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Medicine

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Newly Discovered Immune Cell Type Protects Against Lung Infections During Chemotherapy

St. Jude Children’s Research Hospital scientists have discovered a previously unrecognized form of macrophage in mice; the immune cells survived chemotherapy and protected against life-threatening lung infections.

Medicine

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pembrolizumab, Keytruda, Head And Neck Cancer, Metastatic Cancer, burtness

Pembrolizumab Approval Is Tip of the Iceberg for Immunotherapy in HNSCC

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Immunotherapy is a big change for head and neck cancer and there seems to be no doubt that there is activity for immunotherapies with pembrolizumab as well as nivolumab [Opdivo]” said Burtness, professor of Medicine at Yale Cancer Center.

Medicine

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Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, Atopic Dermatitis, Eczema, Pediatrics, Dermatology, Pediatric Dermatology, Immunology

Pediatric Atopic Dermatitis May Benefit From Early Immune Intervention

Mount Sinai researchers identify association between pediatric eczema and large abnormalities in non-lesional skin and multi T lymphocyte axes activation

Medicine

Science

Channels:

Immunotherapy, Treg cells, Autoimmune Disease, Gastrointestinal Cancers

Ludwig Study Exposes Key Requirement for Regulatory T Cell Function

A Ludwig Cancer Research study published online September 5th in Nature Immunology illuminates a key requirement for the function of regulatory T cells—immune cells that play a critical role in many biological processes, from suppressing inflammation and deadly autoimmunity to helping tumors evade immune attack. The findings also unravel the complex role these cells can play in the genesis and progression of certain gastrointestinal cancers.

Science

Channels:

Ut Southwestern, Neutrophils, abscopal effect, Cancer, Radiation Therapy, tumor-associated neutrophils, radiation-induced neutrophils, RT-Ns

Neutrophils Are Key to Harnessing Anti-Tumor Immune Response From Radiation Therapy, Study Finds

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Combining targeted radiation therapy with a neutrophil stimulant enhances anti-tumor immunity, according to new research into cancer immunology at UT Southwestern Medical Center.

Medicine

Channels:

Immunotherapy, Leukemia, Acute Myeloid Leukemia (AML), Natural Killer Cells

New Immunotherapy for Leukemia Shows Promise in Small Clinical Trial

'Training' immune cells boosts effectiveness in patients with AML

Medicine

Channels:

Pneumonia, Vaccine, Treatment, Bacteria, Mississippi State University, Ear Infection, Immune System, Antibiotic, Pathogen, Cobre

Improved Pneumonia Treatment Focus of Current MSU Research

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Streptococcus pneumoniae likely is not a term immediately recognizable by most individuals, even if they have had unpleasant run-ins with the common bacterium. However, experts at Mississippi State University are pioneering pathways to new treatment options.

Medicine

Channels:

Tecfidera, dimethyl fumarate, multiple sclerosis, DMF, MS, Mechanism Of Action, T Cell, Immunology, Drug Development, Chemical Biology

TSRI Study Illuminates How Mystery MS Drug Works

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A study by scientists at The Scripps Research Institute has helped to de-mystify the molecular workings of the multiple sclerosis drug Tecfidera®. The drug is the most widely prescribed pill-based therapy for MS, but its biological mechanism remains mysterious.

Medicine

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Immune and Targeted Therapies with Radiation Therapy Improves Outcomes for Melanoma Brain Metastases Patients, Say Moffitt Researchers

In their most recent Annals of Oncology publication, Moffitt researchers sought to determine if patients with melanoma brain metastases treated with immune and targeted therapies had improved outcomes over patients treated with conventional chemotherapy. They retrospectively analyzed data from 96 patients with melanoma brain metastases who were treated with stereotactic radiation therapy within 3 months of different targeted therapies (anti–PD-1 therapy, anti–CTLA-4 therapy, BRAF inhibitor plus a MEK inhibitor, or a BRAF inhibitor alone) or conventional chemotherapy.

Medicine

Science

Life

Business

Law and Public Policy

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Presidential Debate: Expert Panel Gives Scientific Analysis of Candidates' Performances

Four expert panelists each day will present their analyses and answer your questions live and face-to-face. This event will be virtual. You can attend with any device -- PC, Mac, iPad, iPhone or Android device (with a webcam) – anywhere with good bandwidth. To participate (ask questions) in the meeting, you must be on video, just as a normal news conference. Register below for guaranteed seating; there is limited seating in the virtual room. Eight experts (four at each event) will present their analyses. The diverse expert team (7 universities and an institute) will analyze both candidates during the debates for their gestures, facial expressions (including smiles--number, type, appropriateness, etc.), posture, language, including sentiment, tone, inflammatory language, repetition, vocabulary, sentence structure, metaphors, framing, themes, suggestions, subtlety, nuance, honesty (deceit/lies—explicit and implicit), transparency, gender issues, and more...

