James A. Brink, MD, FACR, told the House Committee on Science, Space and Technology Subcommittee on Energy today that medical imaging and radiation oncology save lives.
A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.
Sbarro Health Research Organization President Antonio Giordano introduces program at National Italian American Foundation 42nd Anniversary Gala Weekend In Washington D.C.
Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society (APS), will explore SCD—the world’s most prevalent single-gene mutation disease—and new research on preventing and reversing its deadly consequences.
Prenatal exposure to bisphenol A (BPA) at levels below those currently considered safe for humans affects gene expression related to sexual differentiation and neurodevelopment in the developing rat brain.
Mayo Clinic announced today that its Rochester campus is one of 16 cancer centers nationally selected to provide chimeric antigen receptor T-cell therapy (CAR T-cell therapy) for adults with B-cell non-Hodgkin lymphoma who have not responded to, or have relapsed, after two or more lines of treatment.
Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment.
UNC and NC State researchers have developed artificial beta cells that automatically release insulin into the bloodstream when glucose levels rise. This work was done in lab experiments but could lead to a much more patient-friendly treatment than injections.
An infusion of cells from a child’s own umbilical cord blood appears to improve brain connectivity and motor function in children with spastic cerebral palsy, according to a randomized clinical trial published this week by Stem Cells Translational Medicine.
Drug exposure can cause significant changes in gene expression without affecting growth or survival in some cell lines, highlighting strategies to better evaluate drug effectiveness.
Researchers at the University of California San Diego School of Medicine, with colleagues in Brazil, report that the Zika virus is transmitted from mother to fetus by infected cells that, ironically, will later develop into the brain’s first and primary form of defense against invasive pathogens.
For some cancer patients, the road to remission and healing can have its share of speed bumps. That’s particularly true of patients with non-small cell lung cancer (NSCLC) who develop a secondary, or acquired, resistance to immunotherapy, which initially was effective against their tumors.
JoAnn Trejo, professor in the Department of Pharmacology at University of California, San Diego, has been named the 2017 winner of the E.E. Just Award by the American Society for Cell Biology (ASCB). Trejo will receive the award and present a lecture on her research at the 2017 ASCB|EMBO Meeting on December 3 in Philadelphia.
A research advance co-led by Case Western Reserve University School of Medicine’s Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory “hair” cells in the inner ear. USH3 is caused by a mutation in the clarin-1 gene.
Researchers found mutations in a master-switch protein called Epithelial Splicing Regulatory Protein 1 in individuals with a type of congenital hearing loss. In general, what connects most of the unexplained hearing-loss cases is that protein building in the cochlea during development goes awry. The cochlea has the all-important job of transforming mechanical energy in the form of sound waves into electrical signals that run along auditory nerves to the brain.
A research team from Wayne State University has received a $1.85 million grant from the National Institute of General Medical Sciences of the National Institutes of Health for the project “Mechanisms of Non-Shine-Dalgarno Translation Initiation.” The project will be led by Jared Schrader, Ph.D., assistant professor of biological sciences in Wayne State’s College of Liberal Arts and Sciences.
With the advancement of surgical and radiation therapy strategies for stage 1 non-small-cell lung cancer (NSCLC), more patients are being treated, resulting in higher survival rates.
Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury. In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells—neutrophils—can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.
A new type of DNA editing enzyme, developed in HHMI Investigator David Liu’s lab, lets scientists directly and permanently change single base pairs of DNA from A•T to G•C. The process could one day enable precise DNA surgery to correct mutations that cause human diseases.
The MyGeneRank app allows individuals with genetic data from 23andMe to obtain an estimated genetic risk score for coronary artery disease.
In a new study published in Cell Systems, UNC Lineberger's Jeremy Purvis, PhD, and colleagues report that the timing of when DNA damage occurs within these different checkpoints matters to a cell’s fate.
In the body, cells move around to form organs during development; to heal wounds; and when they metastasize from cancerous tumors. A mechanical engineer at Washington University in St. Louis found that cells remember the properties they had in their first environment for several days after they move to another in a process called mechanical memory.
Vanderbilt-Ingram Cancer Center (VICC) has been selected as one of the few authorized treatment centers in the United States approved to administer the first FDA- approved chimeric antigen receptor T cell (CAR T) therapy for treatment of adult patients with a specific type of lymphoma. VICC is the only cancer center in a seven-state region of the Southeast authorized to deliver the new immunotherapy.
A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. Now scientists, reporting in ACS Central Science, have found that insights into a rare genetic disease known as NGLY1 deficiency could help scientists understand how that resistance works — and potentially how drugs can outsmart it.
