A University of Iowa study examined people's preferences with respect to whether and how informed consent should be obtained for the collection and use of tissue samples for research. The results will help develop appropriate informed consent protocols for a new comprehensive tissue biobank.
1) Findings represent a critical step in personalizing cancer treatments; 2) Some early aberrations are required for development of later abnormalities.
A team of North Carolina State University researchers has discovered more about how a gene connected to the production of new brain cells in adults does its job. Their findings could pave the way to new therapies for brain injury or disease.
Scientists isolate single protein in potatoes responsible for an unhealthy compound produced when cooking at high temperatures.
Using the latest gene sequencing tools to examine so-called epigenetic influences on the DNA makeup of colon cancer, a Johns Hopkins team says its results suggest cancer treatment might eventually be more tolerable and successful if therapies could focus on helping cancer cells get back to normal in addition to strategies for killing them.
Using an innovative, precise gene therapy tool called genome editing, scientists treated the blood clotting disorder hemophilia in mice. It's the first time in vivo genome editing has achieved clinically meaningful results.
The MInerals, Metals & Materials Society (TMS) has assumed an international leadership role in supporting the development of Materials Genome Initiative introduced by President Barack Obama in his launch of the Advance Manufacturing Partnership (AMP) at Carnegie-Mellon University in Pittsburgh on June 24 and has experts available to provide comment and background on the President’s announcement of the initiative.
In a step toward personalized genomics, a research team has identified the disease-causing mutation in a newly characterized rare genetic disease, by analyzing DNA from just a few individuals.
Scientists practice a method to help discover specific genes that determine fruit traits.
The Association for Molecular Pathology (AMP) gave public comments at the US Food and Drug Administration’s (FDA) meeting on next generation sequencing and called on officials to partner with professional associations as they develop a program to evaluate sequencing based diagnostics.
Self-conscious about your age? Careful where you spit. UCLA geneticists now can use saliva to reveal how old you are. The June 22 advance online edition of the Public Library of Science ONE publishes the findings, which offer a myriad of potential applications. A newly patented test, for example, could offer crime-scene investigators a new forensic tool for identifying a suspect’s age.
A team of U.S. researchers has identified and compared the genetic codes for all known species of yeasts closely related to bakers’ and brewers’ yeast, which lays the foundation for future understanding of mutation and disease, as studies of yeasts often identify key genes and mechanisms of disease.
An international team of scientists led by researchers at the University of California, San Diego School of Medicine have used induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS) to reveal for the first time how reduced levels of a specific protein may play a central role in causing at least one inherited form of the disease.
Scientists turn to an exotic Chinese wheat cultivar in search of disease resistant genetics.
Johns Hopkins researchers have identified a natural mechanism that might one day be used to block the expression of the mutated gene known to cause Huntington’s disease. Their experiments offer not an immediate cure, but a potential new approach to stopping or even preventing the development of this relentless neurodegenerative disorder.
In an effort to unravel the tangled biology of autism, Johns Hopkins scientists have created a mouse model that mimics a human mutation of a gene known to be associated with autism spectrum disorders.
An international research team, co-led by scientists at Mayo Clinic’s campus in Florida, have discovered three potential susceptibility genes for development of progressive supranuclear palsy (PSP), a rare neurodegenerative disease that causes symptoms similar to those of Parkinson’s disease but is resistant to Parkinson’s medications. Their report is being published online June 19 in Nature Genetics.
Some lung-cancer patients at UT Southwestern Medical Center are responding well to potential new drug therapies targeting genetic mutations. Their participation in a national study is helping to forge new avenues to attack the disease.
Mice exposed to a high concentration of asbestos-contaminated dust, have a higher level of genetic somatic mutations, compared with other regions where asbestos pollution levels are lower. This has been shown in a new study.
Government guidelines published today on the use of dried blood spots collected during mandatory newborn screening underemphasize the importance of getting the public on board with the practice, according to University of Michigan researcher.
Tropical maize is a valuable genetic resource that can help scientists identify the specific genes controlling daylight response.
Over the past decade, much progress has been made regarding the understanding and promise of personalized medicine. Scientists are just beginning to consider the impact of gene-diet interactions in different populations in regards to disease prevention and treatment.
Researchers at Case Western Reserve University School of Medicine discovered a genetic factor that can regulate obesity-induced inflammation that contributes to chronic diseases. If the factor can be controlled, it may provide treatment for obesity, diabetes, heart disease and cancer.
A dramatically better computer tool for finding the genetic missteps that fuel cancer has been developed by St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project investigators. Researchers are using the new algorithm to help identify the chromosomal rearrangements and DNA insertions or deletions unique to cancer.
By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.
The GnuBIO System will make DNA sequencing scalable, simpler and more accessible.
GnuBIO achieves the highest accuracy and longest reads in the desktop DNA Sequencing market.
The 3rd Annual Consumer Genetics Conference, a yearly forum designed to spark meaningful conversation on the current state of direct-to-consumer genetics and shape the future of the field, will convene June 7 through June 9 at the Hynes Convention Center in Boston, Massachusetts.
