Working together, Miller, Boehme, Vardeny and their colleagues have shown that an organic-based magnet can carry waves of quantum mechanical magnetization, called magnons, and convert those waves to electrical signals. It’s a breakthrough for the field of magnonics (electronic systems that use magnons instead of electrons) because magnons had previously been sent through inorganic materials that are more difficult to handle.
The National Institutes of Health recently awarded more than $2.4 million to a research team at the GW School of Medicine and Health Sciences, to study how cell stress in the brain could impact the risk of obesity-induced hypertension.
Data presented from a Late-Breaking Clinical Trial has the potential to change the standard of care for HER2-positive breast cancer patients undergoing chemotherapy.
Tufts biologists have demonstrated for the first time that electrical patterns in developing embryos can be predicted, mapped and manipulated to prevent defects caused by harmful substances such as nicotine. The study suggests that targeting bioelectric states may be a new treatment modality for regenerative repair in brain development and disease.
A team led by engineers at Tufts University has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution. The researchers were able to use the method to identify specific metabolic signatures that could arise in diabetes, cancer, cardiovascular and neurodegenerative diseases.
Researchers found that the fruit fly blood brain barrier has a molecular clock that makes it more penetrable during certain hours of the day. Giving mutant flies a drug for treating seizures at night was more effective.
Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis.
Working with mice, Johns Hopkins researchers report they have found previously known skin itch receptors in the airways that appear to contribute to bronchoconstriction and airway hypersensitivity, hallmarks of asthma and other respiratory disorders. The investigators’ experiments in mice suggest that the receptors’ activation directly aggravates airway constriction and—if the same process is active in people—may be a promising new target for the development of drug therapies.
Researchers report discovery of a strong predictive biomarker for bronchopulmonary dysplasia, and they show a role for the biomarker in the pathogenesis of this neonatal lung disease. These results open the path to possible future therapies to prevent or lessen BPD.
Scientists at The Scripps Research Institute (TSRI) have now shown a path to developing treatments for disease subtype CMT2D.
Researchers at Washington University School of Medicine in St. Louis have designed sugar molecules that block E. coli bacteria from binding to urinary tract tissues, allowing the bacteria to be washed out of the urinary tract. The compounds represent a step toward treating UTIs without antibiotics.
Despite public health campaigns aimed at reducing unnecessary prescriptions for antibiotics, the drugs continue to be prescribed at startlingly high rates in outpatient settings such as clinics and physician offices, according to a new study at Washington University School of Medicine in St. Louis. The researchers analyzed de-identified data from Express Scripts Holding Co., which manages drug benefits for employers, and found that 98 million outpatient antibiotic prescriptions were filled by 39 million people during a three-year period from 2013 to 2015. Moreover, the researchers found no decline in the overall antibiotic prescription rate during that time.
Scientists have conducted the first lab experiments on haze formation in simulated exoplanet atmospheres, an important step for understanding upcoming observations of planets outside the solar system with the James Webb Space Telescope.
SBP researchers have revealed how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function. The research suggests boosting TREM2 levels in the brain may prevent or reduce the severity of neurodegenerative disorders including Alzheimer’s disease.
Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by free radicals and oxidants. The research team showed that this pathway can be activated by a drug called monensin, which is commonly used as an antibiotic in animal feed.
Researchers from St. Jude Children’s Research Hospital have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 (CDK2) protects mice and rats from noise- or drug-induced hearing loss. The study, which will be published March 7 in the Journal of Experimental Medicine, suggests that CDK2 inhibitors prevent the death of inner ear cells, which has the potential to save the hearing of millions of people around the world.
A study of mouse healing after severe heart attacks focused on the heart and spleen, measuring types and numbers of immune cells; types and amounts of lipid signaling compounds; expression of enzymes that produce those signaling compounds; and which enzymes are key to resolution of inflammation.
An interdisciplinary team of scientists at University of Utah Health are using animals' unique traits to pinpoint regions of the human genome that might affect health. The results of this project are available in the March 6 issue of the journal Cell Reports.
SBP researchers have discovered that accumulation of ceramides—a type of lipid (fat)— plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition that often occurs in patients with diabetes and obesity. The study, published today in Cell Reports, also identified several potential therapeutic targets that could prevent or reverse the effects of LCM.
The National Institute for Drug Abuse has awarded NYU Meyers’ Center for Drug Use and HIV/HCV Research (CDUHR) a five-year, nearly $7.5 million grant to continue the center’s research.
By measuring the sagging of the vaginal walls in more than a thousand volunteers for up to nine years annually, a team of Baltimore physicians reports the creation of a long-awaited baseline measure of the rate of progression of so-called pelvic organ prolapse. The baseline, they say, should provide a foundation for reliable studies and a more rational search for factors that prevent or ease the condition.
Researchers in France have discovered that, though a tattoo may be forever, the skin cells that carry the tattoo pigment are not. Instead, the researchers say, the cells can pass on the pigment to new cells when they die. The study, which will be published March 6 in the Journal of Experimental Medicine, suggests ways to improve the ability of laser surgery to remove unwanted tattoos.
Immunotherapy does not work for a majority of cancer patients. Preventing or reversing metabolic exhaustion in cancer-killing T-cells could boost its effectiveness.
Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.