Josh Dubnau, PhD, has received a $3.9 million grant from the National Institutes of Health to investigate the impact of environmental stressors and oexternal factors that contribute to the development of amyotrophic lateral sclerosis (ALS). The research is based on work with “jumping genes” and sporadic forms of ALS.
In fairy tales, all it takes to transform a frog into a prince or a mouse into a horse is the wave of a magic wand. But in the real world, transforming one living cell into another - for instance a skin cell into a nerve cell - isn’t so easy. Now, scientists lay out a possible way to do it directly.
University of Colorado Cancer Center study being presented October 28 at the AACR-NCI-EORTC International Conference on Molecular Targets: By pairing an anti-EGFR drug with a “tail” that only activates the drug when it is very near tumor cells, tarloxitinib brings the drug to tumors while keeping concentrations safe in surrounding tissues.
Allen Institute researchers create stem cell lines that label important genes for cell biologists
The article "A Blueprint to Advance Colorectal Cancer Immunotherapies” was written by leaders in oncology and immunotherapy convened by Fight Colorectal Cancer and Cancer Research Institute with the intent of furthering and guiding colorectal cancer research.
Using data from blood and brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.
Researchers may have found a way to treat insulin resistance, a precursor to type 2 diabetes, while avoiding side effects such as weight gain.
Research to Prevent Blindness-supported researchers in New York (at Columbia University and University of Rochester) made a critical discovery about the gene mutation that causes many retinal degenerative diseases, opening the door for a new line of research into potential treatments.
Sound waves could be the future of biomedical research, diagnosing and treatment, says Peng Li, a chemistry professor at West Virginia University. Li is a data analyst for an ongoing research study using an acoustic device to separate extracellular vesicles for a deeper look at their properties.
Rutgers University–New Brunswick and other institutions have discovered a “molecular pencil sharpener” that chews away its outer coating to release a powerful antibiotic. Their discovery opens the door to finding new antibacterial agents and drugs to fight toxins.
A team of researchers from the University of Wisconsin-Madison reports that in long-lived animals, renewed but thin myelin sheaths are enough to restore the impaired nervous system and can do so for years after the onset of disease.
New research from the University of Illinois at Chicago College of Medicine suggests that the lung microbiome plays a significant role in asthma severity and response to treatment.
Researchers at University of Utah Health have identified a protein (ARF6) that when inhibited reduces diabetic retinopathy, a condition that results when blood vessels at the back of the eye leak fluid into the eye, impairing vision.
An international team of scientists, led by structural biologists at Van Andel Research Institute, has shed new light on a critical step in DNA replication, offering fresh insights into a fundamental process of life and driver of many different diseases, including cancer.
The scientific leader of Chan Zuckerberg Initiative to kick off 2017 ASCB|EMBO Meeting in Philadelphia.
As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells. In a new study, University of Wisconsin–Madison researchers map out the molecular events that direct cells’ energy metabolism down the cancerous path. Their findings could lead to ways to interrupt the process.
Researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways. Myc is a critical gene in governing cell proliferation and survival.
When babies are born with atypical sex anatomy, how a hospital responds has a major impact on a family’s experience and decisions about sometimes irreversible procedures.
By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids – made from human pluripotent stem cells – researchers have taken an important step toward creating a new technology for controlling the growth of these organoids and using them for treating wounds in the gut that can be caused by disorders such as inflammatory bowel disease (IBD).
Three faculty members from the Icahn School of Medicine at Mount Sinai have been elected to the National Academy of Medicine (NAM).
Scientists combine biology, nanotechnology into composites that light up upon chemical stimulation.
A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.
A new study from UT Southwestern suggests that more people with Duchenne muscular dystrophy could live longer by identifying and more aggressively treating patients with certain risk factors.
Biologists have uncovered a mechanism linking a human gene’s function to chronic inflammation and cancer. They discovered that “mutant p53” taps the body’s immune response system to fuel pro-inflammatory responses that increase cancer growth.
Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women’s Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration (FDA) today. Dana-Farber/Brigham and Women’s Cancer Center, the only facility in the northeast to be part of the clinical trial, is one of a few locations certified to offer this new therapy nationwide.
University of California San Diego researchers have developed the first 3D spatial visualization tool for mapping “’omics” data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such as microbial metabolites and medications, on a diseased organ in the context of microbes that also inhabit the region. The work could advance targeted drug delivery for cystic fibrosis and other conditions where medications are unable to penetrate.
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