According to new research summarized by California Pacific Medical Center Research Institute senior scientist Steven Cummings, MD, and colleagues at the University of California, San Francisco (UCSF) and Harvard Medical School, contrary to common beliefs, relatively high doses of vitamin D may increase the risk of falls.
Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology.
A study in aged mice shows that excess folic acid intake causes lowered immune function because important immune cells, called natural killer (NK) cells, are less effective.
Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease, including diabetes. The researchers discovered methods for reducing these conditions in naturally aged mice.
A proof-of-concept, phase 2 trial by an international research team has found promising results for a myostatin antibody in treating the decline in muscle mass and power associated with aging.
Elite runners do not experience the muscle weakening associated with aging as non-athletes do. A new study published in American Journal of Physiology—Cell Physiology examines if their superb fitness is because their muscles have not aged.
An international study of about 43,000 people has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older. Supported by the National Eye Institute (NEI), part of the National Institutes of Health, the findings may help improve our understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
A Kansas State University gerontologist offers tips on coping during the holidays with a family member who has dementia.
A scientist from the Florida campus of The Scripps Research Institute has been awarded approximately $2 million from the National Institutes of Health to study the impact of aging and age-related disease on the inner workings of a single type of nerve cell.
Some decline in memory and cognitive function is a normal part of aging, but what if it could be prevented? Researchers at University of California, San Diego School of Medicine and Washington University in St. Louis have launched a major clinical trial to investigate whether mental decline in seniors can be slowed or halted through exercise and other health-related interventions.
An upcoming study unveils new measures for aging, to be published in the journal Population and Development Review on Dec. 15, 2015. Researchers and authors of the study, Warren Sanderson, a Professor of Economics at Stony Brook University, and Sergei Scherbov, a project leader at an Austrian research institute, suggest that conventional measures of population aging --- or the “old age dependency ratio (see definition below*)” --- are biased and misleading and that aging is multidimensional phenomena. Sanderson and Scherbov say that there are many more characteristics that should be considered that go beyond the conventional measures of aging, which are based on only one characteristic --- chronological age.
Researchers from the University of Arkansas for Medical Sciences (UAMS) and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells.
More than 100 industry executives, association leaders, elected local and state policy makers, private and public sector economists, and other allied professionals are expected to attend. Five speakers will address critical issues in relation to agribusiness
FAU’s Louis and Anne Green Memory and Wellness Center has received a grant for a new project to expand and adapt existing evidence-based services and supportive programs of a university-based, dementia capable system to meet identified gaps in services to targeted populations.
A new study finds some surprising ways in which women’s health at midlife is connected to when they had their first child and to their marital history.
Advancing age leads to more medical problems. It’s not uncommon to see seniors suffering from a host of ailments — and using a range of drugs to deal with them. Approximately two thirds of seniors in Canada regularly take five or more prescription medications. A group of researchers is working to reverse the trend through a new project, "Deprescribing Guidelines for the Elderly."
Prescription opioid abuse has reached epidemic proportions, but new research led by UB psychiatric nursing researcher Yu-Ping Chang found motivational interviewing, a form of behavioral counseling, is an effective tool at curbing misuse.
Older adults who lived in an independent living community that uses sensor technology and onsite care coordination to maintain residents’ health stayed longer at the community than seniors who live in other senior housing across the nation. Length of stay is important because it indicates that residents’ health remains stable enough for them to continue living independently. The technologically enhanced care coordination could serve as a cost-effective care model for improving the health and function of older adults.
How fast elderly people walk may be related to the amount of amyloid they have built up in their brains, even if they don’t yet have symptoms of Alzheimer’s disease, according to a study published in the December 2, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Federal investments in research are paying off in scientific breakthroughs that are “unleashing the power and potential of proteins” in humans, which, by 2034, will have a significant effect on aging, according to an essay published by the Washington, D.C.-based Science Coalition.
With the support of a $2.8 million NIH grant, scientists at The Scripps Research Institute will explore mutations in the nuclear lamina—the outer edge of the cell nucleus— which have been linked to many diseases, from muscular dystrophies and heart disorders to type 2 diabetes and premature aging.
Many human gene variants have evolved specifically to protect older adults against neurodegenerative and cardiovascular diseases, thus preserving their contributions to society, report University of California, San Diego School of Medicine researchers in the November 30 issue of Proceedings of the National Academy of Sciences.
How to age but keep your health? Can science reverse aging? Those are just two of the questions Oscar-winning director Ron Howard will investigate when he hosts the documentary series Breakthrough on the National Geographic channel on Sunday November 29. The segment focuses on Mayo Clinic’s Kogod Center on Aging and features gerontology researcher James Kirkland, M.D., Ph.D.
In a new study that could have implications for future drug discovery efforts for a number of neurodegenerative diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that the interaction between a pair of brain proteins has a substantial and previously unrecognized effect on memory formation.
