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Vaccine Therapy for Prostate Cancer Patients with Rising PSA Examined

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Aiming to increase treatment options for prostate cancer patients who have an early relapse, investigators from a multi-institutional cooperative group – including Rutgers Cancer Institute of New Jersey – have demonstrated that a vaccine therapy that stimulates the body’s own immune defenses can be given safely and earlier in the course of prostate cancer progression.

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Cells Identified That Enhance Tumor Growth and Suppress Anti-Cancer Immune Attack

A study led by St. Jude Children’s Research Hospital scientists has identified the population of white blood cells that tumors use to enhance growth and suppress the disease-fighting immune system. The results, which appear in the December 18 edition of the scientific journal Immunity, mark a turning point in cancer immunology and provide the foundation for developing more effective immunotherapies.

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Multiple Allergic Reactions Traced to Single Protein

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Johns Hopkins and University of Alberta researchers have identified a single protein as the root of painful and dangerous allergic reactions to a range of medications and other substances. If a new drug can be found that targets the problematic protein, they say, it could help smooth treatment for patients with conditions ranging from prostate cancer to diabetes to HIV.

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Extra Vitamin E Protected Older Mice from Getting Common Type of Pneumonia

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Extra vitamin E protected older mice from a bacterial infection that commonly causes pneumonia. The study from researchers at Tufts University found that extra vitamin E helped regulate the mice’s immune system.

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Baylor Research Could Lead to Development of Novel Vaccines from Flu to HIV

Baylor Research Institute investigators found that the lipoprotein LOX-1 promotes humoral responses, which could allow researchers to design effective vaccines against microbial infections.

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Macrophages Chase Neutrophils Away From Wounds to Resolve Inflammation

Macrophages are best known for their Pac Man–like ability to gobble up cellular debris and pathogens in order to thwart infection. A new study describes how these immune cells also help resolve inflammation by inducing white blood cells called neutrophils to leave wounded tissue.

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New Signaling Role for Key Protein May Contribute to Wound Healing, Tumor Growth and Inflammatory Diseases

A key protein may represent a new way to use the immune system to speed healing and counter inflammatory, infectious and autoimmune diseases, according to study led by researchers at the Icahn School of Medicine at Mount Sinai and published in the December issue of Cell Reports.

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Protein Predicts Response to New Immunotherapy Drug

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The presence of an immune-suppressing protein in non-cancerous immune cells may predict how patients with different types of cancer respond to treatment, a multi-center phase I study using an investigational immune therapy drug has found. The study, led by a Yale Cancer Center investigator, is described in the Nov. 27 edition of the journal Nature.

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Vaccines May Make War on Cancer Personal

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In the near future, physicians may treat some cancer patients with personalized vaccines that spur their immune systems to attack malignant tumors. New research led by scientists at Washington University School of Medicine in St. Louis has brought the approach one step closer to reality.

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Researchers Tease Out Glitches in Immune System’s Self-Recognition

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Fast facts: • In order to distinguish self from other, the immune system processes proteins from inside and outside the body in different ways. • A new study revises understanding of how the process works and sheds light on autoimmune disease.

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