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Novel Gene Variants Discovered in a Difficult Childhood Immune Disorder

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Genomics researchers analyzing common variable immunodeficiency disease (CVID) in children have discovered links to a gene crucial to the body’s defense against infections. The finding may represent an inviting target for drug treatment.

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Breastfeeding, Other Factors Help Shape Immune System Early in Life

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Henry Ford Hospital researchers say that breastfeeding and other factors influence a baby’s immune system development and susceptibility to allergies and asthma by what’s in their gut.

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Virus-Cutting Enzyme Helps Bacteria Remember a Threat

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Bacteria may not have brains, but they do have memories, at least when it comes to viruses that attack them. Many bacteria have a molecular immune system which allows these microbes to capture and retain pieces of viral DNA that they have encountered in the past, in order to recognize and destroy it when it shows up again.

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Possible Strategy Identified to Combat Major Parasitic Tropical Disease

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Research led by St. Jude Children’s Research Hospital scientists has identified a potential target in the quest to develop a more effective treatment for leishmaniasis, a parasitic tropical disease that kills thousands and sickens more than 1 million people worldwide each year. The findings were published online in the Journal of Clinical Investigation.

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Combating Bacterial Infections Through Immunoengineering

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A collaboration between Clarkson University and the Trudeau Institute aims to improve the fight against bacterial infections through immunoengineering.

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UTSW Researchers Find New Mechanism That Controls Immune Responses

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UT Southwestern Medical Center researchers have identified a common signaling mechanism to produce interferon − one of the main proteins used to signal the immune system when the body needs to defend itself against a virus, tumor, or other diseases.

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Key to Blocking Influenza Virus May Lie in a Cell’s Own Machinery

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Viruses are masters of outsourcing, entrusting their fundamental function – reproduction – to the host cells they infect. But it turns out this highly economical approach also creates vulnerability.

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Napping Reverses Health Effects of Poor Sleep

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A short nap can help relieve stress and bolster the immune systems of men who slept only two hours the previous night, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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First “Humanized” Mouse Model of Sjögren’s Syndrome Opens Door to Study Other Autoimmune Diseases

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Despite the prevalence of Sjögren’s syndrome – an autoimmune disease most commonly known for causing dry eyes and mouth - a lack of knowledge about how the condition starts has stalled the development of new treatments. Researchers have now developed a specialized animal model of Sjögren’s that engrafts human cells into mice, allowing scientists to track various factors that affect disease development and discover potential new therapies.