Study findings from a team of scientists led by George C. Tsokos, MD, Chief of the Division of Rheumatology at BIDMC, overturn conventional wisdom about kidney disease.
Researchers discovered an unexpected twist in the battle versus tumors. Researchers have found that some tumor cells display not only a weapon, but also a brake, essentially becoming a neutralizing function. The unexpected mechanism could help determine whether a cancer patient will respond to immunotherapy.
Scientists uncovered the microscopic process by which metal wires can lose their superconductivity. The ability to control this transition in nanowires could lead to a new class of energy-efficient information technologies based on tiny superconductors.
Living at higher latitudes, where there is also less sunlight, could result in a higher prevalence rate of obsessive compulsive disorder (OCD), according to new research from Binghamton University, State University of New York.
Scientists have discovered a “Big Bang” of Alzheimer’s disease – the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain.
A comprehensive study by the Keck School of Medicine of USC has found that robotic partial nephrectomy offers significantly better patient outcomes as compared with open or laparoscopic techniques.
A relatively simple, noninvasive biological test conducted shortly after birth could help researchers identify which children are most vulnerable to the effects of maternal postpartum depression.
Brain metastases were found to be fairly common in stage IV ROS1-positive cancers and in 47 percent of ROS1 patients, the brain was the first and only site of progression.
While it’s estimated that more than a third of women have had nonconsensual sexual experiences in their lifetime, the way they define those experiences may influence their sexual wellbeing, according to psychology researchers at The University of Texas at Austin.
Nearly half of all men in a new study about intimate partner violence in male couples report being victims of abuse.
Cornell University assistant professor of operations, technology and information management, Shawn Mankad, found in new research that shifts in bank networks predicted the financial crisis of 2008-09 -- and similar shifts could predict a future crisis.
The bacteria that cause tuberculosis are able to escape destruction and grow after they are engulfed by lung macrophages. Now researchers have described key biochemical steps between the bacteria Mycobacterium tuberculosis and the macrophage responsible for that ability.
Ferroelectric materials are behind some of the most advanced technology available today. Findings that ferroelectricity can be observed in materials that exhibit other spontaneous transitions have given rise to a new class of materials, known as hybrid improper ferroelectrics. The properties of this type of material, however, are still far from being fully understood. New findings published in Applied Physics Letters help shine light on these materials and indicate potential for optoelectronic and storage applications.
Researchers from the University of Utah have discovered why certain people experience dizziness when they hear a particular sound, such as a musical tone. For patients with semicircular canal dehiscence, certain acoustic tones cause the inner ear fluid to pump which sends an incorrect signal to the brain and creates dizziness.
Only about one-third of young children in the U.S. receive recommended screenings or surveillance designed to catch developmental delays. Findings reveal wide variations in rates across states, with as few as 17 percent of children under three years old receiving developmental screening in the lowest performing state.
Superconductor-ferromagnet structures are widely regarded as the building blocks of superconducting spintronic technology. More conventional spintronic devices typically require large currents, so researchers are investigating the viability of low-resistance superconductors. Their new results could answer longstanding questions about how SF structures interact. They reveal a general mechanism of the long-range electromagnetic proximity effect in SF structures in Applied Physics Letters.
An important part of communication is non-verbal. Most people who engage in social interactions recognize a range of emotional states reflected in other people’s facial expressions, body postures, and/or tone of voice. Alcoholism has been linked to difficulties in perceiving and processing emotions expressed in these non-verbal cues. This study examined whether these difficulties persist after long-term abstinence from alcohol.
Patients who suffer from Aspirin Exacerbated Respiratory Disease (AERD) often experience an additional allergic reaction when drinking alcohol, including nasal congestion, wheezing, and a runny nose. Now a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania finds a common treatment for AERD – aspirin desensitization – can also help alleviate the alcohol-induced symptoms of the condition.
A collaboration between professors from The University of Texas at El Paso and the University of North Texas is leading to a better understanding of the composition of dust carried by rain across the state, and how that dust can affect the places where it ends up.
