Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors as a new therapeutic option for ovarian cancer with mutations in the ARID1A gene.
TAMPA, Fla. – Multiple myeloma is a rare incurable disease that is diagnosed in more than 30,000 people each year in the United States. Only half of patients with multiple myeloma are expected to survive five years after their diagnosis. Moffitt Cancer Center researchers are trying to identify patients who are at a higher risk of developing multiple myeloma early in order to improve patient outcomes.
Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death.
New research from Roswell Park Comprehensive Cancer Center and MimiVax LLC, published in Clinical Cancer Research, shows that survivin — one of the most commonly occurring molecules in cancer cells — may be an attractive target for a broad range of immunotherapy approaches, including CAR T.
An organic chemical compound shows effective antiviral activity against Ebola virus and several other viruses, according to a study led by Georgia State University.
University of Wisconsin–Madison researchers Emily Setton and Prashant Sharma show that the common house spider and its arachnid relatives have dispensed with a gene involved in creating segmented heads, instead recycling leg genes to accomplish the task.
Cancer experts debate whether there's a glut of immunotherapy trials.
Optimizing the timing of targeted therapies for melanoma reverses tumor growth, and resistance can be mitigated.
In a news story for the Inside Science News Service this week, staff journalist and editor Jason Socrates Bardi describes a project by California scientists who genetically engineered yeast with basil and mint genes to give beer a hoppy flavor without the need to add the actual flowers. Read the story for free today.
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A team led by LJI researchers reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. This is noteworthy because that chief anti-inflammatory role has been traditionally ascribed to what are called regulatory T cells, or "Tregs", which dampen autoimmune responses. T
A new study has revealed that the human brain's tiniest blood vessels can activate genes known to trigger spinal motor neurons, prompting the neurons to grow during early development. The findings could provide insights into how amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders may develop.
More than a dozen Roswell Park Comprehensive Cancer Center clinicians and researchers have been invited to present new findings at the 71st annual Cancer Symposium of the Society of Surgical Oncology (SSO).
With the ability to leech heavy metals from the environment and digest a potent greenhouse gas, methanotrophic bacteria pull double duty when it comes to cleaning up the environment. But before researchers can explore potential conservation applications, they first must better understand the bacteria's basic physiological processes. Amy C. Rosenzweig's laboratory at Northwestern University has identified two never-before-studied proteins, called MbnB and MbnC, as partially responsible for the bacteria's inner workings.
“This study is a good example of a host/pathogen arms race playing out in real-time—this time with the host a likely winner."
A team of biologists has deciphered how neurons used in the perception of motion form in the brain of a fly —a finding that illustrates how complex neuronal circuits are constructed from simple developmental rules.
Different tissues have shockingly variable sensitivities to genes that drive normal and malignant cell proliferation, study shows. Research unmasks hundreds of cancer-driving genes invisible to gene sequencing. Findings could explain why individual cancer drivers appear in some tumors and not others, could inspire tissue-specific strategies for cancer treatment.
-Scientists identify mechanism behind vascular aging, muscle demise in mice. -Treatment with chemical compounds reversed vascular aging, stimulated blood vessel growth and blood flow, boosted exercise capacity in aging animals. -Findings set the stage for therapies in humans to stave off a range of conditions linked to vascular aging.
Researchers at Houston Methodist used computer modeling to find an existing investigational drug compound for leukemia patients to treat triple negative breast cancer once it spreads to the brain.
The most common gene mutation associated with Parkinson’s alters cells circulating outside the brain, not within, offering a new understanding of what causes the disease.
Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice from scientists at the National Eye Institute (NEI). The cells also re-establish their normal organization and function.
University of Chicago researchers have begun to unravel the role of RNA epigenetics and chromatin structure in regulation of 5-azacytidine (5-AZA), a well-known DNA hypomethylating agent in MDS and AML. The finding may lead to novel strategies, as well as guidance from clinical biomarkers.
Alzheimer's disease is characterized by clumps of two proteins – amyloid beta and tau – in the brain, but the link between the two has never been entirely clear. Now, researchers at Washington University School of Medicine in St. Louis have shown that people with more amyloid in the brain produce more tau, which could lead to new treatments for the disease based on targeting the production of tau.
A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.
This week, a 40-year-old patient was treated at UNC’s Clinical and Translational Research Center (CTRC) with SB-913, an investigational genome editing therapy for individuals with mucopolysaccharidosis type II (MPS II), a rare lysosomal storage disorder also known as Hunter syndrome.
A unique cell surface protein found on triple-negative type breast cancer cells called JAG1 is a promising new therapeutic target for this hard-to-treat and highly metastatic type of breast cancer, according to researchers at the University of Illinois at Chicago.Jan Kitajewski, professor and head of physiology and biophysics at UIC, and his colleagues are working on developing a small drug molecule that can block JAG1.
