Scientists from the Florida campus of The Scripps Research Institute (TSRI) have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer’s.
Jagdish Singh, chair and professor of pharmaceutical sciences at North Dakota State University, is receiving a $1.89 million grant award for his research to develop a nanotechnology-based system that effectively delivers Nerve Growth Factor across the blood brain barrier to treat Alzheimer's disease.
More than 15 million family members and other unpaid caregivers provide care to persons living with dementia in the United States. Yet the current healthcare environment and reimbursement models emphasize obligations toward individual patients, preventing clinicians from reaching out to these caregivers to assess their needs and provide care.
Eli Lilly’s Phase III drug trial attempting to slow the advancement of Alzheimer’s disease disappointed many when it recently was announced that the study did not meet its primary endpoints.
Mayo Clinic Monthly News Tips — November 2016
December 1, 2016 — (BRONX, NY) —The National Institutes of Health has awarded researchers at Albert Einstein College of Medicine and Pennsylvania State University a five-year, $12.2 million grant to continue studies on the aging brain, Alzheimer’s disease and other dementias. More than five million Americans are living with Alzheimer’s disease—a number that is expected to double by 2040 as baby boomers age.
American Autoimmune Related Diseases Association (AARDA) announced today its latest Autoimmune Heroes – the 22 Scientific Advisory Board (SAB) members who have loyally and generously donated their time and talent to helping AARDA realize its mission of promoting collaborative research efforts to better understand autoimmunity and discover new autoimmune disease diagnostic tools and treatments these last 25 years.
Walking is a milestone in development for toddlers, but it’s actually only one part of the complex cognitive task known as gait that includes everything from a person’s stride length to the accompanying swing of each arm. A Mayo Clinic study recently published in the Journal of Alzheimer’s Disease found that problems associated with gait can predict a significant decline in memory and thinking.
Using targeted immunotherapy, doctors have succeeded in curing a type of autoimmune enteritis caused by a recently discovered genetic mutation. This report comes from researchers at the Department of Biomedicine of the University of Basel and University Hospital Basel. Their results raise new possibilities for the management of diarrhea, which is often a side effect of melanoma treatment.
Nucleation processes are a first step in the structural rearrangement involved in the phase transition of matter: a liquid morphing into a gas, a gas becoming a liquid and so on. Understanding this process is critical for preventing, halting or treating cases of nucleation processes gone wrong -- such as in human disease. Now, a team of researchers have made headway toward understanding this problem from a molecular point of view in a new study, which they discuss in this week’s The Journal of Chemical Physics.
Dealing with Alzheimer’s disease can be difficult any time of year, but the holidays present unique challenges for patients and their families.
The American College of Rheumatology (ACR) announced the 2016 recipients of its Master of the ACR designation, Awards of Distinction, and Distinguished Fellow Award honors during the opening lecture of the 2016 ACR/ARHP Annual Meeting in Washington D.C. These recognitions are given annually to members who exhibit outstanding contributions to the field of rheumatology.
In a hopeful sign for the health of the nation’s brains, the percentage of American seniors with dementia is dropping, a new study finds. The downward trend has emerged despite something else the study shows: a rising tide of three factors that are thought to raise dementia risk by interfering with brain blood flow, namely diabetes, high blood pressure and obesity.
The Vasculitis Foundation and Northwestern Memorial Hospital in Chicago establish new center for patients with autoimmune vasculitis.
A new study shows a link between mothers with rheumatoid arthritis and children with epilepsy. The study is published in the November 16, 2016, online issue of Neurology®, a medical journal of the American Academy of Neurology. Rheumatoid arthritis (RA) is an autoimmune disease that causes the body’s own immune system to attack the joints. It differs from osteoarthritis, which is caused by wear and tear on the joints.
Tumor necrosis factor inhibitors, a group of biologic drugs used to treat children with juvenile idiopathic arthritis, are not associated with a significantly increased risk of cancer, according to new research findings presented this week at the ACR/ARHP Annual Meeting in Washington.
The latest research and features on obesity in the Obesity News Source.
Researchers at the University of Virginia School of Medicine have developed an experimental vaccine to battle melanoma, a deadly form of skin cancer. It’s an example of cutting-edge immunotherapy, the harnessing of the immune system’s power to battle disease. But it also represents a fulfillment of potential UVA recognized 25 years ago. In 1991, with financial support from businessman Beirne B.
The Latest in Cell Biology News
American Autoimmune Related Diseases Association (AARDA) announced today its newest Autoimmune Heroes – the 39 autoimmune disease specific patient groups who comprise the National Coalition of Autoimmune Patient Groups (NCAPG).
A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.
A Ludwig Cancer Research study published online September 5th in Nature Immunology illuminates a key requirement for the function of regulatory T cells—immune cells that play a critical role in many biological processes, from suppressing inflammation and deadly autoimmunity to helping tumors evade immune attack. The findings also unravel the complex role these cells can play in the genesis and progression of certain gastrointestinal cancers.
A team of scientists led by Stony Brook University researchers have discovered a new mechanism for a bacterial toxin to inhibit inflammation.
