A low-cost version of ketamine to treat severe depression has performed strongly in a double-blind trial that compared it with placebo.
Artificial intelligence is becoming increasingly important in drug discovery.
Researchers at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered an Alzheimer's biomarker in the cerebrospinal fluid known as MTBR-tau243 can be used to track the progression of disease and could speed drug development.
Psychedelic-based therapies are poised to change the treatments that psychiatrists can offer patients.
Researchers at the University of Illinois Urbana-Champaign and collaborators at Merck & Co. developed a rapid and efficient method of making large quantities of metabolites directly from a drug or drug precursors via carbon-hydrogen oxidation catalysis.
On July 6, 2023, the U.S. Food and Drug Administration (FDA) granted full approval to lecanemab, marketed as Leqembi, for the treatment of Alzheimer’s disease. The University of Kentucky’s Sanders-Brown Center on Aging has been working with this drug and others like it for more than a decade.
Researchers at Sylvester Comprehensive Cancer Center have developed a first-of-its-kind, orally administered drug to disrupt prostate cancer cells’ metabolism and deliver the chemotherapy agent cisplatin directly into treatment-resistant prostate cancer cells. The compound – Platin-L – works in two ways, breaking down a process that malignant prostate cancer cells use to fuel their growth, and delivering cisplatin directly into treatment-resistant cancer cells.
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Prostate cancer is resistant to one of the most powerful chemotherapy medications — cisplatin. Now, researchers in ACS Central Science have developed the first therapy of its kind that disrupts prostate cancer cells’ metabolism and releases cisplatin into the weakened cells, causing them to die.
A new analysis finds that up to millions of dollars could be saved annually on cancer immunotherapy treatments across the Veterans Health Administration by reconsidering how those drugs are delivered.
A gift of $1.5 million from Eugene Jhong will help launch a new research program within the UC San Diego Psychedelic and Health Research Initiative to learn more about the biological and psychological effects of DMT in humans.
The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell targeting therapies based on its proprietary Alluminox™ platform, today announced that new data from the ASP-1929-181 study was presented at the American Head and Neck Society's (AHNS) 11th International Conference on Head and Neck Cancer (AHNS 2023) on July 10, 2023.
Two drugs commonly used to treat inflammatory diseases such as rheumatoid arthritis and psoriasis did not shorten recovery time for patients hospitalized with severe COVID-19 but did reduce the likelihood of death when compared with standard care alone, according to a national study led by Washington University School of Medicine in St. Louis.
The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, promote standardization of testing across different laboratories, and improve patient care.
Hackensack Meridian Health Physicians react to FDA approval of Alzheimer's drug lecanemab/ Leqembi. Available to discuss its uses, side effects and instances when they have prescribed it.
Prof. Pol.Capt. Pharm. Dr. Suchada Sukrong, lecturer at the Faculty of Pharmaceutical Sciences and a researcher at the Center of Excellence in DNA Barcoding of Thai Medicinal Plants, Chulalongkorn University, Dr. Kannika Thongkhao, and Pharm. Chayaphol Tangpatthong have won the gold medal and two Special Awards, namely the FIRI Award in the Best Invention category from “The first institute of inventors and researchers of Iran” (FIRI), Iran, and a Special Awards from “The Industrial Property Office of the Czech Republic the Czech Metallurgical Society,” The Czech Republic, in The 16th International Invention and Innovation Show (INTARG 2023) on May 24-25, 2023, at Katowice International Conference Center, Katowice, Republic of Poland, with their “Rapid DNA immunochromatographic assay for detection of toxic Aristolochia species, the plants responsible for aristolochic acid nephropathy”.
Rutgers Institute for Health researchers observe decrease in use of antipsychotic medications in children since early 2000s.
With $7 million in funding from the National Institutes of Health, researchers from Wake Forest University School of Medicine and Wake Forest University will study whether a combination of resistance training plus bone-strengthening exercises and/or osteoporosis medication use can help older adults safely lose weight without sacrificing bone mass.
