El adenocarcinoma pancreático (PDAC, por sus siglas en inglés) es un cáncer mortal y muy a menudo refractario a la quimioterapia. Por ello, los investigadores buscan maneras de mejorar la sensibilidad tumoral a los fármacos contra el cáncer.
Expanding Medicaid to more low-income adults helped many of them feel healthier, and do a better job at work or a job search, in just one year after they got their new health coverage, a new study finds.
A common tuberculosis (TB) vaccine could decrease the risk of lung cancer if administered during early childhood, according to a study published Sept. 25 in JAMA Network Online.
UCLA researchers have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice.
High-intensity cycling is less painful when combined with virtual reality, according to a new study by University of Georgia researchers.
A satellite on schedule to launch in 2021 could offer a more comprehensive look at flooding in vulnerable, under-studied parts of the world, including much of Africa, South America and Indonesia, a new study has found.
Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3.
Research determines optimal heat conditions for weed seed control in Louisiana sugarcane fields
Schools serving disadvantaged and minority children teach as much to their students as those serving more advantaged kids, according to a new nationwide study.
A hypothetical nuclear process known as neutrinoless double beta decay ought to be among the least likely events in the universe. Now the international EXO-200 collaboration, which includes researchers from the Department of Energy’s SLAC National Accelerator Laboratory, has determined just how unlikely it is: In a given volume of a certain xenon isotope, it would take more than 35 trillion trillion years for half of its nuclei to decay through this process – an eternity compared to the age of the universe, which is “only” 13 billion years old.
To guide the emerging practice of using video as an integral part of the scientific process, University of Pittsburgh Graduate School of Public Health scientists performed the first review of studies on use of film in public health research.
Fungal bloodstream infections are responsible for the deaths of more than 10,000 people every year. New research from Washington University School of Medicine in St. Louis shows that the death rate can be reduced by 20% if infectious disease specialists oversee care of such patients.
Among the 30 million U.S. adults with Type 2 diabetes, 20% have impaired kidney function. In patients like this, metformin, the recommended first-line drug therapy for Type 2 diabetes, is associated in the new study with 20 percent decreased risk of major adverse cardiovascular events when compared to a class of common diabetes drugs called sulfonylureas.
• In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease. • A healthy dietary pattern was also linked with a 23% lower incidence of albuminuria, an early indicator of kidney damage
A study largely validates that immunoglobulin IgG is a crucial part of the pathogenic immunodeposits in kidneys of patients with IgA nephropathy. The routine clinical test that identifies the presence of IgA in all cases of IgA nephropathy fails to show IgG in 50 to 80 percent of biopsies.
Within six months of the FDA's move to restrict the label of two immunotherapies, usage of those therapies among oncologists dropped by about 50 percent, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania.
A collaboration between researchers from Cornell, Harvard, Stanford and the SLAC National Accelerator Laboratory has resulted in a reactive copper-nitrene catalyst that pries apart carbon-hydrogen (C–H) bonds and transforms them into carbon-nitrogen (C–N) bonds, which are a crucial building block for chemical synthesis, especially in pharmaceutical manufacturing.
Interest rates on healthcare municipal bonds significantly decreased due to the ACA, according to a study from the Government Finance Research Center at the University of Illinois at Chicago.
Everyone is a mutant but some are prone to diverge more than others, report scientists at University of Utah Health. A new study published in eLife shows the number of mutations a child has compared to her parents varies dramatically with some people being born with twice as many as others, and that characteristic runs in families.
University of California San Diego School of Medicine researchers have identified a switch controlling HIV reproduction in immune cells which can eliminate dormant HIV reservoirs.
Dr Michael Pittman of the Vertebrate Palaeontology Laboratory, Department of Earth Sciences
It's billed as a health booster and healing agent, but it may be the source of cognitive defects and other severe ailments.
The impostor syndrome, a phenomenon that manifests when people feel like frauds even if they are actually capable and well-qualified
Researchers have outlined how fishing and farming policies could be created to protect employment opportunities and the environment after Brexit.
Washington State University scientists have developed a way to triple the shelf life of ready-to-eat macaroni and cheese, a development that could have benefits for everything from space travel to military use.
Researchers in Japan have developed a type of processor called PAXEL, a device that can potentially bypass Moore’s Law and increase the speed and efficiency of computing. In APL Photonics, the researchers looked at using light for the data transport step in integrated circuits, since photons are not subject to Moore’s Law. Instead of integrated electronic circuits, much new development now involves photonic integrated circuits. The PAXEL accelerator takes this approach and uses power-efficient nanophotonics.
By studying the brain dynamics of 28 subjects with epilepsy, scientists demonstrated there is no evidence for a previously suspected warning sign for seizures known as “critical slowing down,” which refers to characteristic changes in the behavior of a complex system that approaches a theoretical tipping point; when this point is exceeded, there can be impactful and devastating changes. The researchers discuss their work in this week’s Chaos.
Being able to accurately forecast how much solar energy reaches the surface of the Earth is key to guiding decisions for running solar power plants and new work in the Journal of Renewable and Sustainable Energy looks to provide a standard of reference to the field. Dazhi Yang proposes an improved way to assess day-ahead solar forecasting, which combines two popular reference methods for weather forecasting, namely persistence and climatology. His approach provides a new way to gauge the skill of a forecaster.
