Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.
مدينة روتشستر، ولاية مينيسوتا- يموت عدد متزايد من الناس بسبب العَدوى المقاومة للمضادات الحيوية. وهذه العَدوى تغذيها أنواع الميكروبات التي تتحور لتتجنب الأدوية المطورة بهدف تدميرها. توفي أكثر من 1.2 مليون شخص حول العالم في عام 2019 بسبب العَدوى المقاومة للمضادات الحيوية.
Cada vez mais pessoas estão morrendo por infecções resistentes a antibióticos. Essas infecções são alimentadas por espécies microbianas que estão em mutação para escapar das drogas desenvolvidas para destruí-las.
Una creciente cantidad de personas muere debido a infecciones resistentes a los antibióticos. Estas infecciones son propiciadas por especies bacterianas que mutan a fin de evadir a los fármacos creados para destruirlas.
A new study found that for telemedicine visits related to acute respiratory infection, contractor-supplied physicians prescribed antibiotics to patients nearly twice as often as emergency physicians employed by the hospital system. As the majority of acute respiratory infections are viral, researchers say the findings highlight concerns of antibiotic stewardship amid growing antibiotic resistance.
While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.
New research from the University of Georgia found that fungal infections account for $6.7 billion in health care spending in 2018. And that’s just the cases that were directly responsible for inpatient hospital stays.
The spectacular structure of the protective armour of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.
Using genomic sequencing techniques and machine learning analysis of patient records, Israeli researchers have developed an antibiotic prescribing algorithm that cuts the risk of emergence of antibiotic resistance by half.
MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.
Texas Tech University Health Sciences Center El Paso has received more than a quarter-million dollars to study the proteins that contribute to disease progression and drug resistance in acute myeloid leukemia.
The key to preventing another global pandemic may be found at UNC Charlotte. Expanding upon the University’s award-winning development of a novel COVID-19 wastewater surveillance program and rapidly growing success in bioinformatics, the University is bringing together experts to explore ways to combat threats to human health.
New research from the University of Georgia has shown, for the first time, that compounds used to fight fungal diseases in plants are causing resistance to antifungal medications used to treat people.
A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.
Five days of antibiotics is superior to 10 days for children with community-acquired pneumonia who are not hospitalized, according to a study published in JAMA Pediatrics.
Using drugs in synergistic combinations may clear infections more efficiently and slow the acquisition of drug resistance. Bree Aldridge of Tufts University School of Medicine explains how researchers find the right drug cocktails, slowing AMR, and the role artificial intelligence can have in both.
Countering a rising antibiotic resistance crisis, doctors now prescribe combinations of antibiotics. Yet many risks are involved with such multi-drug combinations. Scientists have developed a way to help doctors evaluate outcomes for different drug pairs and boost the odds of successful treatment.
Australian scientists have made a surprising discovery in the origins of an antibiotic-resistant gene previously thought to have been confined to Adelaide.
Sanford Burnham Prebys professor Andrei Osterman, Ph.D., has been awarded a $3.6 million grant from the National Institutes of Health (NIH) to expand current knowledge of antibiotic resistance, which will inform more precise antibiotic prescribing practices and help researchers develop drugs that are harder for bacteria to resist.
For decades, no one really knew how the drug praziquantel treated a parasitic disease afflicting more than 200 million people around the world. Now, two independent teams of researchers have found the answer, which could help lead to improved treatments that support the W.H.O.’s goal of eliminating Schistosomiasis as a public health problem by 2025.
Conventional wet-chemistry methods used to create biocidal materials are complex, time-consuming, and expensive. In the Journal of Applied Physics, researchers present a tutorial in which they explore a promising alternative called plasma-enabled surface engineering. The technology relies on nonequilibrium plasma that produces chemical reactions to change the properties at the material surface. Reactions can be manipulated by adjusting electric power for surface activation, coating deposition, and surface nanostructuring of virtually any solid material.
