A grant-funded project will produce single-molecule images of the interaction that produces a protein key to Alzheimer's Disease.
After years of paltry funding, research on the possible role of microbes in the causation of Alzheimer's disease will now get a major infusion of grants from the NIH's National Institute on Aging
Critical Step Toward Developing Precision Medicine Treatments
The introduction of computer simulation to the identification of symptoms in children with ADHD could provide an additional objective tool to gauge the presence and severity of behavioral problems, researchers suggest in a new publication.
Texas Biomedical Research Institute Associate Professor Corinna Ross, PhD, is a principal investigator on a $3.38 million National Institutes of Health multi-investigator grant to study “microbiome-mediated therapies for aging and healthspan” in marmosets, which are small monkeys native to South America and are becoming increasingly more important in aging and infectious disease research. Dr. Ross is partnering with University of Texas at Austin College of Pharmacy Assistant Professor Kelly Reveles, PharmD, PhD.
A high-sugar diet creates a ‘double jeopardy’ impact for a protein crucial to cellular housekeeping, a new study suggests. The protein offsets cell damage from sugar, but too much sugar renders it ineffective. The results may offer insight for reducing age-related degenerative disease.
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health and the Federal Reserve Board of Governors found that Medicare beneficiaries who go on to be diagnosed with dementia are more likely to miss payments on bills as early as six years before a clinical diagnosis.
Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease.
Tufts researchers find a key mutation causing abnormal transport of BACE1, the enzyme responsible for processing the Alzheimer’s disease-linked amyloid protein. Identification of this mutation, which is more common among African Americans with Alzheimer’s, may allow early intervention.
The Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute and the University of Texas Health Science Center at San Antonio received a $1.3 million collaborative grant to continue the San Antonio Marmoset Aging Program (SA MAP) and further define the hallmarks of aging in a nonhuman primate (monkey) model. Developing the marmoset model will allow for eventual testing of interventions in additional model systems that could slow or change age-related decline in humans.
Women who work in the paid labor force in early adulthood and middle age may have slower memory decline later in life than women who do not work for pay, according to a new study published in the November 4, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers found an association between working for pay and slower memory decline regardless of a woman’s marital or parenthood status.
In a new medical records analysis of racial disparities in end-of-life care, researchers at Johns Hopkins Medicine and three collaborating institutions report that Black patients voluntarily seek substantially more intensive treatment, such as mechanical ventilation, gastronomy tube insertion, hemodialysis, CPR and multiple emergency room visits in the last six months of life, while white patients more often choose hospice services.
The National Institute on Aging (NIA) has awarded a five-year, $3.6 million research grant to Columbia Nursing faculty member Lusine Poghosyan, Ph.D., for a study on the care of persons with dementia in nurse practitioner practices and on racial and ethnic health disparities. The research will run from September 15, 2020, until May 21, 2025.
Untreated HIV infection is linked with epigenetic changes suggesting rapid aging. A new study by UCLA researchers shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses.
Older adults with severe apathy, or lack of interest in usual activities, may have a greater chance of developing dementia than people with few symptoms of apathy, according to a study published in the October 14, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A $53.6 million grant from the National Institutes of Health will aid brain scientists, including a researcher from The University of Texas Health Science Center at Houston (UTHealth), in studying the role of incidental white matter lesions, or WMLs, in dementia among diverse people with cognitive complaints.
Findings offer potential target for treating behavioral abnormalities associated with neurodegenerative conditions like Alzheimer’s Disease
Testing a readily and rapidly available, discreet in-vehicle sensing system could provide the first step toward future widespread, low-cost early warnings of cognitive change in older drivers. The use of an advanced, multimodal approach involves the development of novel driving sensors and integration of data from a battery of cognitive function tests, eye tracking and driving behaviors and factors. These in-vehicle technologies could help detect abnormal driving behavior that may be attributed to cognitive impairment.
A collaborative team of researchers from the United Kingdom and the Beaumont Research Institute in Royal Oak, Michigan have been awarded more than $1.67 million by the National Institute on Aging, a division of the U.S. National Institutes of Health, to study the link between dementia and post-operative delirium.
Why are men at greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age?
The National Institute on Aging has awarded a grant to researchers at New York University College of Dentistry to explore age-related, chronic low-grade inflammation and changes in the gut microbiome.
Mayo Clinic and collaborators have published a preprint that identifies two main signals of efficacy that can inform future clinical trials on plasma therapy on COVID-19 patients. The data are extracted from the Mayo-led national Expanded Access Program (EAP) for convalescent plasma for the treatment of hospitalized patients with COVID-19.
DALLAS – Aug. 12, 2020 – In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.
The Cornell Veterinary Biobank has received a $2.5 million federal grant to process, store and distribute biological samples for the Dog Aging Project, a massive national effort to study aging in dogs – and humans.
• A study shows female physicians have more equitable income when they work in practices with more doctors who are women. • The analysis shows a 12 percent relative difference in income for practices with equal numbers of female and male physicians, compared with a 20 percent income difference in practices dominated by men. • The findings offer important evidence that workplace diversity can help reduce earnings gaps, other inequities.
