For the first time, UNC School of Medicine scientists report using transcranial alternating current stimulation, or tACS, to target a specific kind of brain activity during sleep and strengthen memory in healthy people.
Clues that point toward new risk mechanisms for developing Parkinson’s disease are hiding in some unusual spots, according to a study published today in Scientific Reports.
Resveratrol, given to Alzheimer’s patients, appears to restore the integrity of the blood-brain barrier, reducing the ability of harmful immune molecules secreted by immune cells to infiltrate from the body into brain tissues, say researchers. The reduction in neuronal inflammation slowed the cognitive decline of patients, compared to a matching group of placebo-treated patients with the disorder.
An FDA approved drug to treat renal cell carcinoma appears to reduce levels of a toxic brain protein linked to dementia in Alzheimer’s and Parkinson’s diseases when given to animals. This finding is the latest from Georgetown University Medical Center’s Translational Neurotherapeutics Program (TNP) examining tyrosine kinase inhibitors in the treatment of neurodegenerative diseases.
An odor identification test may prove useful in predicting cognitive decline and detecting early-stage Alzheimer’s disease, according to research presented at the Alzheimer's Association International Conference.
Researchers comparing mouse and macaque brains have found evidence of an evolutionary universal brain structure in mammals that enables comparisons of cortical networks between species. A new study from a researcher at the University of Notre Dame could provide insights into brain disorders such as Alzheimer’s and schizophrenia.
In a series of experiments at the University at Buffalo, the embryonic stem cell gene Nanog kicked into action dormant cellular processes that are key to preventing weak bones, clogged arteries and other telltale signs of growing old.
The first case of Alzheimer’s disease diagnosed in an HIV-positive individual will be presented in a poster session at the Alzheimer’s Association International Conference 2016 in Toronto July 27. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when Alzheimer’s risk begins to escalate.
In a study of 48 adults with a diagnosis of Early Dementia or Mild Cognitive Impairment, almost half reported positive changes in life outlook and quality of life, countering the assumption that this diagnosis would have a uniformly negative impact.
If Dr. Kalipada Pahan's research pans out, the standard advice for failing students might one day be: Study harder and eat your cinnamon!
A new protein which will help scientists to understand why nerve cells die in people with Alzheimer's disease has been designed in a University of Sussex laboratory.
Long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer’s disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago.
Atlanta, Ga - 07/20/2016 - The Lewy Body Dementia Association (LBDA) and HCR ManorCare announced today that the two organizations are working together to provide a collaborative approach to providing support to those affected by Lewy body dementia.
Two new grants from the New York State Department of Health (NYSDOH) will enable New Yorkers with Alzheimer’s disease and dementia, and their families, to get the most comprehensive care and support services available in the New York City area. NYU Langone Medical Center is launching its Alzheimer’s and Related Dementias Family Support Program and is establishing a Center of Excellence for Alzheimer’s Disease.
New findings published today by a team of researchers led by Dr. Andres Lozano at the Krembil Neuroscience Centre (KNC) of Toronto Western Hospital (TWH) have provided further insight into the effects of Deep Brain Stimulation (DBS) in the treatment of Alzheimer’s disease.
A toxic Alzheimer’s protein can spread through the brain via the extracellular space that surrounds the brain’s neurons, finds a study from Columbia University Medical Center.
Penn Medicine has established the Penn Neurodegeneration Genomics Center (PNGC) as a national focal point for Alzheimer’s disease (AD) genetics research. The Center, an interdisciplinary program that brings together faculty members in neurodegenerative disorders, human genetics, genomics, bioinformatics, and biostatistics.
A new study hopes to develop a faster, more precise and more efficient real-time method for fMRI measurements in patients with Alzheimer’s disease.
A gene associated with Alzheimer’s disease and recovery after brain injury may show its effects on the brain and thinking skills as early as childhood, according to a study published in the July 13, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Can estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer’s disease, a Mayo Clinic study published this month in the Journal of Alzheimer’s Disease found. Ultimately, these deposits harm neurons, leading to cognitive problems.
No single assessment tool is able to consistently determine driving ability in people with Alzheimer's disease and mild cognitive impairment, a St. Michael's Hospital research review has found.
A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson’s disease or dementia with Lewy bodies.
Scientists may have overcome a major roadblock in the development of Alzheimer’s therapies by creating a new technology to observe ― in the back of the eye ― progression of the disease before the onset of symptoms. Clinical trials are to start in July to test the technology in humans according to a paper recently published in Investigative Ophthalmology & Visual Science ( IOVS).
A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, which enables real-time monitoring of amyloid fibrils as they aggregate in lab experiments.
