Curated News:

The insulin-producing beta cells in the pancreas unwittingly produce a signal that may aid their own demise in Type 1 diabetes, according to a study of the lipid signals that drive macrophage cells in the body to two different phenotypes of activated immune cells.

Channels: All Journal News, Diabetes, National Institutes of Health (NIH), Grant Funded News,

Keywords: Diabetes, Type 1 Diabetes, Beta Cells, macrophage activation , Macrophage, Lipids, Lipid signaling

New cancer immunotherapy approaches are revolutionizing treatment options for breast cancer patients. However, many lead to insufficient immune responses rendering the therapies incapable of completely eradicating tumors. In a new study, published today in Science Immunology, University of California, Irvine researchers determined the molecular features of certain cells associated with breast cancer, which may open up new avenues into improving cancer immunotherapy.

Channels: All Journal News, Cancer, Healthcare, Women's Health, National Cancer Institute (NCI), National Institutes of Health (NIH), Grant Funded News,

Keywords: Breast Cancer, immunotherapy cancer treatments, Myeloid Derived Supressor Cells, UCI School of Medicine

An experimental drug already shown to be safe and help some patients with clear cell renal cell carcinoma, a deadly form of kidney cancer, effectively disables its molecular target.

Channels: All Journal News, Cancer, Clinical Trials, Kidney Disease, Pharmaceuticals, National Institutes of Health (NIH),

Scientists find that normal intestinal cells “de-differentiate” en masse into stem cells that generate the cells needed for a healthy intestinal lining. New study establishes de-differentiation as the predominant mode of stem cell recover in the intestine

Channels: All Journal News, Digestive Disorders, Stem Cells, National Institutes of Health (NIH), Cancer Center Featured Story 2, Embargoed Feed - hidden, Grant Funded News,

UC San Diego bioengineers have developed a control system that could make CAR T-cell therapy safer and more powerful when treating cancer. By programming CAR T cells to switch on when exposed to blue light, the researchers controlled the cells to destroy skin tumors in mice without harming healthy tissue.

Channels: All Journal News, Cancer, National Institutes of Health (NIH), Embargoed Feed - hidden,

Keywords: Cancer, CAR T cell therapy, CAR-T, Bioengineering

Harvard researchers have discovered a new mechanism for how the brain and its arteries communicate to supply blood to areas of heightened neural activity. The findings enable new avenues of study into the role of this process in neurological diseases.

Channels: All Journal News, Alzheimer's and Dementia, Blood, Neuro, National Institutes of Health (NIH), Embargoed Feed - hidden, Grant Funded News,

Keywords: Neurovascular Coupling, Alzheimer's, Harvard, Chenghua Gu, Mfsd2a

Study examines the role of small molecule in children with a rare liver disease

Channels: All Journal News, Children's Health, Liver Disease, National Institutes of Health (NIH),

Keywords: Liver Disease, Fish Oil, micro-RNA 122

A molecule identified by UCLA researchers helps maintain a healthy balance of cells in airway and lung tissue. If the compound, so far only studied in isolated human and mouse cells, has the same effect in people, it may lead to new drugs to treat or prevent lung cancer.

Channels: All Journal News, Cancer, Stem Cells, National Cancer Institute (NCI), National Institutes of Health (NIH), Cell (journal),

Keywords: Stem Cell, lung, Cancer, Lung Cancer, Airway, lung tissue

Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how. New findings, in a study led by Steve A. N. Goldstein, MD, PhD, vice chancellor for Health Affairs at the University of California, Irvine, and distinguished professor in the UCI School of Medicine Departments of Pediatrics and Physiology & Biophysics, reveal the underlying mechanism for this dangerous heart disorder.

Channels: All Journal News, Cardiovascular Health, Children's Health, Heart Disease, Public Health, National Institutes of Health (NIH), Grant Funded News,

Keywords: UCI School of Medicine, SUMO, SCN5A, late current, Sudden Death, Arrhythmia, ILATE