The American Autoimmune Related Diseases Association (AARDA) will host their National Summit on Autoimmune Disease Wednesday, March 21, 2018. The National Summit is open to the public and will take place at Sidley Austin law firm located at 1501 K Street, N.W. #600, Washington, DC 20005. The Summit is 10:00 a.m. – 4:30 p.m., with a special reception to follow 5:00 p.m. – 7:00 p.m.
A research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off. This technology could lead to the development of new cancer therapies and other drugs.
An Ohio integrated health system and a national social enterprise have announced a new alliance to mobilize tens of millions of dollars for underinvested communities—starting with a $45 million effort to scale up economic opportunity and improve health outcomes in Toledo and the surrounding region over the next decade.
Researchers have successfully created a novel biomaterial that can be seeded with insulin-producing beta cells. Implantation of the beta cell-seeded biomaterial reversed diabetes in a mouse model by effectively normalizing glucose levels and significantly increasing survival. The research results will be presented Monday, March 19, at ENDO 2018, the annual 100th meeting of the Endocrine Society in Chicago, Ill.
Scientists don’t yet grasp the intricacies of the relationship between sepsis and dementia. Candice Brown, an assistant professor in West Virginia University’s School of Medicine and Rockefeller Neuroscience Institute, is studying that relationship in order to bring about insights that help prevent or mitigate the neurological impact of sepsis.
Eight years in the making, a discovery by neuroscientists in Montreal highlights the value of long-term, fundamental research and provides important information for future drug targets.
Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests. The results of the study will be presented Sunday, March 18, at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill.
Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in Chicago, Ill.
Van Andel Research Institute (VARI) Chief Scientific Officer Peter Jones, Ph.D., D.Sc., will be awarded an honorary doctorate from South Africa’s Stellenbosch University (SU) in recognition of a lifetime of scientific achievement and dedication to improving cancer treatment.
Imagine if doctors could diagnose their patients with lung or esophageal cancer by simply swabbing the inside of their cheeks. Vadim Backman, a biomedical engineer at Northwestern University, has developed a new technology that could make that seemingly simple solution a reality.
Scientists are one step closer to understanding how cells reshape their surfaces to internalize material from their surroundings, thanks to collaboration among researchers from two South Dakota universities and the National Institutes of Health.
Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach — known as SPLiT-seq — reliably tracks gene activity in a tissue down to the level of single cells.
A method currently used by thousands of laboratories across the country to preserve tissue could render samples useless over time for a common test to assess gene activity, a study led by Johns Hopkins researchers suggests. The findings, published in the November 2, 2017 American Journal of Clinical Pathology, could eventually lead to significant changes in how tissues are stored for clinical and research purposes.
Iowa State University researchers found a way to gain new insight into the human immune system by studying material left over after blood donations. The results, published recently in a peer-reviewed journal, illuminate the process of how the human body fights off harmful bacteria.
A UNLV biologist compared the DNA of fat fruit flies to a control group and found nearly 400 candidate genes potentially associated with obesity and other health problems.
•The ability of the “cold sore” herpes simplex virus to establish quiet infections and reawaken periodically has long mystified scientists. •A new study in mice reveals that a key host protein acts as a critical regulator of the virus’s sleep-wake cycle. •Disabling two viral binding sites for the protein weakened the virus’s ability to come out of hiding.
In the journal Clinical Cancer Research, researchers reported that by forcing cancer cells to slow down and developing stronger molecular traps for them, they could identify large numbers of the cells in cancer patients undergoing radiation therapy.
New research by University of Wisconsin-Madison Professor of Pharmacy Seungpyo Hong and his collaborators builds on several years of work in isolating circulating tumor cells, or CTCs, by demonstrating improved methods for their capture on clinical samples for the first time.
Chemical compounds carry distinctive absorption “fingerprints,” within the mid-infrared spectral region; this offers an opportunity to measure and study chemicals at extremely sensitive levels, but researchers currently lack the tools required. In a breakthrough, NIST researchers developed an on-silicon-chip laser source with outputs that consist of precisely defined and equally spaced optical lines within the mid-infrared spectral region. They report their findings in APL Photonics.
UCLA scientists have developed a new method that utilizes microscopic splinter-like structures called “nanospears” for the targeted delivery of biomolecules such as genes straight to patient cells. These magnetically guided nanostructures could enable gene therapies that are safer, faster and more cost-effective.
Spin caloritronics explores how heat currents transport electron spin, and researchers are particularly interested in how waste heat could be used to power next-generation spintronic devices. The thermally driven transport application of spin caloritronics is based on the Seebeck effect; researchers in China have theoretically exposed the fundamental aspects of this thermal transport along double-stranded DNA molecules. They reported their findings in the Journal of Applied Physics.
A Ludwig Cancer Research study shows that ovarian cancer, which has proved resistant to currently available immunotherapies, could be susceptible to personalized immunotherapy. Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells—which kill infected and cancerous cells—and demonstrates how they can be identified and selectively grown for use in personalized, cell-based immunotherapies.
The Journal of Biological Chemistry has appointed Phyllis Hanson, Karin Musier-Forsyth, and Michael Shipston as associate editors. The three new editors bring expertise in intracellular cell membranes, RNA biology, and ion channel signaling to the journal.
