Children with neurologic or neurodevelopmental disorders (NNDDs) are at increased risk of complications from influenza. Although the Advisory Committee on Immunization Practices has recognized NNDDs as high-risk conditions for influenza complications since 2005, little is known about influenza vaccination practices in this population.
If there is a silver lining to the measles outbreaks, it’s that the risk of getting sick might lessen opposition to vaccines. Moving that pendulum will depend in part on how the public responds to news reports and personal stories about the illness.
Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. The research is reported April 2 in Science Express.
In a new study, researchers report progress toward perfecting a radical new method of producing vaccines using genetically modified corn. The approach could lead to an oral hepatitis B vaccine that requires no refrigeration and costs less than $1 per dose to manufacture.
An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance.
Findings by a Saint Louis University researcher parallel earlier results: Adding a strain of influenza B could improve effectiveness of an influenza vaccine.
Using a specially selected library of different hepatitis C viruses, a team of researchers led by Johns Hopkins scientists has identified tiny differences in the pathogens’ outer shell proteins that underpin their resistance to antibodies. The findings, reported in the January 2015 issue of the Journal of Clinical Investigation, suggest a reason why some patients’ immune systems can’t fend off hepatitis C infections, and they reveal distinct challenges for those trying to craft a successful vaccine to prevent them.
The new vaccine was found to be effective against the two most common forms of herpes that cause cold sores (HSV-1) and genital ulcers (HSV-2). Both are known to infect the body’s nerve cells, where the virus can lay dormant for years before symptoms reappear. The new vaccine is the first to prevent this type of latent infection.
Scientists at Albert Einstein College of Medicine have designed a new type of vaccine that could be the first-ever for preventing genital herpes—one of the most common sexually transmitted diseases, affecting 500 million people worldwide. Using a counterintuitive approach, researchers were able to prevent both infections caused by herpes simplex virus type 2, which causes genital herpes. Findings from the research, conducted in mice, were published today in the online journal eLife.
Researchers at Vanderbilt University, the University of Texas Medical Branch at Galveston and The Scripps Research Institute for the first time have shown how human antibodies can neutralize the Marburg virus, a close cousin to Ebola.
The Georgia Institute of Technology and Micron Biomedical have been awarded $2.5 million in grants from the Bill & Melinda Gates Foundation to advance the development of dissolvable microneedle patches for polio immunization.
A doctor’s recommendation and a patient’s race may influence flu vaccination rates, according to researchers at Henry Ford Hospital in Detroit. Researchers found that 90 percent of patients received vaccination if their physician advocated for it compared to 58 percent of patients whose physician did not.
A pivotal international phase 2/3 clinical trial involving Moffitt Cancer Center faculty demonstrated that vaccination with Gardasil 9 protects against nine HPV types, seven of which cause most cases of cervical, vulvar, and vaginal disease. The trial data indicate that if populations are vaccinated with Gardasil 9 approximately 90 percent of all cervical cancers worldwide can be prevented.
Renowned UAB HPV expert, Warner Huh, says new nine-valent HPV vaccine has the potential to eradicate the majority of cervical cancer.
In a remarkable new advance against the virus that causes AIDS, scientists from The Scripps Research Institute have announced the creation of a novel drug candidate so potent and universally effective, it might work as part of an unconventional vaccine.
Antibodies that protect against H7N9 avian flu, which emerged in China in 2013 and sparked fears of a global pandemic, have been isolated in individuals who received seasonal flu vaccinations and appear to broadly neutralize H7 viruses.
Fatalists trump rational thought: A new study by a political scientist at the University of Arkansas examines perceptions of U.S. citizens about the benefits and risks of immunizations.
NIBIB-funded researchers have developed a novel 3D vaccine that could provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful immune response. The vaccine was recently found to be effective in delaying tumor growth in mice.
Measles are becoming more commonplace, due to lack of vaccination, says Jorge Parada, MD, medical director of infectious disease at Loyola University Health System.
A new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune “memory” to improve, an important step toward the development of more effective, longer-lasting vaccines.
A new study suggests that confidence in government may play a key role in the public’s willingness to get at least some vaccines.
The recent measles outbreak linked to Disney amusement parks in southern California should not be a concern for anyone who has had measles in the past or who has received two doses of the measles vaccine.
Combining insecticide-treated bed nets with vaccines and other control measures may provide the best chance at eliminating malaria, which killed nearly 600,000 people worldwide in 2013, most of them African children.
