Fred Hutchinson Cancer Research Center’s latest findings will be featured in about 50 presentations at the annual meeting of the American Association for Cancer Research, “Driving Innovative Cancer Science to Patient Care,” to be held April 14-18 in Chicago. Here are several highlights:
Researchers have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7 — lack of Sp7 interrupts the maturation of two types of specialized cells that help create teeth. Such basic knowledge about development aids understanding of craniofacial abnormalities.
Non-small cell lung cancer Nanoparticles pass the next stage of development in preclinical tests.
Lasting just a few hundred billionths of a billionth of a second, these bursts offer new tool to study chemistry and magnetism.
he American Pain Society (APS) today endorsed aggressive action by the National Institutes of Health to accelerate scientific solutions to help resolve the nation’s opioid crisis by doubling funding for research on opioid misuse and pain management.
New research out of Roswell Park Comprehensive Cancer Center and The Ohio State University has identified rare variants in a number of novel genes that may help improve risk prediction and prognosis for patients undergoing BMT.
In new research published in Nature, a team led by Subhamoy Dasgupta, PhD, of Roswell Park Comprehensive Cancer Center reports its identification of two key proteins involved in glucose metabolism that could be targeted to prevent breast cancer metastasis and recurrence.
Women with polycystic ovary syndrome (PCOS), the most common hormone condition among young women, are prone to mental health disorders, and their children face an increased risk of developing attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
New research from The Ohio State University offers a glimpse into the complexity of interactions between bacteria and the viruses – or phages – that infect them.
The definitive culinary medicine conference—Health Meets Food 2018—will be held June 14-17 in New Orleans. The conference is dedicated to teaching medical professionals and the communities they serve about the important connection between good health and healthy eating.
Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests. Researchers at Cincinnati Children’s Hospital Medical Center report their data in the journal Cell Reports. Studying mice with IPF and donated human cells, they identified a gene called FOXF1 that inhibits the IPF disease.
Researchers at the University of Chicago have developed a genetic screening tool that identified two key factors that allow the influenza virus to infect human lung cells. The technique uses new gene editing tools to create a library of modified cells, each missing a different gene, allowing scientists to see which changes impact their response to flu. This in turn could identify potential targets for antiviral drugs.
Scientists have decoded faint distortions in the patterns of the universe’s earliest light to map huge tubelike structures invisible to our eyes – known as filaments – that serve as superhighways for delivering matter to dense hubs such as galaxy clusters.
More support is needed to help breast cancer patients and survivors manage ‘chemobrain’ symptoms, such as memory loss, short attention span and mental confusion, according to a study led by researchers from the National University of Singapore.
Researchers at Université de Montréal and the research centres of the CHUM and CHU Sainte-Justine are banding together to conquer this rare orphan pediatric disease. They have recently proven what scientists had already suspected: the disease is autoimmune, which means that it attacks patients using their own immune system.
Given the choice of riding in an Uber driven by a human or a self-driving version, which would you choose? Following last month’s fatal crash of a self-driving Uber that took the life of a woman in Tempe, Arizona, and the recent death of a test-driver of a semi-autonomous vehicle being developed by Tesla, peoples’ trust in the technology behind autonomous vehicles may also have taken a hit.
When power generators transfer electricity to homes, businesses and the power grid, they lose almost 10 percent of the generated power. To address this problem, scientists are researching new diamond semiconductor circuits to make power conversion systems more efficient. Researchers in Japan successfully fabricated a key circuit in power conversion systems using hydrogenated diamond. These circuits can be used in diamond-based electronic devices that are smaller, lighter and more efficient than silicon-based devices. They report their findings in this week’s Applied Physics Letters.
Beta blockers have become a prescription drug staple for recovering heart attack patients. However, these blood pressure-reducing medications cannot be tolerated by many patients who are at higher risk for developing cardiovascular disease, including those with chronic obstructive pulmonary disease (COPD) and asthma, the elderly, and diabetics. As seen in the March 26 issue of Thyroid, researchers at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) now pose a new treatment for patients with beta blocker intolerance: thyroid hormone therapy.
