Michael J. Fox is back in the spotlight this fall in a new sitcom “The Michael J. Fox Show” and spreading awareness about Parkinson’s disease, a condition both he and his TV character have in common. Fox has been an outspoken advocate for Parkinson’s disease research and awareness since disclosing his condition to the public in 1998.
Neuroscientist William “Jamie” Tyler uses boxing as an example for how the brain is affected by mechanical impulses — such as a blow to the head — in a cover story this week in The New Scientist. While brain cells communicate along electrical and biochemical pathways, Tyler points out neurons have mechanical clockwork, too.
A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The findings were published today in the online edition of Science Translational Medicine.
Migraine may have long-lasting effects on the brain’s structure, according to a study published in the August 28, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Studies show that migraine is more common among people with lower incomes. This relationship is examined in a study published in the August 28, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology, looking at whether developing migraines limits people’s educational and career achievements, leading to a lower income status, or whether problems related to low income such as stressful life events and poor access to health care increase the likelihood of developing migraines.
Researchers have tied mutations in a gene that causes amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders to the toxic buildup of certain proteins and related molecules in cells, including neurons.
Scientists at Albert Einstein College of Medicine of Yeshiva University have shown that high-functioning autism spectrum disorder (ASD) children appear to outgrow a critical social communication disability. Younger children with ASD have trouble integrating the auditory and visual cues associated with speech, but the researchers found that the problem clears up in adolescence. The study was published today in the online edition of the journal Cerebral Cortex.
Johns Hopkins researchers say they have found a specific protein in nearly 100 percent of high-grade meningiomas — the most common form of brain tumor — suggesting a new target for therapies for a cancer that does not respond to current chemotherapy.
University of Washington researchers have performed what they believe is the first noninvasive human-to-human brain interface, with one researcher able to send a brain signal via the Internet to control the hand motions of a fellow researcher.
Like volunteers handing out cups of energy drinks to marathon runners, specially engineered “helper cells” transplanted along with stem cells can dole out growth factors to increase the stem cells’ endurance, at least briefly, Johns Hopkins researchers report. Their study, published in the September issue of Experimental Neurology, is believed to be the first to test the helper-cell tactic, which they hope will someday help to overcome a major barrier to successful stem cell transplants.
Entomologists have identified a neuropeptide named natalisin that regulates the sexual activity and reproductive ability of insects. The finding may open new possibilities for environmentally friendly pest management.
Perelman School of Medicine researchers at the University of Pennsylvania report the first biomarker results reported from the Parkinson’s Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson’s disease. The study is reported in JAMA Neurology.
The brain’s tactile and motor neurons, which perceive touch and control movement, may also respond to visual cues, according to researchers at Duke Medicine.
Researchers at Johns Hopkins and elsewhere have brought new clarity to the picture of what goes awry in the brain during Parkinson’s disease and identified a compound that eases the disease’s symptoms in mice. Their discoveries, described in a paper published online in Nature Neuroscience on August 25, also overturn established ideas about the role of a protein considered key to the disease’s progress.
Key details of the way nerve cells in the brain remember pleasure are revealed in a study by University of Alabama at Birmingham (UAB) researchers published today in the journal Nature Neuroscience. The molecular events that form such “reward memories” appear to differ from those created by drug addiction, despite the popular theory that addiction hijacks normal reward pathways.
Scientists at Washington University School of Medicine in St. Louis have found a way that corrupted, disease-causing proteins spread in the brain, potentially contributing to Alzheimer’s disease, Parkinson’s disease and other brain-damaging disorders.
A University of Virginia study using brain scans has found that people experience risk to friends in the same way they feel risk to themselves.
In a new study published in Neuron, researchers have identified how a fundamental biological process called protein synthesis is controlled within the body’s circadian clock — the internal mechanism that controls one’s daily rhythms. Their findings may help shed light on future treatments for disorders triggered by circadian clock dysfunction, including jet lag, shift work disorders, and chronic conditions like depression and Parkinson’s disease.
New research suggests that chronic traumatic encephalopathy (CTE), a brain disease associated with repeat brain trauma including concussions in athletes, may affect people in two major ways: initially affecting behavior or mood or initially affecting memory and thinking abilities. The study appears in the August 21, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. CTE has been found in amateur and professional athletes, members of the military and others who experienced repeated head injuries, including concussions and subconcussive trauma.
A leading group of Alzheimer's researchers contends that, as biomarkers to detect signals of the disease improve at providing clinically meaningful information, researchers will need guidance on how to constructively disclose test results and track how disclosure impacts both patients and the data collected in research studies.
New research shows that in a dynamic mind-body interaction during the interpretation of prolonged stress, cells from the immune system are recruited to the brain and promote symptoms of anxiety.
Neurologists report a unique case of a woman who hears music, as if a radio were playing in the back of her head. The case raises “intriguing questions regarding memory, forgetting and access to lost memories.”
A new study suggests that pilots who fly at high altitudes may be at an increased risk for brain lesions. The study is published in the August 20, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.
In patients with early Alzheimer’s disease, disruptions in brain networks emerge about the same time as chemical markers of the disease appear in the spinal fluid, researchers at Washington University School of Medicine in St. Louis have shown.
By directly altering the gene coding for the prion protein (PrP), Whitehead Institute researchers have created mouse models of two neurodegenerative prion diseases, each of which manifests in different regions of the brain. These new models for fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD) accurately reflect the distinct patterns of destruction caused by the these diseases in humans. Remarkably, as different as each disease is, they both spontaneously generate infectious prions.
UC San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson’s disease. A similar approach might ward off cell death in the brains of people afflicted with Parkinson’s disease..