Rift Valley Fever, a mosquito-borne disease, can devastate a sheep herd causing 90 percent mortality in lambs and 100 percent abortion rates in pregnant ewes. Current vaccines either don’t provide long-term immunity or cause spontaneous abortions in pregnant ewes. Medgene Labs is developing a new vaccine that is proving to be both safe and effective.
The antibody response from an HIV vaccine trial in Thailand was made possible by a genetic trait carried over in humans from an ancient ancestry with monkeys and apes, according to a study led by Duke Medicine researchers.
A study led by investigators at Beth Israel Deaconess Medical Center has found that a vaccine that elicits only CD4 T cells resulted in an overwhelming inflammatory response in a mouse model of infection.
Researchers show that when comparing the potency of an isolated strain-specific flu antibody (the type that current vaccines generate) with an isolated broadly-neutralizing flu antibody (the type generated by universal vaccines) in a lab setting, the latter have much weaker neutralization activity than the strain-specific antibodies.
A team from The Scripps Research Institute has designed a more effective nicotine vaccine and proven that the structures of molecules used in vaccines is critical.
HPV testing alone is an effective alternative to current cervical cancer screening methods that use a Pap smear, or Pap smear-plus HPV test.
Researchers at NYU Langone Medical Center and elsewhere say that a vaccination they have developed to fight a brain-based, wasting syndrome among deer and other animals may hold promise on two additional fronts: Protecting U.S. livestock from contracting the disease, and preventing similar brain infections in humans.
The Food and Drug Administration’s (FDA) approval of a new vaccine that targets five additional strains of human papilloma virus (HPV) fortifies a proven cancer-prevention weapon, according to Ronald A. DePinho, M.D., president of The University of Texas MD Anderson Cancer Center.
The Food and Drug Administration’s approval of a nonavalent vaccine against the human papillomavirus (HPV) represents another important step in the eradication of cervical cancer, according to the Society of Gynecologic Oncology (SGO).
Mathematical models predicted it, and now a University of Florida study confirms it: Immunizing school-aged children from flu can protect other segments of the population, as well.
Joy and goodwill aren’t the only things we start spreading to friends, family, colleagues -- even strangers -- this time of year. Late fall and early winter also signal the start of annual spread of the influenza virus.
A new hybrid vehicle is under development. Its performance isn’t measured by the distance it travels, but rather the delivery of its cargo: vaccines that contain genetically engineered DNA to fight HIV, cancer, influenza and other maladies. Described recently in the Proceedings of the National Academy of Sciences, the technology is a biomedical advancement that could help unleash the potential of DNA vaccines, which despite two decades of research, have yet to make a significant impact in the treatment of major illnesses.
The Baltimore study is the second Ebola vaccine trial being led by the University of Maryland School of Medicine CVD, the first currently taking place in Mali, West Africa. The Mali trial is being performed by CVD-Mali in partnership with the Ministry of Health of Mali.
A nasal vaccine in development by researchers at The University of Texas at Austin has been shown to provide long-term protection for non-human primates against the deadly Ebola virus.
In this national sample of parents of child 0-5 years, most indicate that daycare providers should review children’s immunization status every year to ensure they are up-to-date (52 percent strongly agree, 22 percent agree).
People with rheumatoid arthritis who are currently taking biologic drugs may be safely vaccinated for the viral infection herpes zoster, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Boston.
People age 30 or over with autoimmune, inflammatory diseases like rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease, may benefit from vaccinations for the viral infection herpes zoster, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Scientists have demonstrated for the first time that a single-dose, needleless Ebola vaccine given to primates through their noses and lungs protected them against infection for at least 21 weeks.
Among approximately 26,000 women, receipt of the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine during pregnancy was not associated with increased risk of preterm delivery or small-for-gestational-age birth or with hypertensive disorders of pregnancy, although a small increased risk of being diagnosed with chorioamnionitis (an inflammation of the membranes that surround the fetus) was observed, according to a study in the November 12 issue of JAMA.
A new method of developing vaccines could point the way forward in the fight against infectious diseases for which traditional vaccination has failed, according to a new Rutgers study. The method involves training white blood cells that have not previously been the primary focus of vaccine development. William Gause, senior associate dean for research at Rutgers New Jersey Medical School, led the study, which recently was published in the journal Nature Immunology.
In Tennessee, the introduction in 2010 of a new pneumococcal vaccine for infants and young children coincides with a 27 percent decline in pneumonia hospital admissions across the state among children under age 2.
Researchers develop first genetic strain of mice that can be infected with Ebola and display symptoms similar to those that humans experience. This work will significantly improve basic research on Ebola treatments and vaccines.
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