Researchers from the University of Oklahoma Health Sciences Center, in collaboration with the National Institute of Mental Health, have developed the first-of-its-kind biomarker test to help identify autoimmune-induced neuropsychiatric disorders.
American Autoimmune Related Diseases Association (AARDA) announced today its August Autoimmune Heroes – the 46 Board members and advisors who have loyally and generously donated their time and talents to helping AARDA and its mission evolve and grow these last 25 years.
Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unknown way that stress hormones (glucocorticoids) control genes in the liver to help the body adapt to the fasting state. The study, published today in Cell Metabolism, describes an obscure protein, SETDB2, that’s increased during times of fasting and alters the genome to help turn on genes needed to adjust to the absence of food.
Dr. Jeffrey Raines, a General Obstetrician/Gynecologist and supervisor for the Obstetric/Gynecology Department of Fairview Medical Group Fairview Medical Center in Maple Grove, Minnesota earned a special award for his critical early diagnosis of vasculitis.
Rheumatoid arthritis patients taking medications that inhibit interleukin-1beta (IL-1beta), a molecule that stimulates the immune system, are 300 times more likely to experience invasive Group A Streptococcal infections than patients not on the drug, according to University of California San Diego School of Medicine researchers. Their study, published August 19 in Science Immunology, also uncovers a critical new role for IL-1beta as the body’s independent early warning system for bacterial infections.
Dr. Seth Sullivan was awarded the 2016 VF RED Award for his work in diagnosing a patient with vasculitis. The Vasculitis Foundation created the award to honor those medical professionals who have made an early diagnosis of the rare, autoimmune disease, thus improving the patient's outcome.
Molecules that scavenge debris from dying cells appear to halt the cycle of chronic inflammation in lupus, while also enhancing the body’s ability to combat flu, according to Duke Health studies in mice.
The Vasculitis Foundation awarded three doctors the 2016 V-RED Award for making an early diagnosis of vasculitis, a rare autoimmune disease.
The Myositis Association (TMA) hosts its 2016 Annual Patient Conference September 1-4 at the Hilton New Orleans Riverside. The conference aims to raise awareness of myositis, a rare autoimmune disease of the muscles, to educate patients about how best to manage symptoms and to provide patients and caregivers with a supportive community.
Surgical removal of the thymus gland from patients with myasthenia gravis, a rare autoimmune disease that affects neuromuscular function, provides significant benefit in patients who do not have a chest tumor, a new study finds.
Expert can speak on the use of animal toxins to develop a new generation of medicines. Gur Roshwalb, MD, Chief Executive Officer of Akari Therapeutics, is studying the use of Coversin—a molecule derived from the saliva of the Ornithodoros moubata tick—in potential treatments for conditions such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS) and Guillain Barré syndrome (GBS).
A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology, suggesting that members of a cluster of microRNAs work together throughout the different stages of immune cell generation.
A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis.
American Autoimmune Related Diseases Association (AARDA) announced today its July Autoimmune Heroes.
The American Autoimmune Related Diseases Association, Inc. (AARDA) is spotlighting two new research studies originally reported in ScienceDaily.
Recognizing the American Autoimmune Related Diseases Association, Inc’s (AARDA) strong financial health and commitment to accountability and transparency, Charity Navigator has awarded the organization its highest, 4-star rating for the seventh time in the last eight years.
In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.
As part of its ongoing 25th Anniversary celebration, American Autoimmune Related Diseases Association (AARDA) announced today its June Autoimmune Hero – Johns Hopkins University’s Autoimmune Disease Research Center (ADRC).
Researchers at Hospital for Special Surgery (HSS) have uncovered a potential genetic trigger of systemic autoimmune disease.
In a proof-of-principle study, a team of physicians and bioinformatics experts at Johns Hopkins reports they were able to diagnose or rule out suspected brain infections using so called next-generation genetic sequencing of brain tissue samples.
A short video produced by the Vasculitis Foundation to help raise awareness about vasculitis, a rare autoimmune disease. Also, the video promotes the non-profit, Vasculitis Foundation.
The Vasculitis Foundation (VF) is partnering with Olympic hopeful and vasculitis patient Brandon Hudgins to create Victory Over Vasculitis: VF Team Brandon." The initiative is designed to support Hudgins' efforts to increase awareness of his rare, autoimmune disease as he attempts to qualify for the United States Olympic Team.
Genetic master switches that turn the activity of specific types of immune cells up or down have been identified by researchers at Washington University School of Medicine in St. Louis. The regions of DNA that make up these switches include genetic variants linked to a range of autoimmune diseases.
Researchers from University College London have discovered that the widely used antiinflammatory drug HUMIRA doesn’t just work by inhibiting its target protein, TNF, but by enhancing a particular function of TNF in rheumatoid arthritis patients. The study, “Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis,” which will be published online June 6 in The Journal of Experimental Medicine, may help explain the divergent efficacies of different TNF-targeting drugs.
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Research led by scientists at SBP has identified a new regulator of immune responses. The opens the door for a new approach to modulating T cell responses to treat infections, autoimmune diseases, and cancer.
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