Curated News: National Institutes of Health (NIH)

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Newswise: New technique enhances quality control of lab-grown cells for AMD treatment
Released: 18-Jan-2024 3:05 PM EST
New technique enhances quality control of lab-grown cells for AMD treatment
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have improved a crucial step in the production of retinal pigment epithelium (RPE), a tissue they grow in the lab from patient blood cells and are testing in a clinical trial as treatment for age-related macular degeneration (AMD).

Newswise: Metabolomics: A New Approach to Understanding Glaucoma
Released: 14-Nov-2023 6:05 PM EST
Metabolomics: A New Approach to Understanding Glaucoma
NIH, National Eye Institute (NEI)

Glaucoma remains one of the most common causes of vision loss and blindness in the U.S. and much of the world, disproportionately affecting older people, African Americans, and Hispanics and Latinos.

11-Sep-2023 11:55 AM EDT
UMSOM Researchers Identify Important New Signaling Molecule Involved in Vascular Health
University of Maryland School of Medicine

In the 25 years since the Nobel Prize was awarded for discovering the role that nitric oxide (NO) plays in the cardiovascular system, researchers have been racing to learn more about how this mysterious signaling molecule works to repair blood vessels damaged by a heart attack, stroke or other cardiovascular event.

Newswise: FSU chemist earns $1.8M NIH grant to create complex molecules for biomedical and pharmaceutical use
Released: 8-Sep-2023 9:00 AM EDT
FSU chemist earns $1.8M NIH grant to create complex molecules for biomedical and pharmaceutical use
Florida State University

Joel M. Smith, an assistant professor of Chemistry and Biochemistry, received the Maximizing Investigators’ Research Award, or MIRA, from the National Institute of General Medical Sciences to study the potential that synthesizing small, complex molecules could have on the biomedical and pharmaceutical industries.

Newswise: SMU professor wins $1.8M NIH award to study how our bodies may work to repair damaged components in cells
Released: 7-Sep-2023 9:55 AM EDT
SMU professor wins $1.8M NIH award to study how our bodies may work to repair damaged components in cells
Southern Methodist University

SMU biology professor Zhihao Wu has received a $1.8 million, 5-year Maximizing Investigators' Research Award (MIRA) from the National Institutes of Health to determine if different quality control pathways in our bodies might be working together to repair damaged components in cells.

Released: 6-Sep-2023 10:25 AM EDT
Third NIH Grant Moves Novel Anti-Diarrheal Vaccine Forward
College of Veterinary Medicine, University of Illinois Urbana-Champaign

Dr. Weiping Zhang, professor in the Department of Pathobiology, was recently awarded a five-year, $5.6 million R01 grant from the National Institutes of Health (NIH) to optimize a promising vaccine against enterotoxigenic Escherichia coli (ETEC).

Newswise: FSU researcher wins NIH grant to study a hidden part of our sense of smell
Released: 5-Sep-2023 2:05 PM EDT
FSU researcher wins NIH grant to study a hidden part of our sense of smell
Florida State University

A Florida State University researcher has received a five-year, $1.86 million grant from the National Institutes of Health to study how a little-understood part of the brain affects our sense of smell. 

Newswise: Landmark NIH grant awarded to School of Nursing and Health Studies
Released: 5-Sep-2023 11:05 AM EDT
Landmark NIH grant awarded to School of Nursing and Health Studies
University of Miami

The University of Miami School of Nursing and Health Studies (SONHS) has been awarded an unprecedented $23.57 million grant from the National Institutes of Health (NIH) to join the Environmental influences on Child Health Outcomes (ECHO) Program.

Newswise: LJI scientists harness 'helper' T cells to treat tumors
31-Aug-2023 1:05 PM EDT
LJI scientists harness 'helper' T cells to treat tumors
La Jolla Institute for Immunology

La Jolla Institute for Immunology (LJI) scientists have published a pair of studies that show how we might harness CD4+ T cells while boosting the cancer-fighting power of CD8+ "killer" T cells.

Released: 31-Aug-2023 2:05 PM EDT
Expanding the Impact of CAR T Cell Therapy: An Immunotherapy Strategy Against All Blood Cancers
Perelman School of Medicine at the University of Pennsylvania

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer.