TSRI scientists investigate a phenomenon that may guard against disease as we age.
African Americans with a common genetic variation are at increased risk for developing Alzheimer’s disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. They published the study results in the February 22 issue of the Journal of Clinical Endocrinology and Metabolism.
New research from Huntsman Cancer Institute (HCI) at the University of Utah (U of U) indicates steroid and hormone receptors are simultaneously active in many endometrial cancer tissues. The findings, published today in the journal Cell Reports, yield insights about factors that contribute to more aggressive endometrial tumors.
Biologists at Washington University in St. Louis have discovered the molecular brakeman that holds kinesins in check until their cargo is needed.
Drug therapies that target a specific molecule have changed the way patients are treated for cancer and greatly improved survival rates. However, some patients do not respond to these therapies because the drug is not reaching the tumor cells effectively. In a new study published in Scientific Reports, Moffitt Cancer Center researchers combined single-cell imaging of cancer cells in mice with mathematical modeling to determine which drug characteristics are the most important for efficient drug uptake.
Nearly half of newly diagnosed breast cancer patients who should be recommended for genetic testing did not get it. A quarter of these patients were not counseled about their potential risk, a new study finds.
Research Highlights: a proteomics study to understand a rare skin disease; understanding T cell activation through "click chemistry."
Berkeley Lab and Joint Genome Institute researchers took one of the most popular clustering approaches in modern biology—Markov Clustering algorithm—and modified it to run efficiently and at scale on supercomputers. Their algorithm achieved a previously impossible feat: clustering a 70 million node and 68 billion edge biological network in hours.
Pitt and UPMC researchers showed how a common virus hijacks a host cell’s protein to assemble new viruses.
Tufts biologists have demonstrated for the first time that electrical patterns in developing embryos can be predicted, mapped and manipulated to prevent defects caused by harmful substances such as nicotine. The study suggests that targeting bioelectric states may be a new treatment modality for regenerative repair in brain development and disease.
Researchers at Iowa State University, partnering with the LifeServe Blood Center, have used leftover blood donor cells to gain crucial insights into how natural killer cells circulating in the human body differ from those typically studied in the lab. The results of this research are published in the March 9 issue of the Journal of Biological Chemistry.
A team led by engineers at Tufts University has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution. The researchers were able to use the method to identify specific metabolic signatures that could arise in diabetes, cancer, cardiovascular and neurodegenerative diseases.
Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis.
According to a new study by The Wistar Institute, EZH2 inhibitors that are currently in clinical development for hematological malignancies and solid tumors may be effectively targeted to epithelial ovarian cancers overexpressing the CARM1 protein.
Exposure to psychological stress in the form of social conflict alters gut bacteria in Syrian hamsters, according to a new study by Georgia State University.
Deleting a single gene from mosquitoes can make them highly resistant to the malaria parasite and thus much less likely to transmit the parasite to humans, according to a new paper from scientists at Johns Hopkins Bloomberg School of Public Health’s Malaria Research Institute.
A lotion inspired by babies’ skin, membrane binding by an inflammation-linked kinase, and a colorectal cancer-fighting microRNA.
The protein FUS, whose mutation or disruption causes many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), works as a central component of one of the most important regulatory systems in cells, according to a new study in Molecular Cell from scientists at Johns Hopkins Bloomberg School of Public Health.
In a clinical trial at Washington University School of Medicine, Vanderbilt University Medical Center and two medical centers in France, researchers found that a drug that revs up the immune system holds promise in treating sepsis.
HHMI researchers have built mosquitobrains.org, the first map of the female mosquito brain. The new resource may ultimately uncover the circuitry behind biting and other behaviors.
UCLA researchers engineered mice to produce more TREM2, a gene tied to Alzheimer’s disease
A major advancement has been made on how epigenomics are studied that permits mapping a genome-scale profile of epigenetic changes using less than a couple hundred of cells, a factor of 100-300 reduction in the sample amount compared to existing alternatives. Led by Virginia Tech's Chang Lu, the innovative method has implications for deciphering disease processes such as schizophrenia, cancer and inflammation that involve epigenetic mechanisms.
Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by free radicals and oxidants. The research team showed that this pathway can be activated by a drug called monensin, which is commonly used as an antibiotic in animal feed.
CSU Bakersfield microbiology professor Antje Lauer says the state is tracking toward an epidemic of the infectious lung disease.
An interdisciplinary team of scientists at University of Utah Health are using animals' unique traits to pinpoint regions of the human genome that might affect health. The results of this project are available in the March 6 issue of the journal Cell Reports.
SBP researchers have discovered that accumulation of ceramides—a type of lipid (fat)— plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition that often occurs in patients with diabetes and obesity. The study, published today in Cell Reports, also identified several potential therapeutic targets that could prevent or reverse the effects of LCM.
A new study conducted by researchers at The Wistar Institute revealed how a key protein residing in the endoplasmic reticulum (ER) helps cells respond to stress. This process is especially important for B cells to respond to severe stress conditions and their ability to produce antibodies. The research was published online in the Journal of Cell Biology.
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