Feature Channels: Digestive Disorders

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Released: 2-Jan-2019 1:25 PM EST
CMS Approves GIQuIC as a Qualified Clinical Data Registry for the 2019 Reporting Year
American College of Gastroenterology (ACG)

The GI Quality Improvement Consortium, Ltd. (GIQuIC) Registry has been approved as a Qualified Clinical Data Registry (QCDR) for reporting to the Merit-based Incentive Payment System (MIPS) for the 2019 reporting year. GIQuIC will host an informational webinar on reporting via the GIQuIC 2019 QCDR in February 2019.

Released: 2-Jan-2019 12:05 PM EST
Real Housewives of Atlanta’s Gregg Leakes Decides Against Chemotherapy after Surgery for Colorectal Cancer
Fight Colorectal Cancer

Are you a Real Housewives fan? If so, you probably know that the show has recently brought colorectal cancer to the spotlight … again. If not, we’ll catch you up quickly.

Released: 28-Dec-2018 10:05 AM EST
Best of 2018: Healthcare policy and research
Newswise

Experts and research on important topics in the healthcare system

Released: 24-Dec-2018 12:35 PM EST
Organ-sparing treatments effective for bladder cancer; Brachytherapy cost-effective treatment for prostate cancer
Corewell Health

Traditionally, treatment for muscle-invasive bladder cancer is chemotherapy followed by the removal of the bladder. However, researchers have data suggesting that treatment consisting of limited surgery followed by chemotherapy and radiation is just as effective.

Released: 20-Dec-2018 10:30 AM EST
New research shows how a diet high in fat and cholesterol can lead to life-threatening liver disease
Keck Medicine of USC

A new USC study provides new insight on how dietary fat and cholesterol drive the development of non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease

Released: 20-Dec-2018 10:05 AM EST
Genome offers clues to esophageal cancer disparity
Michigan Medicine - University of Michigan

A change in the genome of Caucasians could explain much-higher rates of the most common type of esophageal cancer in this population, a new study finds. It suggests a possible target for prevention strategies, which preliminary work suggests could involve flavonoids derived from cranberries.

17-Dec-2018 8:05 PM EST
Cannabis Use May Lessen Risk of Developing Alcohol-Related Pancreatitis
Research Society on Alcoholism

The pancreas is an organ located behind the stomach that produces enzymes and hormones that help with digestion and blood-sugar regulation. Both heavy drinking and gallstones can cause an inflamed pancreas, called pancreatitis, which is associated with significant illness and, in about 10% of cases, death. The recent use of cannabis to manage the development of pancreatitis and its progression has yielded conflicting results. This study assessed the impact of cannabis use on both acute (sudden onset) and chronic (persistent) pancreatitis.

     
Released: 18-Dec-2018 5:05 PM EST
La Jolla Institute for Immunology renews longtime collaboration with Kyowa Kirin Pharmaceutical Research, Inc.
La Jolla Institute for Immunology

La Jolla Institute for Immunology (LJI) and Kyowa Kirin Pharmaceutical Research, Inc. (KKR), a wholly-owned subsidiary of Kyowa Hakko Kirin Co., Ltd. (KHK), a global specialty pharmaceutical company, today announced the signing of a new agreement. The agreement extends the longest industry-academic collaboration in the world for another three-year term, through until the end of 2021.

14-Dec-2018 9:00 AM EST
Mindfulness training may help support weight loss
Endocrine Society

Mindfulness training may improve the effectiveness of intensive weight management programs, according to a small study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Released: 18-Dec-2018 9:00 AM EST
Vaccine, Checkpoint Drugs Combination Shows Promise for Pancreatic Cancers
Johns Hopkins Medicine

Researchers at the Johns Hopkins Kimmel Cancer Center discovered a combination of a cancer vaccine with two checkpoint drugs reduced pancreatic cancer tumors in mice, demonstrating a possible pathway for treatment of people with pancreatic cancers whose response to standard immunotherapy is poor.

Released: 17-Dec-2018 10:05 AM EST
New approach to bowel cancer analysis could lead to better prognosis for patients
Queen's University Belfast

Researchers at Queen’s University Belfast have discovered a new way to analyse bowel cancer tumours, which could lead to more personalised treatments and better prognosis for patients.

Released: 17-Dec-2018 8:00 AM EST
Malnutrition Common in Children with Crohn’s Disease Increases Risk For Post-Operative Complications
Johns Hopkins Medicine

Results of a medical records study of children with Crohn’s disease by Johns Hopkins researchers have added substantial evidence for a strong and direct link between malnutrition and increased risk of surgical complications and poor outcomes.

