Feature Channels: Alzheimer's and Dementia

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睡眠过程中出现呼吸暂停症状的患者在其大脑管理记忆、方向感和时间感知的部位可能会累积更多的毒性蛋白质tau，该蛋白质是阿尔茨海默症的一个生物学标志。Mayo Clinic于 3 月 3 日星期日发布的一项初步研究将在 5 月 4 日至 10 日期间于费城举行的美国神经病学学会第 71 届年会上发表。

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Pessoas que param de respirar durante o sono podem ter um alto acúmulo da proteína tóxica tau, uma marca biológica da doença de Alzheimer, na parte do cérebro que administra a memória, a navegação e percepção do tempo.

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University of Minnesota engineering researchers have developed a unique new device that provides the first step toward ultrasensitive biosensors to better detect diseases like Alzheimer’s disease and Chronic Wasting Disease at the molecular level.

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Las personas que dejan de respirar mientras duermen pueden acumular más proteína tóxica tau (uno de los distintivos biológicos de la enfermedad de Alzheimer) en la zona cerebral que controla la memoria, la orientación espacial y la percepción del tiempo.

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Scientists at Wake Forest Baptist Health have been awarded $3.9 million from the National Institutes of Health to determine if a procedure used to treat Parkinson’s patients can improve age-related cognitive abilities and counteract the effects of Alzheimer’s and other types of dementia.

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A new pilot study led by researchers at Stony Brook University and the Stony Brook World Trade Center Health and Wellness Program suggests that there may be a link between chronic PTSD in responders and neurodegeneration.

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The science of sleep, and how to get people to do it better, is getting attention from policymakers to researchers who are trying to understand how sleep impacts performance and health.

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A Michigan State University researcher will use a five-year, $5 million grant from the National Institutes for Health to investigate the role pesticides might play in olfactory impairment and their relevance to diseases such as Alzheimer's and Parkinson's.

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A grant from The Harry T. Mangurian, Jr. Foundation will expand FAU’s Dementia Prevention Initiative, a large longitudinal study of brain aging and dementia. Using genetics, biology and the molecular bases of disease, the program incorporates personalized evaluation and prevention plans to reduce risk. Researchers are examining novel biomarkers and peripheral predictors of disease like physical performance, retinal imaging, and gait analyses, and are working with companies to develop novel blood tests to improve diagnosis and prediction.

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Researchers have developed an artificial intelligence platform to detect a range of neurodegenerative disease in human brain tissue samples, including Alzheimer’s disease and chronic traumatic encephalopathy.

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Cognitive impairment affects more than 50 million people worldwide. In the United States alone, one in three seniors dies with some type of dementia. This creates a critical clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment.

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People who stop breathing during sleep may have higher accumulations of the toxic protein tau, a biological hallmark of Alzheimer's disease, in part of the brain that manages memory, navigation and perception of time.

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People who are witnessed by a bed partner to have stopped breathing during sleep may have higher accumulations of an Alzheimer’s disease biomarker called tau in an area of the brain that helps with memory, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 71st Annual Meeting in Philadelphia, May 4 to 10, 2019.

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The Alzheimer’s Foundation of America (AFA) urged President Trump’s administration to continue funding the fight against Alzheimer’s disease by investing an additional $350 million in federal Alzheimer’s research funding for Fiscal Year (FY) 2020.

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The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.

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A powerful tool is available to investigate brain development, memory and learning, and brain dysregulation in neuropsychiatric diseases like addiction, depression, schizophrenia and Alzheimer’s. This molecular biology tool can selectively and robustly turn on genes in brain neurons of living rats.

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What's an s-shaped animal with scales and no legs? What has big ears, a trunk and tusks? What goes 'woof' and chases cats? The brain's ability to reconstruct facts - 'a snake', 'an elephant' and 'a dog'

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In a study of older people with no clinical diagnosis or signs of dementia when hospitalized to repair hip fractures, Johns Hopkins researchers say they found biomarkers of Alzheimer’s disease in most of the patients’ spinal fluid samples. The researchers say results of their study add to evidence that brain alterations that lead to poor balance in older people may underpin both increased risk of hip-fracturing falls and Alzheimer’s disease, and that hip fracture itself may therefore serve as a first sign of undiagnosed disease.

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跟据《阿尔茨海默氏症与痴呆：阿尔茨海默氏症协会杂志》中发表的一项研究，Mayo Clinic的一个研究团队发现患有阿尔茨海默氏症的西班牙裔美国患者的生存期要明显长于患有此病的其他种族人群。据发现，西班牙裔美国人患者自出现症状之时起，平均存活12年。

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Uma equipe de pesquisadores da Mayo Clinic descobriu que pacientes hispano-americanos com Alzheimer costumam sobreviver muito mais tempo com a doença do que outros grupos étnico-raciais, de acordo com um estudo em Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Segundo o estudo, hispano-americanos vivem em média 12 anos com a doença a partir do início dos sintomas.

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Bacteria in the gut do far more than help digest food in the stomachs of their hosts, they can also tell the genes in their mammalian hosts what to do. A study published today in Cell describes a form of “interspecies communication” in which bacteria secrete a specific molecule—nitric oxide—that allows them to communicate with and control their hosts’ DNA, and suggests that the conversation between the two may broadly influence human health.

