Acinetobacter baumannii is a bacterial pathogen responsible for serious hospital-related infections that is becoming increasingly resistant against antibiotics.
A new study from the University of Michigan Rogel Cancer Center suggests androgen receptor inhibitors can fundamentally rewire and reshape how prostate tumors function, and in certain cases even make them more aggressive. These findings will be published in Nature Communications on Sept. 15.
New research from Wake Forest University School of Medicine shows that taking a daily supplement may improve cognition in older adults. In the study, researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years).
The ability of microfungi to destruct organic compounds can be the object of envy for any processing plant. However, they sometimes destroy things that people prefer to keep safe – for example, paints of the masterpieces. The good news is that some of their biochemical reactions can be used in pharmacy.
Can you teach an old drug new tricks? Although drug treatments for the core symptoms of autism spectrum disorder (ASD) are not currently available, could an existing drug provide a new treatment, even if it previously had no association with ASD?
The September issue of SLAS Discovery is now available open access on ScienceDirect.
The oral anticoagulant drug apixaban may offer a safer, more effective alternative to standard home heparin injections for patients taking extended prophylaxis (EP) to prevent blood-clot-related complications after surgery, reports a study in The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Newly released results from the Phase III ADAURA trial reveal that osimertinib yielded a 5.5-year median disease-free survival in the post-surgical treatment of patients with EGFR-mutated lung cancer, and nearly three in four patients treated with adjuvant osimertinib were disease-free at four years. The new results also indicated that the use of osimertinib reduced the risk of disease recurrence in the brain and spinal cord.
Moffitt Cancer Center is one of two institutions in the U.S. investigating a new dual checkpoint inhibitor therapy with or without stereotactic body radiation therapy for patients with Merkel cell carinoma. Results from the phase 2 clinical trial were published in The Lancet, in conjunction with a presentation at the European Society for Medical Oncology Congress.
Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer. Findings from the global FRESCO-2 trial were presented today at the European Society for Medical Oncology (ESMO) Congress 2022.
RUDN biologists in collaboration with scientists from Iran have obtained gold nanoparticles using harmless fungi living on a peach tree. The resulting particles proved to be useful in the fight against a pathogenic fungus that infects rice and potatoes. Potentially, nanoparticles can be used in medicine.
Tobias Gerhard, interim director of Rutgers Institute for Health, Health Care Policy and Aging Research and founding director of Rutgers Center for Pharmacoepidemiology and Treatment Science, has been named president of the International Society for Pharmacoepidemiology (ISPE).
Patients who received trastuzumab deruxtecan (T-DXd) for human epidermal growth factor receptor 2 (HER2)-low metastatic breast cancer reported that the treatment maintained their quality of life (QoL) compared to conventional chemotherapy, according to results presented today by researchers from The University of Texas MD Anderson Cancer Center at the European Society for Medical Oncology (ESMO) Congress 2022.
Preterm and low birth weight babies are routinely given antibiotics to prevent, not just treat, infections, which they have a high risk of developing.
Despite recent claims on social media, the UK government has not changed its position on pregnant or breastfeeding women getting the COVID booster. The NHS says the vaccine is both safe and strongly recommended for this group.
James Turkson, PhD, professor in the Division of Medical Oncology in the Department of Medicine at Cedars-Sinai, is uniquely positioned for a new role developed at Cedars-Sinai Cancer: director for Diversity, Inclusion and Strategy.
Two large clinical trials published by The BMJ today show that boosting vitamin D levels in adults during the SARS-CoV-2 pandemic was not associated with protection against respiratory tract infections or covid-19.
In comments submitted to the Centers for Medicare and Medicaid Services (CMS) in response to the CY 2023 Medicare Physician Fee Schedule and Quality Payment Program proposed rule, the ACR applauded proposals that would provide more flexibility and improve care coordination.
The latest research and expert commentary on pain management.
Based on findings from a new study by a Johns Hopkins Medicine-led research team, an effective means of fighting SARS-CoV-2, the virus that causes COVID-19, may be possible that circumvents the problem of waning immunity often observed when current vaccines deal with emerging COVID variants.
Investigadores de la Universidad de Georgia han descubierto un tratamiento potencial para la enfermedad de Chagas, marcando el primer medicamento con la promesa de atacar con éxito y seguridad la infección parasitaria en más de 50 años. Se espera que los ensayos clínicos en humanos del fármaco, un compuesto antiparasitario conocido como AN15368, pueden empezar en los próximos años.
Researchers from the University of Georgia have discovered a potential treatment for Chagas disease, marking the first medication with promise to successfully and safely target the parasitic infection in more than 50 years. Human clinical trials of the drug, an antiparasitic compound known as AN15368, will hopefully begin in the next few years.
Research led by the University of Exeter and Kent and Medway NHS and Social Care Partnership Trust, published in Age and Ageing, assessed a new tool designed to calculate which medicines are more likely to experience adverse anticholinergic effects on the body and brain.
Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming.