Released: 17-Dec-2018 8:00 AM EST
Diseases of the Colon and Rectum Journal Jan 2019 Video Abstracts and Editor Picks
Diseases of the Colon and Rectum Journal

Diseases of the Colon and Rectum Journal Jan 2019 Video Abstracts and Editor Picks

13-Dec-2018 1:05 PM EST
New RNA sequencing strategy provides insight into microbiomes
University of Chicago Medical Center

In a new study published in Nature Communications, a team of scientists from UChicago demonstrated the application of tRNA sequencing to gut microbiome samples from mice that were fed either a low-fat or high-fat diet.

Released: 12-Dec-2018 4:05 PM EST
Loss of Tight Junction Protein Promotes Development of Precancerous Cells
Beth Israel Lahey Health

BIDMC researchers demonstrated that the lack of claudin 18 prompts the development of precancerous, abnormal cells and polyps in the engineered mouse model.

Released: 12-Dec-2018 1:05 PM EST
Gut hormone increases response to food
McGill University

The holiday season is a hard one for anyone watching their weight. The sights and smells of food are hard to resist. One factor in this hunger response is a hormone found in the stomach that makes us more vulnerable to tasty food smells, encouraging overeating and obesity.

12-Dec-2018 9:30 AM EST
High-Dose Antipsychotics Place Children at Increased Risk of Unexpected Death
Vanderbilt University Medical Center

Children and young adults without psychosis who are prescribed high-dose antipsychotic medications are at increased risk of unexpected death, despite the availability of other medications to treat their conditions, according to a Vanderbilt University Medical Center study published today in JAMA Psychiatry.

Released: 12-Dec-2018 10:00 AM EST
Exercise Following Weight Loss May Reduce Colorectal Cancer Risk, Study Finds
American Physiological Society (APS)

New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.

Released: 11-Dec-2018 11:05 AM EST
Gut Microbiome May Affect Some Anti-diabetes Drugs
Atrium Health Wake Forest Baptist

Why do orally-administered drugs for diabetes work for some people but not others? According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.

6-Dec-2018 12:00 PM EST
Loss of two genes drives a deadly form of colorectal cancer, reveals a potential treatment
Sanford Burnham Prebys

Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with clinicians from Scripps Clinic, have identified that the loss of two genes drives the formation of serrated colorectal cancer—yielding potential biomarkers. The research has also identified a combination treatment that has treated the cancer in mice. The study published today in Immunity.

10-Dec-2018 2:15 PM EST
Harrington Discovery Institute at University Hospitals announces 2019 grant funding to 10 physician-scientists
University Hospitals Cleveland Medical Center

Announcement of 2019 Harrington Scholar-Innovator Award recipients by the Harrington Discovery Institute at University Hospitals in Cleveland.

10-Dec-2018 8:00 AM EST
NCCN Patient Advocacy Summit Examines Disparities in Cancer Care and Explores Solutions
National Comprehensive Cancer Network® (NCCN®)

Advocates, patients, providers, and other experts examine disparities and explore solution at the NCCN Patient Advocacy Summit on Equity in Cancer Care

Released: 10-Dec-2018 12:00 PM EST
Researchers Develop Personalized Medicine Tool for Inherited Colorectal Cancer Syndrome Risk
Huntsman Cancer Institute at the University of Utah

An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The results were published this week in the journal Genetics in Medicine.

4-Dec-2018 1:05 PM EST
Some people uncomfortable discontinuing colorectal cancer screening even when benefit is low
Michigan Medicine - University of Michigan

A new study finds 29 percent of veterans who underwent recommended screening colonoscopies were uncomfortable with the idea of stopping these screenings when the benefit was expected to be low for them personally.

Released: 5-Dec-2018 5:05 PM EST
Heart Patients Reduce Bleeding Risk with Drug Combination
Vanderbilt University Medical Center

Cardiovascular patients at risk for gastrointestinal bleeding from taking oral anticoagulants like warfarin reduce that risk by 34 percent when taking a proton pump inhibitor (PPI) in combination, according to a Vanderbilt University Medical Center study published in JAMA.

4-Dec-2018 4:05 PM EST
A toxin that travels from stomach to brain may trigger Parkinsonism
Penn State College of Medicine

Combining low doses of a toxic herbicide with sugar-binding proteins called lectins may trigger Parkinsonism -- including symptoms like body tremors and slowing of body motions -- after the toxin travels from the stomach to the brain.

