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Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial

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In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana-Farber Cancer Institute and other organizations report.

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Researchers Thwart Cancer Cells By Triggering ‘Virus Alert’

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system “virus alert” that may one day boost cancer patients’ response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells’ ability to avoid detection and destruction by the immune system.

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Mammary Gland Is Shaped by Adaptive Immune System During Development

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty.

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Tiny Antibodies Point to Vulnerability in Disease-Causing Parasites

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially ‘drugable’ target that could prevent parasites from entering and exiting host cells.

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New Research Helps Explain Why a Deadly Blood Cancer Often Affects Children with Malaria

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Children in equatorial Africa who suffer from malaria are at high risk of developing Burkitt’s lymphoma, a highly aggressive blood cancer. A new study sheds light on the long-standing mystery of how the two diseases are connected.

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Traitors in Our Midst: Bacteria Use Toxins to Turn Our Own Bodies Against Us

Researchers who have revealed a highly efficient way that bacteria use toxins to interrupt the immune response say that until now, the trickery of these toxins has been underappreciated in science.

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Scripps Florida Scientists Show How Aging Cripples the Immune System, Suggesting Benefits of Antioxidants

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Scientists from the Florida campus of The Scripps Research Institute have shown how aging cripples the production of new immune cells, decreasing the immune system’s response to vaccines and putting the elderly at risk of infection.

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New Insight Into How the Immune System Sounds the Alarm

Salk scientists unveil how a critical molecule turns on T cells.

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How to Become a T Follicular Helper Cell

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Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the molecular signals that drive their differentiation had remained unclear. Now, a team of researchers at the La Jolla Institute for Allergy and Immunology has identified a pair of master regulators that control the fate of TFH cells.

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Diversion of an HIV Vaccine Immune Response by Antibodies Reactive with Gut Microbiome

A recent HIV vaccine trial testing the HIV envelope as an immunogen was unsuccessful for protection against HIV infection. A new study has found that this vaccine selectively recruited antibodies reactive with both the HIV envelope and common intestinal microbes — a phenomenon previously reported by the same investigators to occur in the setting of acute HIV infection.