Fight CRC’s Clinical Trial Finder App aims to make the web-based resource more accessible to Late-State, MSS colorectal cancer patients
In the first study of its kind in the U.S., researchers found that normally developing preschool children with chronic constipation have underlying sensory issues that contribute to their difficulties with toileting behaviors. These children are often picky eaters who might be overly sensitive to food textures, tastes, or odors. They also might have an exaggerated response to noises, bright lights, or other sensory stimuli. Findings were published in The Journal of Pediatrics.
Small children may one day avoid invasive, painful and often traumatic oesophageal tube-testing for gut damage and coeliac disease with a new method of simply blowing into a glass tube to provide effective diagnoses. Research published in international journal Scientific Reports describes an exciting new breath test that could have global implications on how to detect gastrointestinal damage.
Our guts are home to a cast of billions: bacteria, viruses, and fungi all congregate and collectively make up our microbiome. This vast gastrointestinal tribe shapes the onset, incidence, and treatment of a startling number of diseases including inflammatory bowel disease and cancer. In the past 20 years since the field took off, much has been discovered about how this unseen ecosystem interacts with all aspects of human life, and the rate of discoveries shows no signs of slowing.
A gene that is necessary for prenatal growth has been shown to be essential in maintaining crucial stem cells in the adult brain and intestine, a Rutgers study has discovered.
Costs are on the rise for many kinds of medical treatments. UCLA researchers are looking for cost-effective ways to treat people who have locally advanced rectal cancer, a cancer located in the end section of the large intestine.
A year in space seems to have a small but significant, transient effect on the gut microbiome, according to a new paper on the NASA Twins Study published in the journal Science.The microbiome findings, authored by a team of researchers in Chicago, are among the results from 10 other research teams examining how the human body responds to spaceflight that are reported in the paper.
Diseases of the Colon and Rectum Journal April 2019 Video Abstracts and Editor Picks
Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease, say scientists from Dana-Farber Cancer Institute.
New study uses single-cell RNA sequencing technology to find a target for treating EoE. Findings also raise questions about the dietary supplement butyrate.
ScreenNJ, a collaborative program led by Rutgers Cancer Institute and funded in part by the New Jersey Department of Health, aims to increase prevention efforts for prevalent cancers thanks to recommendations resulting from a statewide gathering of health care and community leaders.
من الناحية التاريخية، معظم المرضى المصابين بسرطان البنكرياس والذين كبرت الأورام لديهم خارج البنكرياس وتعدت إلى الأوردة والشرايين كان يُقال لهم إن السرطان لديهم لا يمكن علاجه بعملية جراحية وينبغي أن يهيئوا أنفسهم بأنهم سيعيشون لمدة تتراوح من 12 إلى 18 شهرًا.
Historicamente, a maioria dos pacientes com câncer de pâncreas, cujos tumores crescem fora do pâncreas afetando veias e artérias, recebe a notícia de que o câncer é incurável através de cirurgia e que eles devem ser preparar para um tempo médio de sobrevida de 12 a 18 meses.
An international team of scientists led by researchers at University of California San Diego School of Medicine employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies – and thus vulnerabilities – of pancreatic cancer stem cells.
Probiotics typically aim to rebalance bacteria populations in the gut, but new research suggests they may also help break apart stubborn biofilms. Biofilms are living microbial communities—they provide a haven for microbes and are often resistant to antibiotics. A new study describes a specific probiotic mix that could help patients with gastrointestinal diseases avoid harmful biofilms that can worsen their symptoms.
University at Buffalo researchers have developed a new method to more accurately predict tumor growth rates, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment.
A UChicago-based team working with collaborators in Bangladesh identified a new genetic variant linked to arsenic metabolism and toxicity.
Switching pancreatic cancer patients to the PARP inhibitor rucaparib as maintenance therapy may represent new treatment paradigm for pancreatic cancer patients with BRCA mutations
The American College of Radiology (ACR) today released the latest edition of the ACR Appropriateness Criteria®, which includes 188 diagnostic imaging and interventional radiology topics with 908 clinical variants covering more than 1,670 clinical scenarios.
A novel approach appears to be an effective alternative to immunosuppressive therapies for acute and chronic intestinal disease.
A new combination of immunotherapy and chemotherapy for pancreatic cancer caused tumors to shrink in the majority of evaluable patients
Combining immunotherapy with chemotherapy shrank tumors in 20 out of 24 patients with advanced pancreatic cancer, according to early phase 1b data being unveiled at AACR 2019 by Parker Institute for Cancer Immunotherapy (PICI) researchers at the University of Pennsylvania.
Penn Medicine study shows technology tied to patient records pushing doctors toward a new therapy was more effective than just peer education.
A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.
A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria – a population that shows resistance to traditional flu and polio vaccines.
Leading physiology and pharmacology researchers will speak in a four-part series centered on the gut microbiome—the microbe population living in the digestive tract—and its role in wound recovery, hypertension and nervous system function. The symposia series is organized by American Physiological Society (APS) President Jeff Sands, MD, and American Society for Pharmacology and Experimental Therapeutics (ASPET) President Edward T. Morgan, PhD, both of Emory University School of Medicine. The APS-ASPET Presidential Symposia Series will be part of the APS and APSET annual meetings at Experimental Biology 2019 in Orlando, Fla.