Johns Hopkins University researchers have developed a way to study the brain of a bat as it flies, recording for the first time what happens as a roving animal focuses and refocuses its attention.
Clostridium difficile infection (CDI) is now the most common hospital-acquired infection, with significant effects on healthcare costs. Surgeons from George Washington University Hospital sought to identify rates of C. difficile infection in patients undergoing common types of colon operations. The authors utilized the American College of Surgeons NSQIP database for 2015 to retrospectively review all cases of elective ileostomy and colostomy reversals.
Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value.
Colon cancer is a common cancer with a relatively high survival for nonmetastatic disease if appropriate treatment is given. A lower survival rate for patients with no or inadequate insurance has previously been documented, but the differences have not been explored in detail on a population level.
Underage drinking can lead to risky or harmful behaviors that include unintentional and unprotected sex, physical and sexual assault, traffic and other injuries, suicide, homicide, and overdoses. Binge drinking among adults is defined as five drinks consumed during two hours by adult men and four drinks by adult women – typically producing a blood alcohol level (BAL) of ≥0.08%. Adolescents can reach a similar BAL after consuming fewer drinks. This paper explored whether and how different levels of adolescent drinking affected associations with health-risk behaviors.
Experts in pediatric kidney disease have published a new staging system to help doctors better predict the length of time until a child with chronic kidney disease will need to undergo a kidney transplant or start receiving dialysis. Although this type of prognostic guide exists for adults, this is the first such tool specific to children.
Researchers are proposing the creation of an open-source network that uses blockchains – the technology behind cryptocurrencies – to share verifiable manufacturing data. The network would allow companies to more easily find manufacturers capable of producing components on a reliable basis.
New research casts doubt on the argument that 'white flight' is motivated by socioeconomic factors, not race. Examining population trends in racially mixed suburbs, sociologist Samuel Kye finds that white flight occurs when nonwhite residents move in, regardless of socioeconomic factors.
A new study of the 2016 U.S. presidential election suggests that narcissism and charisma are both important predictors of voter choice. Researchers found that attributed charisma may serve as a balance to narcissism. Thus, followers of a candidate potentially look beyond negative leadership qualities to select those leaders who they perceive to have redeeming positive attributes and values.
The risk of riding out a storm is symbolic of the decision black men make to pursue a graduate degree in engineering. They know they'll face challenges, but the barriers described by black men interviewed as part of a six-year study show how race was a greater obstacle than they expected.
A new study by the University of Haifa, the Open University of Israel, and The University of Amsterdam found that service staff who express emotions in high intensity - positive or negative - are perceived as less trustworthy and customers are less satisfied with the staff and even less likely to use the product
The University of Glasgow’s Sir Graham Teasdale, co-creator of the Glasgow Coma Scale, has teamed with Paul M. Brennan and Gordon D. Murray of the University of Edinburgh to create new assessment tools that build on the Glasgow Coma Scale to provide greater information on injury severity and prognosis in patients with traumatic brain injury while still offering simplicity of use.
Several groups have championed standardization of this approach in order to optimize outcomes.
Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify all patients who may respond to certain therapies. Other molecular information from patients may reveal these so-called “hidden responders."
Articles on personal care product chemicals; PBPK modeling; 2D vs 3D for drug-induced liver injury; zebrafish and drug discovery; glutathione restoration and acetaminophen; high-throughput screening for thyroid hormone T4; and genetically engineered food crops featured in new Toxicological Sciences.
More people are receiving coronary revascularization under Michigan's Medicaid expansion (the Healthy Michigan Plan). A new analysis finds that the expansion hasn’t caused significant problems for patients.
Researchers at the University of Notre Dame focused on an enzyme in gram-negative bacterium Pseudomonas aeruginosa, a pathogen that causes pneumonia and sepsis.
Many of the “forensic science” methods commonly used in criminal cases and portrayed in popular police TV dramas have never been scientifically validated and may lead to unjust verdicts, according to an editorial in this week’s Proceedings of the National Academy of Sciences.
