Feature Channels: Blood

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Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers say their studies demonstrate that use of an experimental drug called CASIN in laboratory mice results in higher efficiency when harvesting blood stem cells from donors and less toxicity in transplant recipients.

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A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.

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Sickle cell disease is a common inherited blood disorder, affecting an estimated 100,000 Americans of different racial and ethnic groups. A Rutgers Cancer Institute of New Jersey expert shares more about the importance of early diagnosis and comprehensive management of this disease.

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Mercy Medical Center now offers the VenaSeal™ procedure as a new option for treating venous reflux disease and varicose veins.

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In proof-of-concept experiments, researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. Researchers deliver a therapeutic enzyme via the cellular equivalent of a Trojan Horse, using platelets to protect the key enzyme hidden inside.

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Healthy red blood cells are round, but for those with sickle cell disease, the red blood cells become sticky and hard because of an abnormal amount of protein in the blood. The red blood cells form the shape of a sickle, or crescent.

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Researchers at University of California School of Medicine are preparing to launch a novel clinical trial to examine the safety, efficacy and pharmacological properties of cannabis as a potential treatment for adults with essential tremor (ET). Currently, ET is treated using repurposed medications originally developed for high blood pressure or seizures.

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In a new analysis of data submitted to Maryland’s state trauma registry from 2005 to 2017, Johns Hopkins Medicine researchers found that gunshot victims are approximately five times more likely to require blood transfusions, they require 10 times more blood units and are 14 times more likely to die than people seriously injured by motor vehicles, non-gun assaults, falls or stabs.

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A three-year, $1.8 million grant from the National Institutes of Health will enable researchers at the University of Illinois at Chicago to develop portable, easy-to-use sensors that can detect toxic metals in a single drop of blood. The sensors would allow for faster and cheaper research, as well as rapid detection of metals including manganese and lead, both of which are powerful neurotoxins that can affect cognitive development and neuromotor function.

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A DNA-based analysis of blood cells soon after a stem cell transplant can predict likelihood of disease recurrence in patients with myelodysplastic syndrome (MDS), a group of cancerous disorders characterized by dysfunctional blood cells, according to new research at Washington University School of Medicine in St. Louis. Such a practice could help doctors identify patients at high risk of disease recurrence early after a transplant and help guide treatment decisions.

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A new $3 million, five-year grant from the National Heart, Lung and Blood Institute will allow researchers to determine whether a unique program designed to educate people with uncontrolled hypertension — also known as high blood pressure — about the importance of getting their blood pressure under control can help reduce the risk of developing chronic and expensive-to-treat secondary cardiovascular conditions among this high-risk group.

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Omacetaxine (to block protein synthesis) with venetoclax (to block oxidative phosphorylation), was highly effective against CD123+ leukemia stem cells.

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Researchers from St. Jude Children’s Research Hospital and the University of North Carolina Lineberger Comprehensive Cancer Center have made important discoveries that could lead to better treatment for a rare blood cancer in children that has features of both acute myeloid leukemia and acute lymphoblastic leukemia.

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Patients with chronic lymphocytic leukemia (CLL) who feel more stress also have more cancer cells in their blood and elevated levels of three other markers of more advanced disease.

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Ronald G. Victor, MD, a prominent hypertension expert and the first investigator to scientifically prove that thousands of lives could be saved annually if barbers were enlisted to help fight the epidemic of high blood pressure in the African-American community, died Monday, Sept. 10.

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The study published today in the journal Cancer Cell suggests that leukemia cells change in unique ways in response to the chemotherapy, allowing them to masquerade for a short time so they are able to start disease regeneration.

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A New York State requirement that all hospitals report compliance with protocols to treat severe sepsis and septic shock appears to improve care and reduce mortality from one of the most common causes of death in those who are critically ill, according to a new study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

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Mount Sinai promotes early detection and announces new Thyroid Center in New York City

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The Endocrine Society today announced it has chosen 13 leading endocrinologists as winners of its prestigious 2018 Laureate Awards, the top honors in the field.

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Researchers at the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme implicated in a number of cancers. The set of tools and methods, which the researchers used to test more than 16,000 compounds, is described in a new paper published in the Journal of Biological Chemistry.

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Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.

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The Endocrine Society has confirmed the plenary program speaker line-up for ENDO 2019, the world's largest event for endocrine science and medicine. This year features a presidential plenary from Francis S. Collins, M.D., Ph.D., Director of the National Institutes of Health (NIH), the largest supporter of biomedical research in the world. Other noteworthy speakers are Robert Califf, M.D., Duke University School of Medicine and former Food & Drug Administration (FDA) Commissioner, and Cori Bargmann, Ph.D., Rockefeller University and head of the Chan Zuckerberg Initiative’s science work.

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A practice known for providing high-level oncology and hematology services to people in central Pennsylvania for more than 30 years is now part of Penn State Health Medical Group.