By studying mice in late adolescence, Johns Hopkins University researchers have discovered that the rapid bone growth associated with puberty is slowed not only by fewer cartilage cell divisions but also by the “aging” of bone cell precursor cells. After investigating the signaling molecules that promote this transition, the scientists conclude that some weak and brittle bone conditions in both children and adults may be due to the cells’ premature “retirement” caused by glucocorticoid treatments given during puberty to treat chronic inflammation resulting from rheumatoid disorders and other diseases.
A study published in the March 5 online edition of the Proceedings of the National Academy of Sciences (PNAS) describes how the supercomputers at the San Diego Supercomputer Center at UC San Diego were used to simulate the merger of a G-protein “mimetic nanobody” to a G-protein-coupled receptor (GPCR), the largest and most diverse group of membrane receptors in animals, plants, fungi, and protozoa.
Researchers profiled the epigenomic landscape of Alzheimer’s brains, specifically in one of the regions affected early in AD, the lateral temporal lobe. They compared these to both younger and elderly cognitively normal control subjects. The team described the genome-wide enrichment of a chemical modification of histone proteins that regulates the compaction of chromosomes in the nucleus. Changes along the genome in disease versus normal aging brains may signify places for future drug development.
Social amoebae evolve to fight with others but also to die for their kin.
‘This study identifies the missing link between Lewy bodies and the type of damage that’s been observed in neurons affected by Parkinson’s."
A genetics research team at Johns Hopkins Medicine has solved a dilemma facing researchers who use genomewide association studies (GWAS) by developing a new approach that strategically “filters” which genes are worth further study. The researchers hope this strategy will accelerate the study of diseases such as Parkinson’s, Alzheimer’s, schizophrenia and even addiction by helping researchers avoid “dead-end paths.” They are optimistic that this strategy will gain widespread use and will save researchers time and money.
RNA makes salt-loving microbes known as “extremophiles” highly resistant to the phenomenon oxidative stress – the uncontrollable production of unstable forms of oxygen called “free radicals,” which can negatively affect DNA, proteins, and lipids in cells.
"The same mechanisms that viruses use to cause cancer may be key in combating tumors with immune-based therapies or in keeping cancer from developing in the first place," says Sharon Kuss-Duerkop, PhD.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have discovered a new target for treating major depressive disorder, a disease that affects more than 16 million American adults.
Johns Hopkins researchers have invented a new class of cancer immunotherapy drugs that are more effective at harnessing the power of the immune system to fight cancer. This new approach, which was reported in Nature Communications, results in a significant decrease of tumor growth, even against cancers that do not respond to existing immunotherapy.
Researchers have studied the use of bacteria to break down organic contaminants in groundwater; however, this bioremediation process has been met with limited success under some conditions.
Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.
Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate. Scientists describe cells that could become a new tool to treat lung diseases across the lifespan, from premature infants to the elderly.
Researchers at the George Washington University and the University of Georgia are partners in a project that will soon be able to provide a way for questions asked by those studying glycoscience to be answered by big data.
Engineers from the University of Maryland created a non-flammable battery from ceramic materials by using a 'melty' layer that, when cool, unites a solid-state battery.
The breakthrough may expand research on the roles of glycans in human diseases, including cancers.
A new Medicare records study by Johns Hopkins researchers has added to mounting evidence that a common surgery designed to remove damaged, worn ends of the thin rubbery cartilage in the knee joint brings little or no benefit to people over the age of 65.
A study in the Journal of Neuroscience reveals that activation of a pregnant mother’s immune system can affect her baby’s brain development. Researchers at CHLA, found that short- and long-term brain functioning can be influenced by immune system activity during the third trimester of gestation.
New teaching standards like the Next Generation Science Standards call for weaving science, technology, engineering and math (STEM) into classrooms better. What makes this integration effective?
About 3 out of 4 Americans agree that smoking cigarettes causes health problems, but public perception of the risks posed by smoking may be declining, according to a Duke Health study published in the journal Drug and Alcohol Dependence.
SBP researchers have developed the first ever high-throughput, genome-scale imaging-based approach to investigate protein stability. The method has been used to identify several previously unknown human proteins that HIV degrades to enhance its infection process.
A new study from Indiana University suggests that a compound previously tested to treat osteoarthritis pain appears to block neuropathic pain and decrease signs of opioid dependence.
Blood plasma samples from a mouse that received the Angptl3 CRISPR treatment (right) and a mouse that was untreated (left). The cloudiness of the sample on the left is from the high content of cholesterol and triglycerides.
States with robust tobacco control policies and regulations, such as smoke free air laws and taxes on cigarettes, not only have fewer cigarette users but also fewer e-cigarette users, according to research from NYU School of Medicine and the NYU College of Global Public Health.
A new computational resource called Recon3D provides a 3D view of genes, proteins and metabolites involved in human metabolism. Researchers used the tool to map disease-related mutations on proteins and also probed how genes and proteins change in response to certain drugs. The work provides a better understanding of disease-causing mutations and could enable researchers to discover new uses for existing drug treatments.
Critically ill patients who experience long periods of hypoxic, septic or sedative-associated delirium, or a combination of the three, during an intensive care unit (ICU) stay are more likely to have long-term cognitive impairment one year after discharge from the hospital, according to a new study.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right