Johns Hopkins researchers have found that the cellular “garbage disposal,” known to scientists as proteasomes, may not only be responsible for the removal of cellular waste, but actually work on some of the most important proteins to neuronal development.
Lawrence Livermore National Laboratory’s National Ignition Facility (NIF) laser system has set a new record, firing 2.15 megajoules (MJ) of energy to its target chamber – a 15 percent improvement over NIF’s design specification of 1.8 MJ, and more than 10 percent higher than the previous 1.9 MJ energy record set in March 2012. Increasing NIF’s energy limit will expand the parameter space for stockpile stewardship experiments and provide a significant boost to the pursuit of ignition.
A new study led by University of Alabama at Birmingham Researchers shows that multivitamins and mineral supplements do not prevent heart attacks, strokes or cardiovascular death.
New research from South Australian scientists has shown that vitamin D (also commonly known as the sunshine vitamin) is unlikely to protect individuals from multiple sclerosis, Parkinson’s disease, Alzheimer’s disease or other brain-related disorders.
New research shows how two biological control agents have been effective in reducing the numbers of feral rabbits in Australia. Using data from the largest wild rabbit study in the world, scientists have examined the long-term interaction of myxoma and rabbit haemorrhagic disease viruses.
A new study conducted at the University of Michigan reveals a previously unrecognized threat to monarch butterflies: Mounting levels of atmospheric carbon dioxide reduce the medicinal properties of milkweed plants that protect the iconic insects from disease.
New Yorkers are getting heavier. And, like people across the country, many have difficulty sleeping and are suffering from depression. Diabetes rates in NYC remain high and racial and ethnic disparities persist.
Research led by Professor G.V. Shivashankar of the Mechanobiology Institute, Singapore and Italy’s IFOM has revealed that mature cells can be reprogrammed into redeployable stem cells without direct genetic modification – by confining them to a defined geometric space for an extended period of time.
Air pollution; thorax toxicology; PBPK modeling of antibiotics in dairy cattle; PCBs & steatohepatitis; uranium mine particles & cardiopulmonary toxicity; green plasticizers & reproductive health; and antiandrogenic mixtures & male reproduction featured in latest issue of Toxicological Sciences
Los investigadores de Mayo Clinic aplican la genómica de precisión para buscar mutaciones genéticas, aún no descubiertas y hereditarias que aceleran el envejecimiento.
A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor (EGFR), a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme (GBM).
New research shows that death and recurrence are rare in children with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), but children who experience these skin conditions have high rates of complications and that treatment strategies varied among health care providers.
A new study finds that one in four working-age adults with type 1 diabetes had at least one gap of at least 30 days in their private health insurance, within an average of a three-year period. A temporary loss of coverage had a sizable impact on the patients’ use of health care once they got insurance again.
New evidence shows the power of a method aimed at changing the longstanding problem of encouraging patients with chronic diseases to take their medicine faithfully: insurance plans that charge patients less for the medicines that could help them most. Some plans even make some of the medicines free to the patients with certain conditions.
Research reveals dramatic geographic differences in end-of-life care spending across the United States. Spending variations stemmed from doctors’ beliefs about end-of-life care and style of practice and from availability of health care services. Patient beliefs and preferences did not contribute to spending differences. Health care spending in the last month of life for patients with end-stage cancer in some regions is twice as high as that in other regions. The additional spending is wasteful and possibly harmful.
Through x-ray crystallography and kinase-inhibitor specificity profiling, University of California San Diego School of Medicine researchers, in collaboration with researchers at Peking University and Zhejiang University, reveal that curcumin, a natural occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces cancer burden.
People with multiple sclerosis (MS) can find an abundance of conflicting advice suggesting that special diets will ease their symptoms. But the evidence is scanty. Laura Piccio, MD, an associate professor of neurology at Washington University School of Medicine in St. Louis has launched a trial to evaluate whether drastically cutting calories twice a week can change the body’s immune environment and the gut microbiome, and potentially change the course of the disease.
