Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations.
More than $3.7 million was awarded to Mahesh Mohan, DVM, MS, Ph.D., Professor at the Texas Biomedical Research Institute, and Chioma M. Okeoma, Ph.D., Associate Professor at Stony Brook University, to explore the link between cannabinoids (THC) and chronic intestinal inflammation in patients infected with the human immunodeficiency virus (HIV).
Adults who drank sugary beverages daily had an increased risk of developing abnormal blood cholesterol and triglycerides compared to those who did not, according to new findings from a prospective study by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
DHS S&T announced today the selection of the University of Nebraska Omaha to lead a consortium of U.S. academic institutions and other partners for a new COE for TPCR.
The grant will help create a new multi-disciplinary educational program of self-advocacy at UIC
At the University of Pennsylvania School of Nursing (Penn Nursing), researchers conducted an online survey of 362 Pennsylvania school nurses (elementary, middle, and high school) to better understand how they have a supply, administer, and perceive storing naloxone in their schools. The results illustrate that though many nurses have a supply of naloxone in their school, important barriers to access and use of this life-saving medication still exist.
Cognitive processing in people with intellectual disability can now be accurately assessed thanks to UC Davis Health researchers who updated and validated series of tests, part of the NIH Toolbox Cognitive Battery.
Testing of small molecules in mouse models of Duchenne muscular dystrophy shows promise for restoration of muscle structure and function.
In search of new ways to sequence human genomes and read critical alterations in DNA, researchers at Johns Hopkins Medicine say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.
A method developed by a team of geneticists, archaeologists and demographers may make it possible to identify thousands of individuals whose remains lie in unmarked graves.
Experts believe that tuberculosis, or TB, has been a scourge for humans for some 15,000 years, with the first medical documentation of the disease coming out of India around 1000 B.C.E. Today, the World Health Organization reports that TB is still the leading cause of death worldwide from a single infectious agent, responsible for some 1.5 million fatalities annually. Primary treatment for TB for the past 50 years has remained unchanged and still requires patients to take multiple drugs daily for at least six months. Successful treatment with these anti-TB drugs — taken orally or injected into the bloodstream — depends on the medications “finding their way” into pockets of TB bacteria buried deep within the lungs.
Exposure to alcohol advertising changes teens’ attitudes about alcohol and can cause them to start drinking, finds a new analysis led by NYU School of Global Public Health and NYU Grossman School of Medicine. The study, which appears in a special supplement of the Journal of Studies on Alcohol and Drugs funded by the National Institute on Alcohol Abuse and Alcoholism, uses a framework developed to show causality between tobacco advertising and youth smoking and applies it to alcohol advertising.
The insulin-producing beta cells in the pancreas unwittingly produce a signal that may aid their own demise in Type 1 diabetes, according to a study of the lipid signals that drive macrophage cells in the body to two different phenotypes of activated immune cells.
Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research.
New cancer immunotherapy approaches are revolutionizing treatment options for breast cancer patients. However, many lead to insufficient immune responses rendering the therapies incapable of completely eradicating tumors. In a new study, published today in Science Immunology, University of California, Irvine researchers determined the molecular features of certain cells associated with breast cancer, which may open up new avenues into improving cancer immunotherapy.
Two leaders of the University of Arkansas at Little Rock have donated $25,000 to honor academic units who are going above and beyond the call of duty to support student success.
Researchers at Johns Hopkins Bloomberg School of Public Health have demonstrated the use of stem-cell-derived “mini-brains” to detect harmful side effects of a common drug on the developing brain. Mini-brains are miniature human brain models, developed with human cells and barely visible to the human eye, whose cellular mechanisms mimic those of the developing human brain.
Scientists find that normal intestinal cells “de-differentiate” en masse into stem cells that generate the cells needed for a healthy intestinal lining. New study establishes de-differentiation as the predominant mode of stem cell recover in the intestine
The ATS Foundation Research Program/Pulmonary Hypertension Association has awarded Rahul Kumar, PhD, of the University of California, San Francisco, a $80,000 Foundation Partner grant. A $50,000 Foundation Partner grant was awarded to Jason Boehme, MD, also of the University of California, San Francisco. Ke Yuan, PhD, of Boston Children’s Hospital is the 2019 recipient of the Aldrighetti Research Award for Young Investigators. The award, in the amount of $80,000, is sponsored by Actelion Pharmaceuticals US, Inc, through a partnership with the Pulmonary Hypertension Association.
Research into engineering artificial organs that mimic the functions of human lymph nodes at The University of Alabama in Huntsville (UAH) has garnered one of its professors a $507,777 National Science Foundation (NSF) Faculty Early Career Development Program (CAREER) Award.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Harvard University have discovered that mitochondria trigger senescence, the sleep-like state of aged cells, through communication with the cell’s nucleus—and identified an FDA-approved drug that helped suppress the damaging effects of the condition in cells and mice. The discovery, published in Genes & Development, could lead to treatments that promote healthy aging or prevent age-associated diseases such as cancer, Alzheimer’s disease, heart disease and more.
Researchers surveyed 153 transgender youths receiving gender-affirming care at a specialty clinic, and even in this relatively "out" population, nearly half reported intentionally hiding their gender identity from a health care provider outside the clinic.
MD Anderson receives more than $20 million in CPRIT funding for research, clinical translation, prevention and recruitment.
Machine learning is helping Penn Medicine researchers identify the size and shape of brain networks in individual children, which may be useful for understanding psychiatric disorders. In a new study published in Neuron, a multidisciplinary team showed how brain networks unique to each child can predict cognition. The study is the first to show that functional neuroanatomy can vary greatly among kids, and is refined during development.
