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A reporter's PressPass is required to access this story until the embargo expires on 27-Oct-2014 9:00 AM EDT

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MicroRNA Molecules Serve as On/Off Switches for Inflammation

University of Utah scientists have identified two microRNA molecules that control chronic inflammation, a discovery that one day may help researchers prevent certain fatal or debilitating conditions before they start.

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Efficacy of Potential Therapy for Autoimmune Disorder of Muscle Weakness

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Researchers have made a fast-acting “vaccine” that can reverse the course of myasthenia gravis, a non-inherited autoimmune form of muscle weakness, in an animal model of the disease.

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Scientists Discover Pain Receptor on T-Cells

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Researchers at University of California, San Diego School of Medicine have discovered that T-cells – a type of white blood cell that learns to recognize and attack microbial pathogens – are activated by a pain receptor.

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Diet Affects Mix of Intestinal Bacteria and the Risk of Inflammatory Bone Disease

Diet-induced changes in the gut’s bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children’s Research Hospital scientists reported. The findings appeared September 28 as an advanced online publication of the scientific journal Nature.

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Gut Bacteria Are Protected by Host During Illness

To protect their gut microbes during illness, sick mice produce specialized sugars in the gut that feed their microbiota and maintain a healthy microbial balance. This protective mechanism also appears to help resist or tolerate additional harmful pathogens, and its disruption may play a role in human diseases such as Crohn’s disease.

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Virginia Tech Researchers Discover Potential Biomarker to Detect ‘Bubble Boy’ Disorder

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A genetic disease called SCID forces patients to breathe filtered air and avoid human contact because their bodies cannot fight germs. Now, using a mouse model, Virginia Tech researchers describe a potential biomarker to detect SCID.

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Transplant Drug Could Boost the Power of Brain Tumor Treatments, U-M Study Finds

Every day, organ transplant patients around the world take a drug called rapamycin to keep their immune systems from rejecting their new kidneys and hearts. New research suggests that the same drug could help brain tumor patients by boosting the effect of new immune-based therapies.

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Surprising Diversity of Antibody Family Provides Clues for HIV Vaccine Design

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Scientists at The Scripps Research Institute (TSRI) have described how a single family of antibodies that broadly neutralizes different strains of HIV has evolved remarkably diverse structures to attack a vulnerable site on the virus. The findings provide clues for the design of a future HIV vaccine.

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Imaging Studies Open a Window on How Effective Antibodies Are Formed

Sometimes, in order to understand what’s happening in the immune system, you just have to watch it. By imaging the immune response, researchers have observed how two types of immune cells, T and B cells, interact with one another during a critical period following infection in order to prepare the best antibodies and establish long-lasting protection.

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