Feature Channels: Respiratory Diseases and Disorders

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Researchers at Cornell have developed a way to analyze how individual immune cells react to the bacteria that cause tuberculosis. It could pave the way for new vaccine strategies and provide insights into fighting other infectious diseases.

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Researchers at Weill Cornell Medicine and NewYork-Presbyterian in New York have discovered that injecting mice with pulmonary endothelial cells—the cells that line the walls of blood vessels in the lung—can reverse the symptoms of emphysema. The study, which will be published July 21 in the Journal of Experimental Medicine (JEM), may lead to new treatments for chronic obstructive pulmonary disease (COPD), an inflammatory lung disease associated with smoking that is thought to be the third leading cause of death worldwide.

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In response to an announcement from Philip Morris International that the company has agreed to acquire Vectura, a British inhaled medicine company, American Lung Association President and CEO Harold Wimmer and American Thoracic Society President Lynn Schnapp MD, ATSF shared the following statement:

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The struggle to get your child to go to sleep and stay asleep is something most parents can relate to. Once the bedtime battle is over and the kids have finally nodded off, many parents tune out as well. But University of South Australia researcher Professor Kurt Lushington is calling for parents to check on their small snoozers before switching off.

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Resistance to antibiotics is common and often deadly among children with pneumonia in Bangladesh, according to a new study coauthored by researchers from Massachusetts General Hospital (MGH) with colleagues at the International Centre for Diarrhoeal Disease Research, Bangladesh (abbreviated as icddr,b).

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Mayo Clinic Healthcare（妙佑医疗国际医疗保健）是一家提供个性化医疗保健服务的门诊诊所，服务范围涵盖预防性筛查、保健计划定制以及疑难诊断第二诊疗意见。该诊所目前正进行增设如下医学专科：心脏病学、胃肠病学和肺病医学。

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A Mayo Clinic Healthcare, uma clínica ambulatorial que oferece cuidados de saúde desde exames preventivos e planos de bem-estar personalizados até segundas opiniões sobre diagnósticos complexos, passa a oferecer também especialidades como cardiologia, gastroenterologia e pneumologia.

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Mayo Clinic Healthcare es una clínica de consulta externa que ofrece atención médica personalizada con detecciones preventivas, planes individualizados de bienestar y segundas opiniones para diagnósticos complejos que ahora añade varias especialidades médicas, entre ellas, cardiología, gastroenterología y neumología.

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Findings from an international multicenter trials showed that while a full dose of heparin didn't statistically significantly lower incidence of the primary composite of death, mechanical ventilation or ICU admission compared with low-dose heparin, therapeutic heparin did reduce the odds of all-cause death by 78 percent.

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Scientists find that short chain fatty acids can be used to reduce susceptibility to SARS-CoV-2 infection and mortality from COVID-19

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The ATS Research Program is pleased to announce that William Zhang, MD, of Weill Cornell Medical Center is the recipient of the 2020-2021 ATS/CSL Behring Research Award in Acute Respiratory Distress Syndrome. The $50,000 award will support Dr. Zhang’s research study, “Hyperferritinemia in COVID-19 ARDS: Friend or Foe?”

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Mayo Clinic Healthcare, an outpatient clinic that provides personalized health care ranging from preventive screenings and tailored wellness plans to second opinions for complex diagnoses, is adding several medical specialties including cardiology, gastroenterology and pulmonary medicine.

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The ATS Research Program and the chILD Foundation have awarded Anthony Shum, MD, of the University of California, San Francisco $80,000. The award will support Dr. Shum’s research project, “Defining the pathogenesis of childhood ILD in COPA syndrome.”

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Today, the ATS Research Program announced that Jessica Blackburn, PhD, of Vanderbilt University has been awarded the ATS/GSK Research Grant in Obstructive Lung Disease. The grant was funded through GlaxoSmithKline (GSK) support of the ATS Research Program.

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A decade’s worth of data shows that neonatologists are shifting the type of respiratory support they utilize for preterm infants, a move that could lead to improved health outcomes.

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The lung transplant team at UC San Diego Health performed San Diego County’s first transplant surgery with lungs donated after cardiac death, an approach that could mean more opportunities to save the lives of those in critical need of new lungs.

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Working out just five minutes daily via a practice described as "strength training for your breathing muscles" lowers blood pressure and improves some measures of vascular health as well as, or even more than, aerobic exercise or medication, new CU Boulder research shows.