About 30% of stroke patients develop dementia, yet researchers understand very little about why. UChicago Medicine joins a NIH-led national network of institutions working to better understand the risk factors that lead to vascular cognitive impairment and dementia (VCID), early stroke recovery and approaches to prevention.
Why do some people stay sharp into their 90s, even if they have the amyloid plaques in the brain that are associated with Alzheimer’s disease? And why do others reach their 90s without ever developing any plaques? These questions are explored in a new study published in the July 22, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Scientists have unraveled key mechanisms behind the mysteries of aging. They isolated two paths that cells travel during aging and engineered a new way to genetically program these processes to extend life. The researchers also identified a master circuit that guides these aging processes.
Deaths from COVID-19 will have a ripple effect causing impacts on the mental health and health of surviving family members. But the extent of that impact has been hard to assess until now. Every death from COVID-19 will impact approximately nine surviving family members, according to a study.
For decades, family caregiving has been thought to create a type of chronic stress that may lead to significant health risks or even death, alarming potential caregivers and presenting a guilt-ridden obstacle for those needing help.
A study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine finds a link between the stress hormone cortisol and higher blood sugar levels in people with type 2 diabetes.
Alzheimer's disease in its early stages affects the integrity of small blood vessels in the retinas of patients, according to a recent study led by Cedars-Sinai. This discovery holds promise for early diagnosis of Alzheimer's through the retina, a back-of-the-eye organ that is an extension of the brain and easily accessible for live, noninvasive imaging.
Florida State researchers looked at memory replay in mouse models and found there was impaired functional interactions between the hippocampus and the parietal cortex.
Chronic stress is associated with the pathogenesis of psychological disorders such as depression. A study is the first to identify the role of a neuronal receptor that straddles the intersection between social stress, inflammation, and anxiety in rodent models of stress. Findings suggest the possibility of developing better medications to treat the consequences of chronic stress by limiting inflammatory signaling not just generally, which may not be beneficial in the long run, but to specific brain circuits.
Per- and polyfluoroalkyl substance (PFAS) exposure may cause menopause to occur two years earlier in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Middle-aged and older adults who identify as lesbian, gay, or bisexual have higher rates of using certain substances in the past year than those who identify as heterosexual, according to a new study led by researchers at NYU Grossman School of Medicine and the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU School of Global Public Health.
New imaging technology allows scientists to see the widespread loss of brain synapses in early stages of Alzheimer's disease, a finding that one day may help aid in drug development, according to a new Yale University study.
In a new animal study examining Alzheimer’s disease, researchers found that disease progression could be slowed by decreasing neuroinflammation in the brain before memory problems and cognitive impairment were apparent.
Amyloid is a key feature of Alzheimer’s disease, but the accumulation of these sticky proteins may not be the only risk factor for developing Alzheimer’s disease, according to a new study published this week. Other, modifiable risk factors, such as the amount of fats in our blood and how efficiently our bodies generate energy could also play important roles.
The newly awarded $8.6 million funding keeps Coriell in place as the trusted steward of this collection and includes the addition of new innovative products to expand the collection. The NIA Aging Cell Repository was established at Coriell in 1974 and Coriell has continuously managed this unique resource ever since.
With the support of a recent $3 million grant renewal from the National Institute on Aging (NIA), Mariana Figueiro is perfecting a treatment she developed for older adults with Alzheimer’s disease and related dementias that helps to regulate sleep and reduce symptoms of depression — and requires no drugs, only light.
Researchers at UC San Diego School of Medicine report that abnormal levels of beta-amyloid plaques in brain predict cognitive decline and higher risk of developing Alzheimer’s disease, but also that cognitive performance predicts progression from normal to abnormal levels of beta-amyloid.
Consumption of cocoa may improve walking performance for patients with peripheral artery disease, according to the results of a small, preliminary, phase II research trial published today in the American Heart Association's journal Circulation Research.
It can be the bain of brain drug developers: The interface between the human brain and the bloodstream, the blood-brain-barrier, is so meticulous that animal models often fail to represent it. This improved chip represents important features more accurately.
Researchers at Wake Forest School of Medicine have received a five-year grant worth approximately $2.53 million from the National Institute on Aging to evaluate whether a novel brain-imaging technique can identify Alzheimer’s disease in its early stages.
Scientists have found a way to distinguish between two progressive neurodegenerative diseases, Parkinson’s disease (PD) and multiple system atrophy (MSA), using a technology developed by a researcher at UTHealth. The discovery was published today in Nature.
People who eat or drink more foods with the antioxidant flavonol, which is found in nearly all fruits and vegetables as well as tea, may be less likely to develop Alzheimer’s dementia years later, according to a study published in the January 29, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Family caregivers usually are not asked by health care workers about needing support in managing older adults’ care, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
An image of your retina may help determine your risk for Alzheimer’s disease even before other symptoms are detectable. Iowa State researchers will use the retinal images, cognitive measurements and economic data to determine if this information can identify risk for Alzheimer’s disease.
Brain imaging of pathological tau-protein "tangles" reliably predicts the location of future brain atrophy in Alzheimer's patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center.
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