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Discovery Points to a New Path Toward a Universal Flu Vaccine

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The conventional flu vaccine protects only against a few specific strains of flu. However, experiments by Rockefeller University researchers and their colleagues show that by including modified antibodies within the vaccine it may be possible to elicit broad protection against many strains simultaneously.

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Weight Loss, Combined with Vitamin D, Reduces Inflammation Linked to Cancer, Chronic Disease

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For the first time, researchers at Fred Hutchinson Cancer Research Center have found that weight loss, in combination with vitamin D supplementation, has a greater effect on reducing chronic inflammation than weight loss alone. Chronic inflammation is known to contribute to the development and progression of several diseases, including some cancers.

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Discovery Promises New Treatments to Thwart Colon Cancer

Scientists at St. Jude Children’s Research Hospital have discovered how an immune system protein, called AIM2 (Absent in Melanoma 2), plays a role in determining the aggressiveness of colon cancer. They found that AIM2 deficiency causes uncontrolled proliferation of intestinal cells.

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Team Shows AIDS Vaccine Candidate Successfully ‘Primes’ Immune System

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New research led by scientists at The Scripps Research Institute, International AIDS Vaccine Initiative and The Rockefeller University shows in mice that an experimental vaccine candidate designed at TSRI can stimulate the immune system activity necessary to stop HIV infection.

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Keeping a Lid on Inflammation

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Although critically important for shaping the immune response and maintaining self-tolerance, how regulatory T cells (Treg cells) hold on to their immune-suppressive powers had remained unclear. Now, for the first time, researchers at the La Jolla Institute for Allergy and Immunology identified a molecular pathway that maintains the stability and function of Treg cells.

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Focused Ultrasound Could Play a Role in Cancer Immunotherapy

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Cancer immunotherapies are agents that harness the power of the immune system to fight cancer. Unlike traditional cancer treatments that directly kill tumor cells (such as chemotherapy and radiation), immunotherapy operates through the intermediary of the immune system. Immunotherapies empower the immune system to specifically seek out and destroy cancer cells.

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First Functional, Synthetic Immune Organ with Controllable Antibodies Created by Engineers

Cornell University engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism. The engineered organ has implications for everything from rapid production of immune therapies to new frontiers in cancer or infectious disease research.

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How a Gut Feeling for Infection Programmes Our Immune Response

An unexpected finding by an international team of scientists based at The University of Manchester and National Institutes of Health in America has shed new light on how immune cells are programmed to either repair or protect the body.

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Yin and Yang: Immune Signaling Protein Has Opposing Roles in Breast Cancer Development

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Countering previously held beliefs, researchers at The University of Texas MD Anderson Cancer Center have discovered that inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers.

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Homing in on What's Wearing Out T Cells

When the T cells of your immune system are forced to deal over time with cancer or a chronic infection they become exhausted - less effective at attacking and destroying invaders. While the PD-1 protein pathway has long been implicated as a primary player in T cell exhaustion, a major question has been whether PD-1 actually directly causes exhaustion. A new paper seems to, at least partially, let PD-1 off the hook.