Inflammatory response linked to amyloid plaque buildup
COVID-19 has had a lasting global health impact that continues to challenge the health care system.
While it may seem common knowledge that smoking is bad for your lungs, if and how ultrafine particles present in cigarette smoke impact the development and progression of lung cancer remains unclear.
Findings from a Johns Hopkins Medicine research study published today in JAMA Network Open provide strong evidence that people who are pregnant and have been infected with SARS-CoV-2 (the virus that causes COVID-19) can safely take the antiviral drug Paxlovid to reduce the possibility of severe disease.
Researchers compared the effects of three eating patterns on patients' risk of experiencing a cardiovascular event within in the next ten years — the Dietary Approaches to Stop Hypertension (DASH) diet, a diet rich in fruits and vegetables, and the Western diet that is typically low in fruits and vegetables while high in fat and sodium.
A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found.
Research from Quing Zhu’s lab yields a novel method to use ultrasound to enhance machine learning's ability to accurately diagnose - or rule out - ovarian cancer.
While some feared that New Yorkers would re-fill prescriptions to stockpile opioid medications in the early weeks of the COVID-19 lockdown much in the way people hoarded toilet paper, in fact, New York State opioid prescriptions declined in the period around the March 20, 2020 “PAUSE” order, according to new research.
NIBIB-funded researchers are fine-tuning a wearable, cuffless blood pressure monitor. Made of graphene, one of the thinnest materials in the world, the device is worn on the underside of the wrist and can measure blood pressure with comparable accuracy to a standard blood pressure cuff.
UC San Diego researchers identify the PKCα enzyme as a promising therapeutic target in Alzheimer’s disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in mice.
A Cornell-led collaboration used machine learning to pinpoint the most accurate means, and timelines, for anticipating the advancement of Alzheimer’s disease in people who are either cognitively normal or experiencing mild cognitive impairment.
Analysis shows steep increases in organ donations, transplantations during large motorcycle rallies. The increase in organ donations and transplantations appears to be driven by well-documented increases in crash-related deaths during large motorcycle rallies.
A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.
A new animal study points to a gene that is important for the earliest development of basic social behaviors.
Scientists measure how unpaired electrons in atoms at one end of a molecule can drive chemical reactivity on the molecule's opposite side. This work shows how molecules containing these so-called free radicals could be used in a whole new class of reactions.
A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells.
People who eat or drink more foods with antioxidant flavonols, which are found in several fruits and vegetables as well as tea and wine, may have a slower rate of memory decline, according to a study published in the November 22, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Three currently circulating omicron subvariants of SARS-CoV-2 – including two that currently make up almost 50% of reported COVID-19 infections in the U.S. – are better at evading vaccine- and infection-generated neutralizing antibodies than earlier versions of omicron, new research suggests.
Reporting a positive or negative test result just became easier through a new website from the National Institutes of Health. MakeMyTestCount.org, developed through NIH’s Rapid Acceleration of Diagnostics (RADx®) Tech program, allows users to anonymously report the results of any brand of at-home COVID-19 test.
Though antiretroviral therapy has made HIV a manageable disease, people living with HIV often suffer from chronic inflammation. This can put them at an increased risk of developing comorbidities such as cardiovascular disease and neurocognitive dysfunction, impacting the longevity and quality of their lives.
Scientists looking to understand the fundamental brain mechanisms of autism spectrum disorder have found that a gene mutation known to be associated with the disorder causes an overstimulation of brain cells far greater than that seen in neuronal cells without the mutation. The Rutgers-led study, spanning seven years, employed some of the most advanced approaches available in the scientific toolbox, including growing human brain cells from stem cells and transplanting them into mouse brains.
New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients.
Transgender and gender-nonconforming youth are four times more likely to have a sleep disorder compared to cisgender youth, a Michigan Medicine-led study finds. Researchers also found that those who pursued gender-affirming therapy were half as likely to have any sleep disorder than transgender individuals who did not pursue the therapy, suggesting a possible protective effect.
Researchers at UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have grown ‘mini eyes', which make it possible to study and better understand the development of blindness in a rare genetic disease called Usher syndrome for the first time.
Toxins released by a type of bacteria that cause diarrheal disease hijack cell processes and force important proteins to assemble into “roads to nowhere,” redirecting the proteins away from other jobs that are key to proper cell function, a new study has found.
UC San Diego researchers discuss how mimicking sleep patterns of the human brain in artificial neural networks may help mitigate the threat of catastrophic forgetting in the latter, boosting their utility across a spectrum of research interests.
UC San Diego researchers used human brain organoids to study the effects of prenatal alcohol exposure on neural development, revealing significant harms in molecular detail.
A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.
