Feature Channels: Aging

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Two studies examine spousal caregiving in last years of life and the adequacy of training and preparation for paid caregivers

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Five-year survival data for pembrolizumab patients with advanced non-small cell lung cancer were presented June 1 at the 2019 ASCO Annual Meeting, May 31-June 4, in Chicago. The study results showed a marked improvement over 5-year survival rates in the pre-immunotherapy era, which averaged only 5.5%. Pembrolizumab increased the survival rate to 23.2% after five years in people with advanced non-small cell lung cancer who had not previously been treated with chemotherapy and to 15.5% in those who had been previously treated with chemotherapy. The KEYNOTE-001 is the longest follow-up study to date of people with advanced non-small cell lung cancer treated with pembrolizumab.

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A new study indicates that racism is toxic to humans.

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An international research collaboration that includes the University of Arkansas for Medical Sciences (UAMS) has discovered that aging in nematodes (worms) can be slowed and even reversed by a number of Food and Drug Administration (FDA)-approved drugs, findings that have the potential to extend human lifespan. The study findings are published in Scientific Reports.

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Researchers with the Atlanta Veterans Affairs Medical Center and Emory University have found a link between high LDL cholesterol levels and early-onset Alzheimer's disease.

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Something as simple as a phone call could be a way to alert health care providers and caregivers that an elderly person suffering from dementia may be spiraling down to dangerous self-neglect, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).

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Aging adults often show signs of slowing when it comes to managing their finances, such as calculating their change when paying cash or balancing an account ledger. But trouble managing money can also be a harbinger of dementia and, according to new Duke research in The Journal of Prevention of Alzheimer’s Disease, could be correlated to the amount of protein deposits built up in the brain.

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New research indicates that older patients who develop delirium— an acute attentional deficit that waxes and wanes —right after surgery are more likely to show signs of postoperative cognitive dysfunction one month later

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People who drink alcohol while using medications that interact with it are higher risk of harm from overdose, falls, and traffic accidents. In recent years, there has been a documented increase in alcohol-related adverse drug reactions

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A new study from researchers at the Johns Hopkins Bloomberg School of Public Health found that more than one in five older adults who were aging in place with a mobility or self-care disability reported experiencing negative consequences such as having to stay in bed or going without eating due to no one being available to help or the activity being too difficult to perform alone.

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Researchers from the Stowers Institute for Medical Research have discovered a new function of ribosomes in human cells that may show the protein-making particle’s role in destroying healthy mRNAs, the messages that decode DNA into protein.

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As people age, their muscle regeneration capacity declines in part because they can no longer make enough muscle stem cells to replace damaged tissue.

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A new Cornell University-led study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.

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University of Rhode Island Professor of Sociology Melanie Brasher, who earned her master’s and Ph.D. in sociology from Duke University, is a demographer who is fascinated by the topic of birthrate. Brasher, an expert in population aging who has also conducted research on unintended births and health, addressed several questions on the CDC findings – factors behind the decline, possible concerns for the future, and the historical significance of the decline.

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A team led by Ivaylo Ivanov of Georgia State University used the 200-petaflop IBM AC922 Summit system, the world’s smartest and most powerful supercomputer, to develop an integrative model of the transcription preinitiation complex (PIC), a complex of proteins vital to gene expression.

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A dramatic rise in opioid overdose deaths among veterans in recent years has happened mainly among veterans dying from heroin and synthetic opioids, a new study shows.

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A new study by Stony Brook University researchers reveals that higher education is associated with later onset of Alzheimer’s-related accelerated cognitive declines. Their findings will be published early online in the Journal of Gerontology.

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Memorial Day Travel Tips for Families Impacted by Alzheimer's Disease

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Meditation techniques helped Gregory Rutchik make it through his stroke when he was just 51 years old. Now those techniques are helping him keep his cool while running marathons.

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More than one million stem cell treatments have been conducted in the United States during the past ten years. Physicians and other healthcare providers are beginning to realize regenerative medicine is the future of medicine; however major health issues remain unanswered. Dr. Nathan Bryan, one the country’s leading experts in the mechanism of nitric oxide, will tell more than seven thousand physicians attending the 27th Annual Spring Conference of the American Academy of Anti-Aging Medicine on Saturday that “the ability to use our own cells to heal our own body make good medical sense.

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Many Americans in their 50s and early 60s are worried about declining brain health, especially if they have loved ones with memory loss and dementia, a new national poll finds. But while the majority of those polled say they take supplements or do puzzles in an effort to stave off brain decline, very few of them have talked with their doctors about evidence-based ways to prevent memory loss. So they may miss out on proven strategies to keep their brains sharp into their later years.

