Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The research, published in Cell Reports Medicine, aims to create a functional HIV cure by activating and then eliminating all pockets of dormant HIV—an approach called “shock and kill.”
About three-quarters of U.S. workers, or 108 million people, are in jobs that cannot be done from home during a pandemic, putting these workers at increased risk of exposure to disease. This majority of workers are also at higher risk for other job disruptions such as layoffs, furloughs or hours reductions, a University of Washington study shows.
NYU College of Dentistry’s Department of Pediatric Dentistry has received a nearly $2 million grant from the Health Resources and Services Administration (HRSA) to train dentists and other health professionals to provide oral health care to people with disabilities and complex medical conditions.
Medtronic, a global leader in medical technology, has committed $1 million over five years to fund an endowed professorship at the Case Western Reserve University School of Medicine.
The $20 million Louisiana Material Design Alliance (LAMDA) aims to create a diverse and highly skilled STEM workforce for Louisiana.
Loading microparticles with drugs designed to active the macrophages in which TB bacteria hide may lead to therapeutics that can treat drug-resistant and latent TB.
Because of silicon’s relatively high cost, hybrid organic-inorganic perovskites (HOIPs) have emerged as a lower-cost and highly efficient option for solar power, according to a recent study by Georgia Institute of Technology (Georgia Tech) researchers.
Freshwater lakes have often been invaded by species from salty environments. New research shows that fluctuating conditions in the home ranges gave these species the genetic flexibility they needed to evolve and adapt to their new homes.
Scientists at the La Jolla Institute for Immunology (LJI) have discovered a potential new way to better fight a range of infectious diseases, cancers and even autoimmune diseases. The new study, published recently in Nature Immunology, shows how a protein works as a “master regulator” in the immune system.
Researchers at Vanderbilt University Medical Center’s (VUMC) Center for Biomedical Ethics & Society were recently awarded a grant from the National Human Genome Research Institute (NHGRI) of the National Institutes for Health (NIH) to explore LGBTQ+ perspectives on a range of issues related to biomedical research.
Using an enzyme inhibitor in meniscus cells, a Penn team was able to soften their nucleus and promote access to previously impassible areas
DALLAS – June 22, 2020 – For decades, high-density lipoprotein (HDL) cholesterol has been dubbed “good cholesterol” because of its role in moving fats and other cholesterol molecules out of artery walls. People with higher HDL cholesterol levels tend to have lower rates of cardiovascular disease, studies have shown.
Profile of recipient of five-year NSF award to study the evolution of astrophysical magnetic fields and establish a summer school to attract women and underrepresented minorities to plasma physics.
A 2003 hypothesis says Parkinson’s disease is caused by a gut pathogen that could spread to the brain through the nervous system. No evidence was found until now; researchers report for the first time a significant overabundance of a cluster of opportunistic pathogens in the PD gut.
Prostate cancer researchers and clinicians recommend reconsidering screening guidelines, saying benefits may outweigh potential harms.
Engineers at the McKelvey School of Engineering at Washington University in St. Louis have developed high-power, direct borohydride fuel cells that operate at double the voltage of conventional hydrogen fuel cells.
DALLAS – June 17, 2020 – The molecular changes that lead to Fuchs’ endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients, new research by UT Southwestern scientists shows. This insight into this earliest stage of FECD may eventually lead to new ways of screening for and treating the common condition, which affects an estimated 4 percent of U.S. adults over the age of 40.
SS-31, an experimental drug that has been shown to improve the function of diseased and aged mitochondria, binds to 12 key proteins involved in energy production, researchers at the University of Washington School of Medicine have found.
In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.
Fatherhood looks very different across species. Tiny stickleback fish are especially involved in raising their young, and along with other animals, they’re showing us the impact paternal care can have on both offspring and fathers.
The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania received an $8 million grant, to be distributed over the next five years, from the National Institute of Environmental Health Sciences, a renewal of its P30 Environmental Health Sciences Core Center (EHSCC) grant.
FAU’s Schmidt College of Medicine and The Harry T. Mangurian, Jr. Foundation have joined forces again to usher in a new phase of research to prevent dementia. The extension of a three-year, $3 million grant from the foundation will launch the new FAU Center for Brain Health. The grant supports precision medicine approaches to prevent dementia, which will be further strengthened by leveraging multiple patient-centered platforms through state-of-the-art transdisciplinary approaches.
Nanoparticles cloaked in human lung cell membranes and human immune cell membranes can attract and neutralize the SARS-CoV-2 virus in cell culture, causing the virus to lose its ability to hijack host cells and reproduce.
combination of IV and oral antibiotics can effectively treat invasive infections in people who inject illicit drugs, according to a study from Washington University School of Medicine in St. Louis. The findings mean that patients who do not wish to stay in the hospital for weeks of IV antibiotic treatment can leave and complete taking their prescribed antibiotics at home.
For the next several months, visitors to the Atlanta Botanical Garden will be able to observe the testing of a new high-tech tool in the battle to save some of the world’s most endangered species. SlothBot, a slow-moving and energy-efficient robot that can linger in the trees to monitor animals, plants, and the environment below, will be tested near the Garden’s popular Canopy Walk.
