A Mount Sinai-led team of researchers has shed new light on the ways in which cocaine addiction dysregulates the normal function of dopamine neurons and thus the brain’s ability to process and respond to reward-related information, making it more difficult for individuals to change their addictive behaviors.
In a first-of-its-kind study, researchers from the University of California, Irvine have discovered an extraordinary surge in the utilization of weight loss-associated GLP-1 receptor agonists, a class of medications commonly used in the treatment of Type 2 diabetes and obesity, that is poised to accelerate, based on emerging clinical evidence.
The opioid epidemic has continued unabated since its start in the 1990s. According to the Centers for Disease Control and Prevention, nearly 280,000 people in the U.S, died from overdoses involving prescription opioids from 1999 to 2021.
Herceptin has saved millions of women’s lives by targeting cancer at its genetic roots. In this interview, Dr. Slamon talks about the paradigm-shifting approach to cancer treatment and how the discovery has opened up an entirely new area of research.
The first and only panel of specialty reagents designed to detect PS modifications independent of sequence, format, or location, streamlining candidate triage for unparalleled cost and time savings in non-clinical/pre-clinical discovery assessment of oligonucleotide drug candidates, clinical trials for immunogenicity studies, and other applications.
New research shows that both MDMA and methamphetamine deepened personal connections after guided conversations, suggesting different mechanisms for how these drugs produce feelings of closeness.
Highly vulnerable patients with alcohol use disorder (AUD) or substance use disorder (SUD) who received regular assessments after their initial intervention had substantially better outcomes a year later than those who did not receive the same follow-up, according to a new study. Fewer than one in ten people with SUD receive any form of treatment in a given year; among those who do, relapse and treatment reentry are common. A Screening, Brief Intervention, and Referral to Treatment (SBIRT) protocol is intended to facilitate treatment referrals, especially among patients with more severe SUDs, but research has shown it to be relatively ineffective in that regard. Adding a Recovery Management Checkup (RMC) intervention can improve treatment rates; RMC conceptualizes AUD and SUD as chronic conditions requiring longer-term monitoring via regular check-ins, early re-intervention in cases of relapse, and treatment retention strategies. For the study in Alcohol: Clinical & Experimental Resear
Although people with opioid use disorder (OUD) are significantly more likely to overdose or have a complication after major surgery than those without the disorder, using medications for the treatment of OUD before surgery may eliminate that extra risk, suggests a large, first-of-its-kind study presented at the ANESTHESIOLOGY® 2023 annual meeting.
Chemists discover the structures of open and closed states of the channel, which could help the development of antiviral drugs to reduce inflammation
Worries that surgery patients would have a tougher recovery if their doctors had to abide by a five-day limit on opioid pain medication prescriptions didn’t play out as expected, a new study finds. Instead, patient-reported pain levels and satisfaction didn’t change at all for Michigan adults who had their appendix or gallbladder removed, a hernia repaired, a hysterectomy or other common operations after the state’s largest insurer put the limit in place, the study shows.
The University of Kentucky has been selected as the nationwide coordination center for a National Institutes of Health (NIH) initiative. Danelle Stevens-Watkins, Ph.D., will lead the National Institute on Drug Abuse (NIDA) Racial Equity Initiative as principal investigator.
Five years after cannabis legalization in Canada, it appears to be a mixed success, with social justice benefits outweighing health benefits, write authors in a commentary published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230808.
Public scrutiny of Purdue Pharma’s role in the opioid crisis increased sharply in the years after the state of Kentucky filed a lawsuit against the company. New research from David Tan, University of Washington associate professor of management, examines the ensuing behavior of competing prescription opioid companies.
The past decade has seen a significant increase in marijuana use among U.S. college students. This increase has coincided with notable changes in national and local cannabis laws and policies, and perceptions of the associated drug’s risk over the same period.
Researchers at University of California San Diego School of Medicine have used single-cell sequencing to identify a potential new treatment for cocaine addiction and shed new light on the molecular underpinnings of addiction.
Researchers at Wake Forest University School of Medicine have received a five-year $10 million grant from the National Institute on Drug Abuse, part of the National Institutes of Health (NIH), to create a broad research program that will work to reduce opioid-related harms and improve quality of life in patients on long-term opioid therapy.
A report from the university’s Institute for Nicotine and Tobacco Studies and the Campaign for Tobacco-Free Kids shows how companies have flooded the market with products that appeal to young people.
One treatment each of two psychedelic drugs lowered depression and anxiety and improved cognitive functioning in a sample of U.S. special operations forces veterans who sought care at a clinic in Mexico, according to a new analysis of the participants’ charts.
