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Scientists Discover New Therapeutic Target for Lung Cancer Driven by KRAS

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UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully.

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Revolutionary Surgery Helps Children with Severely Restricted Airways Breathe Without a Tracheostomy

Subcranial rotation distraction is enabling children like Hannah Schow to breathe without a tracheostomy for the first time.

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Scientists Use Already-Approved Drugs to Force Cancer Cell Death, How to Decide if Watchful Waiting Is the Right Choice, Some Adolescent Cancer Survivors May Require More Comprehensive Mental Health Screening, and MORE in the Cancer News Source

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UT Southwestern Researchers Identify New Mechanism of Tuberculosis Infection

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Researchers from UT Southwestern Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore

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Beware of Antioxidants, Warns Scientific Review

The lay press and thousands of nutritional products warn of oxygen radicals or oxidative stress and suggest taking so-called antioxidants to prevent or cure disease. Professor Pietro Ghezzi at the Brighton and Sussex Medical School and Professor Harald Schmidt at the University of Maastricht have analyzed the evidence behind this. The result is a clear warning: do not take these supplements unless a clear deficiency is diagnosed by a healthcare professional.

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What Are Gut Bacteria Doing in Critically Ill Lungs? New Discovery Could Change ICU Care

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No one knows for sure how they got there. But the discovery that bacteria that normally live in the gut can be detected in the lungs of critically ill people and animals could mean a lot for intensive care patients.

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UW, Purdue Scientists Solve Structure of Cold Virus Linked to Childhood Asthma

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The atomic structure of an elusive cold virus linked to severe asthma and respiratory infections in children has been solved by a team of researchers at the University of Wisconsin–Madison and Purdue University. The findings provide the foundation for future antiviral drug and vaccine development against the virus, rhinovirus C.

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Revolutionary Surgery for Lung Cancer

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The University of Montreal Hospital Research Centre (CRCHUM) is launching a major international clinical trial to test a minimally invasive and safer surgical approach for patients with lung cancer: video-assisted thoracoscopic (VATS) lobectomy with ultrasonic pulmonary artery sealing.

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Rush Is First to Receive Honor for Excellence in Life Support Using Temporary, Mechanical Assistance for Heart, Lung Functions

Rush University Medical Center received the ELSO Award for Excellence in Life Support – the most prestigious designation in critical care by the Extracorporeal Life Support Organization. Rush is the only full service adult and pediatric academic medical center in Chicago and Illinois to receive the Designated Gold Level Center of Excellence designation.

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Scientists Develop Computer Models to Unravel the Complexities of TB Infection

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NIBIB-funded scientists used computers to model the formation of tuberculosis granulomas in the lung -- the non-active (latent) form of infection found in 2 billion individuals worldwide (11 million in the U.S.) that can activate to become a life-threatening infection. Employing a computer model aims to speed analysis of TB’s complex life-cycle and to identify potential new antibiotics, antibiotic targets, and biomarkers that can predict transition to active infection.

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Researchers Identify the Molecular Roots of Lung Damage in Preemies with GI Disease

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Johns Hopkins researchers report they have figured out a root cause of the lung damage that occurs in up to 10 percent of premature infants who develop necrotizing enterocolitis, a disorder that damages and kills the lining of the intestine.

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International Lung Cancer Experts Seek Public Comments on Revised Molecular Testing Guideline to Improve Patient Selection and Targeted Therapies

The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised evidence-based guideline, “Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors.”

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Faster Detection of Pathogens in the Lungs

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What used to take several weeks is now possible in two days: thanks to new molecular-based methods, mycobacterial pathogens that cause pulmonary infections or tuberculosis can now be detected much more quickly. Time-consuming bacteria cultures no longer need to be taken from the patient samples, meaning that a suitable therapy can be started quickly.

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Regenerative Medicine Offering New Treatment for Bronchopleural Fistulas

For the first time in human application, Mayo Clinic researchers successfully closed an open wound on the upper chest caused by postoperative complications of lung removal. The protocol and approach were based on an ongoing trial investigating this method to treat anal fistulas in Crohn’s disease.

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Zika Mosquitoes Differ From West Nile Mosquitoes; First Zika Vaccine to Be Tested in Human Clinical Trial; Potential Drug Target Identified for Zika, and MORE in the Zika Virus News Source

Go here for the latest research, experts and features on Zika in the Zika Virus News Source

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New Clues to COPD Linked to Proteostasis Imbalance Caused by Cigarette Smoke

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Free radicals can reach the endoplasmic reticulum, a cellular organelle that is critical in manufacturing and transporting fats, steroids, hormones and various proteins, and alter its function by oxidizing and damaging its most abundant and crucial to protein folding chaperone, Protein Disulfide Isomerase (PDI).

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Implantable Device Cuts Obstructive Sleep Apnea Symptoms

Since the 1980s, continuous positive airway pressure (CPAP) – in which positive pressure is pushed through the nasal airways to help users breathe while sleeping – has been by far the most widely used treatment for obstructive sleep apnea (OSA). With more than 18 million people experiencing OSA, a number expected to rise, new results from a Penn case study of a new device implanted in the chest called hypoglossal nerve stimulation (HGNS) offers promise for patients with moderate to severe OSA who cannot tolerate CPAP. Researchers at the Perelman School of Medicine at the University of Pennsylvania will present data (abstract 0378) on their outcomes with hypoglossal nerve stimulation for the treatment of patients with sleep apnea at SLEEP 2016, the 30th annual meeting of the Associated Professional Sleep Societies LLC.

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Lung Cancer Breath ‘Signature’ Presents Promise for Earlier Diagnosis

Being able to identify lung cancer “signature” through a simple breath test has emerged as one of the most promising ways to diagnose the disease. Now the test is being used to monitor for disease recurrence.

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Some Asian-Americans Are Predisposed to Want More Carbs; Breakthrough Toward Fish-Free Aquaculture Feed; Genetically Modified Golden Rice Falls Short, and More in the Food Science News Source

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Study Sheds Light on Uncategorized Genetic Mutations in Cystic Fibrosis

A new study led by researchers at Children’s Hospital Los Angeles and the Genetic Disease Screening Program of the California Department of Public Health sheds light on some of those genetic mutations and the impact for those who carry them.