William Morice II, M.D., Ph.D., has been named CEO and president and Mary Jo Williamson has been named chief administrative officer of Mayo Clinic Laboratories and other diagnostic services in the biopharma and cardiovascular spaces. Mayo Clinic Laboratories is the reference laboratory for Mayo Clinic, providing health care professionals access to the world's most sophisticated test catalog and thousands of Mayo Clinic experts.
Researchers at Linköping University have used computer simulations to show that stable aromatic molecules can become reactive after absorbing light.
RUDN University pharmacists have shown that it is possible to increase the effectiveness of antiviral agents with the help of natural organic substances - humic acids. Due to their complex supramolecular structure, these compounds have the potential for targeted drug delivery of molecules with low bioavailability.
In breakthrough findings, renowned Saint Louis University pain researcher Daniela Salvemini, Ph.D., and her team have uncovered some of the molecular events that happen when chemotherapy drugs cause these deficits. More promising still, they’ve found that an already-approved FDA drug designed to treat multiple sclerosis also appears to work to reduce chemotherapy-related cognitive impairment.
Johns Hopkins Medicine study suggests strategies may prevent dangerous post-surgery condition
RUDN doctors in collaboration with the Research Centre for Medical Genetics found genetic factors that can affect the absorption of an antimicrobial drug prescribed for cystic fibrosis in children. Ciprofloxacin is widely used to treat even the smallest patients. New data will help develop a more accurate protocol for the treatment of cystic fibrosis in children.
Bionanotechnologists proved that adding excipients to biopolymers, which are used in medicine as new dosage forms, can change its crystallinity and physical characteristics. Results indicate the possibility of regulating the resilience to biodegradation. For instance, when controlling the release of medicine from biopolymer composite.
Pain is an important alarm system that alerts us to tissue damage and prompts us to withdraw from harmful situations. Pain is expected to subside as injuries heal, but many patients experience persistent pain long after recovery.
An experimental combination of two drugs halts the progression of small cell lung cancer, the deadliest form of lung cancer, according to a study in mice from researchers at Washington University School of Medicine in St. Louis, Grenoble Alpes University in Grenoble, France, and The University of Texas MD Anderson Cancer Center in Houston.
Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job.
The latest research on plants brought to you by Newswise.
The use of prescribed steroids, including in inhalers, is linked to changes in the structure and volume of white and grey matter in the brain, suggests the findings of the largest study of its kind, published in the open access journal BMJ Open.
A new study that looked at health data from the UK found people with a folic acid prescription were 1.5 times as likely to get COVID-19 and were more than 2.6 times as likely to die from COVID-19 compared to the control group.
The supply of a plant-derived anti-cancer drug can finally meet global demand after a team of scientists from Denmark and the U.S. engineered yeast to produce the precursor molecules. Previously, obtaining one gram of the chemotherapy drug required growing and harvesting 500 kilograms of the native plant's leaves.
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Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response. In a study in ACS Infectious Diseases, researchers report a substance that boosted the immune response to an experimental COVID-19 shot in mice by 25 times, compared to injection with the vaccine alone.
The human papillomavirus (HPV) vaccine is safe and effective – but it’s not for everyone. Michelle Ozbun, PhD, and her team at UNM Cancer Center published a research article earlier this year in Antimicrobial Agents and Chemotherapy in which they describe how a drug called protamine sulfate blocks HPV infection. Like a game of musical chairs among molecules, the drug molecules bind to heparan sulfate cell receptors, preventing HPV virus particles from doing so.
Value in Health announced the publication of a new report that cautioned the universal applicability of a recent change by German health technology assessment organization, IQWiG regarding the process of assessing the added benefit of drug interventions.
Researchers at the University of Maryland School of Medicine have shown that mice respond more to the antidepressant effects of the drug ketamine when administered by men and not by women. The group demonstrated that a stress response detected in the mouse's brain from handling by a man is essential for ketamine to work.
Electroencephalogram (EEG) tests revealed fentanyl’s effects on the brain and indicated that the drug stops people’s breathing before other noticeable changes and before they lose consciousness.
Faculty members with the West Virginia University School of Pharmacy are issuing warnings about the rise of fentanyl in Mountain State communities and elsewhere following the recent seizure of a large amount of “rainbow fentanyl,” potent illegal pills resembling candy, by law enforcement officers in Monongalia County.
In a paper published in JAMA Network Open, physician-scientists assessed the use of these two monoclonal antibodies for patients with COVID-19 before and after FDA deauthorization.
UC Davis Health has published one of the earliest studies assessing the use of tecovirimat to treat monkeypox (MPX) symptoms and skin lesions. The antiviral drug approved for smallpox treatment appeared to be safe and effective in 25 patients with monkeypox.
A three-drug medication known as a “polypill,” developed by the Spanish National Center for Cardiovascular Research (CNIC) and Ferrer, is effective in preventing secondary adverse cardiovascular events in people who have previously had a heart attack, reducing cardiovascular mortality by 33 percent in this patient population.
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