Volume 29, Issue 2 of SLAS Discovery features two review articles, six original research articles covering phenotypic screening perspectives, medulloblastoma therapies and interventions for neurodegenerative diseases.
Volume 29, Issue 2 of SLAS Technology, includes three original research articles covering skin cutaneous melanoma, glycan-bead coupling and acoustic ejection mass spectrometry, and eight articles from the Advances in Synthetic Biology Special Issue.
The American Society for Radiation Oncology (ASTRO) published an updated clinical guideline that details best practices for treating patients who have symptomatic bone metastases and ways to improve their quality of life. The guideline is available as a free access article in Practical Radiation Oncology. “Radiation therapy is a cornerstone of care for patients with symptomatic bone metastases, offering a nonsurgical option for fast pain relief and improved quality of life with minimal side effects,” said Tracy Balboni, MD, MPH, chair of the guideline task force.
A recent review explores the innovative use of self-assembled protein nanoparticles (SAPNs) and virus-like particles (VLPs) in veterinary vaccine development. The research highlights the superior safety and efficacy of these nanovaccines over traditional formulations, offering a promising future for animal health and disease prevention.
An experimental mRNA vaccine against avian influenza virus H5N1 is highly effective in preventing severe illness and death in preclinical models. The vaccine could potentially help manage the outbreak of the H5N1 virus currently circulating in birds and cattle in the United States, and prevent human infections with the virus.
Scientists have made discoveries about light particles known as photons that could aid the quest for fusion energy.
Investigadores de Mayo Clinic están utilizando la tecnología para producir modelos de tejidos de diferentes partes del cuerpo con el fin de estudiar órganos y tejidos dañados o enfermos. Imaginan el día en que una bioimpresora 3D pueda moldear células vivas para tratamientos o curas de trastornos complejos.
Cold stress significantly hampers tomato growth and yield. Recent research reveals that 5-aminolevulinic acid (ALA) enhances cold tolerance in tomatoes by regulating the SlMYB4/SlMYB88-SlGSTU43 gene module. This discovery opens new avenues for genetic engineering to develop cold-resistant tomato varieties, potentially ensuring better crop resilience and productivity under low-temperature conditions.
In the rapidly evolving world of cryptocurrency, volatility management remains a crucial challenge. Researchers have now developed a novel approach that integrates Exponential Generalized Autoregressive Conditional Heteroskedasticity (EGARCH) with genetic algorithms and neural networks to enhance the precision of trading decisions in this volatile market.
A new assembly toolkit, an efficient assembly toolkit (PMAT), is set to revolutionize the study of plant mitochondrial genomes (mitogenomes), offering an unprecedented approach to understanding plant evolution and cytoplasmic male sterile line breeding. This tool stands to overcome significant challenges in the complete assembly of plant mitogenomes, a task previously hindered by complex recombination events and horizontal gene transfers.
A recent study has assembled a gap-free genome for Mentha suaveolens, providing new insights into its genetic structure and terpenoid diversification. The research highlights the unique composition of volatile compounds, particularly piperitenone oxide, and identifies key genetic variations affecting its biosynthesis. These findings enhance our understanding of Mentha's medicinal properties and facilitate targeted breeding for improved traits.
A new study from Case Western Reserve University School of Law seeks to help settle a long-standing debate about how to design incentives to spark economic development in distressed places. It finds that “smart” incentives—those selectively awarded, monitored and adaptable—yield greater community impact.
A recent study offers a thorough analysis of germ-free (GF) animal models, essential tools for unraveling the intricate interactions between microorganisms and their hosts. These models are proving crucial in understanding how microbiota influence a range of physiological processes and could lead to innovative treatments for various diseases.
New research has introduced an approach to minimizing alignment errors in double-sided microlens arrays (DSMLAs) during precision glass molding (PGM), significantly enhancing the quality and functionality of optical devices.
A new paper in Physical Review Letters explores the effects of memory in quantum systems and ultimately offers a novel solution to decoherence, one of the primary problems facing quantum technologies.
Research has highlighted how weather extremes worsened by climate change are now a major national public health threat.
The Korean research team has successfully developed a highly efficient microchannel reactor which reduces the required catalyst amount to 30 percent for electrofuel production, yet offers a capacity 30 times greater than current reactors.
Researchers at the University of South Australia and Edith Cowan University in WA have explored the origins of the iconic Nutbush dance and how it became an Australian cultural phenomenon.
A study from the University of Adelaide has discovered molecular pathways regulated by a gene traditionally used to control wheat-flowering behaviour could be altered to achieve greater yields.
Imagine um futuro em que os cuidados com a saúde sejam adaptados especificamente para você, até mesmo para as moléculas no interior das suas células. Tratamentos direcionados e estratégias preventivas são personalizados para o seu genoma. Seu mapa médico pessoal descreve variantes genéticas hereditárias, fornece orientação sobre riscos ambientais e oferece estratégias para manter a saúde do seu coração e prevenir o câncer, tornando-o tão único quanto o seu DNA.
Public interest in weight loss drugs like Wegovy and Ozempic is surging, but national data on dispensing patterns in the United States are surprisingly scarce.
Imagine un futuro en el que la atención a la salud se adapte específicamente a usted, incluso a las moléculas dentro de sus células. Los tratamientos específicos y las estrategias preventivas se adaptan a su genoma. Su mapa médico personal describe las variantes genéticas hereditarias, le brinda con orientación sobre los riesgos ambientales y ofrece estrategias para mantener la salud de su corazón y prevenir el cáncer, haciéndolo tan único como su ADN.
