidepressant drug, or in talk therapy.
Neglected tropical diseases are a group of chronic and disabling parasitic infections that primarily affect poor and underserved communities. These diseases affect more than 1 billion people globally, yet are rarely the target of new drug discovery efforts. Leveraging its strengths in molecular biology, clinical research and pharmaceutical sciences, the University of California San Diego has now launched a new Center for Anti-Parasitic Drug Discovery and Development to address this unmet need in global health.
The Milken Institute School of Public Health at the George Washington University (Milken Institute SPH) today announced it has received a $3.1 million (£2.74 million) grant from the Wellcome Trust to study the impacts of California’s new legislation limiting the use of antimicrobial drugs given to livestock raised in the state. Wellcome awarded the grant to Lance Price, PhD, a professor in the Department of Environmental and Occupational Health and the director of the school’s Antibiotic Resistance Action Center (ARAC). This grant builds upon a pilot study funded by Wellcome in 2017.
Rutgers New Jersey Poison Control Experts Available to Discuss Allergy Medication and Drugged Driving
The American College of Rheumatology has released a position statement on pharmacovigilance emphasizing the need for the continued monitoring of new drugs once they are introduced to the market.
Peter T. Meinke, PhD, an accomplished chemist with more than 30 years of industry and academic experience, has been selected to lead the Tri-Institutional Therapeutics Discovery Institute.
Extending medical insurance to low-income Michigan residents meant they had better access to health care, earlier detection of serious illnesses, better care for existing health problems and improved ability to work, attend school and live independently, according to a newly published survey of primary care providers.
Changes in cellular struts called microtubules can affect the stiffness of diseased human heart muscle cells, and reversing these modifications can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.
While the opioid epidemic may feel too massive a problem to tackle or too overwhelming to even comprehend, experts in many corners of Penn Medicine are at work combating the deadly toll, including the physicians and researchers of the Center for Health Incentives and Behavioral Economics (CHIBE) at the Perelman School of Medicine. As one of two Roybal Centers on Behavioral Economics and Health nationally funded by the National Institute of Aging of NIH, CHIBE combines psychology and economics with clinical expertise in an effort to understand why individuals make certain decisions that impact their health and how to leverage their findings to advance policy, improve health care delivery, and encourage healthy behaviors among patients and best practices among clinicians. All those elements combine in their efforts to curb prescription opioid misuse.
A Syrian pharmacist who fled his country due to persecution he faced as a relief worker providing essential medications to field hospitals in Aleppo has received a full tuition scholarship to attend the Master of Public Health (MPH) program at the Johns Hopkins Bloomberg School of Public Health. Hazem Rihawi is expected to start the 11-month program in July.
Antimicrobial resistance continues to increase, and antimicrobial stewardship programs are developing plans to report antimicrobial use in order to reduce and optimize the use of antibiotics.
Results from a new clinical study have confirmed the safety and tolerability of using bacteria-specific viruses known as bacteriophages to eliminate disease-causing bacteria in the gut.
• Among individuals with chronic kidney disease, hard illicit drug use was associated with higher risks of kidney disease progression and early death. • Tobacco smoking was associated with a higher risk of early death. • Alcohol drinking was associated with a lower risk of early death.
Researchers at The University of Kansas Cancer Center have discovered a therapy combination that may be helpful in the treatment of certain types of ovarian cancer.
The number of insurance denials for life-saving hepatitis C drugs among patients with both private and public insurers remains high across the United States. Private insurers had the highest denial rates, with 52.4 percent of patients denied coverage, while Medicaid denied 34.5 percent of patients and Medicare denied 14.7 percent.
The Alzheimer’s Foundation of America (AFA) is awarding $206,184 over the next three years to Stony Brook Medicine to support an innovative Positron Emission Tomography (PET) imaging research project that will compare neurons from healthy controls and those with Alzheimer’s disease in an effort to improve drug development.
Many physical therapists use foam rollers to help patients recover from injuries – and for good reason. This flexible piece of equipment can help to increase range of motion, shorten recovery time, and enhance healing.
The Anesthesia Patient Safety Foundation (APSF) and Foundation for Anesthesia Education and Research (FAER), charitable arms of the American Society of Anesthesiologists (ASA), today announced a call for applications for their new perioperative patient safety Mentored Research Training Grant. The grant has been founded jointly by the foundations, recognizing the overlap in their missions regarding developing physician investigators and advancing patient safety. Applications will be accepted between June 7, 2018 and December 14, 2018.
A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers.
Case Western Reserve University School of Medicine researchers have synthesized the first artificial human prion, a dramatic development in efforts to combat a devastating form of brain disease that has so far eluded treatment and a cure. The new findings are published in Nature Communications.
Results of a large-scale study suggest that the oral diabetes drug metformin is safe for most diabetics who also have chronic kidney disease (CKD). The study of more than 150,000 adults by Johns Hopkins Medicine investigators found that metformin’s association with the development of a life-threatening condition called lactic acidosis was seen only among patients with severely decreased kidney function.
Two new directors add expertise to the Board for this independent public charity focused on diversity in research and expanded access to experimental drugs.
The Foundation for Anesthesia Education and Research (FAER), a charitable arm of the American Society of Anesthesiologists (ASA), today announced improvements to its flagship Mentored Research Training Grant (MRTG) for junior faculty physician anesthesiologists embarking on research careers.
Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease.
In a small Phase II study of early-stage breast cancer patients with BRCA1/2 mutations, researchers at The University of Texas MD Anderson Cancer Center found that more than half of the women who took the PARP inhibitor talazoparib once daily prior to surgery had no evidence of disease at the time of surgery. If further validated in larger, confirmatory trials, the oral medication could replace chemotherapy for these patients.
Penn study finds value in collecting patients’ sexual orientation and gender identity, but cautions medical providers from drawing conclusions based on that information alone
Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the “stemness” of chronic lymphocytic leukemia cancer (CLL) cells — their ability to self-renew and resist terminal differentiation and senescence.
The University of Texas MD Anderson Cancer Center and Amgen today announced two multi-year collaboration agreements aimed at accelerating development of a variety of Amgen’s early-stage oncology therapies for patients with leukemia, myelodysplastic syndromes, multiple myeloma, small-cell lung cancer, and other non-lung cancers with small-cell histologies.
A new study led by David Broniatowski, an assistant professor in the George Washington University’s department of engineering management and systems engineering, finds the “Why not take a risk?” mentality is widespread among patients and medical care providers.
The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right