Scientists have discovered that an active ingredient in an over-the-counter skin cream slows or stops the effects of Parkinson’s disease on brain cells. Scientists identified the link through biochemical and cellular studies, and the research team is now testing the drug in animal models of Parkinson’s. In 2004, researchers studying an Italian family with a high prevalence of early-onset Parkinson’s disease discovered mutations in a protein called PINK1 associated with the inherited form of the disease. The HHMI research team began their studies with an eye toward developing a way to turn on or crank up PINK1 activity, therefore preventing excess cell death in those with inherited Parkinson’s disease.
Researchers at the University of Adelaide have discovered a novel and complex visual circuit in a dragonfly's brain that could one day help to improve vision systems for robots.
The research found no evidence of abnormalities in the internal jugular or vertebral veins or in the deep cerebral veins of any of 100 patients with multiple sclerosis (MS) compared with 100 people who had no history of any neurological condition.
Newly released research findings from University of Utah neuroscientists assert that there is no evidence within brain imaging that indicates some people are right-brained or left-brained. For years in popular culture, the terms left-brained and right-brained have come to refer to personality types, with an assumption that some people use the right side of their brain more, while some use the left side more. Following a two-year study, University of Utah researchers have debunked that myth through identifying specific networks in the left and right brain that process lateralized functions.
A study by Johns Hopkins researchers shows that a fifth of U.S. neurologists appear unaware of serious drug safety risks associated with various anti-epilepsy drugs, potentially jeopardizing the health of patients who could be just as effectively treated with safer alternative medications.
UWM researchers uncover a cellular mechanism for memory and learning that provides one avenue for how these take place.
After decades of research, multiple sclerosis patients are seeing a “rapid expansion” of effective new treatment options, according to a review article in the journal Neurologic Clinics.
Researchers at Johns Hopkins have uncovered a protein switch that can either increase or decrease memory-building activity in brain cells, depending on the signals it detects. Its dual role means the protein is key to understanding the complex network of signals that shapes our brain’s circuitry, the researchers say.
A gene variant strongly associated with development of type 2 diabetes appears to interact with a Mediterranean diet pattern to prevent stroke, report researchers from Tufts University and from Spain. The results are a significant advance for nutrigenomics, the study of the linkages between nutrition and gene function.
Pregnant women who don't make nearly enough thyroid hormone are nearly 4 times likelier to produce autistic children than healthy women, report scientists from the Houston Methodist Neurological Institute and Erasmus Medical Centre in an upcoming Annals of Neurology.
A decade-long study in Corpus Christi, Texas, shows steep drops in stroke, but the stroke rate is still 34 percent higher among Mexican Americans than non-Hispanic whites.
A new study suggests that simple tests that measure the ability to recognize and name famous people such as Albert Einstein, Bill Gates or Oprah Winfrey may help doctors identify early dementia in those 40 to 65 years of age. The research appears in the August 13, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology.
A case study using functional magnetic resonance imaging suggests that behaviorally nonresponsive patients can use selective auditory attention to convey their ability to follow commands and communicate, according to a small study by Lorina Naci, Ph.D., and Adrian M. Owen, Ph.D., of Western University, London, Ontario, Canada.
New research from Washington University in St. Louis offers compelling evidence that a well-connected core brain network based in the lateral prefrontal cortex and the posterior parietal cortex — parts of the brain most changed evolutionarily since our common ancestor with chimpanzees — contains “flexible hubs” that coordinate the brain’s responses to novel cognitive challenges.
Neurologists and epilepsy researchers from NYU Langone Medical Center were among scientists who have 329 random genetic mutations associated with two of the most severe forms of epilepsy, according to a paper published today in Nature. Though well-known that many forms of epilepsy are strongly influenced by genetics, there has been relatively little progress in identifying the genetic differences that contribute to most forms of epilepsy.
Researchers from Case Western Reserve University and Cleveland Clinic have created “What you should know about mental health in youth with epilepsy,” an information booklet and CD that answers questions about children’s medical and psychological issues.
A large-scale international study on the genes involved in epilepsy has uncovered 25 new mutations on nine key genes behind a devastating form of the disorder during childhood. Among those were two genes never before associated with this form of epilepsy, one of which previously had been linked to autism and a rare neurological disorder, for which an effective therapy already has been developed.
Researchers have identified two new genes and implicated 25 distinct mutations in serious forms of epilepsy, suggesting a new direction for developing tailored treatments of the neurological disorders. The findings by an international research collaboration, which includes investigators from Duke Medicine, appear Aug. 11 in the journal Nature.
A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer’s Disease. Their findings also point to a potential therapeutic intervention for alleviating memory-related disorders.
Research from McGill University suggests that people who are vulnerable to developing alcoholism exhibit a distinctive brain response when drinking alcohol, according to a new study by Prof. Marco Leyton, of McGill University’s Department of Psychiatry. Compared to people at low risk for alcohol-use problems, those at high risk showed a greater dopamine response in a brain pathway that increases desire for rewards. These findings, published in the journal Alcoholism: Clinical & Experimental Research, could help shed light on why some people are more at risk of suffering from alcoholism and could mark an important step toward the development of treatment options.
Surgery to relieve the damaging pressure caused by hemorrhaging in the brain is a perfect job for a robot. That is the basic premise of a new image-guided surgical system under development at Vanderbilt University.
Before the digital age, neuroscientists got their information in the library like the rest of us. But the field’s explosion has created nearly 2 million papers -- more data than any researcher can read and absorb in a lifetime.
Drinking two cups of hot chocolate a day may help older people keep their brains healthy and their thinking skills sharp, according to a study published in the August 7, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
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