Earlier this month the All of Us Research Program released an initial large batch of genomic data on its cloud-based research platform, the Researcher Workbench, including whole genome sequences of 98,600 research participants and genotype data from 165,200 participants.
Replenishing the body’s high-density lipoprotein (HDL) could be an effective treatment for sepsis, according to a new University of Kentucky College of Medicine study published in Science Signaling. The lab study, led by Xiangan Li, Ph.D., a professor in the Department of Physiology and the Saha Cardiovascular Research Center, found that a synthetic form of HDL provided protection against sepsis in mice.
The National Institute of Mental Health has renewed its support for UCLA’s collaborative Center for HIV Identification, Prevention and Treatment Services, or CHIPTS, with a five-year, $7.5 million grant.
Scientists at Yale Cancer Center have discovered new consequences of specific gene mutations that play a role in the development of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
Researchers at the University of Illinois Chicago are looking at the possibility that gastroenterological changes could be an early warning sign for Lou Gehrig's disease. Their research in animal models also shows a promising treatment to slow the disease’s progression.
A research team led by Chao Zhou at the McKelvey School of Engineering has used a safe, noninvasive imaging technique to observe the development of a human heart organoid over 30 days.
Ajay Jain, M.D., professor of pediatrics, pharmacology, and physiology at Saint Louis University School of Medicine, has received funding from the National Institutes of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to study Short Bowel syndrome (SBS).
UChicago researchers discovered several important mechanisms that affect how ovarian cancer tumors interact with the immune response and how combination therapies can exploit these pathways to improve ovarian cancer treatment.
In what they call surprise findings, Johns Hopkins Medicine scientists report that — unlike fruit flies — mosquitoes’ odor sensing nerve cells shut down when those cells are forced to produce odor-related proteins, or receptors, on the surface of the cell.
With the help of two new grants from the National Institutes of Health totaling more than $4.4 million, Sanford Burnham Prebys professor Charles Spruck, Ph.D., and his team are refining a cutting-edge breast cancer treatment.
A Johns Hopkins Children’s Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that affects the brain.
Irvine, Calif., March 11, 2022 — A new University of California, Irvine-led study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. Going beyond current studies on substance use disorders, which focus on the impact of addictive drugs on the brain, this new research highlights an existing connection between specific neurons and peripheral organs.
Malaria, a mosquito-borne disease, killed more than 620,000 people worldwide in 2020. Jeopardizing the survival of Plasmodium falciparum, the malaria parasite, is one way to control the spread of this deadly disease.
A mouse study detailed the differences between the two forms of the protein PPARgamma, a target of thiazolidinedione, or glitazone, diabetes drugs, could cut out weight gain side effects
The antiviral therapies remdesivir, molnupiravir, and the active ingredient in Pfizer’s Paxlovid pill (nirmatrelvir), remain effective in laboratory tests against the BA.2 variant of SARS-CoV-2, the virus that causes COVID-19. The BA.2 variant also remains susceptible to at least some of the monoclonal antibodies used to treat COVID-19, such as Evusheld by AstraZeneca.
Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and—when dysregulated by mutation—the emergence of blood cancers known as myeloproliferative neoplasms.
Scientists at UC San Diego and Rutgers University have found intriguing new details about a previously missing critical factor in gene expression. An ancient protein called NDF found in all human tissues enhances gene activation and may be involved in diseases such as cancer.
A Florida State University College of Medicine researcher has made a discovery that alters our understanding of how the body’s DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders.The fact that DNA can be repaired after it has been damaged is one of the great mysteries of medical science, but pathways involved in the repair process vary during different stages of the cell life cycle.
In laboratory experiments involving a class of mutations in people with a rare collection of immune system disorders, Johns Hopkins Medicine researchers say they have uncovered new details about how immune system cells respond to disease-causing bacteria, fungi and viruses such as SARS-CoV-2.
Tulane scientists will use the five-year grant to better understand why the brain-protecting benefits of estrogen may not apply to all women, especially those with hypertension and Type 2 diabetes.
Researchers have discovered two types of brain cells that play a key role in dividing continuous human experience into distinct segments that can be recalled later. The discovery provides new promise as a path toward development of novel treatments for memory disorders such as dementia and Alzheimer’s disease.
A new study — in mice — from Washington University School of Medicine in St. Louis suggests that blocking a major inflammatory pathway that is activated in pancreatic cancer makes the tumors sensitive to chemotherapy and a type of immunotherapy that prompts the immune system’s T cells to attack the cancer cells. The therapy more than doubled survival in a mouse model of pancreatic cancer.
South Carolina is strengthening its position as a hub for high-impact biomedical research with a new multi-million-dollar project that undergirds the long-standing partnership between Clemson University and the Medical University of South Carolina (MUSC) and loops in crucial support from the National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH).
In 2010, scientists discovered that African Americans who are born with certain variants of a gene called apolipoprotein L1 (APOL1) have a higher-than-average risk for experiencing chronic kidney disease (CKD). Now, in a new study of African Americans with hypertension, researchers at the Icahn School of Medicine at Mount Sinai find that a community-based approach to reporting APOL1 genetic test results back to individuals may have beneficial effects.
Researchers at the Uniformed Services University in collaboration with University of Washington, have recently uncovered new details about how Nipah and Hendra viruses infect cells and the immune responses that can block them, which could ultimately lead to the development of new tactics to prevent and treat these deadly illnesses.
Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells. Their findings, which could have significant benefits for patients with disease progression, were published today in Nature Medicine.
By using a synthetic scaffold, Georgia Tech researchers created a novel way generate breast tumor models faster, more reliably, and with dramatically less immune variability than existing models - making them highly suitable for immunotherapy research.
While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.
With more than $12 million in new funding from the National Institutes of Health (NIH), the Abramson Cancer Center at the University of Pennsylvania will build on its preclinical research of an emerging form of radiation that provides ultra-fast doses—of under a second, compared to several minutes with conventional radiation—and shows promise of greater protection of normal tissue, thereby minimizing toxic effects to the body.
The research may also advance understanding of the biochemical roots of Parkinson’s disease and other synucleinopathies, which affect more than 6.8 million Americans.
Using genomic sequencing techniques and machine learning analysis of patient records, Israeli researchers have developed an antibiotic prescribing algorithm that cuts the risk of emergence of antibiotic resistance by half.
As organisms grow, older cells can undergo a phenomenon called senescence. This process defines a cell state where cells permanently stop dividing but do not die. Senescent cells secrete toxic pro-inflammatory factors contributing to the development of many diseases.
Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease. The discovery can also help lead to a new treatment approach for people suffering from the disease.
UC San Diego researchers discover a specific antimicrobial skin cell and the role it plays in acne development, which could result in more targeted treatment options.
UCLA researchers presented today the first case of a U.S. woman living with HIV-1 that is in remission after she received a new combination of specialized stem cell transplants for treatment of acute myeloid leukemia (AML). The oral abstract was presented at CROI 2022, the Conference on Retroviruses and Opportunistic Infections.
A research team led by faculty members at Wayne State University has discovered that communication between two key memory regions in the brain determines how what we experience becomes part of what we remember, and as these regions mature, the precise ways by which they interact make us better at forming lasting memories.
In a follow-up study, researchers report that the substantial antidepressant effects of psilocybin-assisted therapy, given with supportive psychotherapy, may last at least a year for some patients.
A new study led by researchers at Yale Cancer Center and the University of Maryland shows ixabepilone plus bevacizumab (IXA+BEV) is a well-tolerated, effective combination for treatment of platinum/taxane-resistant ovarian cancer compared to ixabepilone (IXA) alone.
Researchers at Washington University School of Medicine in St. Louis have shown, in mice, that a new class of compounds they developed can improve several aspects of metabolic syndrome. Such conditions often lead to cardiovascular disease, the leading cause of death worldwide.
. In a new article published in Nature Communications, the laboratory of Elsa R. Flores, Ph.D., in collaboration with the Baylor College of Medicine and MD Anderson Cancer Center, shows how the protein ΔNp63 contributes to disease development through the regulation of stem cells and crucial elements known as enhancers, which regulate genes that control cell identity.
New research led by bioengineers at the University of California San Diego could make it much simpler to repair disease-causing mutations in RNA without compromising precision or efficiency. The new RNA editing technology holds promise as a gene therapy for treating genetic diseases. In a proof of concept, UC San Diego researchers showed that the technology can treat a mouse model of Hurler syndrome, a rare genetic disease, by correcting its disease-causing mutation in RNA.
A team led by UCLA researchers will receive a multi-million dollar grant to study why some people suffer from a devastating fungal infection called Valley Fever, while others suffer seemingly no impact from the disease.
Combining the drug brequniar with remdesivir or molnupiravir — both approved by the U.S. Food and Drug Administration for emergency use — inhibited the SARS-CoV-2 virus in human respiratory cells and in mice, according to a new study published in Nature.
Sequencing more than 170,000 single cells from animal models have provided exceptionally detailed insight into the early immune response to SARS-CoV-2 in the lungs. The findings will help inform future treatment options for the current pandemic and future coronaviruses.
An international team of scientists, led by UC San Diego researchers, has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. The findings illuminate how genes impact the brain and diseases.
Wistar Institute scientists take a promising step in the direction of developing an HIV vaccine that uses a unique native-like trimer to develop Tier-2 neutralizing antibodies—the kind that matter for combatting HIV—in mice for the first time.
Researchers at the Icahn School of Medicine at Mount Sinai created a tailor-made gene sequencing method to accurately measure a biochemical, DNA tagging system, which switches genes on or off. This helped them study the system in any cell type, including human, plant and bacterial cells. While the results published in Science supported the idea that this system may occur naturally in non-bacterial cells, the levels were much lower than some previous studies reported and were easily skewed by bacterial contamination or current experimental methods. Experiments on human brain cancer cells produced similar results.
Researchers from the University of Wisconsin–Madison have revealed the importance of a specific type of connection between brain cells that may explain ketamine’s potential as a treatment for depression.
Some physicians are much more likely to deliver appropriate care than others, even in clinical situations where guidelines for appropriate care are clear. Notable—at times dramatic—differences were found across 14 common clinical scenarios representing seven specialties. The findings highlight the importance of understanding the reasons for these variations and developing ways to minimize them to improve the value of care.
Sanford Burnham Prebys professor Yu Yamaguchi has been awarded a $2.9 million grant from the National Institutes of Health to study the role of heparan sulfate (HS) in Alzheimer’s disease. HS is a structural molecule found in the scaffolding between cells that has been previously observed to influence the development of Alzheimer’s disease. However, the precise function it plays in the brain has not been studied closely.
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