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Medicine

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Microbiome, Gut Bacteria, Salmonella, E. Coli, Mouse, Clostridium

Newborns Get Infection Protection, Not Just Digestion, From Gut Bacteria, New Study in Mice Shows

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Hundreds of thousands of babies worldwide die every year from infections that ravage their digestive systems. New research in mice offers evidence that the difference in survival may come from certain bacteria in their guts, called Clostridia, which appear to provide key protection against infection, in addition to helping digest food.

Medicine

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San Diego, Palm Beach, Neuroscience, Neurotransmission, Brain

Closer Look at Brain Circuits Reveals Important Role of Genetics

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Scientists at The Scripps Research Institute (TSRI) in La Jolla have revealed new clues to the wiring of the brain. A team led by Associate Professor Anton Maximov found that neurons in brain regions that store memory can form networks in the absence of synaptic activity.

Medicine

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Pollution, Ramanathan, mice, Respitory, Sinuses, Breathing

Air Pollution May Directly Cause Those Year-Round Runny Noses, According to a Mouse Study

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Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant. Now, Johns Hopkins researchers report that experiments in mice continually exposed to dirty air have revealed that direct biological effect.

Medicine

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heart attacks, Major Marathons, Cardiac Arrest, Death, Survival Rate, Races, Sporting events, Anupam Jena, Death Rates, Marathons, Health And Safety, Marathoners, Runners

People Suffering Heart Attacks Near Major Marathons Face Grimmer Survival Odds

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At a glance: People who suffer heart attacks and cardiac arrests in the vicinity of major marathons are more likely to die within a month. The bleaker survival odds are linked to delays in transportation to nearby hospitals. The delays are believed to stem from widespread road closures within the radius of the race. The study findings underscore the need for citywide strategies that ensure rapid transport for medical emergencies in the vicinity of major public events.

Medicine

Science

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Nanoparticles, Leukocyte, leukosome, protein corona formation, Cardiovascular Disease, Autoimmune Disease, Cancer Therapy, Regenerative Medicine

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

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A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface.

Medicine

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HIV, Treatment, Prevention, Africa, World Health Organization

Study Finds UN Strategy for Eliminating HIV in Sub-Saharan Africa Is Unfeasible

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Statistical mapping technique shows widely dispersed population could pose challenges for initiative

Medicine

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Paralysis, quadriplegia, Case Western Reserve University, Biotechnology, Cleveland FES Center, Biomedical Engineering

Man with Quadriplegia Employs Injury Bridging Technologies to Move Again—Just by Thinking

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Bill Kochevar, who was paralyzed below his shoulders in a bicycling accident, is believed to be the first person with quadriplegia in the world to have arm and hand movements restored with the help of two temporarily implanted technologies.

Medicine

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Seth Margolis, Alzheimer’s, ephexin5 , Brain, Amyloid

Protein That Regulates Brain Cell Connections Could Be New Target for Treating Alzheimer's Disease

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In experiments with a protein called Ephexin5 that appears to be elevated in the brain cells of Alzheimer's disease patients and mouse models of the disease, Johns Hopkins researchers say removing it prevents animals from developing Alzheimer's characteristic memory losses. In a report on the studies, published online March 27 in The Journal of Clinical Investigation, the researchers say the findings could eventually advance development of drugs that target Ephexin5 to prevent or treat symptoms of the disorder.

Medicine

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Infectious Diseases, zika virus, Pregnancy, Obstetrics, Autism, Neurology, Virology

How Prenatal Maternal Infections May Affect Genetic Factors in Autism Spectrum Disorder

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In a new study, researchers at the University of California San Diego School of Medicine, University of Cyprus and Stanford University map the complex biological cascade caused by MIA: the expression of multiple genes involved in autism are turned up or down by MIA, affecting key aspects of prenatal brain development that may increase risk for atypical development later in life.

Medicine

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Genetics, Psychiatry, Molecular Biology, Neurobiology, Depression, Mental Health, Pharmaceutical Chemistry, Neuroscience

Mouse Study Identifies New Method for Treating Depression

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Standard antidepressant medications don’t work for everyone, and even when they do they are slow to kick in. In an effort to find better depression treatments, researchers at University of California San Diego School of Medicine discovered that inhibiting an enzyme called Glyoxalase 1 (GLO1) relieves signs of depression in mice. Moreover, inhibiting GLO1 worked much faster than the conventional antidepressant Prozac.







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