Released: 30-Aug-2023 11:05 AM EDT
Penn Medicine Researchers Identify the Link Between Memory and Appetite in the Human Brain to Explain Obesity
Perelman School of Medicine at the University of Pennsylvania

Disrupted connections between memory and appetite regulating brain circuits are directly proportional to BMI, notably in patients who suffer from disordered or overeating that can lead to obesity, such as binge eating disorder, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

Newswise: Enhancing Immune Defenses: Researchers Unveil the Secrets of Specialized T Cells to Conquer Tumors
28-Aug-2023 7:00 PM EDT
Enhancing Immune Defenses: Researchers Unveil the Secrets of Specialized T Cells to Conquer Tumors
University of California San Diego

Immunologists have uncovered new approaches to enhance protection from tumors and infections.

Released: 25-Aug-2023 2:20 PM EDT
NIH selects undergraduate winners of 2023 DEBUT Challenge for impressive medical device designs
National Institute of Biomedical Imaging and Bioengineering

The National Institutes of Health and the higher education non-profit VentureWell have selected 10 winners and five honorable mentions of the Design by Biomedical Undergraduate Teams (DEBUT) Challenge, who are set to receive prizes totaling $145,000.

18-Aug-2023 10:50 AM EDT
Scientists discover a previously unknown way cells break down proteins
Harvard Medical School

Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they’ve done their job.

Newswise: Repairing broken brain circuits may offer path to new Parkinson’s treatments
Released: 24-Aug-2023 11:05 AM EDT
Repairing broken brain circuits may offer path to new Parkinson’s treatments
Van Andel Institute

Scientists have identified a series of processes that help the brain adapt to damage caused by breakdowns in circuits that govern movement, cognition and sensory perception.

Newswise: Short-Term Use of Immunosuppressants Not Linked to Cancer Risk
Released: 21-Aug-2023 7:05 PM EDT
Short-Term Use of Immunosuppressants Not Linked to Cancer Risk
University of Pittsburgh

Relatively short-term use of immunosuppressant medications to control an inflammatory disease was not associated with an increased risk of later developing cancer, according to new research.

Newswise: Long-Term Study Reaffirms Benefits of Covid-19 Vaccination for Organ Transplant Recipients
Released: 18-Aug-2023 12:05 PM EDT
Long-Term Study Reaffirms Benefits of Covid-19 Vaccination for Organ Transplant Recipients
Johns Hopkins Medicine

A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus’ omicron subvariant.

Released: 18-Aug-2023 9:30 AM EDT
Tulane University, Ochsner Health and RH Impact receive $16.5 million NIH grant to address maternal death rate, inequity
Ochsner Health

The center will develop and evaluate innovative approaches to reduce pregnancy-related complications and deaths and promote maternal health equity in the Gulf South.

14-Aug-2023 7:05 PM EDT
Immunotherapy drug combo helps extend the lives of patients with metastatic melanoma
University of California, Los Angeles (UCLA), Health Sciences

A research team co-led by UCLA investigators has shown that an immunotherapy drug combination can be an effective second-line therapy for patients with an aggressive and deadly type of melanoma that is resistant to the widely used immunotherapy drugs known as PD-1 inhibitors.

Released: 17-Aug-2023 8:45 AM EDT
Sylvester Comprehensive Cancer Center Tip Sheet - August 2023
Sylvester Comprehensive Cancer Center

New research shows blood cancers are often misdiagnosed, an NCI grant to develop a urine test for prostate cancer, a surgeon-scientist receives Sylvester’s first DoD grant to study pancreatic cancer, bolstering emergency preparedness for climate-driven disasters, and more are included in this month’s tip sheet .

Newswise: Beneficial bacteria sense gut mucus to stay in line
Released: 17-Aug-2023 5:00 AM EDT
Beneficial bacteria sense gut mucus to stay in line
University of Oregon

The findings point to possible mechanisms behind intestinal conditions like Crohn’s disease and ulcerative colitis, and also suggest avenues to develop more effective probiotics.

