Feature Channels: Pharmaceuticals

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New research led by Washington University School of Medicine in St. Louis indicates an investigational therapy for an inherited form of ALS extends survival and reverses signs of neuromuscular damage in mice and rats. The findings, published July 16 in The Journal of Clinical Investigation, have led to a phase one/two clinical trial to investigate whether the drug could benefit people with ALS whose disease is caused by mutations in a gene called SOD1.

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Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA—A, U, C, and Gs—form a blueprint for the protein-making machinery in cells. In a new study published in Nature, scientists describe how the protein-making machinery identifies alternative initiation sites from which to start protein synthesis.

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By some estimates, 18 million people die each year from sepsis triggered by endotoxins – fragments of the outer membranes of bacteria. A biochemical engineer at Missouri University of Science and Technology has patented a method of removing these harmful elements from water and also from pharmaceutical formulations.Her goal: improve drug safety and increase access to clean drinking water in the developing world.

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Among Medicaid recipients taking prescription opioids, high opioid doses and concurrent treatment with benzodiazepine sedatives are among the key, potentially modifiable risk factors for fatal overdose, reports a study in the August issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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If a hepatitis C vaccine were successfully developed, it would dramatically reduce transmission of hepatitis C among drug users. even if the vaccine did not provide complete immunity, according to a study published in Science Translational Medicine.

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Adam Friedman, MD, professor of dermatology at the GW School of Medicine and Health Sciences, and his team investigated the use of nanotechnology to improve efinaconazole treatment and make it more cost effective.

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Nearly half of all men in a new study about intimate partner violence in male couples report being victims of abuse.

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A new study led by University of Alabama at Birmingham Researchers shows that multivitamins and mineral supplements do not prevent heart attacks, strokes or cardiovascular death.

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A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor (EGFR), a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme (GBM).

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McMaster University researchers have developed a new theory on Huntington’s disease which is being welcomed for showing promise to open new avenues of drug development for the condition.

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• The ultimate goal of basic biomedical research is to better the lives of patients through prevention, control or cure of disease. • Crossing that gap between the lab and bedside is difficult to achieve. • One great need for better treatment is diabetes, a disorder that afflicts one of every 10 U.S. adults and doubles the risk of early death.

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Anesthesia’s effect on the developing brain is being researched continually, and you’ll be comforted to know that anesthesia provided during one brief surgery is considered safe by the experts at the American Society of Anesthesiologists (ASA).

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As the roles for telemedicine, robotics, and even augmented reality in medicine expand, some researchers are focusing on making sure conversation and storytelling - tools and skills that have been around since the beginning of time - still play a central role in health care.

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Researchers at Washington University School of Medicine in St. Louis have found that inhibiting a receptor on immune cells called macrophages may help relieve pain in some patients, particularly those with chronic neuropathic pain, such as those with conditions like diabetic neuropathy.

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The Coriell Institute for Medical Research's quality managment system has been certified to the updated ISO 9001:2015 standards.

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The Association of American Cancer Institutes (AACI) has established the Champion for Cures Award to recognize leaders in the effort to cure cancer. The inaugural award will be presented to Richard and Susan Rogel in recognition of their philanthropy.

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Florida State scientists have devised a new strategy for synthesizing notoriously difficult carbocyclic 5-8-5 fused ring systems, a molecular structure with broad therapeutic potential.

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Rutgers Cancer Institute of New Jersey researchers have elucidated the mechanism behind an ‘on/off’ switch in the the most commonly mutated gene in human cancer – p53 – findings which they say could lead to a new paradigm in cancer therapeutics.

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Administering needle-based procedures in anesthesiology, such as epidurals, is a complex and delicate procedure. However, the current training methods for doctors are costly and fall shor

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Researchers have shown — for the first time — that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. This is important because, despite significant advances in the pathological mechanisms of persistent fibrosis, effective interventions are lacking.

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Researchers in the School of Public Health are conducting a clinical trial to see whether psilocybin, the active compound found in Psilocybe mushrooms, will help individuals addicted to cocaine stop using the harmful drug.

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Hackensack Meridian Health Bayshore Medical Center in Holmdel is now home to the da Vinci® Si™ Surgical system, bringing advanced technology in surgery to the medical center’s operating room and to the community. Robotic surgery enables surgeons to perform minimally invasive surgeries on a variety of diseases and conditions including urology, gynecology and general surgery.

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Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

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Beginning July 1, James M. Musser, M.D., Ph.D., becomes the 2018-2019 president of the Federation of American Societies for Experimental Biology (FASEB).

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A study by a team that includes Amrita Banerjee, assistant professor of pharmaceutical sciences at North Dakota State University, Fargo, shows promise in administering insulin in pill form. Banerjee is listed as first author in the study published in the Proceedings of the National Academy of Sciences.

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The research offers another approach for tackling diseases that have been considered "undruggable," including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers.

