Adult-like Human Heart Muscle Grown from Patient-specific Stem Cells
Columbia University School of Engineering and Applied ScienceResearchers have developed a radically new approach to growing in the lab adult-like human heart muscle from human induced pluripotent stem cells in only four weeks. They compressed the development timeframe into a faster, more complete transition to cardiac maturity than any other team has done so far. They formed cardiac tissues from early-stage iPSC-derived cardiomyocytes, soon after the initiation of spontaneous contractions, by subjecting the cells encapsulated in hydrogel to increasingly intense physical conditioning.