Columbia Engineering researchers have invented a new Robotic Spine Exoskeleton, a dynamic spine brace that enabled them to conduct the first study that looks at in vivo measurements of torso stiffness and characterizes the three-dimensional stiffness of the human torso. This device may solve current bracing limitations and lead to new treatments for children with spine deformities such as idiopathic scoliosis and kyphosis.
New Yorkers love apples. The Empire State is the second-largest apple grower in the U.S. and is the No. 1 producer of processedapple products, such as cider, juice and canned apples. Given this appreciation for apples, consumers might be concerned by reports from food scientists of a fungus, Paecilomyces niveus, that spoilsapple products even after heat pasteurization. The fungus also produces an FDA-regulated toxin called patulin that is found in these spoiled processed foods.
This week, the Axion Dark Matter Experiment (ADMX) unveiled a new result, published in Physical Review Letters, that places it in a category of one: It is the world’s first and only experiment to have achieved the necessary sensitivity to “hear” the telltale signs of dark matter axions. This technological breakthrough is the result of more than 30 years of research and development, with the latest piece of the puzzle coming in the form of a quantum-enabled device that allows ADMX to listen for axions more closely than any experiment ever built.
“As researchers, they take risks without knowing the answers...I really admire it.”
UIC researchers have confirmed for the first time the association of a chromosomal genetic variant with increased risk of AFib in Latinos. Latino patients were found to be at a 2.3-fold increased risk for developing AFib if they carried this common genetic variant, which is labeled rs10033464 SNP at chromosome 4q25.
A promising class of drugs known as CD40 monoclonal antibodies could be the spark needed to light the fire in the immune system of patients who don’t respond to the newer cancer immunotherapies. Robert H. Vonderheide, MD, DPhil, director of the Abramson Cancer Center at the University of Pennsylvania and an internationally renowned cancer immunotherapy expert, makes the case for the drugs in a new perspective piece published this week in Cancer Cell, as part of a series in the issue focusing on the next phase of the evolving field of cancer immunotherapy.
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered that that inactivation of a protein called p62 in fat cells fuels aggressive, metastatic prostate cancer in mice. The findings suggest that mTOR inhibitors currently used to treat a wide range of cancers may have the unintended consequence of shutting down fat tissue metabolism and fueling tumor growth.
New research from Florida State University scientists has found that urban areas throughout the Florida peninsula are experiencing shorter, increasingly intense wet seasons relative to underdeveloped or rural areas.
UPTON, NY—Scientists studying plant biochemistry at the U.S. Department of Energy’s Brookhaven National Laboratory have discovered new details about biomolecules that put the brakes on oil production. The findings suggest that disabling these biomolecular brakes could push oil production into high gear—a possible pathway toward generating abundant biofuels and plant-derived bioproducts.
The term “superfluid quasicrystal” sounds like something a comic-book villain might use to carry out his dastardly plans. In reality, it’s a new form of matter proposed by theoretical physicists at The University of Texas at Dallas in a recent study published in the journal Physical Review Letters.
UCLA researchers have tweaked CRISPR technology, enabling them to monitor the outcome of tens of thousands of gene edits in the time it currently takes to analyze a few. The advance will improve scientists’ ability to identify the genetic changes most likely to harm cells and contribute to disease.
EMBARGOED - A team of Cedars-Sinai investigators has developed a new technique for conducting cardiac magnetic resonance imaging (MRI) tests that improves patient comfort, shortens testing time and has the potential to increase diagnostic accuracy and reliability.
Studying data from more than 125,000 individuals, an international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified genetic links between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The link between the seemingly unrelated disorders suggests that some drugs developed to treat ALS also may work against frontotemporal dementia and vice versa.
Examining 44,000 brief text samples collected over 25 years, a study of ego level and language sheds light on ego development, its relationship with other models of personality and individual differences, and its utility in characterizing people, texts and cultural contexts. If ego development can be scored from everyday language, then text from Twitter feeds to political speeches, and from children’s stories to strategic plans, may provide new insights into the state of moral, social and cognitive development.
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