Funded by the Defense Advanced Research Projects Agency, a team of internationally acclaimed researchers led by UNC School of Medicine’s Bryan L. Roth, MD, PhD, aims to create new medications to effectively and rapidly treat depression, anxiety, and substance abuse without major side effects.
New NEI-supported research provides insight into the eye conditions associated with Marfan syndrome, where weakened zonule fibers cause vision problems.
A three-year, $345,000 grant from the National Science Foundation will fund research at Binghamton University, State University of New York that seeks to modify paper’s mechanical properties while still retaining its advantages.
Iowa State engineers are doing wind-tunnel tests and computer simulations to understand and predict how the cables that carry power or support bridges will react to high winds.
Johns Hopkins Kimmel Cancer Center researchers from the Department of Radiation Oncology and Molecular Radiation Sciences identified a lipid-regulating protein that conveys what the researchers describe as “superpowers” onto prostate cancer cells, causing them to aggressively spread.
A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient’s own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment. The study, which will be published June 19 in the Journal of Experimental Medicine (JEM), reveals that the vaccines are a safe and effective way to induce the body’s immune system to attack any tumor cells that could cause disease relapse.
UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
A mouse study by Craig Powell, M.D., Ph.D., and colleagues suggests that early genetic rescue may be a potential therapy in autism spectrum disorder, or ASD. Powell looked at one gene called SHANK3, whose alteration is seen in about 0.5 percent of ASD patients.
Delta opioid receptors have a built-in mechanism for pain relief and can be precisely targeted with drug-delivering nanoparticles—making them a promising target for treating chronic inflammatory pain with fewer side effects, according to a new study from an international team of researchers. The study, published in Proceedings of the National Academy of Sciences (PNAS), was conducted using cells from humans and mice with inflammatory bowel disease, which can cause chronic pain.
(Study publishes 6/17/20. No embargo.) Mystery enshrouds the birth of swirls typical for supernova remnants like the Crab Nebula. A new "supernova machine" may help solve it.
With an eye on adapting solutions to new applications, DHS S&T expanded its SVIP, by offering its first-ever Phase 5 award to Tamr Government Solutions, based in Cambridge, Massachusetts.
A new, multi-ethnic study from researchers at Tufts University and Tufts Medical Center found adults aged 54-76 with low circulating vitamin K levels were more likely to die within 13 years compared to those with adequate levels, suggesting vitamin K may offer protective health benefits as we age.
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.
New preclinical work by a team of researchers from Roswell Park Comprehensive Cancer Center’s Transplant and Cellular Therapy Program suggests that the risk of developing acute graft vs. host disease (GVHD) during allogeneic blood/marrow transplant (BMT) — a potentially curative treatment for selected patients with hematologic disorders — can be decreased using an existing class of drugs called beta adrenergic agonists.
Scientists at St. Jude Children’s Research Hospital, UCSF Benioff Children’s Hospitals and Baylor College of Medicine are investigating how to best treat hemophagocytic lymphohistiocytosis (HLH), a rare immune disorder. Their work, appearing as an advance online publication today in Blood, details how combining two drugs may be a good treatment for HLH.
Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, expected to see retinal degeneration and retinal thinning. They surprisingly found none, calling into question the commonly accepted — though never proved — mechanism for RP59.
Using a new technique originally designed to explore the cosmos, scientists have unveiled structures deep inside the Earth, paving the way towards a new map revealing what Earth’s interior looks like.
Neuroscientists have discovered neurons that control hibernation-like behavior in mice, revealing for the first time the neural circuits that regulate this state. By better understanding these processes, the authors envision the possibility of one day working toward inducing torpor in humans.
In a new Science Immunology study, published on June 12, 2020, scientists at La Jolla Institute for Immunology (LJI) offer a clue to why non-allergic people don’t have a strong reaction to house dust mites. They’ve uncovered a previously unknown subset of T cells that may control allergic immune reactions and asthma from ever developing in response to house dust mites—and other possible allergens.
Understanding the source and network of signals as the brain functions is a central goal of brain research. Now, Carnegie Mellon engineers have created a system for high-density EEG imaging of the origin and path of normal and abnormal brain signals.
The COVID-19 pandemic is having a significant impact on people with obesity as they struggle to manage their weight and mental health during shelter-in-place orders, according to research led by The University of Texas Health Science Center at Houston (UTHealth) and UT Southwestern.
Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
In a new study, Johns Hopkins researchers found that testing people for SARS-CoV-2 — the virus that causes COVID-19 — too early in the course of infection is likely to result in a false negative test, even though they may eventually test positive for the virus.
Researchers at Washington University in St. Louis are the first to study presolar materials that landed on a planet-like body. Their findings may help solve the mystery: where did all the water on Earth come from?
DALLAS – June 9, 2020 – Serotonin, a chemical known for its role in producing feelings of well-being and happiness in the brain, can reduce the ability of some intestinal pathogens to cause deadly infections, new research by UT Southwestern scientists suggests. The findings, publishing online today in Cell Host & Microbe, could offer a new way to fight infections for which few truly effective treatments currently exist.
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