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Keeping physically and mentally active in middle age may be tied to a lower risk of developing dementia decades later, according to a study published in the February 20, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. Mental activities included reading, playing instruments, singing in a choir, visiting concerts, gardening, doing needlework or attending religious services.

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A new study has found that transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. The findings support an emerging model that attributes cognitive decline, in part, to aging of blood cells, which are produced in bone marrow.

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Un equipo de investigadores de Mayo Clinic descubrió que la supervivencia de los pacientes hispanoamericanos con enfermedad de Alzheimer tiende a ser más larga que en otros grupos etnoraciales, según un estudio publicado en Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

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A team of Mayo Clinic researchers found Hispanic-American patients with Alzheimer’s tend to survive significantly longer with the disease than other ethnoracial groups, according to a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Hispanic-Americans were found to live an average of 12 years with the disease from the time of the onset of symptoms.

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Scientists have discovered new ways in which the body regulates blood clots, in a discovery which could one day lead to the development of better treatments that could help prevent and treat conditions including heart diseases, stroke and vascular dementia.

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The American Neurological Association (ANA), the professional organization representing the nation’s top academic neurologists and neuroscientists, has announced the key areas of science to be explored at its 144th Annual Meeting, October 13-15, 2019 at the Marriott St. Louis Grand.

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A unique formulation will allow the development of nutraceutical products by increasing the bioavailability of curcumin, a powerful anti-inflammatory, through the start-up company Turmeric Ultra Inc.

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In a new study, researchers at University of California San Diego School of Medicine report that hearing impairment is associated with accelerated cognitive decline with age, though the impact of mild hearing loss may be lessened by higher education.

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By discovering the culprit behind decreased blood flow in the brain of people with Alzheimer’s, biomedical engineers at Cornell University have made possible promising new therapies for the disease.

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Researchers at Wake Forest Baptist Health have identified a novel mechanism and potential new therapeutic target for Alzheimer’s disease (AD).

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A new Johns Hopkins study found that rats’ ability to recalibrate learned relationships among time, speed and distance is ever-evolving, moment-by-moment.

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A hormone called irisin – produced during exercise – may protect neurons against Alzheimer’s disease.

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Researchers in Finland recently found that lifestyle choices can help older adults stay mentally sharp. Now scientists at Wake Forest School of Medicine hope to find confirmatory evidence this is indeed the case by coordinating a large, national clinical trial sponsored by the Alzheimer’s Association through a $28 million grant.

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Previous studies have suggested that having a higher level of education may protect the brain to some extent against dementia, providing a “cognitive reserve” that buffers against the disease. But results have been mixed, and a new study finds that education does not play a role in when the disease starts or how fast it progresses. The study was published in the February 6, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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A study of the differences between healthy brains and those with Alzheimer's Disease has produced largest dataset of its type ever.

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The conference brings together internationally recognized clinicians, scientists and educators who will share their research and clinical insights into the understanding, diagnosis and management of chronic diseases that are rising at an unprecedented rate throughout the US and internationally.

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Researchers at University of Utah Health and University of Washington found an FDA-approved cancer drug--paclitaxel--offers protection to mice after experiencing mild traumatic brain injuries.

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Ageing can cause damage to support cells in the white matter, which in turn may lead to damage in the grey matter of the hippocampus, finds a new study by Cardiff University.

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Aerobic exercise is known to improve cognition in the elderly; a new study at Columbia University’s Taub Institute shows it’s good for adults as young as 20.

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Researchers have created a new model-in-a-dish of sporadic Alzheimer’s, the most common form of the disease, which arises in people without family history. Findings suggest early changes in neural stem cells raise the likelihood of developing Alzheimer’s later in life. For the first time, the same abnormalities were found in multiple sporadic Alzheimer’s cell lines and in cells with the major Alzheimer’s genetic risk factor APOE4

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Intensive control of blood pressure in older people significantly reduced the risk of developing mild cognitive impairment (MCI), a precursor of early dementia, in a clinical trial led by scientists at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

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High levels could decrease a person’s likelihood of developing Alzheimer’s disease. For individuals who have higher levels of the hormone, their chance of having mild cognitive impairment or Alzheimer’s disease decreased by 65 percent.

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Monash researchers have unlocked a key process in all human cells that contributes to diseases like cancer and neurodegenerative diseases as well as ageing. The discovery reveals how cells efficiently get rid of cellular junk, which when it accumulates, can trigger death and the health problems associated with getting older.

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Using induced pluripotent stem cell-derived neurons from Alzheimer’s patients, UC San Diego researchers say cholesteryl esters — the storage product for excess cholesterol within cells — act as regulators of the protein tau, providing a new druggable target for the disease.

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A study in mice and people from Washington University School of Medicine in St. Louis shows that sleep deprivation causes tau levels to rise and tau tangles to spread through the brain. Tau tangles are associated with Alzheimer's disease and brain damage.

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Researchers at University of California San Diego School of Medicine report that autopsies of patients diagnosed with Alzheimer’s disease when they were alive — and confirmed by autopsy — indicate many cognitive issues symptomatic of the condition are less noticeable in living Hispanic patients.

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Permanently arrested cell growth is known as "cellular senescence", and the accumulation of senescent cells may be one cause of aging in our bodies. Japanese researchers have discovered that a certain enzyme in our bodies promotes cellular senescence by producing reactive oxygen species. Drugs that target this enzyme could potentially suppress this process, and inhibit aging and aging-related illnesses.