Scientists from two institutes at the Vienna BioCenter (VBC) have developed a method to identify and characterise microRNAs in individual cells of living animals.
Researchers from Queen’s University Belfast have demonstrated for the first time how molecular analysis of clinical trial biopsy samples can be used to help clinicians identify the key changes that occur in an individual patient’s bowel (colorectal) tumour prior to surgery, so clinicians can better understand and treat the disease.
A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.
New research from scientists at the La Jolla Institute for Allergy and Immunology shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)—more commonly known as “good cholesterol”—counteract this process, helping the protective immune cells maintain their identity and keep arteries clear.
A report that Americans are drinking a lot of coffee might be good news in the battle against colon cancer, scientists with the Simmons Cancer Center at UT Southwestern Medical Center say.
Treating some elderly people with levothyroxine may put them at increased risk of death, new research from Israel reports. The results will be presented on Tuesday, March 20, at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill.
Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease.
Three tumor samples collected over time from a single patient show how cancer evolves in response to treatment.
UT Southwestern Medical Center geneticist Dr. Helen Hobbs is the 2018 recipient of the Harrington Prize for Innovation in Medicine for her discovery of a novel way to reduce cholesterol. Dr. Hobbs, Director of the Eugene McDermott Center for Human Growth and Development, Professor of Internal Medicine and Molecular Genetics, is the fifth recipient of the Harrington Prize and the first woman to be honored.
Researchers have identified a therapeutic target to prevent or delay heart failure from pressure overload of the heart, and a potential biomarker for the same. They say their animal studies carry clinical and translational potential.
The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) is now certified to offer a groundbreaking treatment for non-Hodgkin lymphoma, in which a patient’s own immune cells are genetically engineered to recognize and attack the cancer.
The American Autoimmune Related Diseases Association (AARDA) will host their National Summit on Autoimmune Disease Wednesday, March 21, 2018. The National Summit is open to the public and will take place at Sidley Austin law firm located at 1501 K Street, N.W. #600, Washington, DC 20005. The Summit is 10:00 a.m. – 4:30 p.m., with a special reception to follow 5:00 p.m. – 7:00 p.m.
A research team at the University of Delaware has developed technology to program strands of DNA into switches that turn proteins on and off. This technology could lead to the development of new cancer therapies and other drugs.
An Ohio integrated health system and a national social enterprise have announced a new alliance to mobilize tens of millions of dollars for underinvested communities—starting with a $45 million effort to scale up economic opportunity and improve health outcomes in Toledo and the surrounding region over the next decade.
Researchers have successfully created a novel biomaterial that can be seeded with insulin-producing beta cells. Implantation of the beta cell-seeded biomaterial reversed diabetes in a mouse model by effectively normalizing glucose levels and significantly increasing survival. The research results will be presented Monday, March 19, at ENDO 2018, the annual 100th meeting of the Endocrine Society in Chicago, Ill.
Scientists don’t yet grasp the intricacies of the relationship between sepsis and dementia. Candice Brown, an assistant professor in West Virginia University’s School of Medicine and Rockefeller Neuroscience Institute, is studying that relationship in order to bring about insights that help prevent or mitigate the neurological impact of sepsis.
Eight years in the making, a discovery by neuroscientists in Montreal highlights the value of long-term, fundamental research and provides important information for future drug targets.
Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests. The results of the study will be presented Sunday, March 18, at ENDO 2018, the 100th annual meeting of the Endocrine Society in Chicago, Ill.
Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in Chicago, Ill.
Van Andel Research Institute (VARI) Chief Scientific Officer Peter Jones, Ph.D., D.Sc., will be awarded an honorary doctorate from South Africa’s Stellenbosch University (SU) in recognition of a lifetime of scientific achievement and dedication to improving cancer treatment.
Imagine if doctors could diagnose their patients with lung or esophageal cancer by simply swabbing the inside of their cheeks. Vadim Backman, a biomedical engineer at Northwestern University, has developed a new technology that could make that seemingly simple solution a reality.
Scientists are one step closer to understanding how cells reshape their surfaces to internalize material from their surroundings, thanks to collaboration among researchers from two South Dakota universities and the National Institutes of Health.
Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach — known as SPLiT-seq — reliably tracks gene activity in a tissue down to the level of single cells.
A method currently used by thousands of laboratories across the country to preserve tissue could render samples useless over time for a common test to assess gene activity, a study led by Johns Hopkins researchers suggests. The findings, published in the November 2, 2017 American Journal of Clinical Pathology, could eventually lead to significant changes in how tissues are stored for clinical and research purposes.
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