More than $2 million in grants from the U.S. Centers for Disease Control and Prevention (CDC) will allow a Penn Medicine team to further develop infrastructure and clinical capacity to address antimicrobial resistance and infectious diseases in Botswana.
UCLA Jonsson Comprehensive Cancer Center researchers led the development of a melanoma model of drug resistance, enabling them to study structures and dynamics resulting in intrachromosomal and extrachromosomal changes that support resistance in cancer cells.
Treating bacterial infections associated with orthopaedic implants has often been a case of too little, too late. The traditional therapy has been a combination of prolonged antibiotics, including rifampin, a 50-year-old drug that has been a staple in the global fight against tuberculosis and other bacterial diseases.
Scientists have spotted signs of ‘pre-resistance’ in bacteria for the first time – signs that particular bacteria are likely to become resistant to antibiotics in the future – in a new study led by UCL and Great Ormond Street Hospital researchers.
Scientists have discovered a new potential treatment that has the ability to reverse antibiotic resistance in bacteria that cause conditions such as sepsis, pneumonia, and urinary tract infections.
With the knowledge that human, animal and environmental health are intertwined, researchers at five of The Ohio State University’s colleges and its medical center are uniquely positioned to collaborate on a “one health” approach to battle antibiotic resistance and prevent the next global health crisis.
Nowadays, single-cell RNA sequencing technologies and related bioinformatics tools are emerging as essential devices for dissecting tumors at single-cell resolution and understanding carcinogenesis and drug response mechanisms, representing a turning point in cancer research.
Researchers at Washington University School of Medicine in St. Louis have found that multidrug-resistant bacteria and bacterial spores can be killed by ultrashort-pulse lasers. The findings could lead to new ways to sterilize wounds and blood products without damaging human cells.
Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria.
Researchers report in ACS Infectious Diseases that they have identified compounds that tackle fungal resistance in a new way — by interfering with fungal enzymes required for fatty acid synthesis — potentially opening the door to better therapies.
In an experiment to find an effective treatment for diabetic foot ulcers, which affect 62 million people worldwide, a team led by University of South Australia physicist Dr Endre Szili has made an unexpected discovery: the same technology kills the SARS-CoV-2 virus.
Un nuevo estudio que se presenta en la Reunión científica anual del ACAAI de este año mostró que la mayoría de las mujeres embarazadas con una etiqueta de alergia a la penicilina a las que se les hizo la prueba no eran alérgicas y podían tolerar la penicilina durante el parto.
A new study being presented at this year’s ACAAI Annual Scientific Meeting showed the majority of pregnant women with a penicillin allergy label who were tested were not allergic and could tolerate penicillin during labor.
A technique that measures the metabolic activity of bacteria with an electric probe can identify antibiotic resistance in less than 90 minutes, a dramatic improvement from the one to two days required by current techniques.
Scientists may have made a giant leap in fighting the biggest threat to human health by using supercomputing to keep pace with the impressive ability of diseases to evolve.
A new study by an international team, co-led by Dr Gerhard Koenig from the University of Portsmouth, tackled the problem of antibiotic resistance by redesigning existing antibiotics to overcome bacterial resistance mechanisms.
New findings by researchers at Yale Cancer Center demonstrate a novel strategy to treat tumor growth in breast and ovarian cancers characterized by HER2 gene amplification, an increase in the number of copies of a gene.
Genes aren’t only inherited through birth. Bacteria have the ability to pass genes to each other, or pick them up from their environment, through a process called horizonal gene transfer, which is a major culprit in the spread of antibiotic resistance.
A researcher at the University of Missouri School of Medicine has discovered an enzyme that plays a key role in the ability of cancer cells to resist drug treatment.
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants.
More than half of U.S. women will experience at least one urinary tract infection (UTI) in their lifetimes, while a quarter will have a subsequent infection. Recurrent urinary tract infections are defined as two or more infections in six months or three or more in a year.