An increase in the Lone Star tick population since 2006, and the ability to recognize the ticks as the source of “alpha gal” allergy to red meat has meant significantly more cases of anaphylaxis being properly identified.
Inhaled vaporized cannabis does not appear to improve or worsen exercise performance and activity-related breathlessness in patients with advanced chronic obstructive pulmonary disease (COPD), according to a randomized controlled trial published online in the Annals of the American Thoracic Society.
Drug resistance is an all-too-common occurrence in cancer treatment. Now, working with physicians at Chaim Sheba Medical Center, the Weizmann Institute of Science’s Prof. Yossi Yarden has identified a three-drug combo that fends off drug resistance in lung cancer. This is particularly promising, as two of the medications are already in use.
The American Thoracic Society led 10 medical professional organizations in filing an amicus brief last week regarding the FDA’s failure to apply pre-market review to new tobacco products. The brief was submitted in support of the American Academy of Pediatrics and its co-plaintiffs and outlines the compelling data indicating that the FDA’s failure to act harms children.
NYU School of Medicine researchers find distinct bacterial populations in airways and gastrointestinal tracts of children with chronic cough
First Optimizer® Smart investigational device for heart disease implanted in the Philadelphia Area
After 42 years as the oldest and largest, independent non-profit organization in the United States solely focused on infectious disease research, The Center for Infectious Disease Research (CIDR) will join Seattle Children’s Research Institute to create a world-class team of researchers working to find viable solutions to infectious diseases that can pose risks to our communities, and disproportionately impact children and those in poverty.
Observations over the eastern U.S. show why emissions reductions haven't achieved the same results in winter as they have in summer.
The governing board of the California Institute for Regenerative Medicine (CIRM) unanimously approved this week two grants worth more than $2.2 million to University of California San Diego School of Medicine researchers investigating stem cell-based therapies for a rare genetic disorder that affects the heart and a chronic, progressive affliction of the lungs.
Supplemental oxygen eliminates the rise in morning blood pressure experienced by obstructive sleep apnea (OSA) patients who stop using continuous positive airway pressure (CPAP), the standard treatment for OSA, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
In this issue, find research on black lung, opioids, police violence and more.
A new delivery system for bacteriophages—viruses that selectively attack harmful bacteria—could help give doctors a new way to battle lung infections that threaten older patients and people with cystic fibrosis.
A new way to examine stress and inflammation in the heart will help Parkinson’s researchers test new therapies and explore an unappreciated way the disease puts people at risk of falls and hospitalization.
A four-protein biomarker blood test improves lung cancer risk assessment over existing guidelines that rely solely upon smoking history, capturing risk for people who have ever smoked, not only for heavy smokers, an international research team reports in JAMA Oncology. “This simple blood test demonstrates the potential of biomarker-based risk assessment to improve eligibility criteria for lung cancer screening with low-dose computed tomography,” said study co-senior author Sam Hanash, M.D., Ph.D., professor of Clinical Cancer Prevention at The University of Texas MD Anderson Cancer Center.
Brain metastases were found to be fairly common in stage IV ROS1-positive cancers and in 47 percent of ROS1 patients, the brain was the first and only site of progression.
The bacteria that cause tuberculosis are able to escape destruction and grow after they are engulfed by lung macrophages. Now researchers have described key biochemical steps between the bacteria Mycobacterium tuberculosis and the macrophage responsible for that ability.
Patients who suffer from Aspirin Exacerbated Respiratory Disease (AERD) often experience an additional allergic reaction when drinking alcohol, including nasal congestion, wheezing, and a runny nose. Now a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania finds a common treatment for AERD – aspirin desensitization – can also help alleviate the alcohol-induced symptoms of the condition.
Air pollution; thorax toxicology; PBPK modeling of antibiotics in dairy cattle; PCBs & steatohepatitis; uranium mine particles & cardiopulmonary toxicity; green plasticizers & reproductive health; and antiandrogenic mixtures & male reproduction featured in latest issue of Toxicological Sciences
Los investigadores de Mayo Clinic aplican la genómica de precisión para buscar mutaciones genéticas, aún no descubiertas y hereditarias que aceleran el envejecimiento.
A drug used in stem cell therapy to treat certain cancers may also protect against cigarette smoke-induced lung injury. The study, published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology, was chosen as an APSselect article for July.
Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in small cell lung cancer (SCLC) that can be targeted by existing drug therapies.
A new microfluidics innovation shows hope to improve artificial placentas so preterm newborns can properly develop lungs following birth. An international team demonstrated the new technique to construct microchannels with a more efficient gas exchange between infant blood and air. The improved design uses both sides of the membrane for gas exchange; the group used this design to develop a prototype that oxygenates blood through a thin membrane. They report their findings in Biomicrofluidics.
Researchers have shown — for the first time — that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. This is important because, despite significant advances in the pathological mechanisms of persistent fibrosis, effective interventions are lacking.
An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine.
Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
Study Could Lead to Better Diagnosis and Treatment of Diseases Affecting the Larynx
The 2018 Warren Alpert Foundation Prizehas been awarded to five scientists for transformative discoveries in the fields of genetics, physiology, pulmonology and pharmacology that have led to the development of life-altering precision-targeted treatments for the devastating multiorgan disease cystic fibrosis (CF).
A pioneering technique developed to analyze genetic activity of Antarctic worms is helping to predict cerebral palsy. The technique uses next-generation genetic sequencing data to measure how cells control the way genes are turned on or off, and can also be used in other human health care research.
A new study shows in an emergency, 52 percent of adults with potentially life-threatening allergies didn’t use the epinephrine auto-injectors (EAI) they were prescribed.
Two Children's Hospital Los Angeles experts - pulmonologist Shirleen Loloyan Kohn, MD, and psychologist Stephanie Marcy, PhD, provide tips on keeping the whole family safe and sound in the event of a wildfire.
Allergic asthma is a chronic inflammatory disease of the lung and airways driven, at least in part, by, a subgroup of overly active T helper cells. Thus, to devise better treatments, it is essential to determine how this cell population, known as TH2 cells, develops, matures and then crosses the line between protection and tissue damage.
FAU’s Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile.
Scientists have captured the most information yet about proteins within a single human cell, giving scientists one of their clearest looks yet at the molecular happenings inside a human cell. The team detected on average more than 650 proteins in each cell – many times more than conventional techniques capture from single cells.
To remain effective, the pertussis vaccine must be modified to keep pace with evolving bacteria. As the vaccines' efficacy is declining, Heath Damron, an assistant professor in the WVU School of Medicine, is pursuing innovations to strengthen the vaccine and still keep it safe.
Donor lungs from individuals infected with hepatitis C have been successfully transplanted into 10 patients at Toronto General Hospital (TG), University Health Network (UHN).
A study led by UNC’s Sylvia Becker-Dreps, MD, MPH, reviewed more than 675,000 pregnancies in the U.S. to determine if the Tdap vaccine given to a mother will reduce the chances of her child developing pertussis during the first 18 months of life. The results show a decrease in overall cases of pertussis, and most notably, in pertussis hospitalization in infants whose mothers were immunized during pregnancy.
Who owns CRISPR gene editing technology? Will insurance pay for gene editing procedures, and is it ethical to change human DNA? Experts addressed these questions on June 8 during CRISPR Gene Editing 360: From Laboratory Science to Ethical Application, a symposium held at Christiana Care's Christiana Hospital.
A chance conversation between researchers at Queen’s University Belfast led to their combined expertise in developing a ground-breaking approach for the treatment of pneumonia.
In a randomized, Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, adding the PARP inhibitor veliparib to a standard chemotherapy agent improved overall response rates (ORR) in patients with small cell lung cancer (SCLC). Researchers also identified a select group of patients – those whose tumors expressed SLFN11— who also saw a progression-free survival (PFS) and overall survival (OS) benefit, suggesting a promising biomarker for the PARP-inhibitor sensitivity in SCLC.
RNA sequencing and machine learning applied to develop new asthma biomarker
A drug discovered and advanced by The University of Texas MD Anderson Cancer Center’s Institute for Applied Cancer Science (IACS) and the Center for Co-Clinical Trials (CCCT) inhibits a vital metabolic process required for cancer cells’ growth and survival.
Bassel Salman, M.D., wanted to create an affordable, portable machine to help people unable to cough. The Commercialization Center and Grand Valley students helped him transform his idea into a promising medical device.
For adults with diabetes, managing the disease is a day-in, day-out effort to control the factors that affect blood sugar levels. A team of scientists, including two West Virginia University professors, is researching how one aspect of a patient’s daily routine could help keep blood sugar levels within a specific range.
Mucus and other airway secretions that are expelled when a person with the flu coughs or exhales appear to protect the virus when it becomes airborne, regardless of humidity levels, a creative experiment conducted by the University of Pittsburgh and Virginia Tech discovered.
By screening 250 user reviews and comments for a once popular -- but proven inaccurate -- mobile app claiming to change your iPhone into a blood pressure monitor, Johns Hopkins researchers have added to evidence that a high “star rating” doesn’t necessarily reflect medical accuracy or value.
Parents have been reading—and sharing—alarming reports of children who died or nearly died due to "dry drowning" over the past year. However, the use of that incorrect, nonmedical term has contributed to confusion about the true dangers of drowning in children and led to serious and fatal conditions being ignored after a “dry drowning” diagnosis was made, according to a special report in the June issue of Emergency Medicine News, published in the Lippincott portfolio by Wolters Kluwer.
Children living in neighborhoods that are not conducive to walking are more likely to develop asthma and to continue to have this condition through later childhood, according to a new study published in the Annals of the American Thoracic Society.
A novel digital health device could help clinicians remotely monitor side effects of lung cancer patients undergoing radiation therapy.
Dpdated data further consolidate alectinib as the standard-of-care for first-line treatment of ALK+ non-small cell lung cancer.
A test that analyzes free-floating DNA in the blood may be able to detect early-stage lung cancer, a preliminary report from the ongoing Circulating Cell-Free Genome Atlas (CCGA) study suggests.
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