Traumatic brain injury (TBI) with a loss of consciousness (LOC) may be associated with later development of Parkinson’s disease but not Alzheimer’s disease or incident dementia.
A deadly bacteria that can be picked up by a simple sniff can travel to the brain and spinal cord in just 24 hours, a new Griffith University and Bond University study has found.
MINNEAPOLIS – New research shows that a genetic risk score may detect those at higher risk for Alzheimer’s disease long before symptoms appear—even possibly in healthy young adults, according to a study published in the July 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Driving is a very complex process. Today, almost half of all drivers on the roadways are over the age of 65. With the decline of cognitive processes in older adults such as Alzheimer’s disease, there is heightened concern for public safety and unsafe driving in this population. Understanding the cognitive factors that inhibit effective driving as well as recognizing older adults who may be at risk for unsafe driving is key.
Researchers at University of California San Diego School of Medicine say tiny micro-vesicle structures used by neurons and other cells to transport materials internally or dispose of them externally carry tell-tale proteins that may help to predict the likelihood of mild cognitive impairment (MCI) developing into full-blown Alzheimer’s disease.
Using a novel, newly developed mouse model that mimics the development of Alzheimer’s disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological “insults” must occur in the brain to cause the dementia that is the hallmark of the disease
While strokes are known to increase risk for dementia, much less is known about diseases of large and small blood vessels in the brain, separate from stroke, and how they relate to dementia. Diseased blood vessels in the brain itself, which commonly is found in elderly people, may contribute more significantly to Alzheimer's disease dementia than was previously believed, according to new study results published in June in The Lancet Neurology, a British medical journal.
Iowa State University researchers have described with single-molecule precision how copper ions cause prion proteins to misfold and seed the misfolding and clumping of nearby prion proteins. The findings are published in Science Advances.
A European study led by Umeå University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia. This new insight can contribute to the understanding of why some but not others are affected by memory impairment. The results have been published in the journal PNAS.
After legendary basketball coach Pat Summitt was diagnosed with early-onset Alzheimer’s disease at Mayo Clinic in 2011, the winningest coach in NCAA Division 1 history went public with her battle against the disease. Today, Mayo Clinic mourns the loss of Coach Summitt and extends condolences to her family.
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
The neurodegeneration that occurs in Parkinson's disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. It was found that the death of neurons associated with the disease was prevented when chemicals that block the effects of endoplasmic reticulum stress were used.
A team of scientists at The Scripps Research Institute (TSRI), University of California, San Diego (UC San Diego) and Illumina, Inc., has completed the first large-scale assessment of single neuronal “transcriptomes.”
New insight into the process that converts experiences into stable long-term memories has been uncovered by neurobiologists from the University of California, Irvine and the University of Queensland.
A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine - a target for anticholinergic drugs - results in dementia-like changes in the brain.
Case Western Reserve University School of Medicine is one of six recipients of a five-year, $10.8 million award from the National Institute on Aging, part of the National Institutes of Health, to establish the Coordinating Center for Genetics and Genomics of Alzheimer’s disease.
A five-year, projected $10.8 million award from the National Institute on Aging will establish the Coordinating Center for Genetics and Genomics of Alzheimer’s Disease, a joint venture of researchers from the Perelman School of Medicine at the University of Pennsylvania and five other institutions.
Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders.
A subtle change to the amyloid beta protein affects its aggregation behavior and stabilizes an intermediate form with enhanced toxicity.
Researchers from Rowan University School of Osteopathic Medicine have announced the development of a blood test that leverages the body’s immune response system to detect early stage of Alzheimer’s disease with unparalleled accuracy. In a “proof of concept” study involving 236 subjects, the test demonstrated an overall accuracy, sensitivity and specificity rate of 100 percent in identifying subjects whose mild cognitive impairment (MCI) was actually caused by an early stage of Alzheimer’s disease.
Nursing homes care for increasing numbers of people with dementia, yet many lack access to geriatric psychiatrists, behavioral neurologists and other specialists who can help manage dementia care. Consequently, nursing home staff may resort to physical restraints or antipsychotic medications to manage behavioral challenges. A new study led by BIDMC has found that use of video consultations between nursing home staff and hospital clinical experts was associated with significant reductions in the use of physical restraints and antipsychotic medication among dementia patients.
Cancer and Alzheimer's disease drugs target specific proteins, blocking or inhibiting their natural interactions, which may be in overdrive. The traditional drug design process typically assumes the protein shapes are static. But tradition turns out to be too limiting, according to new research from the University of Notre Dame.
A study by scientists at The Scripps Research Institute Florida campus uncovers a new aspect of how the process of forgetting works, indicating a protein called “Scribble” orchestrates the intracellular signaling processes for forgetting, joining several molecules to forge a pathway.
A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.
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