Conventional ways of administering medication – by swallowing tablets, consuming bitter syrups, injections or rectal insertions – could be distressing and unpleasant for some patients, especially young children or the elderly. A team of researchers led by Associate Professor Chan Sui Yung, Honorary Fellow at the Department of Pharmacy under the Faculty of Science at the National University of Singapore (NUS), has recently developed easy-to-use oral films that enable painless, efficient, and discreet drug administration.
A team of scientists from around the globe, including those from Trinity College Dublin, has gained high-res structural insights into a key bacterial enzyme, which may help chemists design new drugs to inhibit it and thus suppress disease-causing bacteria.
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell targeting therapies based on its proprietary Alluminox™ platform, today announced that new interim evaluation data from the ASP-1929-103 study has been presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2023 Annual Meeting held from June 24 to 27.
Cedars-Sinai patient care teams are preparing to offer lecanemab, a new Alzheimer’s disease treatment expected to soon receive approval from the U.S. Food and Drug Administration (FDA), to patients in the coming months.
The results of a clinical trial have shown that a drug commonly used for patients with bleeding disorders has the potential to be used to lessen the side effects of blood-thinning drugs for patients who have experienced a stroke.
With the growing popularity of medications like Ozempic® (semaglutide), Trulicity® (dulaglutide), and other glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes and weight loss, the American Society of Anesthesiologists (ASA) suggests withholding the medication before elective surgery to reduce the risk of complications associated with anesthesia in adults and children.
The June special issue of SLAS Technology showcases the latest developments in the field of biotechnology with its collection of seven research articles.
The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer’s and other drug discovery research.
Benzodiazepine use and discontinuation is associated with nervous system injury and negative life effects that continue after discontinuation, according to a new study.
UC San Diego researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical trial.
Dennis Charney, MD, recognized for advancing understanding and treatment of mood and anxiety disorders
Most stroke patients taking the anticoagulant warfarin were no more likely than those not on the medication to experience a brain bleed when undergoing a procedure to remove a blood clot, UT Southwestern Medical Center researchers report in a new study. The findings, published in JAMA, could help doctors better gauge the risk of endovascular thrombectomy (EVT), potentially expanding the pool of eligible patients for this mainstay stroke treatment.
Leaders from 12 nuclear medicine organizations around the world have issued a white paper about the challenges and opportunities in theranostics education.
Today, the Abigail Wexner Research Institute at Nationwide Children’s Hospital praised the Food and Drug Administration (FDA) for its accelerated approval of SRP-9001/ELEVIDYS for Duchenne muscular dystrophy (DMD) following decades of research in its Center for Gene Therapy to help patients with neuromuscular diseases.
Neeraj Agarwal, MD, led a global study analyzing the combination of two cancer drugs to treat metastatic prostate cancer. Results showed this reduces the risk of cancer progression by 55%.
A laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI) has been issued a major grant to repurpose drugs to combat non-tuberculous mycobacteria (NTM), an emerging family of germs naturally found in soil and water and which can be deadly to those with compromised immune systems and pre-existing lung diseases.
Antitumor agents must kill off cancer cells while protecting healthy tissue and having no toxic side-effects. A novel approach based on “self-immolative” polyferrocenes—copolymers that split apart into their components as soon as they enter a tumor cell—could meet these demands.
In a new study published June 21, 2023, in Science Translational Medicine, researchers from Johns Hopkins University and the University of Chicago invented a new reporting technique to monitor activity of CaMKII while screening the effects of nearly 5,000 FDA approved drugs on human cells that expressed the enzyme.
Research at Argonne National Laboratory’s Advanced Photon Source has revealed a key mechanism behind a promising drug for copper deficiency disorders.
New McMaster research has found that a disease-causing fungus — collected from one of the most remote regions in the world — is resistant to a common antifungal medicine used to treat infections.
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