Released: 4-Dec-2018 2:05 PM EST
Large-scale genomic study discovers 40 new genetic variants associated with colorectal cancer risk
Fred Hutchinson Cancer Center

Large-scale genomic study discovers 40 new genetic variants associated with colorectal cancer risk

Released: 4-Dec-2018 1:40 PM EST
How microbial interactions shape our lives
Carnegie Institution for Science

Baltimore, MD--The interactions that take place between the species of microbes living in the gastrointestinal system often have large and unpredicted effects on health, according to new work from a team led by Carnegie's Will Ludington. Their findings are published this week in the Proceedings of the National Academy of Sciences.

   
Released: 4-Dec-2018 1:05 PM EST
Single workout can boost metabolism for days
UT Southwestern Medical Center

A new study from UT Southwestern Medical Center shows neurons in mice that influence metabolism are active for up to two days after a single workout.

Released: 4-Dec-2018 11:05 AM EST
Moffitt Researchers Identify Novel Mechanism to Thwart KRas-driven Tumor Growth
Moffitt Cancer Center

Researchers at Moffitt Cancer Center are trying to devise alternative mechanisms to block KRas. Their recent study demonstrates that the protein GSK3 is an important mediator of KRas-dependent tumor viability. Their research was published today in Nature Communications.

Released: 4-Dec-2018 9:05 AM EST
Study Evaluates Efficacy and Safety of Pancreatic Cancer Treatment in Complex Patient Care Cases
Beth Israel Lahey Health

In a new study published in the Journal of Clinical Oncology, Manuel Hidalgo, MD, PhD, and colleagues conducted a phase I/II trial designed to evaluate the efficacy and safety of nab-paclitaxel given in combination with gemcitabine in patients with pancreatic cancer and reduced health status. The team – based at the Centro Nacional de Investigaciones Oncologicas (Spanish National Cancer Center), where Hidalgo previously served as Director of the Clinical Research Program and Vice Director of Translational Research – reported that the combination of therapies significantly improved survival even in less robust patients with metastatic pancreatic ductal adenocarcinoma (PDAC) compared to gemcitabine alone.

3-Dec-2018 3:00 PM EST
Researchers Develop Accurate, Non-Invasive Method to Detect Bladder Cancer
Tufts University

A research team has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features of cancerous cells found in patients’ urine by developing a nanoscale resolution map of the cells’ surface.

Released: 3-Dec-2018 1:05 PM EST
New tumor model helps researchers treat pancreatic cancer
South Dakota State University

Patients diagnosed with pancreatic cancer face a poor prognosis because the tumor forms dense scar-like tissue that is difficult for chemotherapy drugs to penetrate, but a new model may help researchers develop new therapies.

Released: 3-Dec-2018 1:05 PM EST
MDCalc Launches Beta GI Guideline Summaries with American College of Gastroenterology
American College of Gastroenterology (ACG)

NEW YORK, NY — December 3, 2018 — MDCalc, the global leader in online evidence-based medical calculators, has launched its new guideline summaries in a public beta. The first set of 11 summaries debuted at the annual scientific meeting of the American College of Gastroenterology (ACG) in Philadelphia in early October 2018.

Released: 3-Dec-2018 12:05 PM EST
Just How Healthy is Chicken Noodle Soup?
Beth Israel Lahey Health

You may remember a loved one making you a bowl of chicken noodle soup whenever you were feeling under the weather as a child. Just how healthy is this culinary cure-all? BIDMC clinical dietitian Sandy Allonen, RD, weighs in.

Released: 3-Dec-2018 11:05 AM EST
To curb maternal deaths in developing countries, researchers use X-rays to map a lifesaving drug in action
SLAC National Accelerator Laboratory

A team that includes researchers from the Bridge Institute at the University of Southern California (USC) and the Department of Energy’s SLAC National Accelerator Laboratory used X-rays to map the shape of a receptor in the body as it binds with misoprostol. This research, published in Nature Chemical Biology, could help in the quest to design low-cost drugs that can tackle postpartum bleeding without affecting other tissues.

Released: 30-Nov-2018 2:05 PM EST
PhRMA Foundation Releases Highlights of its 2018 Funding Efforts
PhRMA Foundation

The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in areas of great importance: Alzheimer’s Disease, Melanoma, Parkinson’s Disease, Schizophrenia, Breast Cancer, Lung Cancer, Leukemia, Ulcerative Colitis, Vascular Disease, and Colorectal Cancer. This year the Foundation also funded two Centers of Excellence in Value Assessment.

