Feature Channels: Heart Disease

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Announcement of a new $15 million gift for University Hospitals to develop a new model for the delivery of health care to men.

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An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. Failing human hearts showed reduced amounts of this kinase, and restoring the amount of this kinase in a kinase-depleted mouse model rescued the animal from heart failure.

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A Mayo Clinic-led study involving 488 cardiac patients whose cases were followed for up to 12 years finds that microvascular endothelial dysfunction, a common early sign of cardiovascular disease, is associated with a greater than twofold risk of cancer. The study, published in the European Journal of Preventive Cardiology, finds that microvascular endothelial dysfunction may be a useful marker for predicting risk of solid-tumor cancer, in addition to its known ability to predict more advanced cardiovascular disease, says Amir Lerman, M.D., a Mayo Clinic cardiologist and the study's senior author.

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A mother’s exposure to particulate air pollution during pregnancy is associated with reduced cardiac response to stress in six-month-old infants, according to Mount Sinai research published in Environmental Health Perspectives in October. This study is the first to find that particulate air pollution exposure in utero can affect heart rate variability, which is a known risk factor for health issues.

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When Mick Jagger received an artificial heart valve via catheter, he made the transcatheter replacement valve famous. Iconic "Dr. Y" made it possible. Ajit Yoganathan's lab has tested every valve on the market for quality, and his analyses shaped the industry and its designs, including of the valve in Jagger's chest.

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More than one-third of Americans get less than seven hours of sleep each night, putting them at risk for serious, chronic health conditions such as diabetes, heart disease and obesity. The real victim of a lack of sleep, however, is the brain.

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Retired U.S. Army Colonel Norman M. Rich, MD, FACS, DMCC, MC, of Rockville, Md., received the first American College of Surgeons (ACS) Distinguished Military Lifetime Achievement Award last night during the Convocation ceremony that preceded the opening of the College's Clinical Congress 2019.

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Middle-aged adults who show symptoms of borderline personality disorder may be at greater risk for a heart attack, as they show physical signs of worsening cardiovascular health more than other adults, according to research published by the American Psychological Association.

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Thiazide diuretics demonstrate better effectiveness and cause fewer side effects than ACE inhibitors as first-line antihypertensive drugs, according to a report published Oct. 24 in The Lancet. Marc A. Suchard, MD, PhD, professor of biostatistics at the UCLA Fielding School of Public Health served as lead author.of the study.

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A new study of nearly 5 million patients shows the most-popular first-line treatment for hypertension is less effective and causes more side effects than thiazide diuretics.

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A dual-acting osteoporosis drug. Minimally invasive mitral valve surgery. New treatment for peanut allergies. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of doctors and researchers.

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Since its inception in 1995, the mission for A Woman’s Journey has remained the same: to empower women to make the right health care decisions for their families and themselves.

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Chronic kidney disease, which afflicts an estimated 6.4% of U.S. adults 45 and older, is associated with an increased risk of heart attack and other adverse cardiovascular outcomes, according to new research from Mayo Clinic.

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David Eisner has been selected to serve as the eighth editor-in-chief of the Journal of General Physiology (JGP), effective January 1, 2020. Eisner, the British Heart Foundation Professor of Cardiac Physiology at the University of Manchester, succeeds Sharona Gordon, who has led the journal since 2014.

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Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images—allowing for high-throughput epigenetic drug screens that could unlock new treatments for cancer, heart disease, mental illness and more. The study was published in eLife.

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The University of Chicago Medicine, in partnership with the American Heart Association, has installed a hands-only CPR kiosk in the Center for Care and Discovery. It's one of three in Chicago.

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Research has shown that while elite athletes overall are at decreased risk of death from cardiovascular problems, a certain group of athletes -- football linemen in the United States

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Dransfield said their findings showed no evidence that beta-blockers were helpful in reducing the risk of exacerbations.

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According to a new study, published in the Journal of Clinical Endocrinology and Metabolism, health scientists at the Universities of Bath and Birmingham found that by changing the timing of when you eat and exercise, people can better control their blood sugar levels.

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When young athletes experiences sudden cardiac death as they run down the playing field, it’s usually due to arrhythmogenic cardiomyopathy (ACM), an inherited heart disease. Now, Johns Hopkins researchers have shed new light on the role of the immune system in the progression of ACM and, in the process, discovered a new drug that might help prevent ACM disease symptoms and progression to heart failure in some patients.