CHLA has received a new five-year award of $3.2 million from the National Institutes of Health (NIH) to research the underlying mechanisms that lead to kidney failure and to develop new treatments to protect kidney function.
Researchers have demonstrated in mice a new approach for delivering medication across the blood-brain barrier to treat tumors that cause aggressive, lethal brain cancer.
UC San Diego researchers expand and deepen understanding of how genetic aberrations fuel human papilloma virus-negative head and neck cancers and, potentially, provide paths to further refinement and improvement of immune checkpoint inhibitors for HPV-negative head and neck cancers.
Many estimates of how strongly traits and diseases share genetic signals may be inflated, and therefore some genetic correlations that have been attributed to shared biology may instead represent incorrect statistical assumptions.
The Department of Emergency Medicine has been awarded two National Institutes of Health grants totaling over $5 million to improve patient care. They include an effort to better evaluate pediatric trauma patients and another to identify effective treatments early in emergency care.
The National Institutes of Health has awarded Albert Einstein College of Medicine a five-year, $6.6 million grant to lead a New York-based consortium of medical schools to train young scientists in kidney, urology, and hematology research.
Two new studies from researchers at Fred Hutchinson Cancer Center in Seattle reveal how bacteria infiltrate tumors and could be helping tumors progress and spread and suggest a link between oral health and cancer, as microbes in the mouth are associated with cancers elsewhere in the body. The two papers – one published Nov. 15 in Cell Reports and the other published Nov. 16 in Nature – focus on an oral bacterium called Fusobacterium nucleatum, which has been linked to colorectal cancer.
Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.
Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer. The team developed a mouse model of pediatric glioma with a histone mutation called H3.3-G34, which allowed them to study the tumor’s biology in the presence of a functional immune system, revealing a promising outlook for long-term survival.
Researchers at the Icahn Mount Sinai have identified 35 genes that are particularly highly expressed in people with long-term Lyme disease. These genes could potentially be used as biomarkers to diagnose patients with the condition, which is otherwise difficult to diagnose and treat. The findings, published November 15 in the journal Cell Reports Medicine, may also lead to new therapeutic targets. The study is the first to use transcriptomics as a blood test to measure RNA levels in patients with long-term Lyme disease.
An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.
Researchers at the University of Maryland School of Medicine posit that a region of the brain that Francis Crick thought to impart consciousness may have been incorrect: They developed a new theory — built on data — that the claustrum behaves more like a high-speed internet router, taking in executive commands from “boss” areas of the brain’s cortex that forms complex thoughts to generate “networks” in the cortex.
A team of equity researchers at Mount Sinai’s Institute for Health Equity Research (IHER) will use a $2.5 million grant from the National Institutes of Health (NIH) to assess how unequal access to health care impacts patient health.
Muscle weakness marked by grip strength is associated with accelerated biological age, a new study suggests. Results were found using "age acceleration clocks" based on DNA methylation, a process that provides a molecular biomarker and estimator of the pace of aging. Researchers say this suggests potential to adopt use of grip strength as a way to screen individuals for future risk of functional decline, chronic disease and early mortality.
Cocaine disrupts the balance of microbes in the guts of mice, part of a cycle of waxing and waning neurochemicals that can enhance the drug’s effects in the brain. But the same chemicals may also be harnessed to prevent addiction, according to new research from the University of Wisconsin–Madison.Cocaine increases levels of a hormone called norepinephrine in users’ intestines, triggering an explosion of growth of proteobacteria, a family of microbes that includes the common and sometimes harmful bacterium E.
Researchers at the University of Pennsylvania’s Basser Center for BRCA at the Abramson Cancer Center have discovered factors that may make breast and ovarian cancers associated with BRCA1/2 gene mutations more likely to recur.
Dimension Inx, a regenerative biomaterials company, and Ann & Robert H. Lurie Children’s Hospital of Chicago have been jointly awarded an NIH Exploratory/Developmental Research Grant.
A team of researchers at The University of Texas MD Anderson Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy. The preclinical findings suggest this adaptable immune conversion approach has the potential for broad application across many cancer types.
De acuerdo a un nuevo análisis dirigido por investigadores de Cedars-Sinai y llevado a cabo en tres grandes sistemas de salud, el control y manejo de la hipertensión empeoraron durante los primeros meses de la pandemia de COVID-19.
The National Institutes of Health (NIH) has awarded the Case Western Reserve University (CWRU) School of Medicine a five-year, $7.3 million grant to identify new technology, methods and models to study the impact of inflammation and pain on eye health, specifically the surface.
Pioneering research into the chronic inflammation often seen in certain blood cancers has identified a promising treatment approach for myelofibrosis, a potentially deadly bone marrow cancer.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