Among various genetic mutations for individuals with Lynch syndrome, a hereditary cancer syndrome that carries a high risk of colon cancer and an above-normal risk of other cancers, researchers have identified mutations associated with a lower cancer risk and mutations associated with an increased risk for ovarian and endometrial cancer, according to a study in the June 8 issue of JAMA, a theme issue on cancer.
Genetic analysis of the tumors from patients with advanced melanoma can clue researchers in to how well patients will respond to a therapy that targets the growth-promoting protein called BRAF, a researcher from the Perelman School of Medicine at the University of Pennsylvania will report on Monday, June 6 at the annual meeting of the American Society of Clinical Oncology. Looking outside of the BRAF gene, the researchers found loss of the tumor suppressor gene PTEN also appears to be associated with patient response to GSK436, which could help guide researchers to even more personalized approaches to melanoma therapy.
Scientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies.
At the 3rd Annual Consumer Genetics Conference, in Boston June 7-9, the field’s preeminent researchers, clinicians, government regulators and industry leaders will provide their varying perspectives on genetic testing.
Researchers have discovered two classes of yeast genes that may hold clues as to why proteins take on the misfolded prion form, a condition associated with several neurodegenerative diseases, such as "mad cow." The findings are reported in the journal PLoS Genetics.
Researchers at the Johns Hopkins University School of Medicine have devised a new technique, which helps couples that are affected by or are carriers of genetic diseases have in vitro fertilized babies free of both the disease in question and other chromosomal abnormalities.
A team of international researchers, including Case Western Reserve University School of Medicine, have discovered regions of the genome that affect the severity of the genetic disease cystic fibrosis (CF), the most common lethal genetic disease affecting children in North America. The findings provide insight into the causes of the wide variation in lung disease severity experienced by CF patients. It also points the way to new diagnostic markers and therapeutic approaches for this and more common lung diseases, such as asthma and COPD.
Key microbiome sequencing data being released for use by scientific community.
Microbiome researchers and a DNA analysis company will collaborate to develop a database of high quality, finished, annotated microbial sequences.
Johns Hopkins Institute for Genetic Medicine researchers working as part of the North American Cystic Fibrosis Consortium have discovered two regions of the genome that affect the severity of cystic fibrosis, a genetic condition that causes scarring throughout the body, affecting most notably the pancreas and lungs. Reporting online this week in Nature Genetics, the team describes the first-ever study to identify genetic variations that are associated with more severe cases of CF.
In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.
A new comparison of proteins shared across species finds that complex organisms, including humans, have accumulated structural weaknesses that may have actually launched the long journey from microbe to man. The study, published in Nature, suggests that the random introduction of errors into proteins, rather than traditional natural selection, may have boosted the evolution of biological complexity.
Children whose mothers or grandmothers smoked during pregnancy are at increased risk of asthma in childhood, but the underlying causes of this are not well understood. Now a new study indicates changes in a process called DNA methylation that occurs before birth may be a root cause.
Nearly everyone who has tried to quit smoking says it’s incredibly difficult, and the struggle is due in part to genetic factors. Now, a new study from the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania sheds light on how one specific genetic risk for smoking relapse may work: Some of the difficulties may be due to how many receptors, called "mu opioid" receptors, a smoker has in his or her brain. The results, published online this week in the Proceedings of the National Academy of Science, may lead to the development of new treatments that target these receptors and help smokers increase their chances of success when they try to quit.
A variation in a gene involved in regulating cholesterol in the bloodstream also appears to affect progesterone production in women, making it a likely culprit in a substantial number of cases of their infertility, a new study from Johns Hopkins researchers suggests.
Researchers have linked a variant in the vitamin D receptor gene (VDR) with the onset of chronic obstructive pulmonary disease (COPD) in Caucasian men. The study population consisted of participants in the Veterans Administration Normative Aging Study, a multidisciplinary study of aging that began in 1963.
A little-studied gene known as notum plays a key role in the planarian’s regeneration decision-making process, according to Whitehead Institute scientists. At head-facing wounds, the gene acts as a dimmer switch to dampen the Wnt pathway—an signaling circuit that operates in all animals—and promote head regeneration.
Scientists have used a genetically re-engineered herpes virus that selectively hunts down and infects cancerous tumors and then delivers genetic material that prompts cancers to secrete a biomarker and reveal their presence, according to a study appearing May 11 in PLoS (Public Library of Science) ONE.
An international team of researchers led by scientists at Scripps Institution of Oceanography at UC San Diego has deciphered the genome of a tropical marine organism known to produce substances potentially useful against human diseases.
Discovery of a new class of insect repellant raises the possibility of formulations that are thousands of times more effective than current repellants.
Researchers develop fruit fly model to study fat production gene
Cardiologists from the Cardiac & Vascular Institute at NYU Langone Medical Center presented new research at The Heart Rhythm Society’s 32nd Annual Scientific Sessions, May 4 -7 in San Francisco, California. Researchers presented recent findings about the value of expanding genetic screening for life threatening arrhythmia, advanced risk stratification for genetic conditions like Brugada Syndrome and the promise of novel spinal cord stimulation technology to treat atrial fibrillation.
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