Harvard researchers have discovered a new mechanism for how the brain and its arteries communicate to supply blood to areas of heightened neural activity. The findings enable new avenues of study into the role of this process in neurological diseases.
Sepsis causes nearly 270,000 deaths in the United States each year. Find out how big data approaches are helping clinicians catch it sooner, treat it better, and help survivors cope with long-term effects.
The W. P. Carey Foundation, whose generosity launched Johns Hopkins Carey Business School, has made a $25 million commitment to the school to recruit renowned faculty, enhance academic programs, and help launch student careers. The gift will be matched with commitments from Johns Hopkins University and contributions from other donors for a total of $50 million.
Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how. New findings, in a study led by Steve A. N. Goldstein, MD, PhD, vice chancellor for Health Affairs at the University of California, Irvine, and distinguished professor in the UCI School of Medicine Departments of Pediatrics and Physiology & Biophysics, reveal the underlying mechanism for this dangerous heart disorder.
Researchers at Washington University School of Medicine in St. Louis have found that the strain of Zika that circulated in Brazil during the microcephaly epidemic that began in 2015 was particularly damaging to the developing brain.
Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.
Karen Lewis, assistant professor in the Department of Chemistry and Biochemistry at Texas State University, has received a $460,000 competitive grant renewal from the National Institutes of Health to study the RNA-to-protein translation process that is controlled by La-Related Proteins (LaRPs).
The Garver Black Hilyard Family Foundation awarded a $250,000 grant to HARC (Houston Advanced Research Center) to optimize marine debris removal efforts in local waterways.
Having more nurses trained outside of the United States working on a hospital unit does not hurt collaboration among healthcare professionals and may result in a more educated and stable nursing workforce, finds a new study by researchers at NYU Rory Meyers College of Nursing published in the journal Nursing Economic$.
Solutions to some of the problems Iowa communities are facing may be found in the data towns and cities already collect, but lack the resources to access and analyze. Iowa State University researchers are lending their expertise to help communities tap into that information.
A research team from Wayne State University recently received a $1.5 million grant from the National Heart, Lung, and Blood Institute of the NIH to work on potential new targets for treating Barth syndrome, a rare and life-threatening, X-linked genetic disorder that causes cardiomyopathy and other pathologies.
Researchers report the biological effects of influenza protein NS1 binding to RIG-I — the binding directly quiets the alarm that activates the cellular innate immunity defense against the infection. This is a newly described way for flu to antagonize the host cellular antiviral response.
The Thoracic Surgery Foundation (TSF)—the charitable arm of The Society of Thoracic Surgeons (STS)—has awarded 29 new grants totaling $1,047,500 in support of research and education programs in cardiothoracic surgery.
Irvine, Calif., Feb. 13, 2020 — Popular gaming personality Pokimane has donated $50,000 to the University of California, Irvine for student scholarships in its esports program. An initial $25,000 gift this year will be combined with the remaining $25,000 in 2021 to create an endowment that will fund tuition and fees for gamers selected by UCI Esports.
SDSC researchers used SDSC’s ‘Comet’ Supercomputer to analyze genome sequences in a recent study published in Nature Medicine by an international team of scientists led by researchers at UC San Diego School of Medicine. The study describes a method to measure disease-causing mutations found only in the sperm of the father, providing a more accurate assessment of autism spectrum disease (ASD) risk in future children.
The ATS Foundation Research Program has announced that 17 researchers have been awarded one-year $40,000 Unrestricted Research Grants to advance pulmonary, critical care and sleep medicine.
We know that stress can have a profound impact on health. But it’s rare to discover a health issue that is caused directly by stress. That’s exactly what one Michigan State University researcher and his team have found. Nathan Tykocki, an assistant professor of pharmacology and toxicology in the College of Osteopathic Medicine, set out to understand why children who seemingly have nothing wrong with them lose bladder function, a condition also known as stress-induced bladder dysfunction, or SIBD.
Scientists have taken an unprecedented look at proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about which patients will need aggressive treatment and which won’t, and offers clues about why a common cancer treatment is not effective with some patients.
Researchers have developed a new method that could one day replace conventional pressure treating as a way to make lumber not only fungal-resistant but also nearly impervious to water – and more thermally insulating.
The insights from the PEXIVAS Trial, a 10-year study, shows treatment for ANCA-associated vasculitis can become much more patient-friendly by using half the typical dose of steroids and no blood plasma exchanges
“We wanted to answer the question ‘How does HIV bounce back when treatment is stopped?'" said Dr. Florian Hladik.
Researchers at the San Diego Supercomputer Center (SDSC) and the Wisconsin IceCube Particle Astrophysics Center (WIPAC) have conducted a second experimentt marshalled globally available-for-sale GPUs (graphics processing units), proving it is possible to elastically burst to very large scales of GPUs using the cloud, even in this pre-exascale era of computing.
A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice
For the fourth consecutive year, Spirit Halloween has provided a significant grant to Hackensack Meridian Health K. Hovnanian Children’s Hospital at Hackensack Meridian Health Jersey Shore University Medical Center. The recent gift, provided through the Spirit of Children program, represents collections during the 2019 Halloween season, and totaled $71,870, bringing the organization’s overall donations to nearly $280,000.
New findings suggest soils exposed to salt release more greenhouse gas
Binghamton University, State University of New York, today announces its largest gift ever — $60 million committed to a new Baseball Stadium Complex.
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