UC San Diego paper finds young adults are more envious than older adults. They are more envious over looks and for a wider range of other reasons, too. It also appears that both men and women are more likely to envy someone who is of their own gender and approximately their own age
Older people with an age-related loss of muscle mass and strength may be at greater risk of falling and bone fractures, according to new research led by the University of Southampton.
Chronic inflammation, closely associated with frailty and age-related diseases, is a hallmark of aging. Mayo Clinic researchers have discovered that inhibiting key enzyme pathways reduces inflammation in human cells in culture dishes and decreases inflammation and frailty in aged mice.
Latest research from ACSM
Two experts in elder abuse coin the term and explain the concept in an opinion article published in the Oct. 13 issue of the Annals of Internal Medicine. They also call for research to identify and help older adults at risk from age-associated financial vulnerability, or AAFV for short.
It's hard to be unhappy around young children, who lift your spirits while keeping you on the go. This infusion of energy is good both for attitude and physical health, says a Saint Louis University assistant professor of geriatric medicine.
Traditional societies may see the aging process in a more positive light than modern societies, according to a Cornell researcher in a recent study published in the Journals of Gerontology: Psychological Science.
Health care providers must have detailed discussions with their older adult patients to better determine their true life expectancy, as older adults do not accurately predict their own prognosis, a key factor in making decisions about future health interventions, according to researchers at UC San Francisco and San Francisco Veterans Affairs Medical Center.
Nearly four in ten older adults say that managing their health care needs is difficult for them or their families, that medical appointments or tests get delayed or don’t get done, or that all of the requirements of their health care are too much to handle, new Johns Hopkins Bloomberg School of Public Health research suggests.
As we age, our biological clocks wind down – but why? A Weizmann Institute team studying circadian clocks has found a clue: a link between the clocks and a group of metabolites called polyamines. When added to the drinking water of older mice, polyamines reversed some signs of aging; naturally found in many foods, it’s possible they could do the same for us.
The new technique allows scientists to study diseases like Alzheimer’s and Parkinson’s using cells from human patients
A study of up to 433,390 UK adults, led by The University of Manchester, has linked being under and overweight at birth with poorer hearing, vision and cognition in middle age.
Heart valve replacements made from tissue (bioprosthetic valves) have long been thought to be spared the complication of blood clot formation. Researchers have now found that about 15 percent of all bioprosthetic aortic heart valve patients develop blood clots on the leaflets affecting valve opening, regardless of whether the patient received the new valve via open-heart surgery or a minimally-invasive catheter procedure, a new study from the Cedars-Sinai Heart Institute shows.
Like scratchy-sounding old radio dials that interfere with reception, circuits in the brain that grow noisier over time may be responsible for ways in which we slow mentally as we grow old, according to the results of new studies from UC San Francisco on young and older adults.
University of Florida Health researchers have uncovered more evidence of a link between the brain’s stress response and a protein related to Alzheimer’s disease.
A recently identified molecule produced by skeletal muscle in response to exercise, has been shown to increase bone mass, according to a collaborative study between researchers at the Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, the Department of Experimental and Clinical Medicine at University of Ancona in Italy, and the Department of Basic Medical Science, Neuroscience and Sense Organs at the University of Bari in Italy, and published online today in the Proceedings of the National Academy of Sciences (PNAS).
Researchers have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging.
In a consensus paper, a global panel of leading aging experts suggests physicians routinely screen everyone older than 70 annually for cognitive problems.
The aging of the population, shifting diagnostic criteria, and new health care policy initiatives are some of the factors driving changes in mental health treatment for older Americans, according to the September special issue of the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.
With the world’s elderly population expected to double by 2050, understanding how aging affects the body is an important focus for researchers globally. Cardiovascular disease, the No. 1 cause of death worldwide, often is associated with aging arteries that restrict blood flow. Now, University of Missouri researchers have identified an age-related cause of arterial dysfunction, a finding that could lead to future treatments for some forms of vascular disease.
University of Iowa scientists have identified the first known cause of age-related muscle weakness and atrophy (the transcription factor ATF4), as well as two natural compounds (ursolic acid, from apple peel, and tomatidine, from green tomatoes) that blunt ATF4 activity in old skeletal muscle, leading to increased strength and muscle mass.
Sarcopenia is a natural part of aging, but it’s also a growing public health concern for older adults. That’s why an Iowa State University researcher is testing a combination of supplements and resistance training to slow or reverse the progression of sarcopenia.
Building on scientific evidence implicating disturbed calcium regulation in brain aging accumulated during the past 30 years, a research team in the University of Kentucky Department of Pharmacology and Nutritional Sciences has found a connection between unhealthy brain aging and a protein responsible for regulating calcium at the molecular level, FKBP1b.
The incidence of bicycle accidents has increased significantly in the U.S. in recent years, with many serious injuries occurring among riders older than 45, according to a new study led by UC San Francisco.
The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging, Prof. Robert J. Shmookler Reis, has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks.
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