Released: 30-Nov-2018 11:45 AM EST
Altered microbiome after caesarean section impacts baby's immune system
University of Luxembourg

Together with colleagues from Sweden and Luxembourg, scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have observed that, during a natural vaginal birth, specific bacteria from the mother's gut are passed on to the baby and stimulate the baby's immune responses. This transmission is impacted in children born by caesarean section.

Released: 29-Nov-2018 11:05 AM EST
Prevention and Screening Clinic at UC San Diego Health Helping to Reduce Pancreatic Cancer
UC San Diego Health

Moores Cancer Center at UC San Diego Health launched the Pancreatic Cancer Prevention and Screening Clinic in an attempt to reduce the number of people who develop the disease and improve survival for those who do. Every day in the U.S., 145 people are diagnosed and every 12 minutes someone dies.

Released: 29-Nov-2018 10:05 AM EST
“A 4 percent chance is nothing to me”
University of Alabama at Birmingham

Former MLB player Frank Baker says his experience at UAB’s Pancreatobiliary Disease Center was a home run.

Released: 28-Nov-2018 8:30 AM EST
WVU Cancer Institute studies new treatment for colorectal cancer using novel drug combination
West Virginia University

Richard Goldberg, who directs the West Virginia University Cancer Institute, is searching for new ways to slow colorectal cancer’s progression. In a recent study, he and an international team of scientists investigated a new drug combination for treating metastatic colorectal cancer in patients who had no—or only temporary—success with conventional chemotherapy treatments.

Released: 27-Nov-2018 3:45 PM EST
Identifying Bacteria to Improve Gut Health
South Dakota State University

An undergraduate researcher is identifying bacteria that can potentially help improve gut health by colonizing the gut mucosal layer and stimulating the immune system.

Released: 27-Nov-2018 12:05 PM EST
Fatty Liver Disease
Houston Methodist

Millions of Americans have no idea that they have fatty liver disease. This growing problem will soon be the number one reason for liver transplantation, overtaking hepatitis C. Holiday overindulgence in alcohol and food could make the problem dramatically worse.

Released: 26-Nov-2018 10:05 AM EST
Texas Biomed Scientists Targeting Factors Involved in Hispanic Childhood Obesity
Texas Biomedical Research Institute

Are there changes that affect genes and fuel a person’s propensity to develop obesity? That’s a question under study at Texas Biomedical Research Institute. Associate Scientist Melanie Carless, Ph.D., is Principal Investigator of a $3 million, four-year grant from the National Institute of Diabetes, Digestive and Kidney Diseases to research this hypothesis.

   
20-Nov-2018 3:30 PM EST
Probiotic No Better Than Placebo for Acute Gastroenteritis in Children
Ann and Robert H. Lurie Children's Hospital of Chicago

While probiotics are often used to treat acute gastroenteritis (also known as infectious diarrhea) in children, the latest evidence shows no significant differences in outcomes, compared to a placebo.

20-Nov-2018 10:05 AM EST
Pancreatic Cancer Collective awards Dana-Farber Cancer Institute researchers “New Therapies Challenge” grant
Dana-Farber Cancer Institute

• $1 million in initial funding to evaluate DNA repair inhibitors in pancreatic cancer • Aim to accelerate pancreatic cancer research and improve patient outcomes for pancreatic cancer

8-Nov-2018 10:05 AM EST
RIP1 Kinase Identified as Promising Therapeutic Target in Pancreatic Cancer
NYU Langone Health

An experimental drug may be effective against a deadly form of pancreatic cancer when used in combination with other immune-boosting therapies, according to a cover study publishing online Nov. 12 in Cancer Cell.

12-Nov-2018 6:20 AM EST
Fecal transplant effective against immunotherapy-induced colitis
University of Texas MD Anderson Cancer Center

For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors. The study from The University of Texas MD Anderson Cancer Center, which includes two patients, suggests fecal microbiota transplantation is worth investigating in clinical trials as a therapy for this common side effect of immunotherapy.

Released: 12-Nov-2018 9:00 AM EST
Simplifying Life for Diabetics with a Nanotechnology Breakthrough
Oregon State University, College of Engineering

Oregon State University College of Engineering researchers have developed a means of printing transistor-based glucose sensors directly onto a catheter attached to a wearable pump. The catheter’s integrated electronics transmit blood sugar levels to the computerized pump, ensuring that diabetics get the insulin and glucagon they need, when they need it.

   


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