An 18-year ‘report card’ on the American diet shows adults are eating too many low-quality carbohydrates and more than the recommended daily amount of saturated fat. The study of dietary trends, from researchers at Tufts and Harvard, is published today in JAMA.
Profiled is physicist Gaute Hagen of the Department of Energy’s Oak Ridge National Laboratory, who runs advanced models on powerful supercomputers to explore how protons and neutrons interact to “build” an atomic nucleus from scratch.
A new study from a Binghamton University research team uses the topography of human skin as a model not for preventing cracks but for directing them in the best way possible to avoid critical components and make repairs easy.
Hey, physicists and materials scientists: You’d better reevaluate your work if you study iridium-based materials – members of the platinum family – when they are ultra-thin. Iridium “loses its identity” and its electrons act oddly in an ultra-thin film when interfaced with nickel-based layers, which have an unexpectedly strong impact on iridium ions, according to Rutgers University–New Brunswick physicist Jak Chakhalian, senior author of a Rutgers-led study in the journal Proceedings of the National Academy of Sciences.
One of the WHO’s three critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers from the Department of Chemistry - University of Warwick have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.
Scientists show that the location of stem cells is essential in determining tapeworms’ ability to regenerate.
Survey results of a national sample of elderly people with type 2 diabetes suggest that many long-time patients downplay medical and social factors that underpin professional recommendations for fewer medications and less aggressive treatment of high blood sugar.
In a study published online today by the journal Cancer, investigators at Dana-Farber Cancer Institute report that a single-session sleep education program for survivors can cure insomnia in many participants, and that those who don’t benefit from this approach are often helped by a more extensive, but still modest, three-session program.
An algorithm developed by faculty at The University of Texas Health Science Center at Houston (UTHealth) can help physicians outside of major stroke treatment centers assess whether a patient suffering from ischemic stroke would benefit from an endovascular procedure to remove a clot blocking an artery.
PTEN, a tumor suppressor gene mutated in about 20% of prostate cancers, relies on another gene, ARID4B, to function. These findings were published by George Washington University Cancer Center researchers in Nature Communications.
A new clinical trial conducted at The Ohio State University Wexner Medical Center found a cost-effective generic medication works just as well as a more expensive drug in preserving cardiovascular function in boys with Duchenne muscular dystrophy (DMD).
Researchers investigated the safety and efficacy of deep brain stimulation in the treatment of refractory severe tinnitus in a small group of patients. They found the procedure to be safe and the results to be encouraging.
By using sound waves, scientists have begun to explore fundamental stress behaviors in a crystalline material that could form the basis for quantum information technologies.
في تجربة سريرية صغيرة للسلامة والجدوى، أظهر باحثو Mayo Clinic لأول مرة أن الخلايا الهرمة يمكن إزالتها من الجسم باستخدام أدوية تُسمى "الأدوية المضادة للشيخوخة". لم يتم التحقق من النتيجة في تحليل الدم فحسب، بل أيضًا في تغيرات وفرة الخلايا الهرمة في الجلد والأنسجة الدهنية. تظهر النتائج في مجلة EBioMedicine.
在一项小型安全性和可行性临床试验中，Mayo Clinic的研究人员首次证明，使用被称为“senolytic”的抗衰老药物可以清除人体内的衰老细胞。该结果不仅在血液分析中得到验证，而且在皮肤和脂肪组织衰老细胞丰度的变化中得到证实。研究结果发表在 EBioMedicine期刊上。
Em um ensaio clínico de segurança e viabilidade de pequena escala, pesquisadores da Mayo Clinic demonstraram pela primeira vez que células senescentes podem ser removidas do corpo por meio de medicamentos denominados "senolíticos". O resultado foi confirmado por análises sanguíneas e por alterações na abundância de células senescentes nos tecidos epitelial e adiposo. Os resultados foram publicados na revista EBioMedicine.
Dans le cadre d'un essai clinique d'innocuité et de faisabilité de faible portée, les chercheurs de la Mayo Clinic ont démontré pour la première fois que des médicaments qualifiés de « sénolytiques » pouvaient éliminer les cellules sénescentes de l'organisme. Le résultat a été vérifié non seulement dans les analyses sanguines, mais également dans les variations de quantités des cellules sénescentes de la peau et des tissus adipeux. Les résultats sont publiés dans la revue scientifique EBioMedicine.
In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
In einer kleinen klinischen Sicherheits- und Machbarkeitsstudie haben Forscher der Mayo Clinic zum ersten Mal nachgewiesen, dass alternde Zellen mit Medikamenten, die als „Senolytika“ bezeichnet werden, aus dem menschlichen Körper entfernt werden können. Das Ergebnis wurde nicht nur in der Blutanalyse, sondern auch in der veränderten Menge seneszenter Zellen in Haut- und Fettgewebe bestätigt. Die Ergebnisse erscheinen in der Zeitschrift EBioMedicine.
New research from Michigan State University and Johns Hopkins University is the first to uncover the specific data leaked through hospital breaches, sounding alarm bells for nearly 170 million people.
Disrupting a metabolic pathway in the liver in a way that creates a more “cancer-like” metabolism actually reduces tumor formation in a mouse model of liver cancer. This surprising finding from a Univ. of Iowa study identifies the mitochondrial pyruvate carrier as a potential target for preventing liver cancer.
The researchers used a sophisticated electron microscope that can take pictures of structures at the atomic level to examine the virus as it interacted with the transferrin receptor, or TfR, a protein on the surface of the cell that helps manage a body’s iron uptake.
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