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Patients who suffer from infective endocarditis (IE) and struggle with substance use disorder (SUD) have a 240% increased risk of dying within 6 months to 5 years after valve surgery compared to other IE patients.

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Researchers at Penn Medicine discovered that a protein called ANT is critical for a quality control process called mitophagy—which helps to ensure the integrity of the mitochondria network by removing damaged mitochondria—and found that ANT mutations that lead to a defective quality control system cause heart disease

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African Americans reporting high levels of chronic stress tended to develop high blood pressure, or hypertension, more often than those who reported low stress levels, according to new research published in the Journal of the American Heart Association, the open access journal of the American Heart Association.

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A small Bolivian society of indigenous forager-farmers, known for astonishingly healthy cardiovascular systems, is seeing a split in beliefs about what makes a good life. Some are holding more to the traditional — more family ties, hunting and knowledge of forest medicine — but others are starting to favor material wealth, a Baylor University study finds.

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Since August, when the FDA approved a minimally invasive heart valve procedure for an expanded group of patients with aortic stenosis, many more patients are opting for the procedure known as transcatheter aortic valve replacement (TAVR). With this latest approval, the procedure can now be performed on a wide spectrum of patients, from patients too sick to undergo open-heart surgery to those who would be considered low risk for open-heart surgery.

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A new study published in Clinical Cardiology introduces the North Indian (NORIN) ST‐Segment Elevation Myocardial Infarction (STEMI) Registry and provides preliminary data collected since its start in January of this year. The prospective cohort study’s first author, Sameer Arora, MD, UNC School of Medicine cardiology fellow and preventive medicine resident

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Despite their wishes, many patients die in hospitals or other facilities. Cardiovascular disease (CVD) is the leading cause of death both globally and in the U.S., yet little is known about where patients with CVD die.

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Dhruv S. Kazi, MD, MSc, MS, Associate Director of the Smith Center for Outcomes Research at Beth Israel Deaconess Medical Center, writes an accompanying editorial about two new reports showing an association of dog ownership with a better outcome after a major cardiovascular event.

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Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure for the rest of their lives. UPMC Children’s Hospital researchers found that β-blockers could supplement surgery to mitigate the lasting effects of congenital heart disease.

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Dog ownership may be associated with longer life and better cardiovascular outcomes

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When a heart attack occurs, muscle in the heart tissue can be scarred, interfering with electrical activity necessary for healthy heart function. Using artificial materials to patch or rebuild damaged parts has been tried but only recently has work focused on the electrical properties needed for proper cardiac operation. In this week’s APL Bioengineering, investigators review the use of electrically conductive biomaterials for heart repair and treatment.

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Sophia Antipolis, 07 October 2019: Patients with cancer should receive a tailored exercise prescription to protect their heart, reports a paper published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1

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Findings could lead to better understanding of ischemic cardiovascular events and help the development of new treatments

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Cardiologist Bertram Pitt, MD, sees promise in combining two new classes of medication into a treatment regimen for patients with cardiovascular disease. Pitt will discuss the advantages of this treatment plan in his plenary lecture at an American Physiological Society Conference in Estes Park, Colo.

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A common receptor may serve differentiated roles related to aging-associated cardiovascular disease in males and females. Jennifer DuPont, PhD, will present the findings of this first-of-its-kind study today at the American Physiological Society Aldosterone and ENaC Conference in Estes Park, Colo.

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Blocking the mineralocorticoid receptor (MR)—a protein that helps maintain normal levels of salt and water in the body—in immune cells may help reduce the risk of heart attack and stroke by improving blood vessel health. The study will be presented today at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

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A new scientific statement from the American Heart Association identifies the risks and benefits of using novel interventional devices compared to anticoagulation alone to treat patients with pulmonary embolism.

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Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers from The University of Queensland.

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当曾接受冠状动脉旁路移植术(CABG)的患者因胸痛复发而需要二次手术时，大多会施行经皮冠状动脉介入治疗(PCI)，俗称冠状动脉血管成形术及支架植入术。

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A new nationwide clinical trial hopes to discover if patients that experience cardiac arrest survive more often and have a better recovery based on how long they have their body temperature cooled.

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Aldosterone is a steroid hormone important to the regulation of salt, fluid and potassium in the body. Researchers at the “Metabolic and sex differences in aldosterone responses” symposium will explore the growing body of research that finds sex is a major determinant of how aldosterone acts on the body.

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While obesity significantly increases your chances of developing heart failure, for those with established heart failure it may confer a survival benefit compared with normal weight or underweight individuals.