   
Newswise: Scientists discover external protein network can help stabilize neural connections
10-Aug-2023 2:05 PM EDT
Scientists discover external protein network can help stabilize neural connections
NIH, National Eye Institute (NEI)

The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a study in mice from the National Eye Institute (NEI) and the University of Freiberg, Germany.

Newswise: Study finds improved survival for incurable brain tumor, providing ‘a crack in the armor’
14-Aug-2023 10:05 AM EDT
Study finds improved survival for incurable brain tumor, providing ‘a crack in the armor’
Michigan Medicine - University of Michigan

For the first time, researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain tumor for which there are no effective treatments. The compound, called ONC201, nearly doubled survival for patients with diffuse midline glioma (DMG) or diffuse intrinsic pontine glioma (DIPG), compared to previous patients.

Newswise: Sugars affect brain ‘plasticity,’ helping with learning, memory, recovery
7-Aug-2023 11:45 PM EDT
Sugars affect brain ‘plasticity,’ helping with learning, memory, recovery
American Chemical Society (ACS)

Our brains constantly make memories and learn new skills. Understanding the role of the complex sugar molecules responsible for this “plasticity” could also make it possible to repair neural circuits after injury. The researchers will present their results today at ACS Fall 2023.

Released: 15-Aug-2023 1:25 PM EDT
Images of enzyme in action reveal secrets of antibiotic-resistant bacteria
Emory University

Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide in clinical samples in a range of drug-resistant bacteria.

   
Released: 15-Aug-2023 12:50 PM EDT
Weaker transcription factors are better when they work together
Rice University

Bioengineers can tailor the genomes of cells to create “cellular therapies” that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch on bioengineered genes without occasionally turning on some of the cell’s naturally occurring genes.

   
Released: 14-Aug-2023 4:05 PM EDT
Scientists reveal how proteins drive growth of multiple cancer types
Washington University in St. Louis

Led by Washington University School of Medicine in St. Louis and other institutions around the world, the Clinical Proteomic Tumor Analysis Consortium has completed a deep analysis of the proteins driving cancer across multiple tumor types, information that can’t be assessed by genome sequencing alone. Understanding how proteins operate in cancer cells raises the prospect of new therapies.

Newswise: In battle against pancreatic cancer, grant-funded H-FIRE study offers hope
Released: 14-Aug-2023 2:05 PM EDT
In battle against pancreatic cancer, grant-funded H-FIRE study offers hope
Virginia Tech

The National Institutes of Health has awarded $2.6 million to a Virginia Tech team over five years for a study of high frequency irreversible electroporation (H-FIRE) for tumor ablation and immune system activation in cases of pancreatic cancer.

Released: 14-Aug-2023 1:00 PM EDT
Wake Forest University School of Medicine Awarded $1.9 Million to Study Biomarkers for Chronic Pain
Wake Forest University School of Medicine

Chronic pain can be debilitating and can limit the quality of life for the millions who suffer from it. Unfortunately, treatments to manage chronic pain are often ineffective because the functional changes that accompany a disease are not fully understood. Many patients develop chronic pain after surgery, but unfortunately, it is not yet possible to predict which patients are at risk.

Newswise: Gene therapy may offer new treatment strategy for alcohol use disorder
Released: 14-Aug-2023 11:55 AM EDT
Gene therapy may offer new treatment strategy for alcohol use disorder
Ohio State University Wexner Medical Center

Gene therapy might offer a one-time, sustained treatment for patients with serious alcohol addiction, also called alcohol use disorder, according to a new study led by a researcher at The Ohio State University Wexner Medical Center and College of Medicine.

Released: 11-Aug-2023 9:55 AM EDT
UTHealth Houston joins SATURN trial, studying role of statins in recurrent intracerebral hemorrhage
University of Texas Health Science Center at Houston

A clinical trial evaluating the role of statins in the risk of recurrent intracerebral hemorrhage (ICH) in patients presenting with ICH, has opened for enrollment at UTHealth Houston.

Released: 10-Aug-2023 10:40 AM EDT
Research team makes surprising discovery of low-noise genes
Virginia Tech

While engaging in cell division research, Silke Hauf and members of her lab made a surprisingly quiet discovery. When cells express RNA, there are always some fluctuations, or noise, in how much RNA is produced. Hauf’s group found several genes whose noise dips below a previously established minimum threshold, known as the noise floor, during expression “We have solid data for this phenomenon,” said Hauf, associate professor in the Department of Biological Sciences at Virginia Tech.