Earth’s oxygen levels rose and fell more than once hundreds of millions of years before the planetwide success of the Great Oxidation Event about 2.4 billion years ago, new research from the University of Washington shows.
New research from the University of Georgia reveals that exposure to famine during specific moments in early life is associated with depression later in life.
McMaster University researchers have developed a new theory on Huntington’s disease which is being welcomed for showing promise to open new avenues of drug development for the condition.
How do insects survive harsh northern winters? Unlike mammals, they don’t have thick coats of fur to keep warm. But they do have antifreeze. Antifreeze proteins (AFPs) prevent ice from forming and spreading inside their bodies. The existence of these AFPs has been known for decades, but the mechanisms governing this unique survival technique have proven difficult to determine.
روتشستر، مينيسوتا. - إن وجود الخلايا الهرمة أو الخلايا التي بها خلل وظيفي يمكن أن يعجِّل من عملية الشيخوخة لدى الفئران الصغيرة بشكل أسرع. ويؤدي استخدام عقاقير السينوليتيك في الفئران المسنة من أجل إزالة الخلايا الشاذة إلى تحسين الحالة الصحية وإطالة العمر. وتوفِّر هذه النتائج التي يقدمها باحثو Mayo Clinic والمساهمون معهم في العمل أساسًا للمضي قدمًا في هذا المجال الخاص ببحوث الشيخوخة. تتوفر هذه النتائج في Nature Medicine.
Researchers from Case Western Reserve University School of Medicine have found a nanobody that holds promise to advance targeted therapies for a number of neurological diseases and cancer.
明尼苏达州罗切斯特 -- 衰老（senescent）或功能失调细胞的存在会使幼鼠加速衰老，另一方面， 在老年小鼠中使用Senolytics药物来去除这些坏细胞可以改善健康并延长寿命。 Mayo Clinic的研究人员和合作者的这些发现为这一衰老研究领域的发展奠定了基础。 该研究结果发表在《自然 医学》杂志上（Nature Medicine）。
A presença de células senescentes ou disfuncionais pode colaborar com o envelhecimento precoce dos camundongos jovens. Por outro lado, o uso de medicamentos senolíticos para remover essas células nocivas pode melhorar a saúde e prolongar a vida. Esses resultados de pesquisadores e colaboradores da Mayo Clinic fornecem uma base para avançar nesta área de pesquisa do envelhecimento. Os resultados foram publicados na Nature Medicine.
Two years after inventing a microfluidic chip believed to help detect a life-threatening blood infection, researchers in the Texas Tech University Department of Chemistry & Biochemistry and the Texas Tech University Health Sciences Center are finally seeing their product work successfully for human patients.
A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and wirelessly send the results in real time to an electronic device. The chip is at least 1,000 times more sensitive at detecting an SNP than current technology. The advance could lead to cheaper, faster and portable biosensors for early detection of genetic markers for diseases such as cancer.
A multidisciplinary team from Washington University in St. Louis and the Air Force Research Laboratory at Wright-Patterson Air Force Base has developed a high-tech fix that brings some medical diagnostic tests out of the dark and into the light.
La presencia de senescencia, o de células disfuncionales, puede hacer envejecer más rápido a los ratones; pero la administración de fármacos senolíticos para eliminar a estas maliciosas células en los ratones ancianos, les mejoró la salud y les prolongó la vida.
A drug used to treat altitude sickness may help patients with glioblastoma, according to a study published July 4, 2018, in the journal Science Translational Medicine.
Researchers used brain imaging to gauge how the hand, foot and lips are represented in the brains of 2-month-olds – a much younger age than has been studied previously. It is believed to be the first to reveal the greater neurological activity associated with the lips than with other body parts represented in the infant brain. It also indicates how soon infants’ brains begin to make sense of their bodies, a first step toward other developmental milestones.
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