Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body’s initiation of the renal damage.
Penn State researchers co-led a large genetic study that identified more than 2,300 genes predicting alcohol and tobacco use after analyzing data from more than 3.4 million people. They said a majority of these genes were similar among people with European, African, American and Asian ancestries.
A newly discovered link between protein misfolding and liver cancer could help improve gene therapy for hemophilia.
Principal Investigator Ivan Baxter, PhD, member, Donald Danforth Plant Science Center, will lead a five-year, $16 million multi-institutional project to deepen the understanding of water use efficiency (WUE) in sorghum, a versatile bioenergy crop.
Have you ever thought about what you have in common with tiny roundworms? As the “nematodes” are metazoan animals like we are, it is actually quite a lot.
Consistent exercise can change not just waistlines but the very molecules in the human body that influence how genes behave, a new study of twins indicates.
At the heart of every CRISPR reaction, whether naturally occurring in bacteria or harnessed by CRIPSR-Cas gene editing technology, is a strong molecular bond of a Cas protein via a guide RNA to its target site on DNA. It’s like a nanoscale ski binding.
A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine’s Abramson Cancer Center showed.
O biobanco vivo de tecido mamário da Mayo Clinic está ajudando pesquisadores a identificar as formas pelas quais as portadoras de determinados genes podem ter maior risco de câncer de mama.
Un banco biológico de tejido mamario vivo en Mayo Clinic está ayudando a los investigadores a identificar las formas en las que los portadores de ciertos genes pueden tener un mayor riesgo de presentar cáncer de mama.
مدينة روتشستر، ولاية مينيسوتا. — يساعد البنك الحيوي الحي للثدي في مايو كلينك الباحثين في تحديد الطرق التي قد تزيد من احتمالية تعرض حاملي جينات معينة لخطر الإصابة بسرطان الثدي.
The human genome is three billion letters of code, and each person has millions of variations. While no human can realistically sift through all that code, computers can.
Here are some of the latest articles that have been added to the Behavioral Science channel on Newswise, a free source for journalists.
Periprosthetic joint infection (PJI) is a devastating complication of knee and hip replacement surgery that can, in some cases, be difficult to distinguish from other causes of arthroplasty failure. An "omics"-based tool that measures predicted abundance of immune cells may aid in making the diagnosis of failed arthroplasty due to PJI, suggests a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
CRISPR, the Nobel Prize-winning gene editing technology, is poised to have a profound impact on the fields of microbiology and medicine yet again. A team led by CRISPR pioneers Jennifer Doudna and Jill Banfield has developed a tool to edit the genomes of bacteria-infecting viruses called bacteriophages using a rare form of CRISPR. The ability to easily engineer custom-designed phages will help researchers treat dangerous drug-resistant infections and control microbiomes without antibiotics or harsh chemicals.
Annual NCCN Patient Advocacy Summit explores stories and data highlighting barriers to high-quality care that LGBTQ+ people with cancer experience, examining persistent setbacks and promising developments.
The California Institute for Regenerative Medicine has awarded UC San Diego researchers $4.8 million to advance a gene therapy to treat Friedreich’s ataxia, a rare but devastating neuromuscular disorder.
An international team of researchers led by Mass Eye and Ear discovered a new genetic mutation that leads to childhood glaucoma, and in the process uncovered a new mechanism for causing the disease.
A Phase 2 clinical trial has started of DS-1211 in individuals with Pseudoxanthoma Elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity. DS-1211 is a potential first-in-class small molecule developed through a research collaboration between Daiichi Sankyo and Sanford Burnham Prebys.
Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.
A Rutgers analysis showed that early signs of liver damage from high-dose green tea extract were somewhat predicted by one variation in a genotype and strongly predicted by another variation.
Researchers discover that dual knockout of genes in organoids grown from human tissue generates a model of and potential therapeutic target for gastroesophageal junction cancer
In a study using a first-of-its kind mouse model of aging that mimics breast cancer development in estrogen receptor-positive post-menopausal women, investigators at Georgetown Lombardi Comprehensive Cancer Center and colleagues have determined that over-expression, or switching on of the Esr1 gene, could lead to elevated risk of developing estrogen receptor-positive breast cancer in older women.
The origin of all biological movements, including walking, swimming, or flying, can be traced back to cellular movements; however, little is known about how cell motility arose in evolution.