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In an upcoming project, a team of Penn State researchers will use mice as a model for creating high-resolution, 3D maps of the blood vessels in both young and aging brains.

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Physician researchers with The Ohio State University College of Medicine at the Wexner Medical Center say increased levels of the hormone aldosterone, already associated with hypertension, can play a significant role in the development of diabetes, particularly among certain racial groups.

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The latest research, features and announcements in healthcare in the Healthcare News Source

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Biomedical Engineering Professor Rita Alevriadou has spent most of her career, which spans two decades, on cardiovascular disease. Her current research on the effects of blood flow on our artery walls recently earned a $1.8 million grant from the National Institutes of Health (NIH).

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Over the next five years, the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, will award approximately $20 million to four academic centers to launch a new national Career Development Consortium for Excellence in Glycosciences.

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For the first time, researchers have devised a model to predict burn patients who are most likely to develop life-threatening acute respiratory distress syndrome (ARDS).

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The parasites that cause malaria make themselves at home inside a host’s red blood cells. An Iowa State University scientist has shown in a pair of newly published articles just how that process works. This new understanding could help to identify new ways to treat malaria.

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Stroke survivors under age 65 are having less trouble paying for the crucial medications that can stave off a bigger health catastrophe, thanks to expanded Medicaid and other Affordable Care Act provisions.

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A new device allows surgeons to create an access point for dialysis patients using a minimally-invasive approach. This might help the more than 470,000 currently on dialysis.

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The European Commission (EC) has approved a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, making it the first chimeric antigen receptor (CAR) T cell therapy permitted for use in the European Union in two distinct indications.

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Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory bowel disease (IBD), and arthritis. The findings, published in Science Immunology, identify a chemical that potently inhibits inflammatory cell death.

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Best known as a pathogen that causes food poisoning or steals nutrients away from its host, the E. coli bacterium actually plays a critical role in promoting health by producing a compound that helps cells take up iron.

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A University of Kentucky neurologist who stumbled across a family with a gene mutation that can cause Lou Gehrig's Disease is merging science, medicine and family in a quest for a cure.

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Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people to have immature, malfunctioning bone marrow cells that fuel a diverse set of health problems and can lead to leukemia. Researchers report in the journal Cancer Discovery identifying a gene that in laboratory experiments fuels the biological processes that cause the different types of MDS that physicians see in patients.

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AMP has published consensus, evidence-based recommendations to aid clinical laboratory professionals with the management of most Chronic Myeloid Neoplasms (CMNs) and development of high-throughput pan-myeloid sequencing testing panels.

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NYU Langone’s Blood and Marrow Transplant Program expands services and receives accreditation for adult allogeneic transplants.

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In 2008, a contaminant eluded the quality safeguards in the pharmaceutical industry and infiltrated a large portion of the supply of the popular blood thinner heparin, sickening hundreds and killing about 100 in the U.S.

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ROCHESTER, Minn. — Mayo Clinic implemented a patient blood-management program in 2010 on its Rochester campus and has since experienced a 35-percent reduction of blood transfusions, improving patient outcomes and achieving significant savings. Using best practices from the program, Mayo Medical Laboratories, the global reference laboratory of Mayo Clinic, collaborated with National Decision Support Company (NDSC) to combine Mayo’s clinical knowledge with NDSC’s industry-leading expertise in electronic health record (EHR) clinical-decision support.

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Wichita State University is offering an online badge course In what may be one of the only classes nationwide teaching practical blood flow restriction, defined as BFR, using low-cost equipment.

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New study by researchers at Intermountain Medical Center in Salt Lake City found that patients with low-risk blood clots may be better off receiving treatment at home versus being admitted to the hospital.

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A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) pathway.

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The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a $4 million grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease (SCD) in individuals who do not have asthma.

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Adolescents make up more than a quarter of the population in developing countries. Only 1.6 percent of global development assistance for health from 2003-2016 went to adolescent health. Resource allocation failed to address many of the diseases that take the worst toll on adolescent health, such as depressive disorders, anemia and injuries.

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Researchers have now described an underlying mechanism that reprograms the hearts of patients with ischemic cardiomyopathy, a process that differs from patients with other forms of heart failure. This points the way toward future personalized care.

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Previous research has revealed that patients with acute myeloid leukemia who also have a particular mutation in a gene called NPM1 have a higher rate of remission with chemotherapy. About one-third of leukemia patients possess this favorable mutation, but until now, how it helps improve outcomes has remained unknown.Scientists from the University of Illinois at Chicago report on how this mutation helps improve sensitivity to chemotherapy in patients in the journal JCI Insight.

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In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine (UMSOM) are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier. The trial will be conducted with patients undergoing brain cancer surgery at the University of Maryland Medical Center (UMMC).

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Investigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator. The team, led by researchers at the Cancer Center at Beth Israel Deaconess Medical Center, is hopeful that the discovery could lead to new treatment strategies for diverse types of cancer.