New animal studies at Henry Ford Hospital found that sildenafil, a drug commonly used to treat erectile dysfunction, may be effective in relieving painful and potentially life-threatening nerve damage in men with long-term diabetes.
A newly discovered cache of industry documents reveals that the sugar industry worked closely with the National Institutes of Health in the 1960s and ‘70s to develop a federal research program focused on approaches other than sugar reduction to prevent tooth decay in American children.
Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found.
A new study led by researchers at The Scripps Research Institute (TSRI) and the University of California (UC), San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations.
A new study led by researchers at The Scripps Research Institute (TSRI) and the University of California (UC), San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations.
Writing in the February 25 online issue of the journal PLOS ONE, researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute (TSRI), have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.
Writing in the February 25 online issue of the journal PLOS ONE, researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute (TSRI), have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.
Public health researchers have analyzed soda consumption data in order to characterize people’s exposure to a potentially carcinogenic byproduct of some types of caramel color. Caramel color is a common ingredient in colas and other dark soft drinks. The results show that between 44 and 58 percent of people over the age of six typically have at least one can of soda per day, possibly more, potentially exposing them to 4-methylimidazole (4-MEI), a possible human carcinogen formed during the manufacture of some kinds of caramel color.
UT Southwestern Medical Center researchers seeking novel ways to combat cancer found that giving acetate, a major compound produced in the gut by host bacteria, to mice sped up the growth and metastasis of tumors.
Researchers discover that the accepted theory of how Yersinia pestis microbes travel from fleabite to lymph node is off base. Most bacteria get trapped in a bottleneck and never make it to the lymph node, where infection takes root. Finding out why could lead to new ways to stop the pathogen.
Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials.
New research from the Johns Hopkins Bloomberg School of Public Health suggests that a prolonged illness associated with Lyme disease is more widespread and serious in some patients than previously understood.
New research from the Johns Hopkins Bloomberg School of Public Health suggests that a prolonged illness associated with Lyme disease is more widespread and serious in some patients than previously understood.
In a study with mice, Johns Hopkins Bloomberg School of Public Health researchers have found that e-cigarettes compromise the immune system in the lungs and generate some of the same potentially dangerous chemicals found in traditional nicotine cigarettes.
In a study with mice, Johns Hopkins Bloomberg School of Public Health researchers have found that e-cigarettes compromise the immune system in the lungs and generate some of the same potentially dangerous chemicals found in traditional nicotine cigarettes.
"Identification of alterations common to adult tumors, in our case upregulation of PIK3R3 and loss of PTEN, could potentially allow us to adapt therapeutic strategies for adult cancers to treat Ewing Sarcoma," says Paul Jedlicka, MD, PhD, investigator at the University of Colorado Cancer Center.
"Identification of alterations common to adult tumors, in our case upregulation of PIK3R3 and loss of PTEN, could potentially allow us to adapt therapeutic strategies for adult cancers to treat Ewing Sarcoma," says Paul Jedlicka, MD, PhD, investigator at the University of Colorado Cancer Center.
Pancreatic cancer affects approximately 46,000 people each year in the United States and ranks fourth among the leading causes of cancer-related deaths. Only about 6 percent of individuals with pancreatic cancer will live five years after their diagnosis. One reason for this high mortality rate is the lack of effective tools to detect pancreatic cancer early enough to allow its surgical removal. Moffitt Cancer Center researchers are now one step closer to devising an approach to detect pancreatic cancer earlier.
Moffitt Cancer Center researchers have found that breast and lung cancer patients who have low levels of a protein called tristetraprolin (TTP) have more aggressive tumors and a poorer prognosis than those with high levels of the protein. Their study was published in the Dec. 26 issue of PLoS One.
Moffitt Cancer Center researchers have found that breast and lung cancer patients who have low levels of a protein called tristetraprolin (TTP) have more aggressive tumors and a poorer prognosis than those with high levels of the protein. Their study was published in the Dec. 26 issue of PLoS One.
Daniel Chitwood, Ph.D., assistant member, used the world’s largest single-celled organism, an aquatic alga called Caulerpa taxifolia, to study the nature of structure and form in plants. It was recently reported the results of their work in the online journal, PLOS Genetics.
Computer simulations of tumor behavior are generating new research insights — and could lead to personalized therapies.
Computer simulations of tumor behavior are generating new research insights — and could lead to personalized therapies.
Here’s some good news for the New Year: According to new research by Washington University in St. Louis and Cornell University, there’s a 1 in 9 chance that a typical American will hit the jackpot and join the wealthiest 1 percent for at least one year in her or his working life. And now the bad news: That same research says only an elite few get to stay in that economic stratosphere – and nonwhite workers remain among those who face far longer odds.
Here’s some good news for the New Year: According to new research by Washington University in St. Louis and Cornell University, there’s a 1 in 9 chance that a typical American will hit the jackpot and join the wealthiest 1 percent for at least one year in her or his working life. And now the bad news: That same research says only an elite few get to stay in that economic stratosphere – and nonwhite workers remain among those who face far longer odds.
