Feature Channels: Pharmaceuticals

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The July 2023 issue of SLAS Discovery, the open access journal focused on research progressing drug discovery, is now available.

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The first study in the world to compare cholesterol-lowering medications on a range of diseases has good and bad news for more than 200 million people.

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The American Chemical Society will honor researchers and companies as Heroes of Chemistry for developing products that have led to significant advancements in improving health and the environment.

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People who start taking medication soon after the first signs of multiple sclerosis (MS) may have a lower risk of disability later, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Researchers at Indiana University have identified a new method of reversing the effects of fentanyl. Their study could lead to a new way to reverse overdoses either through a new product or working synchronously with naloxone.

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Drs. Jinwook Cha and Jinsoo Park of the Natural Product Informatics Research Center at the Korea Advanced Institute of Science and Technology (KIST) announced that they have developed the first NMR method (Ultraselective Heteronuclear Polarization Transfer Method, or UHPT) that can selectively measure the information of carbon atom nuclei linked to specific hydrogen in a single measurement.

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  Vanderbilt University Medical Center has received a $7 million, five-year funding award from PCORI (Patient-Centered Outcomes Research Institute) to compare two sedatives used to place breathing tubes in the emergency department (ED) or intensive care unit (ICU). To provide support with a breathing machine, doctors must place a breathing tube into a patient’s mouth and throat, and they are given a medication to make them sleep during this procedure.

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The American Association of Nurse Anesthesiology (AANA) has named Ladan Eshkevari, PhD, CRNA, L.Ac.,FAAN to serve as AANA’s Editor-in-Chief of The AANA Journal.

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Penicillin allergy affects more than 25 million people in the United States (up to 1 in 10 Americans) and has been shown to lead to particularly poor health outcomes in pregnant women and surgical patients. It is also a public health threat, leading to antibiotic resistance and infections in hospitalized patients that can be life threatening.

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Berkeley Lab and Genentech are collaborating to make the next generation of lipid nanoparticles (LNPs) for drug delivery. Combining structural biology with cutting edge pharmaceutical science, the team is designing LNPs that can precisely deliver vaccines and therapeutics to target tissues while improving the product’s shelf life and duration of action.

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Researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered an Alzheimer's biomarker in the cerebrospinal fluid known as MTBR-tau243 can be used to track the progression of disease and could speed drug development.

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Psychedelic-based therapies are poised to change the treatments that psychiatrists can offer patients.

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Researchers at the University of Illinois Urbana-Champaign and collaborators at Merck & Co. developed a rapid and efficient method of making large quantities of metabolites directly from a drug or drug precursors via carbon-hydrogen oxidation catalysis.

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On July 6, 2023, the U.S. Food and Drug Administration (FDA) granted full approval to lecanemab, marketed as Leqembi, for the treatment of Alzheimer’s disease. The University of Kentucky’s Sanders-Brown Center on Aging has been working with this drug and others like it for more than a decade.

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Prostate cancer is resistant to one of the most powerful chemotherapy medications — cisplatin. Now, researchers in ACS Central Science have developed the first therapy of its kind that disrupts prostate cancer cells’ metabolism and releases cisplatin into the weakened cells, causing them to die.

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Researchers at Sylvester Comprehensive Cancer Center have developed a first-of-its-kind, orally administered drug to disrupt prostate cancer cells’ metabolism and deliver the chemotherapy agent cisplatin directly into treatment-resistant prostate cancer cells. The compound – Platin-L – works in two ways, breaking down a process that malignant prostate cancer cells use to fuel their growth, and delivering cisplatin directly into treatment-resistant cancer cells.

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A new analysis finds that up to millions of dollars could be saved annually on cancer immunotherapy treatments across the Veterans Health Administration by reconsidering how those drugs are delivered.

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A gift of $1.5 million from Eugene Jhong will help launch a new research program within the UC San Diego Psychedelic and Health Research Initiative to learn more about the biological and psychological effects of DMT in humans.

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The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.

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Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by Washington University School of Medicine in St. Louis.

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The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, promote standardization of testing across different laboratories, and improve patient care.

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Hackensack Meridian Health Physicians react to FDA approval of Alzheimer's drug lecanemab/ Leqembi. Available to discuss its uses, side effects and instances when they have prescribed it.

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Prof. Pol.Capt. Pharm. Dr. Suchada Sukrong, lecturer at the Faculty of Pharmaceutical Sciences and a researcher at the Center of Excellence in DNA Barcoding of Thai Medicinal Plants, Chulalongkorn University, Dr. Kannika Thongkhao, and Pharm. Chayaphol Tangpatthong have won the gold medal and two Special Awards, namely the FIRI Award in the Best Invention category from “The first institute of inventors and researchers of Iran” (FIRI), Iran, and a Special Awards from “The Industrial Property Office of the Czech Republic the Czech Metallurgical Society,” The Czech Republic, in The 16th International Invention and Innovation Show (INTARG 2023) on May 24-25, 2023, at Katowice International Conference Center, Katowice, Republic of Poland, with their “Rapid DNA immunochromatographic assay for detection of toxic Aristolochia species, the plants responsible for aristolochic acid nephropathy”.

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Rutgers Institute for Health researchers observe decrease in use of antipsychotic medications in children since early 2000s.

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Conventional ways of administering medication – by swallowing tablets, consuming bitter syrups, injections or rectal insertions – could be distressing and unpleasant for some patients, especially young children or the elderly. A team of researchers led by Associate Professor Chan Sui Yung, Honorary Fellow at the Department of Pharmacy under the Faculty of Science at the National University of Singapore (NUS), has recently developed easy-to-use oral films that enable painless, efficient, and discreet drug administration.

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Cedars-Sinai patient care teams are preparing to offer lecanemab, a new Alzheimer’s disease treatment expected to soon receive approval from the U.S. Food and Drug Administration (FDA), to patients in the coming months.

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With the growing popularity of medications like Ozempic® (semaglutide), Trulicity® (dulaglutide), and other glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes and weight loss, the American Society of Anesthesiologists (ASA) suggests withholding the medication before elective surgery to reduce the risk of complications associated with anesthesia in adults and children.

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The June special issue of SLAS Technology showcases the latest developments in the field of biotechnology with its collection of seven research articles.

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The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer’s and other drug discovery research.

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Benzodiazepine use and discontinuation is associated with nervous system injury and negative life effects that continue after discontinuation, according to a new study.

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UC San Diego researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial.

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