Newswise: Johns Hopkins Researchers Develop Gut-Restricted Drug to Treat IBD
Released: 10-Aug-2023 9:05 AM EDT
Johns Hopkins Researchers Develop Gut-Restricted Drug to Treat IBD
Johns Hopkins Medicine

A new study of mice and lab-grown human colon “organoids” indicates that an experimental drug developed by Johns Hopkins Medicine researchers can substantially reduce symptoms of inflammatory bowel disease (IBD) in pre-clinical models.

Newswise: New Machine-Learning Method May Aid Personalized Cancer Therapy
Released: 9-Aug-2023 11:00 AM EDT
New Machine-Learning Method May Aid Personalized Cancer Therapy
Johns Hopkins Medicine

Deep-learning technology developed by a team of Johns Hopkins engineers and cancer researchers can accurately predict cancer-related protein fragments that may trigger an immune system response. If validated in clinical trials, the technology could help scientists overcome a major hurdle to developing personalized immunotherapies and vaccines.

   
Newswise: Nanozymes drive tumor-specific drug delivery while minimizing toxicity
Released: 9-Aug-2023 10:35 AM EDT
Nanozymes drive tumor-specific drug delivery while minimizing toxicity
National Institute of Biomedical Imaging and Bioengineering

Nanozymes—artificial enzymes that can carry out pre-determined chemical reactions—could selectively activate a cancer drug within a tumor while minimizing damage to healthy tissue in a mouse model of triple negative breast cancer.

Newswise: UTHealth Houston researcher awarded $3.1M NIH grant to study sudden unexpected death in epilepsy
Released: 8-Aug-2023 1:10 PM EDT
UTHealth Houston researcher awarded $3.1M NIH grant to study sudden unexpected death in epilepsy
University of Texas Health Science Center at Houston

A five-year, $3.1 million grant to study preventive strategies for sudden unexpected death in epilepsy (SUDEP) has been awarded to UTHealth Houston by the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke.

Released: 8-Aug-2023 12:05 PM EDT
Modulating type 1 Interferon may expand treatment options for COVID-19
Emory Health Sciences

In their continuing work to limit the impact of COVID-19, Emory University researchers have, for the first time in nonhuman primates, studied how modulating the signaling of type 1 Interferon (IFN-I), one of the body’s initial defenses against infection, impacts SARS-CoV-2 viral replication and disease progression.

Released: 7-Aug-2023 12:15 PM EDT
Current estimates of Lake Erie algae toxicity may miss the mark
Ohio State University

A new study analyzing toxins produced by Microcystis, the main type of cyanobacteria that compose the annual harmful algal bloom (HAB) in Lake Erie, suggests that the toxicity of the bloom may be overestimated in earlier warm months and underestimated later in the summer.

   
Newswise: Team discovers broken ‘brake' of cancer mutation machine
Released: 7-Aug-2023 11:45 AM EDT
Team discovers broken ‘brake' of cancer mutation machine
UT Southwestern Medical Center

Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical Center researchers discovered. The findings, published in Cancer Cell, could lead to new interventions that thwart this process in prostate and other cancer types, making them far easier to treat.

Newswise: Surgeon-Scientist Receives $3.2 Million NIH Grant to Continue Program for Hearing Loss Research
Released: 7-Aug-2023 11:40 AM EDT
Surgeon-Scientist Receives $3.2 Million NIH Grant to Continue Program for Hearing Loss Research
University of Miami Health System, Miller School of Medicine

The University of Miami Miller School of Medicine Department of Otolaryngology has received a new $3.2 million, five-year grant from the National Institutes of Health (NIH) to support their multidisciplinary translational research program on human genetic hearing loss (HL), a common sensory disorder affecting more than 28 million Americans.

