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Ebola Whole Virus Vaccine Shown Effective, Safe in Primates

An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 29-Mar-2015 12:05 PM EDT

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UCLA Researchers Combine Benefits of Immunotherapy and Cancer-Targeted Treatment in Triple Combo Drug for Melanoma

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Results of a new study by UCLA researchers has found that a groundbreaking new triple combination therapy shows promising signs of more effectively controlling advanced melanoma than previous BRAF + MEK inhibitor or BRAF inhibitor + immunotherapy combos alone, and with increased immune response and fewer side effects.

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New Antibody Therapy Dramatically Improves Psoriasis Symptoms in Clinical Trial

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Many patients suffering from psoriasis showed significant recovery after just a single dose of an experimental treatment with a human antibody that blocks an immune signaling protein crucial to the disease, researchers report. By the end of the trial, conducted at Rockefeller University and seven other centers, nearly all of the 31 patients to receive treatment saw dramatic, if not complete, improvement in their symptoms.

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New Antibody Therapy Dramatically Improves Psoriasis Symptoms in Clinical Trial

150313_krueger_psoriasis.jpg

Many patients suffering from psoriasis showed significant recovery after just a single dose of an experimental treatment with a human antibody that blocks an immune signaling protein crucial to the disease, researchers report. By the end of the trial, conducted at Rockefeller University and seven other centers, nearly all of the 31 patients to receive treatment saw dramatic, if not complete, improvement in their symptoms.

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Immune System-in-a-Dish Offers Hope for “Bubble Boy Disease"

Salk researchers have been able to grow patient-derived, healthy cells in the lab, coming a step closer to treating fatal blood disorders

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Tetanus Shot Improves Patient Survival with Brain Tumor Immunotherapy

An innovative approach using a tetanus booster to prime the immune system enhances the effect of a vaccine therapy for lethal brain tumors, dramatically improving patient survival, according to a study led by Duke Cancer Institute researchers.

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Radiation Plus Immunotherapy Combo Revs up Immune System to Better Attack Metastatic Melanoma, Penn Study Suggests

Treating metastatic melanoma with a triple threat—including radiation therapy and two immunotherapies that target the CTLA4 and PD-1 pathways—could elicit an optimal response in more patients, one that will boost the immune system’s attack on the disease, suggests a new study from a multidisciplinary team of researchers from Penn’s Abramson Cancer Center published today in Nature.

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Experimental Herpes Vaccine Upends Traditional Approach and Shows Promise

Scientists at Albert Einstein College of Medicine have designed a new type of vaccine that could be the first-ever for preventing genital herpes—one of the most common sexually transmitted diseases, affecting 500 million people worldwide. Using a counterintuitive approach, researchers were able to prevent both infections caused by herpes simplex virus type 2, which causes genital herpes. Findings from the research, conducted in mice, were published today in the online journal eLife.

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Novel Gene Variants Discovered in a Difficult Childhood Immune Disorder

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Genomics researchers analyzing common variable immunodeficiency disease (CVID) in children have discovered links to a gene crucial to the body’s defense against infections. The finding may represent an inviting target for drug treatment.