Researchers have identified several genetic variants associated with increased risk of cancer in children with non-chromosomal birth defects, such as congenital heart disease and defects of the central nervous system. While the risk of developing cancer is not as high as children with chromosomal birth defects, it is significantly higher than children with no birth defects at all, and the findings may provide a basis for early detection in these understudied patients.
Researchers have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy.
The Children’s Tumor Foundation (CTF) and the University of Arkansas for Medical Sciences (UAMS) announced the opening of the first CTF-sponsored, fully multidisciplinary clinic dedicated to the care of adults with neurofibromatosis (NF) at the UAMS Winthrop P. Rockefeller Cancer Institute.
Less than 20% of diagnosed breast cancers are designated “triple-negative,” lacking three types of receptors often found in other breast cancer types.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.
UNC School of Medicine's Jin Szatkiewicz, PhD, and colleagues conducted one of the first and the largest investigations of tandem repeats in schizophrenia, elucidating their contribution to the development of this devastating disease.
A majority of younger women diagnosed with breast cancer reported significant sexual health impacts, which most health care providers were unable to help address, according to an LBBC study to be presented at the 2022 San Antonio Breast Cancer Symposium®.
ROSEMONT, Ill. (November 30, 2022) — Board-certified dermatologist John Browning MD, FAAD, FAAP, adjunct associate professor of pediatrics and dermatology at UT Health in San Antonio, was named an American Academy of Dermatology Patient Care Hero for his expertise in laser treatments that helped relieve his pediatric patient's pain and improve his quality of life.
Inflammatory response linked to amyloid plaque buildup
An innovative protocol called PepSeq is changing the way researchers test for contagious diseases—and this knowledge should change the way humanity responds to future pandemics. NAU researcher Jason Ladner and a team of collaborators from TGen published a comprehensive study about PepSeq that lays out the process, the tool and how to interpret the results.
A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found.
Measuring the amount of DNA that’s been shed by a tumor compared to the body’s typical amount of DNA may be a new tool to predict survival and guide treatment discussions for patients whose cancer has spread from the breast, prostate, lung or colon, a new study finds.
UC San Diego researchers identify the PKCα enzyme as a promising therapeutic target in Alzheimer’s disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in mice.
A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.
A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.
MYC genes and their proteins play a central role in the emergence and development of almost all cancers.
About 600 seemingly disparate fungi that never quite found a fit along the fungal family tree have been shown to have a common ancestor, according to a University of Alberta-led research team that used genome sequencing to give these peculiar creatures their own classification home.
A new animal study points to a gene that is important for the earliest development of basic social behaviors.
A prescrição de determinados nutrientes, grãos, frutas e legumes personalizados para os genes e outras características biológicas de uma pessoa pode ajudar a melhorar sua saúde? Os pesquisadores da Mayo Clinic estão explorando os possíveis benefícios da orientação personalizada de dieta e de nutrientes para os genes, o metabolismo, o microbioma e outras características distintas de uma pessoa.
Puede ayudar a mejorar la salud de una persona la prescripción de una dieta específica de nutrientes, cereales, frutas y verduras adaptada a sus genes y otras características biológicas? Los investigadores de Mayo Clinic están explorando los posibles beneficios de adaptar los nutrientes y la orientación alimentaria a los genes, el metabolismo, el microbioma y otras características distintivas de una persona. El objetivo final del enfoque holístico es promover la salud y ayudar a prevenir las enfermedades relacionadas con la dieta, como las enfermedades cardíacas, la diabetes y algunos tipos de cáncer.
Revealing various signaling pathways in metabolism of oxygen, glucose, lipids, proteins and other nutrients is crucial for better understanding of human physiology and diseases.
罗切斯特，明尼苏达州 — 如果根据一个人的基因和其他生物学特征来制定包含特定营养物质、谷物、水果和蔬菜的专门食谱，是否有助于改善他们的健康状况？妙佑医疗国际(Mayo Clinic) 的研究人员正在探索根据一个人的基因、新陈代谢、微生物群系和其他区别特征来定制营养物质和膳食指南的潜在益处。这种综合方法的最终目标是改善健康，帮助预防与饮食相关的疾病，包括心脏病、糖尿病和某些癌症。
The same complex genetics that contribute to a higher risk of type 2 diabetes may also increase the risk of developing diabetes during pregnancy among women of South Asian descent, a study published today in eLife shows.
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UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
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