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Cytokine May Play a Major Role in Multiple Sclerosis

Researchers discover the role of a major cytokine in multiple sclerosis that could be a target for new therapy against the disease.

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University of Louisville Researchers Detail Role of Silica and Lung Cancer

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Researchers at the University of Louisville have detailed a critical connection associated with a major environmental cause of silicosis and a form of lung cancer. Their study is reported in today’s Nature Communications.

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Trending Stories Report for 23 April 2015

Trending news releases with the most views in a single day. Topics include: diet supplements and cancer risk (3 days on top 10 list), oral mucositis in cancer treatment, updated breast cancer screening guidelines, climate change, materials science, asthma, mental health and gun violence, genetics and immunology, and multiple sclerosis treatment.

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Researchers Discover New Drugs to Combat the Root Cause of Multiple Sclerosis

New research published in Nature has found several drugs could lead to new treatment options for multiple sclerosis, including two drugs that effectively treat MS at the source, in vivo.

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Protein Identified That Serves as a “Brake” on Inflammation

Researchers have identified a protein that offers a new focus for developing targeted therapies to tame the severe inflammation associated with multiple sclerosis (MS), colitis and other autoimmune disorders. St. Jude Children’s Research Hospital scientists led the study which appears today in the scientific journal Immunity.

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Immune System Protein Regulates Sensitivity to Bitter Taste

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New research from the Monell Center reveals that tumor necrosis factor (TNF), an immune system regulatory protein that promotes inflammation, also helps regulate sensitivity to bitter taste. The finding may explain taste abnormalities and decreased food intake associated with infections, autoimmune disorders, and chronic inflammatory diseases.

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Iowa State, Ames Lab Scientists Describe Protein Pumps That Allow Bacteria to Resist Drugs

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Research teams led by Edward Yu of Iowa State University and the Ames Laboratory have described the structure of two closely related protein pumps that allow bacteria to resist certain medications.

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Experimental Immune Therapy Tested in Preliminary Study of Women with Triple-Negative Breast Cancer

Early data in a preliminary human study show that an experimental immune system drug is generally safe and well tolerated in women with metastatic, triple-negative breast cancer, a persistently difficult form of the disease to treat.

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Immunotherapy Combination Promising for Untreated Patients with Advanced Melanoma

A Phase 2 clinical trial led by Ludwig Harvard’s Stephen Hodi and Ludwig Memorial Sloan Kettering (MSK)’s Jedd Wolchok has found that the combination of two immunotherapies for first-line treatment of advanced melanoma induces better responses and far longer progression-free survival than giving one of those drugs alone. Further, the combination was effective in the portion of melanoma patients—the majority—who currently have few effective treatment options. The results of the trial, which compared a combination of checkpoint inhibitors ipilimumab and nivolumab against ipilimumab alone in previously untreated patients, were presented today at the 2015 Annual Meeting of the American Association for Cancer Research and have been simultaneously published in the New England Journal of Medicine.

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UNM Cancer Center Opens International Clinical Trial for Personalized Kidney Cancer Vaccine

The University of New Mexico Cancer Center enrolled its first patient in a phase 3 clinical trial that uses a person’s own kidney cancer cells to make a vaccine tailored to kill those cells.