After boys and young men with Duchenne muscular dystrophy received cardiac progenitor cell infusions, medical tests indicated that the patients’ hearts appeared improved, results from a new study show. Patients in the study also scored higher on arm strength tests after receiving the cell infusions.
Seattle Children’s today launched a $1 billion initiative, It Starts With Yes: The Campaign for Seattle Children’s, with a bold vision: to transform children’s health. It Starts With Yes is the largest campaign in Seattle Children’s 110-year history.
A research team at The University of Texas at El Paso is one step closer to developing an effective human vaccine for cutaneous leishmaniasis, a tropical disease found in Texas and Oklahoma, and affecting some U.S. troops stationed in Afghanistan and Iraq.
Seven years ago Cincinnati Children’s scientists first used pluripotent stem cells to mimic natural human development and grow working human intestine in a lab. Today medical center doctors can bioengineer the gastrointestinal tissues of sick children to find clues about a child’s disease and how to treat it. Cincinnati Children’s is building on this early research advancement in personalized medicine by launching the Center for Stem Cell and Organoid Medicine (CuSTOM).
In a study published in Stem Cell Reports, Rui Zhao and colleagues have partly solved a long-unanswered basic question about stem cells — why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate?
Brahim Chaqour, PhD, professor of cell biology and ophthalmology at SUNY Downstate Medical Center, has received two awards to support research into treatment of currently incurable vision-threatening diseases. The new awards, totaling $2,008,973, are from the National Eye Institute of the National Institutes of Health (NIH).
New research from the University of Maryland School of Medicine suggests that the system for choosing transplant recipients in chronic obstructive pulmonary disease (COPD) may underestimate how long a person might survive without a lung transplant and therefore, may mislead clinicians.
A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant “driver” mutation that can be treated in isolation with a single targeted drug.
Primary liver cancer is now the second leading cause of cancer-related death worldwide, and its incidences and mortality are increasing rapidly in the United Stated. In late stages of the malignancy, there are no effective treatments or drugs. However, an unexpected finding made by a team of University of California San Diego School of Medicine researchers sheds light on the development of a new strategy for prevention of liver cancer.
Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?
Results from two early clinical trials show that it may be possible to use human embryonic stem cells as treatment for the dry form of macular degeneration, according to presentations given today at AAO 2017, the 121st Annual Meeting of the American Academy of Ophthalmology.
The American Society for Cell Biology (ASCB) is pleased to announce the 2017 cohort of ASCB Fellows. The honor of being named an ASCB Fellow is bestowed to ASCB members by their peers. Fellows are recognized for their meritorious efforts to advance cell biology and its applications and for their service to ASCB.
In experiments with mice that have a rodent form of Marfan syndrome, Johns Hopkins researchers report that even modestly increasing stress on the animals’ hearts — at levels well-tolerated in normal mice — can initiate heart failure. The findings, described August 4 in the Journal of Clinical Investigation Insight, revealed a novel cellular pathway in heart tissue that leads to heart failure and may serve as a model for a new standard of treatment for children with this aggressive form of Marfan syndrome.
Researchers at Queen’s University Belfast together with the University of Vienna have discovered that treatment for the antibiotic resistant bacteria Klebsiella pneumoniae could lie within our bodies’ natural defences.
It takes less than one-tenth of a second — a fraction of the time previously thought — for the sense of smell to distinguish between one odor and another, new experiments in mice show.
Scientists have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease.
In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF activity, paves the way for blood tests to predict which patients will respond to allergy therapy, and strongly supports the idea that drugs designed to block HRF could prevent food allergy attacks.
UT Southwestern’s O’Donnell Brain Institute will help in an international effort to map and characterize all the cells in the human body, an ambitious project aimed at gaining insight into how cellular changes can cause disease.
Wistar researchers discovered a novel form of crosstalk among tumor cells and other cell types in the tumor microenvironment, elucidating the mechanism of action of an immunotherapeutic strategy that inhibits tumor-associated macrophages (TAMs) and instructing a more effective use of this therapeutic approach. This work was published online in Cancer Cell.
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
Although estimates vary, scientists believe that 50 to 64 percent of the risk of alcohol use disorders (AUDs) is inherited. One way to identify this risk is through a person’s subjective response to alcohol. This study investigated the effects of two single-nucleotide polymorphisms (SNPs) or changes in DNA sequence called rs279858 (in the GABRA2 gene) and rs2832407 (in the GRIK1 gene) – previously linked to AUD risk – on individuals’ subjective responses to intravenously administered alcohol.
Ludwig Cancer Research has released the scope of its participation at this year’s Annual Meeting and Education Day of the Society for Neuro-Oncology in San Francisco, California, November 16-19.
A research team has identified the pathological mechanism for a certain type of autism and intellectual disability by creating a genetically modified mouse. They are hopeful it could eventually lead to a therapeutic fix.
Researchers at SBP have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries and stroke.
Editor's Highlights include papers on aryl hydrocarbon receptor activation and neutrophil function; transcriptomic analysis of TCE and PCE in the liver and kidney; functional genomics of TCE metabolites genotoxicity; and increased aflatoxin b1 damage in pregnant mice.
Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.