For the first time, nuclear physicists made precision measurements of the short-lived radioactive molecule, radium monofluoride (RaF). The researchers combined ion-trapping and specialized laser systems to measure the fine details of the quantum structure of RaF. This allowed them to study the rotational energy levels of RaF and determine its laser-cooling scheme.
Even slight cognitive changes can affect an older person’s decision to stop driving, according to a new study by researchers at Washington University School of Medicine in St. Louis. The findings suggest that routine cognitive testing — in particular, the kind of screening designed to pick up the earliest, most subtle decline — could help older adults and their physicians make decisions about driving that maximizes safety while preserving independence as long as possible.
What factors lead older adults to stop driving? A new study followed older adults who had no memory or thinking problems to examine this question. The study is published in the May 22, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
People who eat more ultra-processed foods like soft drinks, chips and cookies may have a higher risk of having memory and thinking problems and having a stroke than those who eat fewer processed foods, according to a new study published in the May 22, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that eating ultra-processed foods causes memory and thinking problems and stroke. It only shows an association.
When the Danish bulk carrier Nordic Orion set sail on Sept. 17, 2013, from Vancouver, British Columbia, on a journey to Finland, it set a course for a groundbreaking journey. Rather than turn south to pass through the Panama Canal, it headed north to traverse the Northwest Passage, a winding sea route through the archipelago off Canada’s north and east coasts.
A new study that investigated the presence of the smallest particles of microplastics (MPs) in ocean waters from the Caribbean to the Arctic found that the most abundant (and tiny) MPs in the ocean are not being detected by net tow surveys.
Off the southeastern tip of Greenland in mid-June, Hayley DeHart, a genomics and marine scientist at APL, disembarked Lindblad Expedition’s National Geographic Endurance — a 407-foot (124-meter) ice-cutting cruise ship — and stepped into a small Zodiac inflatable motorboat.
In February 2016, 215 soldiers from the U.S. and Canadian militaries conducted a 10-day exercise called Arctic Ram. Their objective was to demonstrate they could rapidly respond to an emergency in the Arctic. In this case, they simulated retrieving a military satellite that crash-landed north of the small town of Resolute on Cornwallis Island in Nunavut, Canada.
Many scientists study the proteins in our cells in order to fight diseases like cancer, but Cornell College Assistant Biochemistry Professor Collin O’Leary and a team of researchers are turning their focus to the structure of RNA.
Location, race and insurance status play a significant part in the odds of a patient being diagnosed with early-stage or late-stage cancer, according to a detailed medical records analysis of more than 94,000 patients with cancer by researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Kimmel Cancer Center.
Move over, graphene. There’s a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers at Penn State have made the material potentially more useful by imparting chirality — or handedness — on it, which could make for advanced sensors and implantable medical devices.
Off the north coast of Alaska in the Beaufort Sea, the Sun won’t make its appearance until roughly nine in the morning, its edge arcing over the horizon where a spill of puffy clouds briefly hides its emerging face.
A study co-led by researchers at UCLA Health has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD).
Engineers at the University of California San Diego have developed a wearable ultrasound patch that can offer continuous, non-invasive monitoring of blood flow in the brain. The soft and stretchy patch can be comfortably worn on the temple to provide three-dimensional data on cerebral blood flow—a first in wearable technology.
Scientists have long been studying the brain with a goal of aiding healthier aging. While much is known about risk factors for accelerated brain aging, less has been uncovered to identify ways to reduce cognitive decline.
Lucy, with her boundless puppy-like energy even at 12 years old, is more than just a pet to Susan Ketcham. She's now part of a research project that could transform the way we treat brain cancer – in both dogs and humans. This study at Virginia Tech's Virginia-Maryland College of Veterinary Medicine explores an innovative therapy called histotripsy.
A team of scientists at the Massachusetts Institute of Technology (MIT), Brigham and Women’s Hospital, and Harvard University have developed a noninvasive alternative—an oral capsule containing a tiny vibrating motor that is designed to stimulate the stomach to produce the same sense of fullness people experience after eating a large meal.
Available for interview on breaking news, trending topics in respiratory medicine
The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center researchers reported in a retrospective study. The findings, published in Nature Cancer, upend long-held conventional wisdom and could lead to more effective ways of deciding which patients will benefit most from this type of treatment.
New research shows that real-world ocean conditions – specifically, low-phosphate areas – makes a huge difference in how viral infection affects host bacteria.
The Sonoran Desert of southern Arizona and northern Mexico has long been largely immune to fires, despite its intense heat. There simply wasn't enough fuel to feed severe fires. In the last two decades, wetter winters and the increase of invasive species have caused a rapid shift to the desert environment.
Scientists at St. Jude Children’s Research Hospital reveal the role of iRhom2’s defunct protein-cleaving domain in lifecycle of ADAM17, a key signaling molecule-activating protein.
Scientists with Cedars-Sinai Guerin Children’s, the University of California, San Francisco (UCSF), and other institutions have identified the critical first steps in how the digestive system develops.
Irina Petrache, MD, ATSF, today added president of the American Thoracic Society to her list of accomplishments. The announcement came on the heels of the Plenary Session at the ATS 2024 International Conference.
Scientists have uncovered the properties of a rare earth element that was first discovered 80 years ago at the very same laboratory, opening a new pathway for the exploration of elements critical in modern technology, from medicine to space travel.
Scientists have developed DIProT, an innovative, user-friendly toolkit for protein design. The toolkit utilizes a non-autoregressive deep generative model to address the protein inverse folding problem, integrating human expertise into the design loop for efficient and effective protein design.
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