Articles published today by UAB and its Geroscience Network collaborators explore new interventions in aging processes as part of an effort to increase the healthy, independent years of life for the elderly.
Researchers from the Schepens Eye Research Institute of Massachusetts Eye and Ear have identified new underlying mechanisms of proptosis, or bulging of the eyes, in patients with acute thyroid eye disease. In a report published online in the journal Ophthalmology, the researchers describe vascular growth factors causing an abnormal proliferation of blood vessels, as well as the rare formation of lymphatic vessels, that may contribute to the dangerous swelling and inflammation that occurs in the orbits of these patients. The findings point to new potential targets for non-surgical therapies to decompress the eye in the acute phase of thyroid eye disease.
Molecules that scavenge debris from dying cells appear to halt the cycle of chronic inflammation in lupus, while also enhancing the body’s ability to combat flu, according to Duke Health studies in mice.
Scientists have discovered a new way to attack Staphylococcus aureus bacteria. The team, from Imperial College London, have revealed how the bacteria regulates its salt levels.
Researchers at The University of Texas Health Science Center at Houston (UTHealth) have developed a culturally appropriate, online sexual health curriculum for American Indian/Alaska Native (AI/AN) youth, adapted from It’s Your Game…Keep it Real, an evidence-based teen pregnancy prevention program.
For the study, The research team conducted a three-year trial in a Hutterite colony, where people live communally and are relatively isolated from cities and towns, to determine whether vaccinating children and adolescents with the flu nasal spray provided better direct and community protection than the standard flu shot.
A new study published in the Journal of Clinical Investigation shows that when kidneys fail, urea that builds up in the blood can cause diabetes.
In the late 1800s, William B. Coley created a concoction out of bacteria and injected it into cancer patients. The first patient treated with what became known as “Coley’s Toxins” — a 21-year-old man with an inoperable tumor — was cured of his cancer. Though that might not have been the very first foray into immunotherapy as cancer treatment, it certainly was one of the earliest. Coley spent decades studying how bacterial infections affected cancers, earning him the moniker of the “father of immunotherapy.” Since then, the field has come a long way.
UF/IFAS is helping ID mosquitoes that can spread disease.
Albert Einstein College of Medicine and Montefiore, in collaboration with the City University of New York (CUNY), have received a $9.4 million grant from the National Institutes of Health (NIH) to lead research in Central Africa to improve clinical care and health outcomes for patients with HIV. The ongoing, five-country observational study, called Central Africa International Epidemiologic Databases to Evaluate AIDS (CA-IeDEA), involves more than 50,000 HIV-positive children and adults taking anti-retroviral therapy (ART).
Mount Sinai Health System receives $420k for reducing HIV viral loads for VNSNY’s CHOICE SelectHealth Plan members
Researchers have discovered that secondary infection with the Methicillin-resistant Staphylococcus aureus (MRSA) bacterium (or “superbug”) often kills influenza patients because the flu virus alters the antibacterial response of white blood cells, causing them to damage the patients’ lungs instead of destroying the bacterium. The study, which will be published online August 15 ahead of issue in The Journal of Experimental Medicine, suggests that inhibiting this response may help treat patients infected with both the flu virus and MRSA.
House dust differences between Amish and Hutterite communities affect immune development and asthma risk, according to a study co-authored by UA Health Sciences researcher Dr. Donata Vercelli.
The Myositis Association (TMA) hosts its 2016 Annual Patient Conference September 1-4 at the Hilton New Orleans Riverside. The conference aims to raise awareness of myositis, a rare autoimmune disease of the muscles, to educate patients about how best to manage symptoms and to provide patients and caregivers with a supportive community.
With more than 20 cases of non-travel related Zika reported in South Florida, tourists express more concern with travel to the state but still plan to come, a new study shows.
One of the biggest challenges to discovering a cure for the human immunodeficiency virus (HIV) is when the disease becomes dormant — hidden and inactive within the human body. Modern therapy can practically wipe out the virus, but stores of latent HIV soon become active and multiply all over again.
Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today’s most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50% and cause an estimated 1.5 million deaths worldwide annually.
It’s the first study to examine Zika infection in human neural stem cells from second-trimester fetuses, USC researchers say.
The risk of sports fans catching dengue fever during the Rio Olympics is very low, according to a new study involving mathematicians at the University of Strathclyde.
A method for "silencing" RNA that emerged from a University of Wisconsin-Madison spinoff company is in clinical trials in Europe, Asia and the United States against hepatitis B, an infection that can destroy the liver.
With Zika sparking anxiety at the Summer Olympic Games in Brazil, and now being transmitted in Florida through contact with mosquitoes, accurately mapping the distribution of the virus is increasingly urgent.
Health researchers predict that the transmission of dengue could decrease in a future warmer climate, countering previous projections that climate change would cause the potentially lethal virus to spread more easily.
Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.
An analysis of stowaway frogs coming into Australia has shown that strict biosecurity measures at borders and within the country are reducing the risk of introduction of new diseases by up to 50%.
Patients with sickle cell anemia (SCA) develop heart complications and nearly a quarter die a sudden death. Now, researchers have linked malfunctioning molecular pathways to specific heart anomalies in SCA that result from progressive fibrosis and result in sudden death. A study published online this week by PNAS (Proceedings of the National Academy of Sciences) reports the findings open a path to earlier non-invasive diagnosis and development of new targeted therapies to help SCA patients live longer with better quality of life.