Inside cells, protein “motors” act like trucks on tiny cellular highways to deliver life-sustaining cargoes. Now a team led by Rutgers University–New Brunswick researchers has discovered how cells deploy enzymes to place traffic control and “roadway under construction” signs along cellular highways.
UC Santa Cruz’s genomics investigators have built a research powerhouse in sequencing, storing, cataloging, assembling, validating, and analyzing huge volumes of genomic data in their mission to use genomics to positively impact health, nature, and society. The UC Santa Cruz Genomics Institute is leading the effort to establish global standards to capture and share genomic data fairly and responsibly. Without a medical school and hospital, UCSC has become a neutral, trusted genomics research partner to medical institutions and universities around the world, contributing databases and research, and improving human health. This is made possible by its world-class computational abilities.
New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression.
A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.
Computer modeling has helped a team of scientists, including several scholars from the University of Chicago, to decode previously unknown details about the "budding" process by which HIV forces cells to spread the virus to other cells. The findings, published Nov. 7 in Proceedings of the National Academy of Sciences, may offer a new avenue for drugs to combat the virus.
In a report published this week (Nov. 8, 2017) in Science Advances, researchers from the University of Wisconsin-Madison detail a defined, step-by-step process to make a more exact mimic of the human blood-brain-barrier in the laboratory dish. The new model will permit more robust exploration of the cells, their properties and how scientists might circumvent the barrier for therapeutic purposes.
Elevated levels of chronic stress hormones, such as those produced by psychological distress, may promote resistance to drugs commonly used to treat lung cancer patients with EGFR mutations, according to new research from The University of Texas MD Anderson Cancer Center. Retrospective analysis of clinical patient data suggests that beta blocker drugs may slow or prevent the development of resistance to EGFR inhibitors.
Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that’s because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death. But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes cancer by suppressing immunosurveillance — a natural defense mechanism in which it’s thought the immune system suppresses cancer development. The study is published November 8 in Nature.
Human cells have a way of detecting and mending DNA damage caused by some common chemotherapy drugs, according to a new study from Washington University School of Medicine in St. Louis. The findings could have important implications for treating cancer.
The pancreatic cancer and immunotherapy experts at Memorial Sloan Kettering Cancer Center (MSK) have shown for the first time why some people with pancreatic cancer live many more years than others with the deadly disease.
Publishing online this week in Cell Host & Microbe, researchers at Johns Hopkins report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema. Toxin-producing bacteria on the surface of our skin induces a protein that causes our own cells to react and cause inflammation.
Rural counties continue to rank lowest among counties across the U.S., in terms of health outcomes. A group of national organizations including the Robert Wood Johnson Foundation and the National 4-H Council are leading the way to close the rural health gap.
Researchers have found a vital role for miR-204 in beta cells — regulating the cell surface receptor that is the target of many of the newer type 2 diabetes drugs, such as Byetta, Victoza, Trulicity, Januvia, Onglyza and Tradjenta. This drug target is the glucagon-like peptide 1 receptor, or GLP1R.
The delicately mannered dance between discerning eggs and vying sperm is more complicated than scientists once believed, and it may hold secrets about the evolution of new species.
A team of neuroscientists have developed an intervention that normalizes multiple biological functions in mice afflicted with Fragile X Syndrome.
Researchers in the University of Wisconsin–Madison Department of Biochemistry have discovered that a cellular pump known to move drugs like antibiotics out of E. coli bacteria has the potential to bring them in as well, opening new lines of research into combating the bacteria.
Researchers at the University of Michigan Life Sciences Institute found that a previously dismissed genetic mechanism may contribute to nicotine dependence, and to the withdrawal effects that can make quitting smoking so difficult.
Northwestern University molecular bioscientists have discovered that a little stress can be good for cellular health. The findings will help researchers better understand the molecular mechanisms that drive aging and risk for age-associated degenerative diseases.
Many cancers depend on glucose consumption for energy, but good pharmacological targets to stop cancers’ ability to uptake and metabolize glucose are missing. CU Cancer Center study finally identifies a way to restrict the ability of cancer to use glucose for energy.
Some of the first living things to greet a newborn baby do a lot more than coo or cuddle. In fact, they may actually help the little one’s digestive system prepare for a lifetime of fighting off dangerous germs. But these living things aren’t parents, grandparents or siblings – they’re helpful bacteria.
Research at the Southwest National Primate Research Center (SNPRC) on the campus of Texas Biomedical Research Institute helped advance a new treatment now in human trials for chronic hepatitis B virus (HBV) infection.
A study revealing a connection between circulating tumor cells (CTCs) and relapse in stage IV melanoma patients points to liquid biopsy as a potential predictor of patients at high risk for disease progression. CTCs, tumor cells shed into the bloodstream or lymphatic system, can lead to additional tumor growth and/or metastasis to distant sites. Findings from the study, led by Anthony Lucci, M.D., professor of Breast Surgical Oncology and Surgical Oncology at The University of Texas MD Anderson Center, will be presented at the Nov. 7 annual meeting of the Western Surgical Association.
Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer’s. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies to combat neurodegenerative diseases.
Want to restore hearing by injecting stem cells into the inner ear? Well, that can be a double-edged sword. Inner ear stem cells can be converted to auditory neurons that could reverse deafness, but the process can also make those cells divide too quickly, posing a cancer risk, according to a study led by Rutgers University–New Brunswick scientists.
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