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Can science measure what it means to be wise? A growing body of evidence suggests that wisdom is a complex concept that contributes to mental health and happiness, according to a review in the May/June issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Scientists might have found an early detection method for some forms of dementia

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First causal evidence that oxidative stress works directly on telomeres to speed cellular aging

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Proposed quality standards for improving the surgical care of older adults received feedback from a sample of North American hospitals, and those deemed most feasible to implement are undergoing pilot testing before a national rollout.

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Dr. Joseph S. Takahashi, Chairman of Neuroscience at UT Southwestern Medical Center, has received an international award for his pioneering work on the molecular and genetic bases of circadian rhythms in mammals.

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Em colaboração com a Universidade de Kentucky, Centro Médico da Universidade de Texas Southwest, o Centro Médico da Universidade Rush e a Universidade de Cambridge no Reino Unido, entre outras instituições, os pesquisadores da Mayo Clinic ajudaram a estabelecer um nome para uma doença cerebral degenerativa que aflige os idosos e imita características da doença de Alzheimer.

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A diet proven to have beneficial effects on high blood pressure also may reduce the risk of heart failure in people under age 75, according to a study led by researchers at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

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Virtual reality (VR) technology could vastly improve the quality of life for people with dementia by helping to recall past memories

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Anger may be more harmful to an older person’s physical health than sadness, potentially increasing inflammation, which is associated with such chronic illnesses as heart disease, arthritis and cancer, according to new research published by the American Psychological Association.

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In a new study of older adults living in a senior continuing care facility, researchers at University of California San Diego School of Medicine parse how distinctive factors, such as wisdom, loneliness, income and sleep quality, impact the physical and mental functioning of older persons.

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Johns Hopkins scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny “cargo packets” able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.

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More Americans are being diagnosed with eye complications of shingles, but older adults can call the shots on whether they develop the painful rash that can cost them their eyesight.

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Ana Maria Cuervo, M.D., Ph.D., cell biologist and internationally recognized expert on the cellular process autophagy, has been elected to the National Academy of Sciences (NAS). Dr. Cuervo is professor of developmental and molecular biology, of anatomy and structural biology, and of medicine, co-director of the Institute for Aging Research, and holds the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases at Einstein.

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The Dementia Friendly Hospital Initiative will reach a total of 3,900 employees in four hospitals across North Carolina to raise awareness of how patients with dementia experience care, and to meet their unique needs with strategic and compassionate treatment.

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The research team found that older adults with autism report more social communication difficulties than younger adults with autism. Using brain scans, they were able to determine that areas of the brain related to social communication, cognition and executive functions thinned more quickly with age in adults with autism than those without.

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New analysis by academics from the Oxford Internet Institute (OII), part of the University of Oxford

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Using data from the 2016 National Health Interview Survey, Johns Hopkins researchers report that few American adults eligible for diabetes prevention programs are being referred to, or participating in, these programs.

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New research finds while there is a higher risk for suicide in older and younger adults who misuse opioids, the prevalence in older adults is particularly concerning.

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Americans spend more time sitting. Total time spent sitting increased about an hour per day to 8.2 hours for adolescents and 6.4 hours for adults in 2007-2016 in this analysis of nationally representative survey data.

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Texas Biomedical Research Institute and UT Health San Antonio have signed an animal care and joint research agreement to move dozens of important research animals from the Sam and Ann Barshop Institute for Longevity and Aging Studies to the Southwest National Primate Research Center (SNPRC) on the Texas Biomed campus.

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Study found more than half of older adults with end-stage kidney disease died within a year of starting dialysis. Nearly one in four older dialysis patients (23 percent) succumbed to the disease within a month of starting treatment. Analysis reveals markedly higher death rates than previous reports of dialysis outcomes among older patients. Findings can help patients and clinicians make better-informed decisions to determine optimal course of treatment.

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In a small, pilot study, a non-invasive device that uses magnetic fields to stimulate nerve cells in the brain was associated with temporary improvements in age-related memory loss in older people, according to a study published in the April 17, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.

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In 2016, a surprising decline in life expectancy was ascribed to "deaths of despair" among working-class middle-aged white men displaced by a changing economy. However, new research shows indicators of despair are rising among Americans approaching middle age regardless of race, education and gender.

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If you're looking for health and fitness story ideas, here is research from the October 2018 issue of Medicine & Science in Sports & Exercise, ACSM’s flagship journal. ACSM is the largest sports medicine and exercise science organization in the world.

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Mayo Clinic研究人员及其合作者已经证明，将衰老细胞（也称“僵尸细胞”）从肥胖小鼠的脂肪组织中去除后，糖尿病的严重程度及其一系列病因或后果会减少或消失。该研究结果发表在期刊《Aging Cell》上。

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University of Maryland researchers analyzed an evolutionary tree reconstructed from the DNA of a majority of known bat species and found four bat lineages that exhibit extreme longevity. They also identified, for the first time, two life history features that predict extended life spans in bats.