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A new study finds that exposure to e-cigarette vapor leads to higher levels of the coronavirus receptor ACE-2 in lungs of mice, with nicotine enhancing that increase in male mice.

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The compound TA-C is metabolized by TB bacteria – weakening the germ from within like a ‘Trojan horse’ attack

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Immunologists at McMaster University have discovered a previously unknown mechanism which acts like a spider web, trapping and killing pathogens such as influenza or SARS-CoV-2, the virus responsible for COVID-19.

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Aerosol generated by playing woodwind and brass instruments is less than that produced when vocalising (speaking and singing) and is no different than a person breathing, new research has found.

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Researchers at Children’s Hospital of Philadelphia (CHOP) have discovered that a specific type of lung cell exhibits unconventional immune properties and may contribute to the outcome of respiratory viral infections. The researchers focused on type II alveolar (AT2) cells, which are non-immune cells of the lung that are critical for basic lung health and tissue repair after lung injury. They found that AT2 cells express high levels of major histocompatibility complex II (MHC-II), an important immune system trigger, and that AT2 MHC-II expression appears to confer an appreciable advantage in the outcome of respiratory viral infection. The findings were published today in Nature Communications.

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A new study confirms the low likelihood that coronavirus contamination on hospital surfaces is infectious. The study is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.

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Israeli scientists have demonstrated a novel means of diagnosing tuberculosis by means of a sticker patch that catches compounds released by the skin. Using an artificial intelligence (AI) analysis of these compounds, the scientists were able to provide a quick, non-invasive diagnosis.

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Monroe Carell Jr. Children’s Hospital at Vanderbilt is seeing a spike in respiratory illnesses, especially RSV (respiratory syncytial virus) and parainfluenza, which cause croup and bronchiolitis in young children and flu-like symptoms in older children and adults

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All Virtual Conference To Highlight PF Research And Quality Of Life Nov. 8-13

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In a new article published in the Journal for ImmunoTherapy of Cancer, Moffitt Cancer Center researchers show that PET/CT images can be used to measure levels of the PD-L1 biomarker of non-small cell lung cancer (NSCLC) patients in a non-invasive manner and, in turn, predict a patient’s response to therapy.

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Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they’re needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue. Inflammation was completely treated in mice given the nanoparticles, at a drug concentration where standard delivery methods did not have any efficacy.

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From studies in her lab at Stony Brook University in New York to private-sector collaborations, Hertz Fellow Jessica Seeliger is accelerating the fight against multiple deadly diseases.

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Site Features Resources and User-Friendly Tools for Patients

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Immune cells that normally repair tissues in the body can be fooled by tumors when cancer starts forming in the lungs and instead help the tumor become invasive, according to a surprising discovery reported by Mount Sinai scientists in Nature in June.

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Exposure to the rhinovirus, the most frequent cause of the common cold, can protect against infection by the virus which causes COVID-19, Yale researchers have found.

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Public health measures designed to reduce the spread of the COVID-19 virus may have fostered a substantial side benefit: A 53 percent drop in hospital admissions for chronic obstructive pulmonary disease (COPD), likely due to a drop in circulating seasonal respiratory viruses such as influenza.

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A new study finds that manipulating the stiffness of the collagen-based support structure of airway cells could lead to a new treatment for asthma. The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for June.

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The Pulmonary Fibrosis Foundation (PFF) and Paradigm Medical Communications, LLC , have announced a collaborative partnership to design and implement a curriculum of continuing medical education (CME) activities in interstitial lung disease (ILD).

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Researchers have shown that even after lung tissue has been damaged, it may be possible to reverse fibrosis and promote tissue repair through treatment with microgel-coated mesenchymal stromal cells.

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Scientists have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs. The findings may speed the search for drugs to block the most severe effects of COVID-19.

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A new Houston Methodist study shows a rapid return of seasonal respiratory viruses after COVID-19 restrictions were relaxed in Texas, demonstrating the apparent effectiveness of masking, distancing and other precautionary measures at stopping the spread of respiratory illnesses. This rise in infections to pre-pandemic levels followed updated governmental guidelines lifting mask, distancing and occupancy requirements.

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The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial led by Washington University School of Medicine in St. Louis. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients with lung adenocarcinoma, a common type of non-small-cell lung cancer.

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