Some people may be physically unable to use the current evidential breath analysis machines, relied upon by police to gather proof of driving under the influence of alcohol or drugs, new research from the University of Sheffield indicates.
A new study has found that Canadian adults with cannabis use disorder appear to have an approximately 60% higher risk of experiencing their first heart attack, stroke, or other major cardiovascular event than those without cannabis use disorder.
Below are some of the latest headlines in the Women's Health channel on Newswise.
Hospital visits from alcohol- and substance-related disorders are driven by elevated temperatures and could be further affected by rising temperatures due to climate change, according to new research by environmental health scientists at Columbia University Mailman School of Public Health.
Improving the built environment and expanding housing services in low-incoming communities are protective factors against child abuse, Rutgers study finds.
A conversation can be the catalyst for someone struggling with addiction to get the care they need. But tread carefully. Two Penn State Health experts discuss a difficult conversation.
Researchers at Sylvester Comprehensive Cancer Center found that robot-assisted surgeries and new patient-care protocols are enabling lung cancer surgery patients to go home earlier, with less pain and almost always without a need for potentially addictive opioids.
Pregnant women with a history of substance abuse face a dramatically increased risk of death from heart attack and stroke during childbirth when compared with women without history of substance abuse, a new Smidt Heart Institute study shows.
It’s a therapy that’s commonly used to help overcome addiction or substance abuse, but motivational interviewing could improve the health and wellbeing of frontline aged care workers, according to new research by the University of South Australia.
New UCLA-led research has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more than 50-fold since 2010, from 0.6% (235 deaths) in 2010 to 32.3% (34,429 deaths) in 2021. This rise in constitutes the ‘fourth wave’ in the US’s long-running opioid overdose crisis
That CBD product might be legal, but is it safe to use with other medicine? Two Penn State Health experts agree ― talk it over with your provider.
Regardless of race, age, geography or urbanization, drug overdose deaths in the U.S. more than quadrupled from 1999 to 2020, causing 1,013,852 deaths. The rates increased 4.4 times from 6.9 per 100,000 in 1999 to 30 per 100,000 in 2020.
“One of the main takeaways,” said lead author Anna Fiastro, a family medicine research scientist at UW Medicine, “is that the further patients are from a brick-and-mortar clinic, the more likely they are to use telehealth to access medication abortion.”
A growing body of evidence suggests that psychedelic drugs may be useful in treating various mental health conditions. However, many challenges remain in defining their clinical benefits and overcoming the complex regulatory obstacles to their use.
Researchers have received a U.S. patent for a novel method to identify therapeutic agents to treat addiction. The invention, related to the fields of pharmacology, medicine, neurology and psychiatry, targets the protein MBLAC1, which the Blakely lab identified as the mammalian form of a gene the group first identified in worms as a modifier of signaling by the neurotransmitter dopamine.
Cannabis therapy also linked to improvements in anxiety, depression, and pain levels—though no changes in sleep disturbance levels reported.
Aug. 31 marks International Overdose Awareness Day, a time when attention is directed toward raising awareness about opioid overdose and ways to reverse the deadly effects.
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Research suggests that an ADHD drug could serve as a cocaine-replacement therapy, but clinical results have been mixed. Although labs have produced MPH derivatives for testing, parts of the molecule remained inaccessible. Now, researchers reporting in ACS Central Science have cleared that hurdle.
Anxiety remains one of the most diagnosed clinical symptoms in adolescence and is a potent precursor to and exacerbator of substance use disorder. Through this NIH-funded study, UNC Chapel Hill researchers will examine the neural and physiological mechanisms associated with emergence of substance use in adolescence who experience anxiety.
Rutgers researcher leads effort to map associations between mental health disorders, cannabis use and cannabis use disorder during pregnancy and postpartum in the United States
One Virginia Tech researcher wants to spread awareness about the science of breastfeeding, particularly for pregnant women with opioid use disorder and their advocates.
A new study finds law enforcement plays a critical role in launching programs designed to reduce the risk of repeat overdoses in people who use drugs.
Tufts University School of Medicine teams and collaborators are running multiple projects that seek to reduce overdoses and the spread of infections, such as HIV and hepatitis C, in people who use drugs
In a new preclinical study from Wake Forest University School of Medicine, scientists provide the first evidence that changes in the gut microbiome have significant effects on cocaine use and cravings after withdrawal.
Two studies featured today at the 2023 AACC Annual Scientific Meeting & Clinical Lab Expo highlight advances that could boost the accuracy of marijuana tests and provide vital information for addressing the opioid epidemic.
Indiana University researchers have made a substantial discovery in the role genes play in the development of AUDs, finding that alteration of a group of genes known to influence neuronal plasticity and pain perceptions, rather than single gene defect, is linked to AUDs.
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