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A reporter's PressPass is required to access this story until the embargo expires on 29-Jul-2016 2:00 PM EDT

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Scientists Use Already-Approved Drugs to Force Cancer Cell Death, How to Decide if Watchful Waiting Is the Right Choice, Some Adolescent Cancer Survivors May Require More Comprehensive Mental Health Screening, and MORE in the Cancer News Source

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Research Offers New Hope for Understanding Deadly Infections

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Research published today in the journal, Nature Communications, provides new insights into the evolution of Mucorales fungi, which cause a fatal infection in ever-increasing segments of patient population, and several molecular pathways that might be exploited as potential therapeutic or diagnostic targets.

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Technology Improves Clinical Trial Management and Patient Experience

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UAB has implemented a new application suite to improve clinical trial management, and enhance communication among trial sites and with study participants.

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Genetic Drivers of Immune Response to Cancer Discovered Through ‘Big Data’ Analysis

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Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified over 100 new genetic regions that affect the immune response to cancer. The findings, published in Cancer Immunology Research, could inform the development of future immunotherapies—treatments that enhance the immune system’s ability to kill tumors. By analyzing a large public genomic database, the scientists found 122 potential immune response drivers—genetic regions in which mutations correlate with immune cell infiltration into tumors.

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Scientists Find a New Way to Protect Against Lethal Fungal Infections

Scientists at the Institute of Molecular Biotechnology (IMBA) and the Max F. Perutz Laboratories (MFPL) in Vienna have discovered a new way to turn the immune system’s weapons against fungal invaders. This knowledge could lead to the development of new and improved anti-fungal treatments.

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Long Noncoding RNA Found to Quell Inflammation

WORCESTER, MA - A long non-coding RNA (lincRNA) - called lincRNA-EPS - responsible for regulating innate immunity has been identified by a team of scientists at the University of Massachusetts Medical School. Abundantly found in macrophages, lincRNA-EPS keeps the genes that trigger inflammation turned off until a pathogen is encountered. This discovery points to an unrecognized role for lincRNAs in the immune system and may lead to new insights into inflammatory diseases caused by uncontrolled immune responses such as lupus or inflammatory bowel disease.

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Checkpoint in B Cell Development Discovered with Possible Implications on Vaccine Potency

University of Alabama at Birmingham researchers report a new quality-control checkpoint function in developing B cells, cells that produce antibodies to protect the body from pathogens.

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New Research Studies Identify Potential Cause of and New Treatment for Autoimmune Diseases

The American Autoimmune Related Diseases Association, Inc. (AARDA) is spotlighting two new research studies originally reported in ScienceDaily.

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2016 Recommendations for Antiretroviral Drugs for the Treatment and Prevention of HIV Infection in Adults

In a report appearing in the July 12 issue of JAMA, an HIV/AIDS theme issue, Huldrych F. Gunthard, M.D., of University Hospital Zurich, Switzerland, and colleagues with the International Antiviral Society-USA panel, updated recommendations for the use of antiretroviral therapy in adults with established HIV infection, including when to start treatment, initial regimens, and changing regimens, along with recommendations for using antiretroviral drugs for preventing HIV among those at risk, including preexposure and postexposure prevention.

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Brain Inflammation Linked to Depression in Multiple Sclerosis

Philadelphia, PA, July 7, 2016 - Patients with multiple sclerosis have higher rates of depression than the general population, including people with other life-long disabling diseases. Symptoms of multiple sclerosis arise from an abnormal response of the body's immune system. Immune response has also been linked to depression, leading researchers to think it could be a shared pathological mechanism that leads to the increased rates of depressive symptoms in patients with multiple sclerosis.

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Research Brings New Understanding of Chronic Inflammatory Disease

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Research from life scientists at The University of Manchester has shone new light on the way cells tune in to different inflammatory signals to understand what is happening in the body.

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When Suppressing Immunity Is a Good Thing

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A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.

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LJI Researchers Reveal Dominant Player in Human T Helper Cell Maturation

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A powerful arm of the immune system is production of antibodies that circulate through the blood and neutralize invading pathogens. Although B cells actually manufacture antibody proteins, the process is aided by neighboring T cells, which shower B cells with cytokines to make them churn out high-quality antibody proteins—and remember how to do so. Given the essential function of "helper" T cells, researchers have long sought to define biological signals that encourage their development.

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Viral Protein Silences Immune Alarm Signals

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Viruses must avoid a host’s immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. New research demonstrates a novel mechanism by which viruses shut down alarm signals that trigger immune responses. This finding may open the door to future tools for controlling unwanted inflammation in severe infections, cancers and other settings.

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“Inflamm-Aging:” Alcohol Makes It Even Worse

The immune system in the elderly is dysfunctional and infections are more prevalent, more severe, and harder to defeat. Drinking alcohol has a variety of damaging effects on the immune system and organs – like the gut, liver and lung – which can be worsened by pre-existing conditions as well as consumption of prescription and over-the-counter medications that aged individuals often take. This presentation addresses how alcohol affects the elderly more dramatically, and also suppresses their ability to battle infections, like pneumonia, much more severely than it does younger individuals.

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Metabolic Flexibility and Immune Defenses May Influence Species Spread

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Wide-ranging species may have different levels of bacterial immunity than their rarer relatives, new research suggests.

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A reporter's PressPass is required to access this story until the embargo expires on 31-Jul-2016 12:00 AM EDT

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Dengue Virus Exposure May Amplify Zika Infection

Previous exposure to the dengue virus may increase the potency of Zika infection, according to research from Imperial College London.

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Zika Mosquitoes Differ From West Nile Mosquitoes; First Zika Vaccine to Be Tested in Human Clinical Trial; Potential Drug Target Identified for Zika, and MORE in the Zika Virus News Source

Go here for the latest research, experts and features on Zika in the Zika Virus News Source