Cancer cells demand enormous amounts of molecular “food” to survive and grow, and a study published March 27 online in Nature by researchers at The University of Texas MD Anderson Cancer Center may have identified a new approach to starve the cells of one of the most common and deadly cancers, pancreatic cancer.
Probiotics – which are living bacteria taken to promote digestive health – evolve once inside the body and have the potential to become less effective and sometimes even harmful, according to a new study from Washington University School of Medicine in St. Louis. The findings suggest that developers of probiotic-based therapeutics must consider how the probiotics might change after administration.
A frontline chemotherapy drug given to patients with pancreatic cancer is made less effective because similar compounds released by tumor-associated immune cells block the drug’s action, research led by the University of Michigan Rogel Cancer Center found.
Following the self-disclosure of Jeopardy's Alex Trebek that he is battling pancreas cancer, ABC7 News sat down with UCSF's Dr. Andrew Ko at our Mission Bay campus to discuss common questions about the disease.
In the January 2019 issue of Diseases of the Colon & Rectum, Christie Cauley and her coauthors from the Massachusetts General Hospital describe a phenotype of fecal incontinence with concurrent constipation and compares these patients to those with isolated fecal incontinence.
In the January 2019 issue of Diseases of the Colon & Rectum, Dr. Chouhan and colleagues from the Cleveland Clinic sought to answer this question by performing detailed molecular studies on nearly 500 colorectal cancers. Roughly 12% of cancers occurred in individuals who were less than 50 years old.
In a surprising finding, researchers at the University of Michigan Rogel Cancer Center showed the protein NLRP6 aggravated the difficult symptoms of gastrointestinal graft-vs.-host disease. Knocking out this protein in mice led to significantly better survival and less severe GVHD.
Researchers at Joslin Diabetes Center have uncovered a new mechanism of lifespan extension that links caloric restriction with immune system regulation.
Researchers at The University of Texas MD Anderson Cancer Center revealed the common oncogene KRAS as a possible explanation for why many patients with metastatic colorectal cancer (CRC) do not respond to immune checkpoint blockade (ICB) therapy.
March is Colorectal Cancer Awareness Month, and the Colorectal Cancer Alliance is urging everyone to talk with their health care providers about screening.
Age-related changes in our gut bacteria play a key role in making arteries stiff, degrading blood vessels and boosting risk of heart attack and stroke as we get older, according to a new, first-of-its kind study.
The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) and Eli Lilly and Company (NYSE: LLY) today announced six projects that aim to improve the delivery of gastric and gastroesophageal junction (GEJ) cancer care in the United States.
Findings published in the Journal of Clinical Oncology could help define strategies to more effectively treat colorectal cancer, the second leading cause of cancer death in the United States.
Colon cancer is the second leading cause of cancer death and the third most common cancer diagnosed in the United States, but it is preventable. While more than 90 percent of new cases occur in people 50 or older, more cases are being diagnosed at increasing rates in younger and middle-aged adults, according to a recent study.
researchers at Washington University School of Medicine in St. Louis have found a compound that may treat IBD without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice.
KU Cancer Center researcher Shahid Umar, PhD, is examining the microbiome's connection to colorectal cancer.
Paul M. Stewart, M.D., F.R.C.P., F.Med.Sci., Executive Dean and Professor of Medicine at the University of Leeds in the United Kingdom, has been named the next Editor-in-Chief of the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
New research reveals how a bacteria in dental plaque-- involved in 1/3 of colon cancer cases-- speeds up colon cancer growth and makes the disease more deadly.
A preliminary diagnosis of Celiac disease in a child can be a stressful life event for an entire family. In addition to the prospect of following a completely gluten-free diet for life, a child must also face a series of tests – some invasive – to confirm the disease. While this should be a seamless and effective process, a recent study from McMaster University, The Hospital for Sick Children (SickKids) and William Osler Health System (Osler) shows this is not always the case. An additional, costly blood test is routinely prescribed and performed as part of the screening process and results of the study show it rarely predicts the disease.
Blocking two molecular pathways that send signals inside cancer cells could stave off esophageal adenocarcinoma (EAC), the most common esophageal malignancy in the United States, according to new research out of Case Western Reserve University School of Medicine.
BETHESDA, MD (February 27, 2019) – The American College of Gastroenterology (ACG) is pleased to announce the publication of the ACG Clinical Guideline on Ulcerative Colitis (UC) in Adults, which was published online today in The American Journal of Gastroenterology and which serves as an update to the College’s 2010 UC guideline.
During March 2019 - Colorectal Cancer Awareness Month - the leading advocacy organization is rallying advocates to raise awareness so all Americans can access life-saving colorectal cancer screenings.
Bacteria in the gut do far more than help digest food in the stomachs of their hosts, they can also tell the genes in their mammalian hosts what to do. A study published today in Cell describes a form of “interspecies communication” in which bacteria secrete a specific molecule—nitric oxide—that allows them to communicate with and control their hosts’ DNA, and suggests that the conversation between the two may broadly influence human health.
Cue-based feeding is a broad term to describe a process by which parents and medical providers can successfully attend to developmental cues to promote optimal feeding opportunities. It is also referred to as infant-led or demand feeding. This approach may be used to heighten the quality of a baby’s feed through use of a developmentally supportive model to improve the caregiver-infant relationship during the transition to full oral feeds. When the focus of a feed is led by volume expectations, negative consequences may ensue—such as disinterest, oral aversion and reduced quality of feed—that may compromise safety of swallow.
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