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AACC, a global scientific and medical professional organization dedicated to better health through laboratory medicine, is pleased to announce that the impact factor of its journal, Clinical Chemistry, has risen to 8.636 in the 2017 Thomson Reuters Journal Citation Reports. This impact factor places Clinical Chemistry in the top 2.5% of 12,271 ranked academic journals and speaks to the significant influence of the science it publishes on laboratory medicine and patient care.

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With applications for asylum in the United States increasing sharply, a new paper from a team of asylum medicine and law experts is highlighting physicians’ important role in evaluating refugees’ claims of torture and persecution.

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University of Utah President Ruth V. Watkins has appointed Michael L. Good, M.D., as the university’s new senior vice president for health sciences, CEO of University of Utah Health, and executive dean of the U’s School of Medicine.

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Drs. Kenneth Shroyer and Luisa Escobar-Hoyos receive $500,000 from PanCAN to advance research

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Millions of samples of blood, saliva, tissue and much more will receive advanced testing at new facility built as part of a $160 million project to serve patients around the state and nation.

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Clinical Research Pathways has launched an effort to learn what information and other resources physicians need to seek access to experimental drugs for desperately ill or terminal patients, using the expanded access program.

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To improve water treatment, researchers use modeling to understand how chemical byproducts form during the advanced oxidation process.

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To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.

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New research, published this month by the American Pain Society (APS), adds to burgeoning scientific evidence showing that interdisciplinary pain rehabilitation programs are an effective alternative to opioids for chronic pain management. Despite several studies documenting favorable outcomes, access to multi-modal pain management programs remains out of reach for most patients due to inadequate insurance coverage. This discourages providers from opening new interdisciplinary pain clinics.

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The American Pain Society today announced its selections of clinical psychologist Tonya Palermo, Ph.D. as Treasurer and three new members of the Board of Directors: John Markman, M.D., Jamie Rhudy, Ph.D. and David Tauben, M.D.

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ISPOR, the professional society for health economics and outcomes research, announced a new ISPOR Summit “New Approaches to Value Assessment: Towards More Informed Pricing in Healthcare” scheduled for October 19, 2018 in Washington, DC, USA.

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A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic. The findings may provide important information for identifying which patients potentially fare better when treated with an alternate therapy.

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A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways — one that has previously been linked to how the brain senses “itch” — may improve pain relief when combined with conventional ways to blunt pain using opioid drugs, such as morphine.

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Microbiologist Aimee Shen at Tufts University School of Medicine is one of 12 new recipients nationwide of the Burroughs Wellcome Fund 2018 Investigators in the Pathogenesis of Infectious Disease (PATH) award for her research on Clostridium difficile.

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A new study to be published online June 25 in JAMA Internal Medicine reports that hospital at home (HaH) care provides a shorter length of stay; reductions in hospital readmissions, emergency department visits, and transfers to skilled nursing facilities; and, improved patient experience versus traditional inpatient care. The study, which spans nearly three years, includes patients with the broadest set of admitting diagnoses ever to be researched, thus strengthening the evidence base for hospital at home care.

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A new study published online today by Pediatrics and conducted by researchers at the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that from January 2007 through December 2016 there were more than 11,000 calls to US Poison Centers for pediatric exposures to buprenorphine.

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Breaking News!! The House of Representatives minutes ago just passed legislation to allow nurse anesthetists and other APRNs to administer medical-assisted medicine independently in an effort to fight the opioid crisis by increasing access to treatment for individuals who are addicted.

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It’s been known for years that humans and other mammals possess an antiviral gene called RSAD2 that prevents a remarkable range of viruses from multiplying. Now, researchers at Albert Einstein College of Medicine, part of Montefiore, have discovered the secret to the gene’s success: The enzyme it codes for generates a compound that stops viruses from replicating. The newly discovered compound, described in today’s online edition of Nature, offers a novel approach for attacking many disease-causing viruses.

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Health care insurers including Medicare, Medicaid and major private insurers have not done enough to combat the opioid epidemic, suggests a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

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In the first 90 days of concurrent opioid and benzodiazepine use, the risk of opioid-related overdose increases five-fold compared to opioid-only use among Medicare recipients, according to a new study from the University of Pittsburgh School of Pharmacy.

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Cardiologist Dr. James de Lemos, Professor of Internal Medicine, and pediatrician Dr. Dorothy Sendelbach, Assistant Dean of Undergraduate Medical Education at UT Southwestern, have been recognized with the UT System’s highest educational honor, the Regents’ Outstanding Teaching Awards, for their academic prowess and mentoring talent.

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Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB).

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In contrast to most antidepressant medications, which can take several weeks to reduce depressive symptoms, ketamine — a commonly used veterinary anesthetic — can lift a person out of a deep depression within minutes of its administration, and its effects can last several weeks. Researchers have long-wondered how ketamine can both act quickly and be so long-lasting.

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The microbiome may harbor a gene for drug resistance