Medicine

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thyroidology, Thyroid Disease

Plenary and Award Lectures, Latest Research on Thyroid Disease and Cancer, Hot Topic Debates, and Oral and Poster Presentations Featured at American Thyroid Association Annual Meeting

Key opinion leaders, thyroid specialists, clinical and basic researchers, and young trainees will come together for five exciting and information-filled days of symposia, scientific presentations, and discussions on the latest advances in thyroidology and clinical management of thyroid disease as members of the American Thyroid Association (ATA) gather in Denver, Colorado for the 86th Annual Meeting of the ATA. With nearly 1300 registered attendees to date, and 395 regular abstracts and 77 late breaking abstracts submitted, the meeting promises to be an outstanding educational and networking opportunity.

Medicine

Science

Business

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GBSI, Antibody Validation, Antibody, Antibodies, irreproducibility, Irreproducible, Reproducibility, Freedman, Leonard Freedman, Leonard P. Freedman, PhD, Global Biological Standards Institute , Asilomar

GBSI’s Workshop Gathers 100+ Biomedical Research Experts at Asilomar to Develop the First Practical, Implementable Antibody Validation Guidelines

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Global Biological Standards Institute (GBSI) gathers 100+ biomedical research experts from around the world next week at the scientifically historic Asilomar Conference Grounds in California for a workshop to discuss, define and vote on the first detailed standardized guidelines for validating research antibodies. Antibody Validation: Standards, Policies, and Practices will build upon the conceptual framework published September 5, in Nature Methods, in order to establish practical, applicable and implementable antibody validation guidelines. A webcast press briefing will present broad consensus-based outcomes September 28. Follow along on Twitter with #AbValidate.

Medicine

Channels:

Cancer, Immunotherapy, Immunology, cancer immunotherapy, Molecular Medicine

Molecular Switch Controlling Immune Suppression May Help Turn Up Immunotherapies

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Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to maximize the effectiveness of anti-cancer immune therapy. The researchers identified a molecular switch that controls immune suppression, opening the possibility to further improving and refining emerging immunotherapies that boost the body’s own abilities to fight diseases ranging from cancer to Alzheimer’s and Crohn’s disease.

Medicine

Channels:

Melanoma, Skin Cancer, Immunology, sznol, Immune System, immunotheraphy

Treating Skin Cancer Using the Body's Immune System

Medicine

Channels:

Cancer, Immunotherapy, cancer immunotherapy, immune-based therapies, The Cancer Genome Atlas, genome-wide associated studies

Researchers Say to Conquer Cancer You Need to Stop It Before It Becomes Cancer

In a Perspective piece published this week in PNAS, cancer researchers from across the country, including faculty at University of California San Diego School of Medicine and Moores Cancer Center, write that a greater emphasis on immune-based prevention should be central to new efforts like the federal Cancer Moonshot program, headed by Vice President Joe Biden.

Medicine

Channels:

Autoimmune, Autoimmune Advocacy, phrma, Lupus, Myositis, Psoriasis, Research, Sjogren's Syndrome, Type 1 Diabetes

AARDA Founder and Executive Director Virginia T. Ladd Named 2016 Research & Hope Award Recipient by PhRMA

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Ladd was one of six patient advocates and researchers PhRMA cited for their tireless efforts to advance the treatment and care of patients with autoimmune diseases, a group of more than 100 diseases in which a person’s own immune system attacks the body’s healthy tissues and cells.

Medicine

Channels:

Acute, Pancreatitis, Loyola, Liver, Necrotizing, Stomach, Vomit, Chronic Disease, Fatal, Chronic, Ambulance, IV, Pancreatic Cancer, Cancer, Abdomen, Organ, trasnplant, Transplant, Digestive Health, Gastroenterologist, Gastroenterology, inflamed, Inflammation, Bacterial Infection, Pseudocyst

Loyola Patient Overcomes Rare Acute Necrotizing Pancreatitis

Larry Jacob got the call every parent fears. His daughter was sick, away at college and needed help. Mr. Jacob left his home in the Chicago suburbs and was driving to Western Illinois University when he suddenly doubled over in pain. "I pulled on to the shoulder of the road, buckled over and began throwing up," the 51 year-old remembers. "Ironically, I was going to care for my daughter and now I was the one getting ill. I felt like an 800 pound elephant was sitting on my stomach."

Medicine

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More Than 1,300 Leading Pathologists to Collaborate About Immunotherapy Strategies at CAP Annual Meeting

Leading pathologists will collaborate in Las Vegas to discuss the specialty's role in the promising area of immunotherapy, as well as several other health care issues at the annual meeting of the College of American Pathologists.

Medicine

Channels:

Annual Meeting, media registration, Pathology, Molecular Diagnostics, liquid biopsy, Immunotherapies, Laboratory Developed Procedures, Microbiome, AMP, PAMA, Eric Lander

Media Alert: Complimentary Media Registrations for Upcoming Association for Molecular Pathology 2016 Annual Meeting

Complimentary media registration packages are available for AMP's upcoming 2016 Annual Meeting in Charlotte, North Carolina.

Medicine

Channels:

HIV, AIDS, Vaccine, glycoprotein trimer, Immunology, Virology, rational vaccine design

TSRI Scientists Discover Antibodies that Target Holes in HIV’s Defenses

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A new study from scientists at The Scripps Research Institute shows that “holes” in HIV’s defensive sugar shield could be important in designing an HIV vaccine.







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