Complex Interactions Between Proteins Rbm38 and p53 Govern Tumor Suppression, Aging
UC Davis HealthScientists have long known the p53 protein suppresses tumors. However, a recent animal study by UC Davis researchers has uncovered a complicated relationship between p53 and another protein, Rbm38, highlighting how the body calibrates protein levels. Too much Rbm38 reduces p53 levels, increasing the risk of cancer. Too little Rbm38 allows p53 overexpression, causing premature aging. The study was published online in the journal PNAS Dec. 15.