4-Aug-2023 12:55 PM EDT
Dana-Farber AI-model predicts primary source of cancer using gene sequencing data
Dana-Farber Cancer Institute

Researchers at Dana-Farber Cancer Institute have created an AI-based tool that uses tumor gene sequencing data to predict the primary source of a patient’s cancer. The study, published in in Nature Medicine, suggests that this predictive tool, called OncoNPC, could help guide treatment of cancer and improve outcomes in difficult to diagnose cases.

Newswise: Sylvester Researcher, Collaborators Receive NIH Grant to Study New Technology for At-Home Cancer Care
Released: 4-Aug-2023 10:05 PM EDT
Sylvester Researcher, Collaborators Receive NIH Grant to Study New Technology for At-Home Cancer Care
Sylvester Comprehensive Cancer Center

Researchers with Sylvester Comprehensive Cancer Center and collaborating organizations will study how new technology can help cancer patients manage symptoms and related stress from cancer treatment while at home.

Newswise:Video Embedded how-good-is-that-ai-penned-radiology-report
VIDEO
Released: 4-Aug-2023 8:55 AM EDT
How Good Is That AI-Penned Radiology Report? 
Harvard Medical School

New study identifies concerning gaps between how human radiologists score the accuracy of AI-generated radiology reports and how automated systems score them.

   
Newswise: Changes in Gut Microbiome Alters Rewarding Effects of Cocaine and Cravings
Released: 3-Aug-2023 10:30 AM EDT
Changes in Gut Microbiome Alters Rewarding Effects of Cocaine and Cravings
Wake Forest University School of Medicine

In a new preclinical study from Wake Forest University School of Medicine, scientists provide the first evidence that changes in the gut microbiome have significant effects on cocaine use and cravings after withdrawal.

Newswise: Researchers discover a novel pathway that minimizes liver injury during transplantation
1-Aug-2023 4:05 PM EDT
Researchers discover a novel pathway that minimizes liver injury during transplantation
University of California, Los Angeles (UCLA), Health Sciences

New research shows how using molecular tools and alternative gene splicing can make a protein called CEACAM1 more protective against liver injury during transplantation, thus reducing organ injury and ultimately improving post-transplant outcomes.

Newswise: Better training for the brain: FAMU-FSU College of Engineering dean to develop surgical simulator that sparks learning
Released: 2-Aug-2023 12:50 PM EDT
Better training for the brain: FAMU-FSU College of Engineering dean to develop surgical simulator that sparks learning
Florida State University

Suvranu De, dean of the FAMU-FSU College of Engineering, is building a better simulator — one that uses brain stimulation to improve learning for physicians undergoing training for robotic surgeries for oral cancers.

   
Released: 2-Aug-2023 11:45 AM EDT
UC Irvine is part of $16 million effort to increase dementia research representation
University of California, Irvine

With a $16 million grant from the National Institute on Aging, the University of California, San Francisco and the University of California, Irvine will work with community partners to improve the representation of Asian American, Native Hawaiian and Pacific Islander adults in research on aging, caregiving, and Alzheimer’s disease and related dementias.

Newswise: Bladder Cancer: Cedars-Sinai Begins Project to Study Sex Differences
Released: 2-Aug-2023 10:45 AM EDT
Bladder Cancer: Cedars-Sinai Begins Project to Study Sex Differences
Cedars-Sinai

Cedars-Sinai Cancer investigators are spearheading a project, funded by a five-year, $11.2 million grant from the National Cancer Institute, part of the National Institutes of Health, to advance scientific knowledge of how biological differences between men and women affect bladder cancer.

28-Jul-2023 8:00 AM EDT
Mimicking the body’s own defenses to destroy enveloped viruses
American Chemical Society (ACS)

Viruses often mutate or hide themselves within cells. But by mimicking the way the immune system naturally deals with invaders, researchers reporting in ACS Infectious Diseases have developed a “peptoid” antiviral therapy that effectively inactivates three viruses in lab tests.

   
Released: 1-Aug-2023 4:30 PM EDT
Amygdala Neurosciences Awarded $2.0 million NIH Grant to Conduct IND Enabling Studies
Amygdala Neurosciences Inc.

ANS-858, a new selective ALDH2 Inhibitor in pre-clinical development to reduce craving and relapse for patients being treated for alcohol and other substance use disorders.



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