Among U.S. adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, while the prevalence of albuminuria declined and the prevalence of reduced estimated glomerular filtration rate increased, according to a study appearing in the August 9 issue of JAMA.
People who ate a diet high in nuts and legumes, low-fat dairy, whole grains, fruits, and vegetables and low in red and processed meat, sugar-sweetened beverages and sodium were at a significantly lower risk of developing chronic kidney disease over the course of more than two decades, new Johns Hopkins Bloomberg School of Public Health research suggests.
WHAT: On August 10, the American Thoracic Society and the Marron Institute of Urban Management at New York University will share findings from their seminal report on the annual health benefits of meeting more protective air pollution standards as recommended by the ATS. The report focuses on ozone (O3), a component of smog, and fine particulate matter (PM2.5), tiny particles that are released when fuel is burned by motor vehicles and power plants, and also other sources.
In developing nations, the current test to diagnose tuberculosis (TB) is error-prone, complicated and time-consuming. Furthermore, patients in these resource-limited areas can’t easily travel back to a clinic at a later date to get their results. To make diagnoses simpler, faster and more accurate, chemists have developed a quick and easy diagnostic tool. Field trials of the experimental new test began in June in South Africa, which has a high incidence of TB.
Despite the wishes of some schoolchildren, there's no such thing as an endless summer, and a Rowan Medicine physician says it's not too soon for kids - and their parents - to start preparing for the big changes that arrive with the first school bells of fall.
Scientists at The Scripps Research Institute now have a high-resolution view of exactly how the experimental therapy ZMapp targets Ebola virus.
ROCHESTER, Minn — An international research team led by Mayo Clinic has developed a first-of-its-kind model to predict mortality in patients suffering from celiac disease (CD).
Hay fever may do more than give you a stuffy nose and itchy eyes, seasonal allergies may change the brain, says a study published in the open-access journal Frontiers in Cellular Neuroscience.
After fully sequencing the latent HIV “provirus” genomes from 19 people being treated for HIV, scientists at Johns Hopkins Medicine report that even in patients who start treatment very early, the only widely available method to measure the reservoir of dormant HIV in patients is mostly counting defective viruses that won’t cause harm, rather than those that can spring back into action and keep infections going.
Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.8-million federal grant to study how changes in intestinal bacteria could lead to obesity and metabolic syndrome.
Scientists have clarified details in understanding the beneficial function of a type of protein normally associated with prion diseases of the brain, such as bovine spongiform encephalopathy (commonly known as mad cow disease) and its human counterpart, variant Creutzfeldt-Jakob disease.
Whether an HIV-positive man has met cultural expectations of masculinity might impact how much stigma he experiences, according to a new study from Binghamton University, State University of New York.
Expert can speak on the use of animal toxins to develop a new generation of medicines. Gur Roshwalb, MD, Chief Executive Officer of Akari Therapeutics, is studying the use of Coversin—a molecule derived from the saliva of the Ornithodoros moubata tick—in potential treatments for conditions such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS) and Guillain Barré syndrome (GBS).
ROCHESTER, Minn. — Zika isn’t the only health concern now that the games have begun in Rio. Massive crowds from around the globe will be at the Olympics, and that means a world-class array of germs will mix with them. Mayo Clinic infectious diseases expert Gregory Poland, M.D., offers several tips for avoiding illness when you are around lots of people, whether at the Olympics, a professional sports event, convention, concert or other major event.
The Center for Vaccine Development at the University of Maryland School of Medicine’s Institute for Global Health has been chosen as one of three study sites in a human safety trial of a new Zika vaccine. The early-stage study will evaluate the experimental vaccine’s safety and ability to generate an immune system response in participants.
Researchers have found that the infant airway is already colonized with bacteria when a baby is born — and this is true for infants born as early as 24 weeks gestation. The pattern of colonization appears to have an important link to later severe neonatal lung disease.
Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era. But new discoveries may help explain what happens in the developing brains that causes babies to be born with small brains and heads.
A study led by Professor Daniel Tenen, Director of the Cancer Science Institute of Singapore at the National University of Singapore, found that inhibiting a protein called BMI1 could inhibit the development of lung cancer.
A month after announcing that two promising vaccine candidates provided mice with complete protection against the Zika virus, a research team at Beth Israel Deaconess Medical Center (BIDMC), in collaboration with scientists at Walter Reed Army Institute of Research (WRAIR) and the University of São Paulo, now reports achieving complete protection against Zika virus in rhesus monkeys. The research team’s findings were published online today in the journal Science.
AACC welcomed thousands of medical professionals and healthcare leaders at the 68th AACC Annual Scientific Meeting & Clinical Lab Expo in Philadelphia from July 31–August 4. The meeting featured pioneering advances in medical testing research and technology that will help patients get accurate diagnoses and more effective treatment. As of Wednesday, August 3, a total of 20,000 laboratory medicine professionals had registered for the meeting, which is a 14% increase over meeting attendance in 2015 and the highest number of attendees that have come to the meeting in the last four years. More attendees are expected today, the last day of the meeting.
A new study published Aug. 4 in the New England Journal of Medicine indicates that among African American U.S. Army Soldiers, sickle cell trait is not associated with an increase in mortality, but is associated with a modest increase in the risk of exertional rhabdomyolysis.
Text-mining tool developed at CU Cancer Center and published today in Bioinformatics helps researchers map connections between genes, proteins, drugs, diseases.
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