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… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …

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The authors of “Impact of Electronic Health Records on Information Practices in Mental Health Contexts: Scoping Review” have effectively brought to our attention the failure of the electronic health record (EHR) to represent the human context. Be...

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Background: The adoption of electronic health records (EHRs) and electronic medical records (EMRs) has been slow in the mental health context, partly because of concerns regarding the collection of sensitive information, the standard...

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Background: Although well recognized for its scientific value, data sharing from clinical trials remains limited. Steps toward harmonization and standardization are increasing in various pockets of the global scientific community. Th...

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… related to complications of hematopoietic stem cell transplantation. This highlights a non-… The most frequent ocular complication of autologous hematopoietic stem cell transplantation is … periorbital edema in a patient after hematopoietic stem cell …

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… This article provides a review of the most frequently used CSCs and stem cell markers. … of stem cells, because they play a role in stem cell pluripotency and their interactions with various co-… Indeed, the functional role of stem cell factors in …

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… the multitude of stem cell types (adipose derived, bone marrow derived, embryonic and induced pluripotent) and techniques employed to induce stem cell proliferation and differentiation … Here, we curate several studies on stem cell …

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… Instead, using stem cell models, it is possible to recapitulate neurodevelopment in vitro, essentially observing risk in a laboratory dish. We … The first human embryonic stem cell lines were grown in 1998, with the theoretical capability to …

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PO-660-03 OPTICAL CONTROL OF ARRHYTHMIA MORPHOLOGY IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED … To develop a method for the induction of morphologically and physiologically defined arrhythmias in human …

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Background: Although text messaging has the potential to be the core intervention modality, it is often used as an adjunct only. To improve health and alleviate the distress related to insomnia, pain, and dysregulated eating of peopl...

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Background: Social media recruitment for clinical studies holds the promise of being a cost-effective way of attracting traditionally marginalized populations and promoting patient engagement with researchers and a particular study. ...

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Much has been learned about the genes and pathways that contribute to a diverse array of hematopoietic malignancies and other hematopoietic diseases. However, for many of these diseases, an allogeneic hematopoietic stem cell (HSC) transplant …

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… Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus …

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… In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/… , which promotes stem cell-like characteristics [20, 21]. Thus, we aimed to determine …

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Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient …

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… ASCL1 is required to establish the neuronal and stem cell-like lineage … To determine whether ASCL1 is required for the development of neuronal and stem cell-like phenotype… neuronal and stem cell differentiation and functions to bias the cell fate …

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… of the gut microbiota correlate with superior outcomes after hematopoietic stem cell transplantation. Correlative data support the impact of … discuss data describing the key role of microbiota in hematopoietic stem cell transplantation for …

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… Stem cell quiescence is regulated by multiple factors including p53, Rb, cyclin-dependent kinase inhibitors, such as p21 and p27, and Notch signaling (5–10). How these pathways may integrate to maintain stem cell … Dysregulation or loss of quiescence …

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… Human induced pluripotent stem cell (hiPSC) technology can be used for disease … Culturing hiPSC-CM or human embryonic stem cell-derived cardiomyocytes (hESC-CM) within … sufficient to induce full maturation of pluripotent stem cell-derived …

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Background: A growing amount of health research uses social media data. Those critical of social media research often cite that it may be unrepresentative of the population; however, the suitability of social media data in digital ep...

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Background: The emerging health technologies and digital services provide effective ways of collecting health information and gathering patient-generated health data (PGHD), which provide a more holistic view of a patient’s health ...

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Background: Patients with chronic pain often experience insomnia symptoms. Pain initiates, maintains, and exacerbates insomnia symptoms, and vice versa, indicating a complex situation with an additional burden for these patients. Hen...

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… stem cell niche. Here, we hypothesized that regulation of cell-cell interactions using a polymeric scaffold as synthetic extracellular matrix (ECM) could be critical in creating a hematopoietic stem cell … and cell-instructive characteristics for stem cell …

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Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication after allogeneic stem cell transplantation (allo-HCT). However, there is no uniform consensus on the optimal strategy for SOS prevention. Ursodeoxycholic acid is the …

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… In this study, we found that the PDMS substrate coated with a combination of polydopamine (PDA) and laminin-511 E8 fragments (PDA + LME8-coated PDMS) can support human-induced pluripotent stem cell (hiPSC) attachment and growth for …

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… Its impact in any cancer stem cell (CSC) subtype remained elusive. In a recent study, we characterized the expression of LAMP2A and CMA activity in glioblastoma revealing its enrichment in a glioma stem cell (GSC) subpopulation. LAMP2A …

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Benzophenones are widely used in industry and commonly added in many personal care products. However, the neurotoxicity, in particular neurodevelopmental toxicity, of benzophenone family chemicals and metabolites has not been fully elucidated …

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… Human neuronal models range from various neuroblastoma cell lines to stem cell–derived systems, including those derived from mesenchymal stem/stromal cells (hMSC). hMSCs exhibit numerous advantages, including the fact that they can be obtained in …

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… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …

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The United States has abysmal reproductive health indices that, in part, reflect stark inequities experienced by people of color and those with preexisting medical conditions. The growth of “femtech,” or technology-based solutions to women’s he...

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Background: In 2020 and 2021, people increasingly used the internet to connect socially and professionally. However, people with an acquired brain injury (ABI) experience challenges in using social media, and rehabilitation professio...

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Background: The internet has become a major source of health information for general consumers. Web-based health information quality varies widely across websites and applications. It is critical to understand the factors that shape ...

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Background: Sensors embedded in smartphones allow for the passive momentary quantification of people’s states in the context of their daily lives in real time. Such data could be useful for alleviating the burden of ecological mome...