Women whose bodies have high levels of chemicals found in plastics, personal-care products, common household items and the environment experience menopause two to four years earlier than women with lower levels of these chemicals, according to a new study at Washington University School of Medicine in St. Louis. The findings are reported online Jan. 28 in the journal PLOS ONE.
Women whose bodies have high levels of chemicals found in plastics, personal-care products, common household items and the environment experience menopause two to four years earlier than women with lower levels of these chemicals, according to a new study at Washington University School of Medicine in St. Louis. The findings are reported online Jan. 28 in the journal PLOS ONE.
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform.
In a new study from Sanford-Burnham Medical Research Institute, researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. The research was published online in PLOS One yesterday.
A new study shows that more than half the people in some developing countries could become newly at risk for malnutrition if crop-pollinating animals — like bees — continue to decline.
A new study shows that more than half the people in some developing countries could become newly at risk for malnutrition if crop-pollinating animals — like bees — continue to decline.
Researchers at the University of Louisville’s James Graham Brown Cancer Center have identified for the first time mutations that destabilize a DNA structure that turns a gene off. The mutations occur at four sites in the hTERT promoter in more than 75 percent of glioblastomas and melanomas.
University of Utah researchers ran biochemical analysis and computer simulations of a livestock virus to discover a likely and exotic mechanism to explain the replication of related viruses such as Ebola, measles and rabies. The mechanism may be a possible target for new treatments within a decade.
A new retrospective study by epidemiologists at Tufts finds significant geographic disparities in HIV and hepatitis C related mortality in Massachusetts from 2002-2011. The study, published in PLOS ONE, used geospatial techniques to identify hotspots and coldspots in the state.
Researchers at Loyola University Chicago Stritch School of Medicine may have identified a way to assess who is at risk for developing a urinary tract infection (UTI) following pelvic-floor surgery. These findings were reported in the latest issue of PLOS ONE.
As if holiday travel isn't stressful enough. Now University of Michigan researchers say we're likely sharing that already overcrowded airline cabin with countless tiny creatures including house dust mites.
Mathematical models predicted it, and now a University of Florida study confirms it: Immunizing school-aged children from flu can protect other segments of the population, as well.
Despite many similarities between Dreissena species, quagga mussels infested native unionids less severely than zebra mussels. The study suggests that minor differences between closely related invasive species can have major differences in environmental impacts on the native communities.
Despite many similarities between Dreissena species, quagga mussels infested native unionids less severely than zebra mussels. The study suggests that minor differences between closely related invasive species can have major differences in environmental impacts on the native communities.
Physical aggression in toddlers has been thought to be associated with the frustration caused by language problems, but a recent study by researchers at the University of Montreal shows that this isn’t the case. The researchers did find, however, that parental behaviours may influence the development of an association between the two problems during early childhood. Frequent hitting, kicking, and a tendency to bite or push others are examples of physical aggression observed in toddlers.
Whether we’re paying attention to something we see can be discerned by monitoring the firings of specific groups of brain cells. Now, new work from Johns Hopkins shows that the same holds true for the sense of touch. The study brings researchers closer to understanding how animals’ thoughts and feelings affect their perception of external stimuli.
A University of Tennessee, Knoxville, study shows that just as our family histories dictate what we look like and how we act, plant evolutionary history shapes community responses to interacting agents of global change.
Scientists from WCS (Wildlife Conservation Society), the American Museum of Natural History (AMNH), the Environment Society of Oman, and other organizations have made a fascinating discovery in the northern Indian Ocean: humpback whales inhabiting the Arabian Sea are the most genetically distinct humpback whales in the world and may be the most isolated whale population on earth. The results suggest they have remained separate from other humpback whale populations for perhaps 70,000 years, extremely unusual in a species famed for long distance migrations.
Women and families in rural areas of the Democratic Republic of Congo (DRC) have been beaten down physically and mentally by years of war, poverty, and violence, but a Johns Hopkins School of Nursing researcher and her team suggest that a baby pig has the power to turn despair into hope, even reducing symptoms of PTSD and depression.
This year, a computer system developed at the University of Wisconsin-Madison equaled or bested scientists at the complex task of extracting data from scientific publications and placing it in a database that catalogs the results of tens of thousands of individual studies.
Experimental anti-cancer drugs PF-04691502 and PD-0325901 excel in tests against colorectal cancer models and enter phase 1 clinical trial.
High blood pressure and nonalcoholic fatty liver disease (NAFLD) are two emerging health problems related to the epidemic of childhood obesity. In a recent study, researchers at University of California, San Diego School of Medicine sought to determine the prevalence of high blood pressure in children with NAFLD, which places them at risk for premature cardiovascular disease.
Berkeley Lab scientists have learned new details about how an important tumor-suppressing protein, called p53, binds to the human genome. As with many things in life, they found that context makes a big difference.
Doubling saturated fat in the diet does not drive up total levels of saturated fat in the blood, according to a controlled diet study. Increasing levels of carbohydrates in the study diet promoted a steady increase in the blood of a fatty acid linked to higher risk for diabetes and heart disease.
In the first-ever GPS-based study of leopards in India, led by WCS and partners has delved into the secret lives of these big cats, and recorded their strategies to thrive in human-dominated areas.
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