Scientists have revealed the atomic-level structure of a molecular complex responsible for modifying proteins, possibly paving the way for the development of new medications for cancer and a host of other diseases.
A new article in the February 2018 issue of SLAS Technology describes a new platform that could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient blood. The article provides unique insight into the development of a commercial system that has the potential to change the standard of care in cancer diagnosis and treatment.
A study led by UNC Lineberger Comprehensive Cancer Center and published in the Journal of Cell Biology examined the role of the physical structure of the nucleus in cell movement through different surfaces.
Using an approach that combines ultrasound imaging and genetic engineering of bacterial microbes, a team from California Institute of Technology (Caltech), with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), has created a powerful new system to track bacteria dispatched to deliver therapies deep inside the body.
La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.
Apply for ASCB’s Public Engagement Grants. Grantees will receive from $10,000 to $35,000 for bold ideas that engage local communities with the process of science and increase public scientific literacy. The application deadline is March 31.
A new Michigan State University study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer.
For the first time, scientists can see in minute-time resolution how cells package chromosomes into highly condensed structures prior to cell division.
What lives in your dirt? University of Colorado Boulder researchers are one step closer to finding out after compiling the first global atlas of soil bacterial communities and identifying a group of around 500 key species that are both common and abundant worldwide.
Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide. The tiny molecule can change how proteins function. But new research featured in Molecular Cell suggests supplementing nitric oxide—NO—is only the first step. Researchers have discovered previously unknown enzymes in the body that convert NO into “stopgap” molecules—SNOs—that then modulate proteins. The newly discovered enzymes help NO have diverse roles in cells. They may also be prime therapeutic targets to treat a range of diseases.
Wistar is pleased to announce it has been awarded a $1,494,972 grant by the Bill & Melinda Gates Foundation to advance a DNA-based vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab of David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Research.
Columbia University researchers have identified two new breast cancer genes that also cause Lynch syndrome.
A research team at GW School of Medicine and Health Sciences found that latent HIV reservoirs exhibit resistance to elimination by CD8+ T-cells of people living with the virus.
Columbia biomedical engineers design a new, biomaterials-based system that takes a soft approach to improving cell manufacturing and may bring new hope to cancer patients for T-cell therapy.
Los pacientes con gammapatía monoclonal de significado incierto corren más riesgo de avanzar hacia mieloma múltiple u otro cáncer afín, incluso después de 30 años de estabilidad.
Gender-based differences may influence several ocular conditions, suggesting that fluctuations in sex steroid homeostasis may have direct effects on eye physiology and the pathogenesis of conditions like Age-Related Macular Degeneration (AMD).
No individual fish or bee or neuron has enough information by itself to solve a complex problem, but together they can accomplish amazing things. In research recently published in Science Advances, Eleanor Brush (University of Maryland), David Krakauer, and Jessica Flack address how this is possible through a study of the emergence of social structure in primate social groups.
Using Oak Ridge National Laboratory's Titan supercomputer, a team led by Brown University’s George Karniadakis devised a multiscale model of sickle cell disease that captures what happens inside a red blood cell affected by the disease.
A three-year, $675,000 grant from the National Institutes of Health (NIH) to understand cell-size control in the unicellular green alga Chlamydomonas reinhardtii.
A research team at the Duke Cancer Institute has found a new way to keep the immune system engaged, and is planning to test the approach in a phase 1 clinical trial.
A team of scientists from Singapore and France, led by Professor Lim Chwee Teck, Principal Investigator at the Mechanobiology Institute, Singapore and the Department of Biomedical Engineering at the National University of Singapore, has described a novel ‘microtube’-based platform to study how tubular organs, such as the heart and the kidneys, form under the various topographical restrictions commonly experienced inside the body.
Scientists in Montreal develop a unique technique to map, on a scale of milliseconds, the elasticity of the components inside a cell.
Prostate tumors tend to be what scientists call “indolent” – so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal. In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high-fat diet as a key environmental factor driving metastasis.
Scientists at the University of Washington announced that they have built and tested a new biomaterial-based delivery system — known as a hydrogel — that will encase a desired cargo and dissolve to release its freight only when specific physiological conditions are met.
By analyzing immune cells of children who came to the emergency department with flu symptoms, researchers found that the suite of genes these early-response cells expressed was shaped by factors such as age and previous exposures to viruses. Better understanding how early infections influence long-term immune response has implications for the diagnosis and treatment of young patients who suffer from acute respiratory tract infections.
The field of immunotherapy – the harnessing of patients’ own immune systems to fend off cancer – is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.
The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.
A multi-institutional research team led by Indiana University School of Medicine scientists has developed a new way to harvest blood stem cells for bone marrow donation that is faster and more effective than the current standard of care.
A discovery by scientists at Dana-Farber Cancer Institute and University of Texas Southwestern Medical Center presents drug developers with an entirely new tack in targeting one of the most-wanted molecular culprits in cancer.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.
Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.
A protein involved in cognition and storing long-term memories looks and acts like a protein from viruses. The protein, called Arc, has properties similar to those that viruses use for infecting host cells, and originated from a chance evolutionary event that occurred hundreds of millions of years ago.
Canadian researchers’ innovative work promises to make vaccines more effective against tuberculosis and other infectious diseases like the flu.
UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life
Desmoplastic melanoma is a rare subtype of melanoma that is commonly found on sun-exposed areas, such as the head and neck, and usually seen in older patients. Treatment is difficult because these tumors are often resistant to chemotherapy and lack actionable mutations commonly found in other types of melanoma that are targeted by specific drugs. However, Moffitt Cancer Center researchers report in the Jan. 10 issue of Nature that patients with desmoplastic melanoma are more responsive to immune-activating anti-PD-1/PD-L1 therapies than previously assumed.
Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. A group of medical experts recommend performing systematic scientific studies to test precise nutritional interventions for patients.
A new study shows how stress accelerates pancreatic cancer development. Beta-blockers, which block stress hormones, may increase survival for patients with the disease.
A Michigan State University researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.
“Decorating” cardiac stem cells with platelet nanovesicles can increase the stem cells’ ability to find and remain at the site of heart attack injury and enhance their effectiveness in treatment.
Biological clocks throughout the body play a major role in human health and performance. Now, Texas A&M University researchers found that circadian rhythms could hold the key to novel therapies for glioblastoma, the most prevalent type of brain cancer in adults—and one with a grim prognosis.
January 2018 issue of SOT journal honors the publication's 20-year history and features the newest, groundbreaking research in toxicology.
While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin-Madison unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.
Cancer cells can be destroyed more effectively and selectively with a unique new reusable treatment, activated with a substance found in stinging nettles and ants - thanks to new research by the University of Warwick.
Scientists at the Keck School of Medicine of USC use enzymes responsible for marine animal bioluminescence to help researchers test whether cancer immunotherapies work.
The most commonly used gene expression profile test, Oncotype DX®, used to help predict breast cancer recurrence may not be as cost-effective as once thought, say a team of researchers.
St. Jude Children’s Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children. Previously, scientists thought the cancer arose from immature muscle cells, because the tumor resembled muscle under the microscope. However, the St. Jude researchers discovered the cancer arises from immature progenitors that would normally develop into cells lining blood vessels.
Following the chemistry, scientists develop fascinating new theory for how life on Earth may have begun.
New models identify factors that put coral reefs at risk of extinction in the face of climate change, and suggest that facilitating migration of corals could allow reefs to adapt. The results of this research will be presented at the annual conference of the Society for Integrative and Comparative Biology in San Francisco, CA on January 7, 2018.
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